GREMLIN Database
MREB - Rod shape-determining protein MreB
UniProt: Q01465 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (313)
Sequences: 11088 (6303)
Seq/√Len: 356.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_Y129_R3.4691.00
157_V260_I3.2591.00
179_S259_T3.1521.00
216_G220_A3.0411.00
190_A255_D3.0061.00
226_N243_E2.9631.00
265_K303_E2.9471.00
198_T248_E2.8651.00
63_V185_D2.7171.00
313_D316_D2.6141.00
18_T86_Y2.5331.00
105_V123_T2.3531.00
254_R258_S2.3491.00
298_K302_E2.2951.00
168_I267_T2.2571.00
80_A125_Q2.2261.00
87_I91_I2.2251.00
301_S307_P2.2011.00
191_I244_I2.1951.00
210_A214_E2.1891.00
290_G293_L2.1411.00
106_C322_T2.1281.00
117_R121_D2.0791.00
24_G27_I2.0761.00
245_T248_E2.0401.00
261_V303_E2.0381.00
37_L81_T2.0121.00
85_Y89_Q1.9711.00
299_V302_E1.9641.00
248_E251_N1.9551.00
153_G170_S1.9211.00
292_L315_L1.8961.00
21_F323_G1.8811.00
187_M256_T1.8801.00
297_D310_I1.8671.00
194_Y252_A1.8351.00
159_I164_T1.8061.00
261_V299_V1.7991.00
16_A161_G1.7911.00
194_Y198_T1.7831.00
168_I271_T1.7321.00
257_V295_N1.7171.00
253_L293_L1.7171.00
228_E241_T1.7101.00
15_T162_G1.7031.00
228_E243_E1.6911.00
18_T33_S1.6901.00
249_I293_L1.6841.00
120_I124_R1.6451.00
187_M253_L1.6421.00
73_I78_T1.6391.00
81_T84_K1.6321.00
152_T281_D1.6321.00
49_N53_N1.6271.00
190_A193_N1.6241.00
20_V86_Y1.6221.00
21_F319_A1.6141.00
316_D320_I1.6111.00
102_Y131_A1.6011.00
195_I215_I1.5901.00
246_G250_S1.5871.00
155_M168_I1.5821.00
195_I242_I1.5811.00
76_Y121_D1.5761.00
87_I128_A1.5721.00
251_N254_R1.5571.00
192_I212_K1.5501.00
121_D124_R1.5461.00
254_R299_V1.5431.00
218_A229_I1.5351.00
253_L257_V1.5251.00
257_V299_V1.5011.00
112_T115_E1.4811.00
266_S270_K1.4771.00
84_K88_N1.4711.00
9_L20_V1.4611.00
79_T119_V1.4581.00
19_L30_R1.4571.00
159_I187_M1.4511.00
262_E266_S1.4321.00
261_V265_K1.4161.00
58_T61_N1.4151.00
253_L256_T1.4121.00
267_T271_T1.4121.00
190_A256_T1.4041.00
250_S298_K1.3821.00
107_V133_P1.3821.00
67_P70_D1.3811.00
264_V300_I1.3801.00
77_E125_Q1.3731.00
274_E277_A1.3341.00
85_Y88_N1.3321.00
168_I279_I1.3251.00
313_D320_I1.3231.00
214_E217_S1.3181.00
19_L319_A1.3171.00
135_E138_F1.3081.00
197_K200_N1.3061.00
45_V81_T1.3021.00
198_T201_L1.3011.00
286_L300_I1.2891.00
166_V267_T1.2891.00
164_T260_I1.2881.00
157_V164_T1.2811.00
155_M166_V1.2811.00
194_Y248_E1.2801.00
116_E135_E1.2781.00
178_Q266_S1.2721.00
152_T280_M1.2701.00
217_S221_P1.2581.00
295_N298_K1.2581.00
64_A79_T1.2561.00
189_D193_N1.2481.00
191_I215_I1.2471.00
13_L79_T1.2461.00
