GREMLIN Database
MREC - Cell shape-determining protein MreC
UniProt: Q01466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (258)
Sequences: 2766 (2162)
Seq/√Len: 134.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_T242_I5.1921.00
133_I275_V4.5341.00
78_K83_T4.5091.00
79_L82_Q4.1181.00
137_T163_L3.9451.00
71_E76_R3.4981.00
246_T262_K3.4741.00
243_G261_V3.3481.00
241_T264_A2.8471.00
88_K93_E2.8241.00
141_V158_I2.7411.00
137_T165_N2.6921.00
244_E262_K2.6641.00
98_S272_N2.4951.00
138_Q166_F2.4651.00
188_G225_D2.4341.00
117_A273_V2.3711.00
95_E100_R2.3601.00
147_V170_V2.3501.00
85_Y90_Q2.2921.00
185_K238_E2.1521.00
159_K171_Q2.1491.00
72_N75_L2.1281.00
118_T134_N2.0911.00
187_S226_L2.0911.00
184_T210_M2.0501.00
133_I168_S2.0491.00
221_V245_V1.9781.00
71_E74_R1.9431.00
133_I170_V1.9381.00
113_K277_N1.9311.00
78_K81_G1.9241.00
92_L96_N1.9161.00
117_A135_K1.9071.00
68_T72_N1.8951.00
186_I227_I1.8541.00
86_E89_L1.8491.00
188_G220_D1.8341.00
155_I270_L1.8131.00
184_T198_I1.7881.00
138_Q165_N1.7851.00
131_V172_L1.7611.00
85_Y89_L1.7511.00
199_E211_T1.7351.00
147_V275_V1.7321.00
154_L240_L1.7281.00
46_N134_N1.6941.00
174_S267_L1.6551.00
158_I170_V1.6421.00
227_I261_V1.6281.00
249_E258_V1.6281.00
198_I261_V1.6161.00
96_N100_R1.6001.00
207_R246_T1.5711.00
243_G264_A1.5671.00
160_S169_A1.5591.00
115_I141_V1.5551.00
135_K139_Q1.5531.00
226_L264_A1.5361.00
247_D260_Y1.5221.00
72_N76_R1.4971.00
141_V275_V1.4891.00
226_L244_E1.4851.00
221_V248_I1.4851.00
187_S228_E1.4781.00
115_I135_K1.4701.00
154_L182_V1.4481.00
115_I277_N1.4441.00
158_I168_S1.4321.00
185_K239_G1.4261.00
65_L68_T1.4231.00
73_E77_E1.4051.00
154_L229_T1.4011.00
95_E99_L1.3751.00
193_K271_N1.3721.00
144_D235_V1.3641.00
181_R199_E1.3581.00
119_V131_V1.3561.00
186_I225_D1.3411.00
62_I66_K1.3191.00
213_I259_A1.3151.00
207_R260_Y1.3111.00
74_R77_E1.2911.00
149_N265_A1.2841.00
196_G210_M1.2781.00
85_Y88_K1.2761.00
141_V163_L1.2621.00
171_Q175_D1.2611.00
70_K74_R1.2581.00
69_Y73_E1.2501.00
77_E81_G1.2491.00
208_L263_P1.2461.00
198_I208_L1.2221.00
170_V275_V1.2061.00
198_I242_I1.2041.00
146_A237_P1.2011.00
154_L242_I1.1991.00
39_D165_N1.1750.99
139_Q166_F1.1740.99
227_I243_G1.1670.99
144_D157_K1.1660.99
96_N103_L1.1590.99
198_I210_M1.1440.99
223_K247_D1.1370.99
201_Y209_K1.1330.99
114_P274_I1.1240.99
183_A230_S1.1230.99
116_L274_I1.1140.99
207_R262_K1.0930.99
267_L270_L1.0720.99
105_H116_L1.0700.99
188_G222_K1.0690.99
12_C16_L1.0580.99
18_A22_F1.0580.99
244_E264_A1.0540.99
143_K163_L1.0470.99
155_I273_V1.0470.99
209_K258_V1.0410.99
98_S102_E1.0370.99
223_K248_I1.0370.99
72_N79_L1.0170.98
210_M213_I1.0100.98
102_E274_I1.0080.98
226_L241_T1.0070.98
221_V259_A1.0010.98
74_R78_K0.9950.98
130_Q169_A0.9880.98
148_T276_V0.9860.98
31_T34_E0.9860.98
