GREMLIN Database
MRED - Rod shape-determining protein MreD
UniProt: Q01467 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (162)
Sequences: 442 (375)
Seq/√Len: 29.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_R115_E5.8021.00
81_G117_Y4.3071.00
63_F66_L3.0421.00
44_L86_C2.8841.00
43_V158_F2.7451.00
46_F69_M2.4250.99
58_I62_I2.3900.99
22_D121_I2.3730.99
5_L45_I2.2490.99
59_Y119_F2.1700.98
60_G86_C2.1180.98
39_F154_L2.0710.97
115_E135_F2.0070.97
116_F132_F1.9180.96
101_F128_D1.8940.96
109_L133_N1.8730.95
39_F150_A1.8570.95
9_V115_E1.8310.95
6_L47_M1.8180.95
73_S158_F1.7700.94
8_F124_L1.7500.93
35_L146_L1.6800.92
18_S71_Y1.6580.91
72_T75_L1.6470.91
37_P139_R1.6430.91
36_A43_V1.5960.90
70_N164_S1.5870.89
67_Y82_F1.5640.89
44_L82_F1.5520.88
100_A155_V1.5160.87
68_D76_G1.5140.87
65_F75_L1.5080.87
36_A146_L1.4990.86
113_L148_I1.4930.86
42_L89_A1.4920.86
146_L150_A1.4900.86
116_F148_I1.4700.85
28_F126_H1.4300.84
78_Y114_L1.4160.83
59_Y72_T1.4090.83
27_P152_L1.3910.82
140_F147_N1.3570.80
21_T158_F1.3570.80
143_T147_N1.3390.79
25_H82_F1.3230.79
88_L91_K1.3150.78
84_G127_K1.2740.76
7_P72_T1.2730.76
41_M66_L1.2590.75
16_A28_F1.2540.75
150_A154_L1.2510.75
17_E70_N1.2440.74
45_I110_A1.2410.74
75_L136_V1.2350.74
42_L109_L1.2310.73
46_F136_V1.2280.73
66_L71_Y1.2040.72
61_F160_L1.1980.71
21_T42_L1.1840.70
74_L156_L1.1810.70
42_L150_A1.1680.69
102_V162_F1.1630.69
60_G151_A1.1600.69
29_V149_A1.1570.69
60_G66_L1.1560.69
105_L108_V1.1550.68
114_L162_F1.1540.68
89_A110_A1.1370.67
107_A130_M1.1120.65
70_N81_G1.1110.65
18_S26_F1.0950.64
67_Y72_T1.0890.64
42_L152_L1.0850.64
20_F108_V1.0820.63
20_F39_F1.0800.63
12_L153_I1.0590.62
21_T37_P1.0500.61
12_L148_I1.0450.61
60_G112_C1.0430.60
93_F111_V1.0390.60
18_S21_T1.0320.60
115_E139_R1.0240.59
4_F38_R1.0200.59
47_M162_F1.0170.58
6_L43_V1.0020.57
111_V147_N0.9980.57
61_F75_L0.9940.57
85_L154_L0.9870.56
112_C140_F0.9740.55
82_F137_L0.9690.55
104_I151_A0.9650.54
41_M96_L0.9650.54
143_T162_F0.9560.54
46_F146_L0.9520.53
17_E69_M0.9480.53
120_G152_L0.9450.53
37_P78_Y0.9400.52
75_L121_I0.9370.52
131_T138_D0.9370.52
104_I127_K0.9330.52
52_N111_V0.9320.52
39_F97_H0.9200.51
113_L134_G0.9180.51
9_V16_A0.9110.50
6_L10_M0.9110.50
106_I123_S0.8960.49
45_I149_A0.8860.48
67_Y135_F0.8740.47
65_F118_V0.8720.47
17_E53_Q0.8670.47
61_F91_K0.8610.46
70_N73_S0.8590.46
96_L147_N0.8540.46
16_A149_A0.8390.45
8_F160_L0.8310.44
60_G150_A0.8230.43
95_V99_N0.8150.43
49_A103_V0.8150.43
19_I151_A0.8130.43
40_L99_N0.8130.43
50_F63_F0.8110.42
25_H151_A0.8070.42
97_H146_L0.8030.42
42_L111_V0.8020.42
79_M125_I0.7990.41
4_F145_L0.7930.41
20_F32_D0.7880.41
18_S75_L0.7860.40
7_P59_Y0.7760.40
89_A144_I0.7740.40
