GREMLIN Database
JAG - Protein jag
UniProt: Q01620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (199)
Sequences: 1159 (909)
Seq/√Len: 64.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_G54_L5.5441.00
32_T53_K4.2621.00
153_L204_I4.0931.00
192_Y205_S3.3871.00
24_L56_E3.3771.00
143_K147_S3.1491.00
19_L29_V2.8801.00
6_A21_E2.8471.00
165_Q201_H2.4051.00
16_Q20_Q2.3891.00
71_I113_L2.3881.00
82_T95_T2.3421.00
30_E57_K2.3201.00
16_Q26_K2.3121.00
111_N170_P2.2901.00
181_L191_T2.2741.00
34_I51_I2.2301.00
5_T51_I2.1881.00
15_V31_I2.1551.00
24_L29_V2.1211.00
64_A92_Y2.1041.00
157_V160_T2.0841.00
11_V50_A2.0761.00
79_S94_I2.0681.00
161_K206_H2.0561.00
66_L70_T2.0021.00
96_G99_A1.9831.00
181_L189_I1.9671.00
81_V92_Y1.9251.00
140_L144_E1.8801.00
157_V206_H1.8501.00
8_G17_S1.8341.00
105_K108_Q1.8311.00
65_K69_Q1.8251.00
114_E172_S1.8221.00
113_L133_V1.7951.00
64_A117_T1.7561.00
5_T53_K1.7220.99
11_V37_G1.7060.99
15_V52_V1.6130.99
24_L28_K1.6120.99
29_V54_L1.6050.99
25_T28_K1.5970.99
144_E147_S1.5500.99
151_I180_T1.5440.99
67_Y120_A1.4860.98
17_S21_E1.4790.98
35_E51_I1.4590.98
29_V52_V1.4530.98
153_L157_V1.4360.98
78_K97_E1.4160.98
147_S180_T1.4130.98
7_A51_I1.3800.97
65_K83_V1.3750.97
70_T74_A1.3710.97
30_E55_V1.3360.97
6_A52_V1.3240.97
121_L131_V1.3190.97
6_A17_S1.3150.97
200_R203_V1.3110.96
32_T55_V1.2980.96
146_L177_I1.2730.96
15_V26_K1.2340.95
35_E48_K1.2050.94
165_Q194_M1.2030.94
13_E16_Q1.1980.94
64_A119_L1.1820.94
103_I138_Y1.1750.94
4_V21_E1.1420.93
198_E201_H1.1370.92
6_A22_L1.1300.92
106_R142_R1.1230.92
82_T93_H1.1030.91
85_E129_K1.0990.91
108_Q175_K1.0910.91
69_Q73_E1.0860.91
37_G50_A1.0810.90
40_G48_K1.0670.90
59_D63_Q1.0630.90
183_G191_T1.0620.90
197_G201_H1.0570.89
150_A177_I1.0540.89
59_D62_Q1.0530.89
188_Q206_H1.0360.88
10_N14_A1.0130.87
13_E17_S1.0070.87
104_G138_Y1.0070.87
171_S175_K1.0000.87
31_I52_V0.9910.86
158_L189_I0.9890.86
15_V18_G0.9850.86
96_G136_E0.9840.86
142_R145_T0.9830.86
145_T177_I0.9610.84
106_R167_E0.9580.84
65_K92_Y0.9460.83
189_I202_L0.9420.83
53_K180_T0.9390.83
62_Q66_L0.9330.82
69_Q80_D0.9320.82
169_M200_R0.9280.82
181_L188_Q0.9250.82
12_D26_K0.9240.82
17_S20_Q0.9200.82
154_A180_T0.9120.81
26_K31_I0.9050.81
11_V15_V0.9040.80
178_H193_S0.9030.80
174_R178_H0.8890.79
197_G200_R0.8820.79
163_S205_S0.8810.79
150_A181_L0.8800.79
100_A145_T0.8790.79
111_N171_S0.8630.77
63_Q66_L0.8630.77
142_R167_E0.8610.77
43_G48_K0.8500.76
149_L167_E0.8490.76
9_R13_E0.8430.76
144_E148_Q0.8410.75
103_I109_T0.8370.75
31_I54_L0.8350.75
190_K205_S0.8340.75
64_A120_A0.8290.74
149_L153_L0.8240.74
10_N13_E0.8210.74
67_Y117_T0.8210.74
63_Q124_Y0.8180.73
19_L31_I0.8170.73
43_G50_A0.8080.72
114_E139_R0.8050.72
134_D140_L0.8050.72
19_L26_K0.8020.72
163_S206_H0.8000.72
137_N140_L0.7920.71
99_A135_A0.7890.71
40_G46_G0.7880.71
69_Q92_Y0.7870.70
90_V176_I0.7780.70
64_A83_V0.7760.69
80_D95_T0.7730.69
37_G40_G0.7690.69
174_R193_S0.7660.68
118_Q182_S0.7590.68
120_A137_N0.7570.67
4_V29_V0.7560.67
104_G107_G0.7530.67
112_A128_Y0.7520.67
39_K46_G0.7490.67
153_L164_I0.7450.66
179_D182_S0.7430.66
95_T136_E0.7410.66
154_A189_I0.7410.66
111_N114_E0.7410.66
72_A76_A0.7400.66
99_A202_L0.7370.65
106_R145_T0.7330.65
34_I53_K0.7320.65
