GREMLIN Database
FLHF - Flagellar biosynthesis protein FlhF
UniProt: Q01960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (284)
Sequences: 6652 (3208)
Seq/√Len: 190.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_A234_L6.3321.00
131_N333_A3.5571.00
208_A253_Y3.3871.00
199_S255_H3.3851.00
303_V307_S3.1261.00
272_D275_K3.0751.00
180_L192_L3.0071.00
210_I246_A2.9761.00
135_K158_I2.8741.00
206_K253_Y2.8651.00
156_Q362_R2.8401.00
158_I161_D2.8341.00
224_K236_V2.7761.00
275_K308_S2.6811.00
224_K228_E2.6341.00
109_P137_L2.4231.00
221_E224_K2.3551.00
209_F227_A2.3511.00
243_F258_V2.3001.00
287_F315_I2.2971.00
197_A202_E2.2881.00
237_C245_Q2.1971.00
356_S359_G2.1851.00
198_I203_K2.1801.00
345_G351_D2.1591.00
304_K307_S2.1591.00
200_M231_Q2.1541.00
285_Q340_G2.1221.00
303_V334_E2.0961.00
230_L348_V2.0821.00
306_F337_I2.0751.00
192_L257_F2.0521.00
278_I310_P1.9661.00
139_F158_I1.9571.00
191_T315_I1.8921.00
210_I256_V1.8831.00
265_F297_E1.8811.00
212_T243_F1.8511.00
233_P253_Y1.8341.00
147_T150_N1.7731.00
302_I335_S1.7681.00
160_C358_L1.7251.00
208_A233_P1.7011.00
316_F328_V1.6971.00
287_F313_Q1.6931.00
268_P272_D1.6721.00
285_Q312_N1.6691.00
171_E176_K1.6591.00
198_I341_F1.6581.00
225_T228_E1.6581.00
311_V337_I1.6561.00
200_M232_A1.6201.00
180_L257_F1.6111.00
135_K161_D1.6011.00
139_F157_E1.5861.00
131_N135_K1.5641.00
198_I354_T1.5621.00
171_E174_H1.5581.00
196_A209_F1.5371.00
193_A226_Y1.5241.00
272_D276_E1.5161.00
177_Y247_K1.5141.00
287_F340_G1.5001.00
124_I329_F1.4621.00
292_A316_F1.4541.00
197_A350_E1.4531.00
159_L329_F1.4041.00
160_C361_V1.3971.00
192_L209_F1.3961.00
353_Q359_G1.3781.00
197_A348_V1.3761.00
159_L361_V1.3751.00
209_F223_L1.3741.00
224_K234_L1.3701.00
86_R91_Q1.3671.00
178_I255_H1.3591.00
205_K254_D1.3441.00
180_L195_L1.3401.00
247_K256_V1.3261.00
193_A230_L1.3151.00
196_A232_A1.3081.00
313_Q340_G1.3021.00
120_Q129_K1.3021.00
242_E276_E1.2911.00
179_V258_V1.2881.00
156_Q160_C1.2711.00
205_K255_H1.2601.00
176_K284_I1.2591.00
319_I342_M1.2521.00
238_Y241_E1.2471.00
235_E245_Q1.2451.00
306_F311_V1.2351.00
246_A256_V1.2321.00
191_T343_T1.2321.00
209_F257_F1.2301.00
92_I96_Q1.2221.00
208_A256_V1.2211.00
127_S334_E1.2191.00
245_Q248_E1.2191.00
129_K133_L1.2161.00
226_Y348_V1.2151.00
275_K279_P1.2141.00
344_N353_Q1.2121.00
237_C241_E1.2091.00
347_N350_E1.2081.00
177_Y258_V1.1931.00
80_S84_E1.1741.00
153_G157_E1.1731.00
300_K304_K1.1671.00
290_L316_F1.1591.00
180_L315_I1.1591.00
300_K303_V1.1561.00
220_V236_V1.1431.00
191_T352_I1.1311.00
258_V281_E1.1221.00
186_A192_L1.1211.00
294_A298_D1.1191.00
221_E239_T1.1071.00
130_T134_K1.1051.00
244_Q248_E1.0961.00
207_I253_Y1.0871.00
197_A200_M1.0741.00
177_Y256_V1.0691.00
295_K298_D1.0691.00
341_F354_T1.0681.00
172_P176_K1.0661.00
139_F161_D1.0591.00
197_A230_L1.0501.00
161_D165_S1.0371.00
90_P93_P1.0371.00
178_I257_F1.0341.00
265_F300_K1.0291.00
173_I176_K1.0171.00
193_A348_V1.0161.00
239_T242_E1.0151.00
181_F286_S1.0131.00
278_I286_S0.9830.99
167_D356_S0.9810.99
86_R90_P0.9800.99
95_Q99_G0.9790.99
314_Y331_I0.9790.99
211_T220_V0.9780.99
319_I360_F0.9750.99
