MREC - BACSU - GREMLIN Contacts

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MREC - Cell shape-determining protein MreC

UniProt:	Q01466	Sequences: MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVFQNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDELGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKSSGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDKQDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVVNRDVPTVDTEEEGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	290 (258)
Sequences:	2766 (2162)
Seq/√Len:	134.6

ECOLI - MREC
BACSU - MREC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
184_T	242_I	5.192	1.00
133_I	275_V	4.534	1.00
78_K	83_T	4.509	1.00
79_L	82_Q	4.118	1.00
137_T	163_L	3.945	1.00
71_E	76_R	3.498	1.00
246_T	262_K	3.474	1.00
243_G	261_V	3.348	1.00
241_T	264_A	2.847	1.00
88_K	93_E	2.824	1.00
141_V	158_I	2.741	1.00
137_T	165_N	2.692	1.00
244_E	262_K	2.664	1.00
98_S	272_N	2.495	1.00
138_Q	166_F	2.465	1.00
188_G	225_D	2.434	1.00
117_A	273_V	2.371	1.00
95_E	100_R	2.360	1.00
147_V	170_V	2.350	1.00
85_Y	90_Q	2.292	1.00
185_K	238_E	2.152	1.00
159_K	171_Q	2.149	1.00
72_N	75_L	2.128	1.00
118_T	134_N	2.091	1.00
187_S	226_L	2.091	1.00
184_T	210_M	2.050	1.00
133_I	168_S	2.049	1.00
221_V	245_V	1.978	1.00
71_E	74_R	1.943	1.00
133_I	170_V	1.938	1.00
113_K	277_N	1.931	1.00
78_K	81_G	1.924	1.00
92_L	96_N	1.916	1.00
117_A	135_K	1.907	1.00
68_T	72_N	1.895	1.00
186_I	227_I	1.854	1.00
86_E	89_L	1.849	1.00
188_G	220_D	1.834	1.00
155_I	270_L	1.813	1.00
184_T	198_I	1.788	1.00
138_Q	165_N	1.785	1.00
131_V	172_L	1.761	1.00
85_Y	89_L	1.751	1.00
199_E	211_T	1.735	1.00
147_V	275_V	1.732	1.00
154_L	240_L	1.728	1.00
46_N	134_N	1.694	1.00
174_S	267_L	1.655	1.00
158_I	170_V	1.642	1.00
227_I	261_V	1.628	1.00
249_E	258_V	1.628	1.00
198_I	261_V	1.616	1.00
96_N	100_R	1.600	1.00
207_R	246_T	1.571	1.00
243_G	264_A	1.567	1.00
160_S	169_A	1.559	1.00
115_I	141_V	1.555	1.00
135_K	139_Q	1.553	1.00
226_L	264_A	1.536	1.00
247_D	260_Y	1.522	1.00
72_N	76_R	1.497	1.00
141_V	275_V	1.489	1.00
226_L	244_E	1.485	1.00
221_V	248_I	1.485	1.00
187_S	228_E	1.478	1.00
115_I	135_K	1.470	1.00
154_L	182_V	1.448	1.00
115_I	277_N	1.444	1.00
158_I	168_S	1.432	1.00
185_K	239_G	1.426	1.00
65_L	68_T	1.423	1.00
73_E	77_E	1.405	1.00
154_L	229_T	1.401	1.00
95_E	99_L	1.375	1.00
193_K	271_N	1.372	1.00
144_D	235_V	1.364	1.00
181_R	199_E	1.358	1.00
119_V	131_V	1.356	1.00
186_I	225_D	1.341	1.00
62_I	66_K	1.319	1.00