166_L177_I0.7300.65
189_I206_H0.7260.64
98_K101_L0.7260.64
15_V19_L0.7220.64
7_A49_P0.7150.63
81_V133_V0.7150.63
65_K82_T0.7150.63
149_L177_I0.7140.63
170_P175_K0.7090.62
61_I65_K0.7080.62
58_I61_I0.7060.62
134_D137_N0.7030.62
153_L166_L0.7020.62
43_G46_G0.7020.62
18_G22_L0.6960.61
28_K59_D0.6950.61
24_L88_K0.6930.61
119_L167_E0.6920.61
64_A90_V0.6920.61
63_Q121_L0.6920.61
72_A102_L0.6860.60
66_L86_S0.6790.59
166_L169_M0.6750.59
110_L156_Q0.6720.58
147_S151_I0.6710.58
163_S196_E0.6710.58
40_G43_G0.6670.58
83_V90_V0.6620.57
70_T73_E0.6610.57
100_A138_Y0.6600.57
194_M201_H0.6590.57
84_Q91_R0.6570.57
18_G52_V0.6560.56
111_N175_K0.6560.56
15_V54_L0.6540.56
36_E64_A0.6510.56
142_R173_E0.6470.55
19_L54_L0.6470.55
121_L124_Y0.6450.55
65_K90_V0.6440.55
67_Y71_I0.6440.55
120_A123_R0.6420.55
148_Q152_K0.6410.55
143_K176_I0.6410.55
175_K179_D0.6390.54
115_T119_L0.6370.54
157_V164_I0.6370.54
111_N139_R0.6350.54
66_L83_V0.6340.54
18_G29_V0.6270.53
17_S97_E0.6260.53
21_E85_E0.6260.53
81_V135_A0.6220.53
27_D83_V0.6200.52
192_Y203_V0.6200.52
163_S194_M0.6160.52
102_L153_L0.6160.52
94_I133_V0.6150.52
180_T189_I0.6150.52
43_G47_K0.6140.52
136_E141_K0.6120.51
159_K162_K0.6120.51
149_L169_M0.6110.51
72_A79_S0.6100.51
67_Y191_T0.6100.51
67_Y116_L0.6080.51
106_R149_L0.6060.51
74_A166_L0.6030.50
86_S154_A0.6010.50
158_L175_K0.5970.50
171_S206_H0.5950.49
102_L135_A0.5930.49
135_A175_K0.5900.49
122_N125_P0.5890.49
154_A181_L0.5870.48
38_N47_K0.5870.48
156_Q167_E0.5850.48
67_Y182_S0.5840.48
86_S89_T0.5820.48
67_Y170_P0.5780.47
73_E78_K0.5780.47
59_D85_E0.5750.47
12_D16_Q0.5740.47
119_L139_R0.5720.47
183_G187_H0.5710.47
5_T32_T0.5700.46
83_V92_Y0.5700.46
71_I76_A0.5700.46
17_S66_L0.5680.46
41_F59_D0.5670.46
109_T169_M0.5650.46
145_T167_E0.5630.46
100_A103_I0.5620.46
42_L169_M0.5610.45
158_L188_Q0.5610.45
114_E132_T0.5600.45
106_R128_Y0.5600.45
117_T120_A0.5590.45
72_A98_K0.5570.45
49_P119_L0.5560.45
58_I63_Q0.5560.45
68_L120_A0.5550.45
41_F44_I0.5520.44
164_I191_T0.5520.44
12_D47_K0.5510.44
59_D176_I0.5490.44
18_G87_K0.5480.44
6_A29_V0.5470.44
43_G105_K0.5450.44
14_A18_G0.5450.44
175_K199_N0.5420.43
40_G47_K0.5400.43
160_T164_I0.5400.43
63_Q144_E0.5360.43
84_Q133_V0.5340.42
118_Q121_L0.5330.42
21_E66_L0.5320.42
110_L171_S0.5320.42
99_A102_L0.5300.42
105_K160_T0.5300.42
34_I39_K0.5280.42
33_V43_G0.5270.42
86_S91_R0.5240.41
22_L54_L0.5220.41
17_S53_K0.5170.40
69_Q94_I0.5160.40
141_K194_M0.5150.40
68_L72_A0.5140.40
16_Q187_H0.5120.40
40_G50_A0.5120.40
178_H191_T0.5120.40
165_Q172_S0.5110.40
103_I107_G0.5090.40
30_E170_P0.5070.39
103_I131_V0.5040.39
52_V74_A0.5020.39
121_L167_E0.5010.39
115_T118_Q0.5010.39
92_Y133_V0.5010.39
81_V94_I0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gkuA 2 0.976 100 0.084 Contact Map
2pt7G 2 0.6683 100 0.438 Contact Map
2cpmA 1 0.3462 99.7 0.741 Contact Map
1mszA 1 0.2933 99.3 0.797 Contact Map
1whrA 1 0.4327 97 0.893 Contact Map
1wh9A 1 0.4423 91.6 0.921 Contact Map
4qmfD 1 0.7115 86.5 0.929 Contact Map
3zeyX 1 0.7019 85.8 0.929 Contact Map
4ujpE 1 0.7115 85.7 0.93 Contact Map
3j20C 1 0.6923 82 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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