88_Y92_I0.9740.99
132_T136_L0.9630.99
299_M330_N0.9630.99
220_V237_C0.9580.99
87_T90_P0.9550.99
131_N134_K0.9530.99
134_K138_R0.9490.99
128_T333_A0.9440.99
212_T258_V0.9420.99
238_Y242_E0.9310.99
142_E145_G0.9300.99
210_I258_V0.9290.99
306_F310_P0.9270.99
228_E231_Q0.9170.99
170_Q173_I0.9150.99
131_N162_M0.9150.99
357_P361_V0.9150.99
186_A294_A0.9110.99
199_S257_F0.9110.99
134_K137_L0.9100.99
210_I243_F0.9100.99
164_P357_P0.9060.99
114_K117_K0.9000.99
156_Q365_C0.8970.99
116_E129_K0.8930.99
139_F143_A0.8840.99
209_F234_L0.8840.99
123_G297_E0.8810.99
263_R273_E0.8790.99
179_V286_S0.8770.99
198_I202_E0.8740.99
200_M230_L0.8740.99
290_L331_I0.8740.99
343_T352_I0.8730.99
237_C242_E0.8710.99
243_F281_E0.8650.99
276_E279_P0.8600.98
176_K285_Q0.8600.98
170_Q176_K0.8450.98
288_L314_Y0.8420.98
167_D354_T0.8400.98
180_L191_T0.8380.98
358_L362_R0.8370.98
208_A251_S0.8360.98
85_E88_Y0.8310.98
135_K138_R0.8300.98
83_I87_T0.8230.98
275_K307_S0.8180.98
177_Y284_I0.8140.98
207_I233_P0.8120.98
119_L124_I0.8100.98
286_S309_V0.8090.98
328_V339_V0.8090.98
109_P113_R0.8060.98
159_L365_C0.8050.98
93_P97_E0.8030.98
227_A230_L0.8010.98
269_Q272_D0.7980.98
154_K158_I0.7970.98
299_M334_E0.7970.98
130_T133_L0.7940.97
100_D107_V0.7910.97
96_Q100_D0.7880.97
81_P84_E0.7830.97
179_V277_T0.7820.97
107_V151_V0.7820.97
304_K308_S0.7810.97
81_P85_E0.7810.97
118_L121_E0.7790.97
138_R142_E0.7770.97
170_Q174_H0.7750.97
139_F154_K0.7720.97
166_A169_W0.7710.97
135_K333_A0.7700.97
226_Y230_L0.7680.97
224_K227_A0.7670.97
265_F301_H0.7650.97
160_C357_P0.7630.97
94_A97_E0.7620.97
117_K121_E0.7620.97
164_P358_L0.7600.97
136_L158_I0.7590.97
160_C362_R0.7590.97
298_D322_T0.7540.97
112_L137_L0.7540.97
285_Q313_Q0.7520.96
344_N352_I0.7510.96
124_I132_T0.7490.96
210_I235_E0.7490.96
235_E249_L0.7460.96
158_I162_M0.7440.96
209_F230_L0.7410.96
96_Q110_E0.7410.96
197_A352_I0.7400.96
226_Y229_L0.7380.96
306_F309_V0.7340.96
249_L252_E0.7300.96
332_L336_K0.7210.96
184_T346_Q0.7200.96
290_L298_D0.7190.95
278_I309_V0.7170.95
292_A319_I0.7150.95
220_V224_K0.7130.95
286_S312_N0.7120.95
243_F247_K0.7120.95
112_L151_V0.7100.95
125_K330_N0.7060.95
112_L133_L0.7060.95
95_Q98_L0.7060.95
160_C164_P0.7040.95
199_S203_K0.7030.95
218_A261_A0.7030.95
146_L150_N0.7020.95
227_A233_P0.7010.95
211_T237_C0.7010.95
233_P251_S0.7000.95
272_D279_P0.6970.95
179_V278_I0.6950.95
277_T281_E0.6930.94
183_S266_K0.6930.94
111_P148_E0.6920.94
299_M335_S0.6920.94
157_E161_D0.6910.94
170_Q255_H0.6880.94
321_E346_Q0.6880.94
107_V110_E0.6860.94
108_L111_P0.6860.94
112_L140_S0.6830.94
180_L287_F0.6810.94
265_F304_K0.6810.94
181_F232_A0.6810.94
157_E160_C0.6760.94
139_F144_G0.6750.94
143_A150_N0.6720.94
213_D222_Q0.6720.94
95_Q100_D0.6720.94
220_V239_T0.6690.93
244_Q280_F0.6670.93
218_A265_F0.6640.93
206_K252_E0.6620.93
133_L137_L0.6600.93
276_E280_F0.6580.93
297_E300_K0.6570.93
174_H249_L0.6570.93
333_A336_K0.6540.93
140_S154_K0.6530.93
232_A240_K0.6520.92
211_T236_V0.6520.92
165_S357_P0.6510.92
149_E152_V0.6510.92
257_F352_I0.6460.92
298_D327_S0.6450.92
127_S130_T0.6420.92
140_S151_V0.6420.92