10_G322_T1.2451.00
23_K327_E1.2341.00
87_I103_V1.2281.00
102_Y130_D1.2091.00
262_E265_K1.2031.00
298_K301_S1.2031.00
299_V303_E1.2001.00
35_V78_T1.1981.00
17_N315_L1.1981.00
8_D326_L1.1981.00
254_R295_N1.1901.00
91_I99_R1.1891.00
109_S137_P1.1891.00
155_M264_V1.1881.00
195_I229_I1.1861.00
297_D301_S1.1801.00
65_L136_E1.1701.00
88_N92_K1.1701.00
8_D131_A1.1691.00
187_M290_G1.1681.00
258_S262_E1.1631.00
218_A227_M1.1591.00
300_I308_V1.1581.00
13_L119_V1.1531.00
284_I304_T1.1511.00
134_I325_A1.1431.00
268_L276_A1.1421.00
136_E165_E1.1411.00
190_A253_L1.1281.00
64_A78_T1.1221.00
187_M293_L1.1211.00
153_G273_P1.1191.00
166_V263_A1.1121.00
31_E89_Q1.1031.00
159_I296_L1.1001.00
187_M249_I1.0931.00
286_L291_A1.0821.00
64_A82_M1.0701.00
189_D212_K1.0661.00
230_R241_T1.0601.00
192_I215_I1.0521.00
124_R129_R1.0521.00
10_G319_A1.0481.00
295_N299_V1.0481.00
221_P224_S1.0461.00
113_A117_R1.0441.00
162_G165_E1.0421.00
47_V85_Y1.0411.00
325_A328_H1.0371.00
218_A244_I1.0361.00
203_I238_L1.0301.00
18_T82_M1.0281.00
38_Q41_T1.0281.00
274_E278_D1.0241.00
36_A62_V1.0191.00
134_I139_A1.0171.00
281_D309_L1.0141.00
36_A54_M1.0111.00
249_I290_G1.0101.00
158_D165_E1.0031.00
184_G290_G1.0021.00
189_D192_I0.9961.00
86_Y89_Q0.9941.00
8_D102_Y0.9901.00
266_S269_E0.9781.00
198_T202_M0.9781.00
36_A46_A0.9661.00
194_Y244_I0.9521.00
140_A318_V0.9521.00
168_I273_P0.9501.00
88_N91_I0.9501.00
73_I81_T0.9481.00
89_Q92_K0.9421.00
120_I133_P0.9331.00
140_A287_T0.9301.00
158_D163_T0.9291.00
58_T62_V0.9241.00
37_L73_I0.9241.00
208_A212_K0.9221.00
13_L83_M0.9201.00
258_S261_V0.9191.00
225_D246_G0.9171.00
247_K250_S0.9151.00
287_T317_C0.9151.00
144_A285_V0.9131.00
161_G165_E0.9111.00
33_S82_M0.9081.00
250_S295_N0.9041.00
121_D125_Q0.9001.00
198_T242_I0.8991.00
76_Y118_A0.8991.00
233_D240_K0.8941.00
101_P129_R0.8921.00
221_P227_M0.8891.00
158_D162_G0.8841.00
265_K269_E0.8821.00
80_A84_K0.8761.00
248_E252_A0.8751.00
258_S299_V0.8731.00
188_D216_G0.8711.00
107_V135_E0.8681.00
75_D79_T0.8671.00
9_L90_A0.8641.00
320_I324_K0.8611.00
54_M58_T0.8571.00
182_V259_T0.8541.00
250_S254_R0.8531.00
263_A267_T0.8501.00
104_M326_L0.8491.00
117_R120_I0.8481.00
105_V119_V0.8461.00
107_V116_E0.8451.00
34_V52_K0.8451.00
158_D161_G0.8441.00
159_I290_G0.8411.00
253_L295_N0.8361.00
116_E120_I0.8341.00
259_T262_E0.8331.00
301_S308_V0.8321.00
214_E218_A0.8301.00
80_A122_A0.8271.00
66_R186_E0.8241.00
187_M257_V0.8231.00
226_N245_T0.8231.00
9_L103_V0.8211.00
37_L78_T0.8211.00
193_N197_K0.8161.00
