GREMLIN Database
MAF - Septum formation protein Maf
UniProt: Q02169 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (182)
Sequences: 5651 (4121)
Seq/√Len: 305.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_R131_E2.9751.00
86_Q139_E2.8251.00
100_S125_A2.7711.00
90_A135_W2.7311.00
78_E95_R2.7101.00
76_D99_R2.4811.00
15_K19_D2.3671.00
102_S123_E2.3061.00
88_E91_S2.2961.00
102_S121_K2.2801.00
123_E164_D2.2091.00
47_Q119_Y2.1471.00
32_V52_Q2.0431.00
125_A162_K2.0371.00
125_A161_K2.0211.00
4_P26_S2.0201.00
50_A108_S1.9841.00
90_A138_I1.9281.00
100_S123_E1.8951.00
51_K55_K1.8291.00
122_T170_V1.7891.00
84_Q88_E1.7701.00
116_E184_H1.7641.00
130_S133_E1.7331.00
97_S129_L1.6201.00
86_Q138_I1.6091.00
104_I121_K1.5921.00
15_K25_Y1.5901.00
108_S117_T1.5861.00
120_D169_S1.5751.00
138_I144_M1.5741.00
55_K115_S1.5461.00
122_T169_S1.5371.00
75_L99_R1.5201.00
156_G159_F1.5021.00
173_L178_T1.5001.00
54_A68_G1.4951.00
120_D177_K1.4841.00
116_E181_A1.4681.00
129_L134_I1.4641.00
10_Q29_V1.4571.00
51_K117_T1.4501.00
90_A94_R1.4491.00
86_Q90_A1.4431.00
118_F177_K1.4401.00
86_Q144_M1.4221.00
28_I60_L1.4061.00
92_M149_A1.3761.00
90_A134_I1.3731.00
16_E20_L1.3731.00
19_D25_Y1.3701.00
5_L67_I1.3691.00
118_F181_A1.3591.00
142_E154_G1.3581.00
40_F48_W1.3501.00
30_S57_V1.3461.00
167_Y171_M1.3211.00
104_I119_Y1.3201.00
107_V118_F1.3141.00
51_K115_S1.2811.00
158_L179_M1.2671.00
74_C104_I1.2661.00
97_S128_S1.2641.00
127_W176_S1.2581.00
54_A110_Q1.2571.00
41_S44_E1.2431.00
47_Q117_T1.2401.00
131_E135_W1.2301.00
97_S131_E1.2091.00
127_W180_R1.2051.00
8_A68_G1.1981.00
86_Q135_W1.1961.00
91_S95_R1.1881.00
127_W133_E1.1831.00
101_H150_Y1.1771.00
45_N72_M1.1661.00
48_W52_Q1.1651.00
75_L95_R1.1481.00
85_D88_E1.1361.00
109_I181_A1.1351.00
80_L92_M1.1341.00
138_I143_P1.1211.00
15_K27_I1.1141.00
89_A149_A1.1071.00
107_V178_T1.1061.00
13_R145_D1.1061.00
67_I178_T1.0981.00
127_W161_K1.0971.00
4_P64_A1.0851.00
56_A60_L1.0781.00
90_A131_E1.0681.00
132_E136_T1.0631.00
133_E183_R1.0601.00
51_K108_S1.0481.00
146_K151_G1.0241.00
152_I171_M1.0101.00
10_Q30_S1.0061.00
135_W139_E1.0051.00
116_E185_F1.0011.00
16_E19_D0.9971.00
89_A143_P0.9941.00
20_L157_A0.9941.00
122_T163_I0.9881.00
31_E56_A0.9881.00
126_F156_G0.9681.00
45_N79_C0.9681.00
67_I109_I0.9661.00
111_A185_F0.9641.00
45_N49_L0.9641.00
74_C77_G0.9601.00
36_L45_N0.9551.00
6_I64_A0.9501.00
163_I170_V0.9421.00
37_N40_F0.9331.00
141_K144_M0.9321.00
94_R134_I0.9301.00
72_M79_C0.9271.00
69_A105_T0.9231.00
80_L95_R0.9231.00
110_Q115_S0.9171.00
28_I61_H0.9141.00
61_H64_A0.9101.00
37_N52_Q0.8981.00
28_I57_V0.8921.00
88_E92_M0.8901.00
177_K181_A0.8871.00
46_V106_A0.8861.00
32_V49_L0.8811.00
58_A110_Q0.8811.00
179_M183_R0.8741.00
6_I28_I0.8741.00
32_V56_A0.8721.00
140_T155_R0.8651.00
52_Q55_K0.8641.00
93_L149_A0.8641.00
125_A164_D0.8561.00
46_V104_I0.8461.00
19_D24_P0.8391.00
74_C102_S0.8321.00
6_I57_V0.8301.00
37_N48_W0.8291.00
65_I109_I0.8281.00
89_A138_I0.8221.00
108_S115_S0.8121.00