217_I226_Y0.6410.92
235_E251_S0.6400.92
103_A142_E0.6380.92
199_S204_H0.6370.92
116_E133_L0.6340.91
216_R222_Q0.6330.91
243_F277_T0.6300.91
97_E102_S0.6300.91
286_S311_V0.6280.91
310_P337_I0.6280.91
206_K254_D0.6270.91
230_L233_P0.6270.91
295_K322_T0.6270.91
152_V156_Q0.6260.91
113_R117_K0.6250.91
237_C251_S0.6220.91
212_T277_T0.6210.91
270_Y274_L0.6180.90
227_A236_V0.6140.90
206_K233_P0.6140.90
97_E101_F0.6130.90
207_I257_F0.6120.90
195_L199_S0.6120.90
196_A230_L0.6110.90
299_M327_S0.6110.90
108_L112_L0.6100.90
166_A332_L0.6080.90
183_S186_A0.6070.90
202_E350_E0.6050.89
83_I363_M0.6050.89
263_R271_I0.6020.89
209_F232_A0.6020.89
315_I341_F0.6000.89
86_R344_N0.5970.89
211_T234_L0.5960.89
208_A250_F0.5940.89
88_Y91_Q0.5940.89
132_T158_I0.5930.88
87_T91_Q0.5910.88
181_F309_V0.5910.88
83_I344_N0.5880.88
106_S109_P0.5870.88
243_F246_A0.5870.88
303_V331_I0.5860.88
184_T215_Y0.5860.88
267_D270_Y0.5840.88
179_V329_F0.5780.87
97_E118_L0.5760.87
342_M355_V0.5760.87
192_L294_A0.5730.87
286_S310_P0.5730.87
184_T264_N0.5720.87
275_K309_V0.5710.87
236_V239_T0.5700.86
226_Y346_Q0.5700.86
192_L212_T0.5690.86
220_V238_Y0.5690.86
123_G295_K0.5690.86
207_I254_D0.5680.86
196_A348_V0.5660.86
127_S333_A0.5640.86
199_S205_K0.5630.86
237_C240_K0.5620.86
355_V360_F0.5620.86
181_F311_V0.5610.86
99_G104_Y0.5610.86
297_E301_H0.5600.86
328_V363_M0.5600.86
267_D307_S0.5600.86
245_Q251_S0.5590.85
281_E284_I0.5590.85
118_L152_V0.5580.85
317_T321_E0.5570.85
229_L351_D0.5560.85
171_E175_S0.5530.85
88_Y93_P0.5510.85
327_S330_N0.5500.85
83_I90_P0.5470.84
140_S148_E0.5460.84
182_G185_G0.5450.84
300_K334_E0.5450.84
186_A267_D0.5450.84
258_V284_I0.5440.84
220_V242_E0.5420.84
107_V112_L0.5410.84
83_I86_R0.5410.84
103_A141_V0.5380.83
197_A229_L0.5380.83
186_A292_A0.5380.83
178_I341_F0.5370.83
175_S256_V0.5360.83
175_S254_D0.5350.83
219_A222_Q0.5350.83
200_M206_K0.5350.83
187_G259_D0.5310.82
89_P92_I0.5300.82
348_V351_D0.5290.82
143_A154_K0.5290.82
265_F271_I0.5290.82
332_L340_G0.5280.82
130_T135_K0.5260.82
129_K132_T0.5260.82
108_L141_V0.5250.82
298_D302_I0.5240.82
295_K324_S0.5240.82
143_A147_T0.5200.81
247_K280_F0.5180.81
82_K86_R0.5160.81
164_P167_D0.5160.81
295_K325_L0.5150.80
86_R93_P0.5140.80
243_F256_V0.5130.80
103_A112_L0.5130.80
268_P308_S0.5100.80
220_V318_K0.5100.80
112_L136_L0.5090.80
120_Q126_E0.5090.80
84_E88_Y0.5090.80
183_S321_E0.5080.80
222_Q262_G0.5070.79
313_Q338_G0.5070.79
163_L360_F0.5070.79
80_S83_I0.5060.79
119_L129_K0.5050.79
141_V144_G0.5030.79
261_A289_V0.5010.79
124_I326_G0.5010.79
221_E238_Y0.5000.79
101_F118_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2px0A 4 0.7049 100 0.487 Contact Map
1vmaA 1 0.7678 100 0.531 Contact Map
2yhsA 1 0.8005 100 0.546 Contact Map
2og2A 1 0.7814 100 0.553 Contact Map
2v3cC 1 0.7705 100 0.563 Contact Map
4c7oA 1 0.7732 100 0.563 Contact Map
3b9qA 1 0.7623 100 0.566 Contact Map
1ls1A 1 0.7568 100 0.577 Contact Map
2j37W 1 0.7514 100 0.588 Contact Map
1zu4A 1 0.7678 100 0.589 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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