11_I83_M0.8141.00
143_G317_C0.8111.00
179_S182_V0.8081.00
216_G219_E0.7961.00
113_A116_E0.7951.00
60_G205_D0.7931.00
261_V264_V0.7931.00
132_Y325_A0.7931.00
159_I260_I0.7911.00
141_A169_I0.7761.00
194_Y242_I0.7741.00
17_N30_R0.7721.00
249_I253_L0.7711.00
13_L64_A0.7701.00
137_P165_E0.7691.00
264_V303_E0.7671.00
153_G280_M0.7671.00
153_G279_I0.7651.00
9_L100_K0.7581.00
247_K251_N0.7581.00
155_M279_I0.7571.00
47_V82_M0.7571.00
273_P278_D0.7531.00
46_A50_D0.7531.00
74_A77_E0.7531.00
215_I220_A0.7511.00
123_T133_P0.7461.00
65_L163_T0.7441.00
123_T126_A0.7421.00
227_M232_R0.7411.00
77_E81_T0.7401.00
192_I196_R0.7351.00
182_V186_E0.7331.00
91_I100_K0.7331.00
29_V93_N0.7301.00
214_E227_M0.7291.00
160_G289_G0.7281.00
103_V128_A0.7260.99
77_E80_A0.7260.99
143_G320_I0.7220.99
142_I325_A0.7210.99
177_S263_A0.7200.99
244_I252_A0.7190.99
137_P140_A0.7190.99
10_G323_G0.7190.99
222_E294_R0.7180.99
79_T83_M0.7170.99
111_I119_V0.7150.99
200_N203_I0.7140.99
177_S266_S0.7100.99
116_E133_P0.7090.99
68_M79_T0.7040.99
309_L317_C0.7020.99
144_A317_C0.6990.99
76_Y80_A0.6990.99
137_P163_T0.6980.99
81_T85_Y0.6970.99
36_A58_T0.6960.99
111_I115_E0.6950.99
244_I249_I0.6930.99
286_L310_I0.6850.99
181_R186_E0.6850.99
68_M119_V0.6830.99
136_E163_T0.6810.99
185_D188_D0.6780.99
157_V264_V0.6770.99
157_V166_V0.6770.99
12_D15_T0.6770.99
138_F169_I0.6760.99
192_I208_A0.6760.99
30_R316_D0.6750.99
145_N148_V0.6750.99
49_N52_K0.6710.99
210_A232_R0.6680.99
15_T163_T0.6630.99
194_Y197_K0.6620.99
215_I218_A0.6610.99
246_G294_R0.6550.99
136_E318_V0.6550.99
136_E161_G0.6540.99
107_V119_V0.6540.99
193_N196_R0.6460.99
161_G289_G0.6460.99
199_Y203_I0.6460.99
166_V177_S0.6440.99
217_S220_A0.6420.99
76_Y125_Q0.6410.99
232_R237_G0.6410.99
109_S119_V0.6390.99
276_A303_E0.6380.99
54_M57_R0.6380.99
11_I103_V0.6360.99
140_A161_G0.6360.99
122_A126_A0.6360.99
224_S246_G0.6360.99
123_T128_A0.6320.99
22_V93_N0.6310.99
198_T240_K0.6300.99
191_I252_A0.6280.99
50_D53_N0.6270.99
106_C318_V0.6250.99
210_A239_P0.6250.99
37_L45_V0.6220.98
160_G163_T0.6210.98
276_A304_T0.6200.98
19_L28_V0.6190.98
177_S267_T0.6190.98
84_K87_I0.6180.98
64_A68_M0.6180.98
229_I232_R0.6180.98
31_E85_Y0.6180.98
153_G278_D0.6110.98
258_S303_E0.6100.98
83_M87_I0.6100.98
257_V261_V0.6070.98
12_D158_D0.6040.98
46_A54_M0.6030.98
59_P62_V0.6030.98
286_L308_V0.6020.98
156_V285_V0.6020.98
52_K216_G0.6000.98
19_L316_D0.5980.98
252_A255_D0.5980.98
219_E290_G0.5970.98
205_D209_E0.5960.98
224_S227_M0.5940.98
119_V122_A0.5920.98