17_E36_A0.7690.39
23_L84_G0.7680.39
85_L98_T0.7660.39
74_L153_I0.7630.39
45_I52_N0.7530.38
56_A60_G0.7460.37
114_L160_L0.7420.37
43_V47_M0.7410.37
39_F42_L0.7400.37
24_V117_Y0.7360.37
8_F151_A0.7360.37
69_M123_S0.7320.36
156_L160_L0.7280.36
60_G80_F0.7270.36
41_M111_V0.7240.36
13_V62_I0.7240.36
63_F74_L0.7230.36
59_Y130_M0.7140.35
9_V43_V0.7110.35
123_S128_D0.7100.35
92_A117_Y0.7090.35
78_Y139_R0.7080.35
44_L56_A0.7050.34
106_I113_L0.7020.34
117_Y141_I0.7000.34
69_M137_L0.6970.34
15_S19_I0.6950.34
119_F128_D0.6900.33
32_D65_F0.6890.33
40_L129_I0.6870.33
50_F71_Y0.6820.33
70_N122_Q0.6770.33
108_V148_I0.6760.32
77_V82_F0.6720.32
65_F156_L0.6710.32
92_A133_N0.6700.32
10_M43_V0.6660.32
62_I96_L0.6590.31
13_V149_A0.6570.31
4_F159_R0.6520.31
109_L132_F0.6480.31
98_T102_V0.6460.30
156_L159_R0.6420.30
125_I153_I0.6420.30
107_A111_V0.6400.30
11_M18_S0.6380.30
42_L154_L0.6360.30
56_A93_F0.6330.30
4_F123_S0.6320.29
111_V115_E0.6320.29
60_G63_F0.6300.29
70_N160_L0.6260.29
46_F151_A0.6250.29
17_E56_A0.6250.29
96_L100_A0.6240.29
125_I139_R0.6200.29
100_A157_P0.6180.29
35_L45_I0.6180.29
43_V157_P0.6160.28
59_Y63_F0.6150.28
146_L157_P0.6130.28
21_T63_F0.6120.28
37_P100_A0.6070.28
46_F150_A0.6070.28
23_L145_L0.6000.27
135_F139_R0.5920.27
50_F160_L0.5910.27
8_F162_F0.5880.27
18_S25_H0.5850.27
141_I154_L0.5830.26
80_F124_L0.5810.26
65_F109_L0.5810.26
40_L74_L0.5800.26
41_M113_L0.5800.26
87_Y119_F0.5790.26
11_M19_I0.5780.26
78_Y115_E0.5780.26
108_V124_L0.5770.26
9_V131_T0.5760.26
74_L109_L0.5760.26
53_Q142_P0.5750.26
15_S75_L0.5700.26
38_R103_V0.5700.26
14_F131_T0.5630.25
142_P159_R0.5600.25
112_C125_I0.5590.25
59_Y117_Y0.5580.25
102_V128_D0.5550.25
140_F162_F0.5490.24
5_L85_L0.5410.24
44_L149_A0.5400.24
109_L141_I0.5370.24
104_I110_A0.5360.24
137_L145_L0.5360.24
86_C151_A0.5350.24
39_F51_I0.5340.24
29_V106_I0.5260.23
16_A43_V0.5220.23
79_M98_T0.5210.23
113_L128_D0.5200.23
77_V151_A0.5190.23
135_F140_F0.5180.23
10_M31_D0.5140.22
17_E39_F0.5140.22
78_Y131_T0.5130.22
65_F125_I0.5130.22
44_L140_F0.5110.22
48_S131_T0.5080.22
31_D113_L0.5080.22
37_P54_K0.5050.22
56_A73_S0.5010.22
121_I124_L0.5010.22
135_F147_N0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4z7fA 2 0.8953 68.6 0.912 Contact Map
3rlbA 1 0.9244 63.9 0.915 Contact Map
4huqS 1 0.8721 56.3 0.919 Contact Map
4rfsS 1 0.8953 55.1 0.919 Contact Map
4tkrA 2 0.907 49.9 0.922 Contact Map
4hzuS 1 0.9012 40.6 0.926 Contact Map
2ksfA 1 0.564 14.2 0.941 Contact Map
3p5nA 2 0.8605 13.7 0.941 Contact Map
4j72A 2 0.2035 12.6 0.942 Contact Map
4dveA 3 0.9477 12.5 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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