213_I	259_A	1.315	1.00
207_R	260_Y	1.311	1.00
74_R	77_E	1.291	1.00
149_N	265_A	1.284	1.00
196_G	210_M	1.278	1.00
85_Y	88_K	1.276	1.00
141_V	163_L	1.262	1.00
171_Q	175_D	1.261	1.00
70_K	74_R	1.258	1.00
69_Y	73_E	1.250	1.00
77_E	81_G	1.249	1.00
208_L	263_P	1.246	1.00
198_I	208_L	1.222	1.00
170_V	275_V	1.206	1.00
198_I	242_I	1.204	1.00
146_A	237_P	1.201	1.00
154_L	242_I	1.199	1.00
39_D	165_N	1.175	0.99
139_Q	166_F	1.174	0.99
227_I	243_G	1.167	0.99
144_D	157_K	1.166	0.99
96_N	103_L	1.159	0.99
198_I	210_M	1.144	0.99
223_K	247_D	1.137	0.99
201_Y	209_K	1.133	0.99
114_P	274_I	1.124	0.99
183_A	230_S	1.123	0.99
116_L	274_I	1.114	0.99
207_R	262_K	1.093	0.99
267_L	270_L	1.072	0.99
105_H	116_L	1.070	0.99
188_G	222_K	1.069	0.99
12_C	16_L	1.058	0.99
18_A	22_F	1.058	0.99
244_E	264_A	1.054	0.99
143_K	163_L	1.047	0.99
155_I	273_V	1.047	0.99
209_K	258_V	1.041	0.99
98_S	102_E	1.037	0.99
223_K	248_I	1.037	0.99
72_N	79_L	1.017	0.98
210_M	213_I	1.010	0.98
102_E	274_I	1.008	0.98
226_L	241_T	1.007	0.98
221_V	259_A	1.001	0.98
74_R	78_K	0.995	0.98
130_Q	169_A	0.988	0.98
148_T	276_V	0.986	0.98
31_T	34_E	0.986	0.98
210_M	259_A	0.981	0.98
15_I	22_F	0.969	0.98
16_L	21_G	0.967	0.98
142_A	277_N	0.960	0.98
91_E	193_K	0.958	0.98
238_E	271_N	0.956	0.98
64_D	69_Y	0.954	0.98
209_K	260_Y	0.948	0.97
164_N	167_T	0.943	0.97
122_R	127_W	0.942	0.97
96_N	99_L	0.925	0.97
159_K	163_L	0.923	0.97
79_L	83_T	0.912	0.97
101_D	104_G	0.902	0.97
59_F	62_I	0.899	0.96
81_G	85_Y	0.890	0.96
119_V	270_L	0.887	0.96
214_E	219_Q	0.884	0.96
16_L	19_M	0.882	0.96
106_V	114_P	0.878	0.96
123_S	128_A	0.877	0.96
147_V	273_V	0.865	0.96
97_K	101_D	0.857	0.95
86_E	90_Q	0.855	0.95
12_C	19_M	0.845	0.95
210_M	261_V	0.830	0.95
14_I	17_V	0.829	0.95
251_D	254_G	0.828	0.94
121_A	132_T	0.823	0.94
136_G	140_N	0.819	0.94
80_D	83_T	0.819	0.94
19_M	23_S	0.819	0.94
16_L	23_S	0.816	0.94
171_Q	236_F	0.812	0.94
61_N	64_D	0.808	0.94
65_L	69_Y	0.806	0.94
173_L	267_L	0.806	0.94
70_K	73_E	0.803	0.94
142_A	145_M	0.793	0.93
23_S	34_E	0.788	0.93
89_L	92_L	0.787	0.93
185_K	195_Y	0.782	0.93
157_K	171_Q	0.781	0.93
120_I	167_T	0.781	0.93
186_I	221_V	0.779	0.92
220_D	225_D	0.779	0.92
11_L	15_I	0.778	0.92
67_N	71_E	0.778	0.92
65_L	72_N	0.777	0.92
188_G	227_I	0.763	0.92
13_I	17_V	0.759	0.91
196_G	245_V	0.759	0.91
185_K	228_E	0.758	0.91
132_T	167_T	0.755	0.91
118_T	238_E	0.754	0.91
245_V	248_I	0.753	0.91
79_L	229_T	0.750	0.91
61_N	65_L	0.749	0.91
77_E	80_D	0.746	0.91
72_N	152_G	0.744	0.91
144_D	183_A	0.742	0.91