210_M259_A0.9810.98
15_I22_F0.9690.98
16_L21_G0.9670.98
142_A277_N0.9600.98
91_E193_K0.9580.98
238_E271_N0.9560.98
64_D69_Y0.9540.98
209_K260_Y0.9480.97
164_N167_T0.9430.97
122_R127_W0.9420.97
96_N99_L0.9250.97
159_K163_L0.9230.97
79_L83_T0.9120.97
101_D104_G0.9020.97
59_F62_I0.8990.96
81_G85_Y0.8900.96
119_V270_L0.8870.96
214_E219_Q0.8840.96
16_L19_M0.8820.96
106_V114_P0.8780.96
123_S128_A0.8770.96
147_V273_V0.8650.96
97_K101_D0.8570.95
86_E90_Q0.8550.95
12_C19_M0.8450.95
210_M261_V0.8300.95
14_I17_V0.8290.95
251_D254_G0.8280.94
121_A132_T0.8230.94
136_G140_N0.8190.94
80_D83_T0.8190.94
19_M23_S0.8190.94
16_L23_S0.8160.94
171_Q236_F0.8120.94
61_N64_D0.8080.94
65_L69_Y0.8060.94
173_L267_L0.8060.94
70_K73_E0.8030.94
142_A145_M0.7930.93
23_S34_E0.7880.93
89_L92_L0.7870.93
185_K195_Y0.7820.93
157_K171_Q0.7810.93
120_I167_T0.7810.93
186_I221_V0.7790.92
220_D225_D0.7790.92
11_L15_I0.7780.92
67_N71_E0.7780.92
65_L72_N0.7770.92
188_G227_I0.7630.92
13_I17_V0.7590.91
196_G245_V0.7590.91
185_K228_E0.7580.91
132_T167_T0.7550.91
118_T238_E0.7540.91
245_V248_I0.7530.91
79_L229_T0.7500.91
61_N65_L0.7490.91
77_E80_D0.7460.91
72_N152_G0.7440.91
144_D183_A0.7420.91
135_K275_V0.7420.91
71_E79_L0.7410.90
250_S257_K0.7400.90
188_G193_K0.7310.90
101_D151_K0.7230.89
246_T260_Y0.7190.89
47_I51_P0.7180.89
40_T43_V0.7170.89
133_I158_I0.7130.89
181_R197_L0.7080.88
223_K246_T0.7060.88
9_L16_L0.7020.88
93_E97_K0.7000.88
54_F58_I0.6980.88
41_T45_Q0.6960.88
33_P36_V0.6950.87
42_G167_T0.6930.87
135_K240_L0.6890.87
143_K160_S0.6880.87
98_S271_N0.6880.87
99_L103_L0.6870.87
117_A134_N0.6870.87
20_I23_S0.6860.87
63_N66_K0.6850.87
135_K138_Q0.6840.87
164_N168_S0.6840.87
180_N233_G0.6790.86
224_G244_E0.6780.86
185_K193_K0.6780.86
180_N236_F0.6780.86
104_G222_K0.6760.86
114_P276_V0.6750.86
21_G24_L0.6740.86
231_G238_E0.6720.86
39_D42_G0.6650.85
50_T54_F0.6640.85
129_K175_D0.6630.85
55_F107_K0.6610.85
17_V22_F0.6600.85
133_I273_V0.6590.85
186_I210_M0.6590.85
91_E239_G0.6580.84
8_L12_C0.6510.84
133_I147_V0.6510.84
245_V259_A0.6480.84
90_Q93_E0.6480.84
231_G239_G0.6460.83
201_Y260_Y0.6440.83
103_L106_V0.6440.83
157_K233_G0.6430.83
136_G168_S0.6410.83
64_D68_T0.6400.83
83_T86_E0.6390.83
83_T87_A0.6380.83
167_T233_G0.6360.82
185_K198_I0.6350.82
34_E43_V0.6350.82
118_T272_N0.6340.82
142_A275_V0.6300.82
248_I259_A0.6280.82
167_T172_L0.6280.82
184_T227_I0.6260.81
210_M227_I0.6260.81
76_R79_L0.6250.81
51_P265_A0.6250.81
78_K82_Q0.6220.81
132_T169_A0.6220.81
172_L175_D0.6200.81
194_G219_Q0.6200.81
57_G60_E0.6180.81
21_G25_K0.6160.80
107_K110_K0.6140.80
168_S171_Q0.6120.80
93_E193_K0.6110.80
145_M278_R0.6050.79
87_A241_T0.6040.79
75_L79_L0.6040.79
229_T242_I0.6030.79
57_G168_S0.6030.79
200_G210_M0.6010.79
122_R125_D0.6010.79