79_T82_M0.5910.98
222_E227_M0.5870.98
83_M123_T0.5870.98
183_A186_E0.5860.98
153_G168_I0.5830.98
224_S247_K0.5820.98
199_Y248_E0.5800.98
35_V82_M0.5780.98
190_A252_A0.5770.97
118_A121_D0.5760.97
260_I296_L0.5760.97
159_I291_A0.5740.97
237_G240_K0.5730.97
56_G209_E0.5720.97
34_V51_A0.5710.97
213_M217_S0.5710.97
191_I249_I0.5700.97
284_I300_I0.5690.97
268_L271_T0.5690.97
74_A82_M0.5680.97
212_K215_I0.5680.97
64_A67_P0.5650.97
188_D212_K0.5640.97
82_M86_Y0.5630.97
207_T210_A0.5620.97
246_G249_I0.5610.97
225_D294_R0.5600.97
68_M118_A0.5590.97
195_I199_Y0.5580.97
76_Y122_A0.5560.97
264_V304_T0.5560.97
197_K201_L0.5560.97
188_D219_E0.5560.97
257_V293_L0.5540.97
250_S257_V0.5530.97
65_L162_G0.5530.97
206_R239_P0.5520.97
210_A231_G0.5520.97
263_A266_S0.5510.97
23_K323_G0.5490.97
210_A233_D0.5490.97
249_I252_A0.5480.97
110_G179_S0.5460.97
108_P111_I0.5460.97
10_G106_C0.5460.97
151_P170_S0.5430.96
263_A268_L0.5430.96
199_Y235_L0.5430.96
148_V151_P0.5420.96
300_I304_T0.5410.96
83_M119_V0.5400.96
261_V302_E0.5400.96
284_I306_M0.5400.96
45_V84_K0.5380.96
177_S180_I0.5370.96
256_T259_T0.5370.96
161_G184_G0.5370.96
276_A305_K0.5360.96
28_V320_I0.5350.96
250_S293_L0.5350.96
199_Y240_K0.5340.96
11_I105_V0.5330.96
202_M232_R0.5330.96
156_V287_T0.5330.96
183_A290_G0.5330.96
63_V68_M0.5290.96
69_K118_A0.5290.96
33_S64_A0.5290.96
124_R130_D0.5270.96
155_M304_T0.5270.96
58_T64_A0.5270.96
186_E189_D0.5250.96
64_A70_D0.5250.96
50_D89_Q0.5250.96
10_G326_L0.5240.96
301_S309_L0.5240.96
156_V161_G0.5240.96
154_S281_D0.5200.95
265_K304_T0.5200.95
119_V133_P0.5190.95
230_R234_L0.5180.95
297_D311_A0.5180.95
46_A49_N0.5170.95
190_A194_Y0.5160.95
13_L82_M0.5140.95
253_L290_G0.5140.95
209_E213_M0.5120.95
106_C138_F0.5120.95
178_Q270_K0.5100.95
195_I211_I0.5100.95
27_I93_N0.5080.95
207_T211_I0.5060.95
287_T318_V0.5060.95
281_D285_V0.5060.95
166_V264_V0.5060.95
102_Y132_Y0.5020.94
265_K276_A0.5020.94
187_M252_A0.5010.94
136_E162_G0.5000.94
110_G165_E0.5000.94
143_G285_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jneA 2 0.9674 100 0.239 Contact Map
4fl9A 1 0.9466 100 0.242 Contact Map
3d2fA 1 0.9585 100 0.249 Contact Map
2v7yA 1 0.9644 100 0.253 Contact Map
4rtfD 1 0.9347 100 0.265 Contact Map
3i33A 1 0.9377 100 0.273 Contact Map
4kboA 1 0.9407 100 0.284 Contact Map
4j8fA 2 0.9644 100 0.307 Contact Map
4gniA 2 0.9377 100 0.321 Contact Map
1jceA 1 0.9496 100 0.367 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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