135_K	275_V	0.742	0.91
71_E	79_L	0.741	0.90
250_S	257_K	0.740	0.90
188_G	193_K	0.731	0.90
101_D	151_K	0.723	0.89
246_T	260_Y	0.719	0.89
47_I	51_P	0.718	0.89
40_T	43_V	0.717	0.89
133_I	158_I	0.713	0.89
181_R	197_L	0.708	0.88
223_K	246_T	0.706	0.88
9_L	16_L	0.702	0.88
93_E	97_K	0.700	0.88
54_F	58_I	0.698	0.88
41_T	45_Q	0.696	0.88
33_P	36_V	0.695	0.87
42_G	167_T	0.693	0.87
135_K	240_L	0.689	0.87
143_K	160_S	0.688	0.87
98_S	271_N	0.688	0.87
99_L	103_L	0.687	0.87
117_A	134_N	0.687	0.87
20_I	23_S	0.686	0.87
63_N	66_K	0.685	0.87
135_K	138_Q	0.684	0.87
164_N	168_S	0.684	0.87
180_N	233_G	0.679	0.86
224_G	244_E	0.678	0.86
185_K	193_K	0.678	0.86
180_N	236_F	0.678	0.86
104_G	222_K	0.676	0.86
114_P	276_V	0.675	0.86
21_G	24_L	0.674	0.86
231_G	238_E	0.672	0.86
39_D	42_G	0.665	0.85
50_T	54_F	0.664	0.85
129_K	175_D	0.663	0.85
55_F	107_K	0.661	0.85
17_V	22_F	0.660	0.85
133_I	273_V	0.659	0.85
186_I	210_M	0.659	0.85
91_E	239_G	0.658	0.84
8_L	12_C	0.651	0.84
133_I	147_V	0.651	0.84
245_V	259_A	0.648	0.84
90_Q	93_E	0.648	0.84
231_G	239_G	0.646	0.83
201_Y	260_Y	0.644	0.83
103_L	106_V	0.644	0.83
157_K	233_G	0.643	0.83
136_G	168_S	0.641	0.83
64_D	68_T	0.640	0.83
83_T	86_E	0.639	0.83
83_T	87_A	0.638	0.83
167_T	233_G	0.636	0.82
185_K	198_I	0.635	0.82
34_E	43_V	0.635	0.82
118_T	272_N	0.634	0.82
142_A	275_V	0.630	0.82
248_I	259_A	0.628	0.82
167_T	172_L	0.628	0.82
184_T	227_I	0.626	0.81
210_M	227_I	0.626	0.81
76_R	79_L	0.625	0.81
51_P	265_A	0.625	0.81
78_K	82_Q	0.622	0.81
132_T	169_A	0.622	0.81
172_L	175_D	0.620	0.81
194_G	219_Q	0.620	0.81
57_G	60_E	0.618	0.81
21_G	25_K	0.616	0.80
107_K	110_K	0.614	0.80
168_S	171_Q	0.612	0.80
93_E	193_K	0.611	0.80
145_M	278_R	0.605	0.79
87_A	241_T	0.604	0.79
75_L	79_L	0.604	0.79
229_T	242_I	0.603	0.79
57_G	168_S	0.603	0.79
200_G	210_M	0.601	0.79
122_R	125_D	0.601	0.79
90_Q	94_E	0.599	0.79
59_F	210_M	0.599	0.79
226_L	243_G	0.599	0.79
171_Q	180_N	0.596	0.78
113_K	278_R	0.594	0.78
42_G	120_I	0.593	0.78
110_K	114_P	0.593	0.78
194_G	213_I	0.592	0.78
30_T	34_E	0.591	0.78
270_L	273_V	0.588	0.77
149_N	270_L	0.586	0.77
124_P	150_E	0.586	0.77
102_E	150_E	0.585	0.77
62_I	65_L	0.582	0.77
68_T	214_E	0.581	0.76
124_P	154_L	0.580	0.76
222_K	249_E	0.577	0.76
95_E	98_S	0.574	0.76
71_E	75_L	0.573	0.75
116_L	272_N	0.571	0.75
122_R	172_L	0.569	0.75
38_G	164_N	0.569	0.75
117_A	147_V	0.568	0.75
102_E	152_G	0.568	0.75
212_I	251_D	0.567	0.75
49_H	261_V	0.567	0.75
118_T	271_N	0.567	0.75
76_R	168_S	0.564	0.74
92_L	100_R	0.564	0.74