90_Q94_E0.5990.79
59_F210_M0.5990.79
226_L243_G0.5990.79
171_Q180_N0.5960.78
113_K278_R0.5940.78
42_G120_I0.5930.78
110_K114_P0.5930.78
194_G213_I0.5920.78
30_T34_E0.5910.78
270_L273_V0.5880.77
149_N270_L0.5860.77
124_P150_E0.5860.77
102_E150_E0.5850.77
62_I65_L0.5820.77
68_T214_E0.5810.76
124_P154_L0.5800.76
222_K249_E0.5770.76
95_E98_S0.5740.76
71_E75_L0.5730.75
116_L272_N0.5710.75
122_R172_L0.5690.75
38_G164_N0.5690.75
117_A147_V0.5680.75
102_E152_G0.5680.75
212_I251_D0.5670.75
49_H261_V0.5670.75
118_T271_N0.5670.75
76_R168_S0.5640.74
92_L100_R0.5640.74
225_D228_E0.5630.74
46_N50_T0.5610.74
135_K141_V0.5610.74
93_E96_N0.5610.74
9_L47_I0.5600.74
64_D67_N0.5600.74
92_L95_E0.5580.74
157_K180_N0.5580.74
48_F51_P0.5560.73
122_R195_Y0.5550.73
157_K175_D0.5530.73
42_G164_N0.5530.73
51_P54_F0.5520.73
13_I16_L0.5520.73
164_N169_A0.5510.73
39_D53_E0.5510.73
145_M240_L0.5500.72
149_N155_I0.5500.72
182_V236_F0.5480.72
222_K225_D0.5480.72
261_V264_A0.5480.72
56_A60_E0.5480.72
55_F59_F0.5480.72
99_L105_H0.5470.72
184_T259_A0.5460.72
137_T141_V0.5460.72
17_V89_L0.5450.72
149_N152_G0.5440.72
183_A195_Y0.5440.72
76_R80_D0.5440.72
89_L93_E0.5440.72
183_A232_T0.5430.72
229_T240_L0.5420.71
39_D166_F0.5400.71
196_G259_A0.5390.71
21_G275_V0.5390.71
82_Q85_Y0.5380.71
199_E209_K0.5370.71
155_I265_A0.5370.71
97_K244_E0.5360.71
62_I68_T0.5350.70
137_T142_A0.5350.70
208_L261_V0.5350.70
68_T71_E0.5340.70
146_A276_V0.5340.70
19_M35_K0.5320.70
135_K273_V0.5310.70
63_N147_V0.5290.70
49_H53_E0.5280.69
46_N49_H0.5280.69
142_A163_L0.5280.69
124_P127_W0.5270.69
114_P179_N0.5270.69
32_W36_V0.5260.69
131_V273_V0.5250.69
115_I244_E0.5250.69
158_I275_V0.5240.69
260_Y263_P0.5240.69
17_V21_G0.5240.69
231_G234_G0.5230.69
214_E218_K0.5230.69
18_A21_G0.5210.68
129_K278_R0.5200.68
186_I245_V0.5190.68
37_I41_T0.5180.68
45_Q236_F0.5180.68
175_D200_G0.5180.68
126_N276_V0.5170.68
15_I51_P0.5160.68
8_L131_V0.5160.68
157_K181_R0.5160.68
120_I268_T0.5140.67
248_I263_P0.5140.67
247_D259_A0.5130.67
229_T269_D0.5120.67
94_E98_S0.5110.67
139_Q142_A0.5100.67
65_L233_G0.5090.67
14_I19_M0.5090.67
33_P165_N0.5090.67
37_I144_D0.5070.66
197_L200_G0.5070.66
220_D223_K0.5050.66
168_S275_V0.5050.66
82_Q86_E0.5030.66
188_G195_Y0.5000.65
185_K271_N0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5uA 4 0.7172 100 0.186 Contact Map
2qf4A 1 0.5862 100 0.367 Contact Map
2yy0A 6 0.1828 64.2 0.94 Contact Map
4bhqA 2 0.3138 54.4 0.944 Contact Map
3ra3B 1 0.0931 45.1 0.947 Contact Map
4u5tA 2 0.1276 42.4 0.947 Contact Map
4dznA 3 0.1103 38.6 0.949 Contact Map
2jeeA 2 0.2552 38.6 0.949 Contact Map
1go4E 4 0.2345 38.4 0.949 Contact Map
4cbcA 3 0.1138 37.2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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