107_V174_P0.8071.00
136_T139_E0.8061.00
78_E91_S0.8061.00
43_E47_Q0.8031.00
47_Q51_K0.8031.00
114_H185_F0.7981.00
57_V66_V0.7941.00
142_E155_R0.7921.00
55_K110_Q0.7901.00
44_E47_Q0.7891.00
107_V181_A0.7840.99
96_L101_H0.7810.99
96_L150_Y0.7790.99
67_I173_L0.7780.99
21_L179_M0.7740.99
168_Y175_I0.7720.99
109_I178_T0.7710.99
17_L173_L0.7690.99
42_P79_C0.7640.99
36_L79_C0.7600.99
87_E91_S0.7590.99
17_L175_I0.7560.99
181_A184_H0.7490.99
22_Q140_T0.7460.99
54_A108_S0.7330.99
13_R153_Q0.7320.99
129_L159_F0.7240.99
106_A119_Y0.7190.99
106_A169_S0.7190.99
43_E121_K0.7150.99
118_F180_R0.7140.99
68_G110_Q0.7080.99
75_L96_L0.7070.99
13_R16_E0.7060.99
30_S56_A0.6990.99
76_D95_R0.6970.99
74_C79_C0.6970.99
118_F184_H0.6940.99
168_Y171_M0.6930.99
166_D176_S0.6920.99
57_V68_G0.6910.99
81_G147_A0.6890.99
18_L25_Y0.6840.99
75_L80_L0.6800.99
46_V72_M0.6790.99
73_V103_V0.6750.98
71_T103_V0.6730.98
73_V80_L0.6730.98
111_A114_H0.6710.98
45_N48_W0.6660.98
18_L67_I0.6610.98
166_D169_S0.6590.98
43_E119_Y0.6540.98
28_I64_A0.6540.98
150_Y160_V0.6500.98
98_G128_S0.6480.98
49_L52_Q0.6400.98
161_K180_R0.6390.98
86_Q141_K0.6390.98
49_L68_G0.6350.98
5_L23_L0.6340.98
66_V110_Q0.6280.98
17_L171_M0.6230.97
178_T181_A0.6220.97
134_I138_I0.6210.97
42_P46_V0.6190.97
65_I111_A0.6180.97
141_K154_G0.6180.97
17_L168_Y0.6180.97
17_L20_L0.6170.97
68_G108_S0.6170.97
163_I167_Y0.6160.97
85_D91_S0.6150.97
13_R146_K0.6150.97
48_W51_K0.6140.97
55_K59_D0.6130.97
89_A93_L0.6110.97
35_K38_R0.6100.97
146_K153_Q0.6100.97
81_G92_M0.6100.97
69_A169_S0.6050.97
52_Q56_A0.5940.97
26_S64_A0.5930.97
122_T165_G0.5890.96
136_T140_T0.5890.96
36_L40_F0.5860.96
27_I57_V0.5860.96
23_L179_M0.5860.96
21_L175_I0.5850.96
132_E135_W0.5830.96
105_T174_P0.5730.96
10_Q32_V0.5720.96
72_M81_G0.5670.96
41_S45_N0.5670.96
10_Q27_I0.5640.95
97_S134_I0.5630.95
45_N81_G0.5610.95
155_R158_L0.5610.95
152_I167_Y0.5590.95
91_S94_R0.5590.95
87_E90_A0.5530.95
181_A185_F0.5520.95
43_E102_S0.5510.95
157_A175_I0.5510.95
124_V160_V0.5480.95
109_I185_F0.5450.95
84_Q145_D0.5450.95
65_I182_L0.5400.94
4_P61_H0.5400.94
135_W138_I0.5360.94
13_R171_M0.5350.94
69_A173_L0.5310.94
38_R81_G0.5310.94
10_Q31_E0.5300.94
42_P74_C0.5300.94
50_A68_G0.5270.94
176_S180_R0.5270.94
58_A66_V0.5270.94
168_Y176_S0.5260.93
5_L65_I0.5220.93
140_T143_P0.5220.93
65_I185_F0.5210.93
67_I107_V0.5160.93
36_L39_N0.5120.93
71_T153_Q0.5080.92
157_A160_V0.5060.92
43_E104_I0.5050.92
18_L21_L0.5000.92
33_E37_N0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ex2A 2 0.9788 100 0.007 Contact Map
4p0eA 2 0.9894 100 0.027 Contact Map
4jhcA 2 0.9894 100 0.027 Contact Map
4oo0A 2 1 100 0.035 Contact Map
2p5xA 1 0.9894 100 0.04 Contact Map
2amhA 1 0.9577 100 0.051 Contact Map
4bnqA 2 0.8995 99.8 0.698 Contact Map
3tquA 2 0.8836 99.5 0.76 Contact Map
1v7rA 1 0.7778 97 0.883 Contact Map
1k7kA 1 0.8836 96.6 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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