225_D	228_E	0.563	0.74
46_N	50_T	0.561	0.74
135_K	141_V	0.561	0.74
93_E	96_N	0.561	0.74
9_L	47_I	0.560	0.74
64_D	67_N	0.560	0.74
92_L	95_E	0.558	0.74
157_K	180_N	0.558	0.74
48_F	51_P	0.556	0.73
122_R	195_Y	0.555	0.73
157_K	175_D	0.553	0.73
42_G	164_N	0.553	0.73
51_P	54_F	0.552	0.73
13_I	16_L	0.552	0.73
164_N	169_A	0.551	0.73
39_D	53_E	0.551	0.73
145_M	240_L	0.550	0.72
149_N	155_I	0.550	0.72
182_V	236_F	0.548	0.72
222_K	225_D	0.548	0.72
261_V	264_A	0.548	0.72
56_A	60_E	0.548	0.72
55_F	59_F	0.548	0.72
99_L	105_H	0.547	0.72
184_T	259_A	0.546	0.72
137_T	141_V	0.546	0.72
17_V	89_L	0.545	0.72
149_N	152_G	0.544	0.72
183_A	195_Y	0.544	0.72
76_R	80_D	0.544	0.72
89_L	93_E	0.544	0.72
183_A	232_T	0.543	0.72
229_T	240_L	0.542	0.71
39_D	166_F	0.540	0.71
196_G	259_A	0.539	0.71
21_G	275_V	0.539	0.71
82_Q	85_Y	0.538	0.71
199_E	209_K	0.537	0.71
155_I	265_A	0.537	0.71
97_K	244_E	0.536	0.71
62_I	68_T	0.535	0.70
137_T	142_A	0.535	0.70
208_L	261_V	0.535	0.70
68_T	71_E	0.534	0.70
146_A	276_V	0.534	0.70
19_M	35_K	0.532	0.70
135_K	273_V	0.531	0.70
63_N	147_V	0.529	0.70
49_H	53_E	0.528	0.69
46_N	49_H	0.528	0.69
142_A	163_L	0.528	0.69
124_P	127_W	0.527	0.69
114_P	179_N	0.527	0.69
32_W	36_V	0.526	0.69
131_V	273_V	0.525	0.69
115_I	244_E	0.525	0.69
158_I	275_V	0.524	0.69
260_Y	263_P	0.524	0.69
17_V	21_G	0.524	0.69
231_G	234_G	0.523	0.69
214_E	218_K	0.523	0.69
18_A	21_G	0.521	0.68
129_K	278_R	0.520	0.68
186_I	245_V	0.519	0.68
37_I	41_T	0.518	0.68
45_Q	236_F	0.518	0.68
175_D	200_G	0.518	0.68
126_N	276_V	0.517	0.68
15_I	51_P	0.516	0.68
8_L	131_V	0.516	0.68
157_K	181_R	0.516	0.68
120_I	268_T	0.514	0.67
248_I	263_P	0.514	0.67
247_D	259_A	0.513	0.67
229_T	269_D	0.512	0.67
94_E	98_S	0.511	0.67
139_Q	142_A	0.510	0.67
65_L	233_G	0.509	0.67
14_I	19_M	0.509	0.67
33_P	165_N	0.509	0.67
37_I	144_D	0.507	0.66
197_L	200_G	0.507	0.66
220_D	223_K	0.505	0.66
168_S	275_V	0.505	0.66
82_Q	86_E	0.503	0.66
188_G	195_Y	0.500	0.65
185_K	271_N	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j5uA	4	0.7172	100	0.186	Contact Map
2qf4A	1	0.5862	100	0.367	Contact Map
2yy0A	6	0.1828	64.2	0.94	Contact Map
4bhqA	2	0.3138	54.4	0.944	Contact Map
3ra3B	1	0.0931	45.1	0.947	Contact Map
4u5tA	2	0.1276	42.4	0.947	Contact Map
4dznA	3	0.1103	38.6	0.949	Contact Map
2jeeA	2	0.2552	38.6	0.949	Contact Map
1go4E	4	0.2345	38.4	0.949	Contact Map
4cbcA	3	0.1138	37.2	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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