GREMLIN Database
MIND - Septum site-determining protein MinD
UniProt: Q01464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (232)
Sequences: 17016 (11090)
Seq/√Len: 728.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_A231_A3.9421.00
85_Y114_F3.8041.00
20_S118_I3.7381.00
30_L237_R3.1641.00
32_K116_Y3.0381.00
6_V136_A2.8771.00
27_L116_Y2.8651.00
3_E138_K2.8171.00
19_T232_Y2.7881.00
144_T175_R2.7591.00
36_L46_L2.6521.00
35_C114_F2.6191.00
175_R206_D2.5311.00
21_A46_L2.5131.00
180_L183_N2.2591.00
24_G36_L2.1821.00
49_V148_S2.1161.00
19_T172_V2.1031.00
209_E212_K2.0951.00
76_K85_Y2.0651.00
7_I23_L2.0561.00
29_I233_R2.0251.00
26_A221_A1.9821.00
177_R206_D1.9761.00
26_A236_A1.9701.00
33_R115_D1.9521.00
48_V151_R1.9371.00
20_S36_L1.9331.00
190_D194_Q1.9031.00
172_V235_I1.8511.00
27_L118_I1.8501.00
138_K169_P1.7421.00
39_T132_A1.7191.00
21_A49_V1.7041.00
85_Y88_P1.6791.00
4_A119_I1.6461.00
30_L233_R1.6271.00
24_G118_I1.6201.00
6_V121_C1.6161.00
178_N187_M1.6101.00
32_K115_D1.6031.00
32_K240_L1.5841.00
71_H113_E1.5781.00
207_D228_A1.5781.00
7_I140_I1.5601.00
39_T60_L1.5341.00
92_T95_K1.5291.00
176_I203_I1.4611.00
23_L239_I1.4611.00
190_D203_I1.4441.00
191_E195_H1.4371.00
59_D62_D1.4281.00
91_Q94_D1.4271.00
185_D188_D1.4161.00
95_K99_A1.4141.00
138_K170_R1.4101.00
21_A50_M1.4051.00
184_G188_D1.4001.00
202_G238_R1.3931.00
173_V189_I1.3921.00
140_I172_V1.3901.00
39_T119_I1.3881.00
183_N187_M1.3481.00
23_L236_A1.3401.00
45_N152_D1.3391.00
24_G46_L1.3341.00
3_E137_D1.3321.00
170_R201_L1.3231.00
145_P173_V1.3211.00
208_D212_K1.3061.00
15_G174_N1.2801.00
139_A160_L1.2741.00
230_I233_R1.2661.00
35_C117_V1.2651.00
8_T156_I1.2601.00
7_I20_S1.2571.00
226_N229_S1.2531.00
202_G235_I1.2481.00
146_E149_A1.2431.00
19_T174_N1.2361.00
27_L34_V1.2141.00
192_I196_L1.2071.00
30_L240_L1.2031.00
209_E223_D1.1961.00
17_T49_V1.1911.00
91_Q95_K1.1841.00
58_Y62_D1.1751.00
204_V228_A1.1641.00
98_V102_Q1.1601.00
50_M84_L1.1511.00
28_A84_L1.1461.00
210_V228_A1.1331.00
218_E222_M1.1291.00
207_D226_N1.1071.00
92_T96_T1.1021.00
25_T29_I1.0931.00
70_M87_M1.0921.00
8_T121_C1.0891.00
68_C72_Q1.0891.00
61_V65_E1.0781.00
44_R47_D1.0721.00
212_K216_H1.0671.00
231_A234_N1.0661.00
200_L203_I1.0621.00
234_N237_R1.0531.00
45_N148_S1.0471.00
22_N25_T1.0471.00
94_D97_A1.0431.00
5_I116_Y1.0411.00
233_R237_R1.0381.00
103_I106_M1.0351.00
17_T46_L1.0301.00
26_A233_R1.0221.00
191_E194_Q1.0141.00
116_Y240_L1.0111.00
184_G187_M1.0101.00
27_L236_A1.0091.00
22_N221_A1.0021.00
148_S214_S1.0011.00
138_K167_E0.9931.00
146_E211_I0.9911.00
98_V101_E0.9911.00
93_S96_T0.9871.00
71_H74_L0.9851.00
104_K108_Q0.9781.00
237_R241_G0.9771.00
19_T23_L0.9741.00
96_T100_P0.9671.00
18_T210_V0.9631.00
84_L88_P0.9531.00
26_A30_L0.9511.00
69_K72_Q0.9451.00
142_V174_N0.9391.00
58_Y68_C0.9331.00
95_K100_P0.9331.00
4_A117_V0.9231.00
33_R113_E0.9221.00
99_A102_Q0.9181.00
121_C132_A0.9101.00
234_N238_R0.9061.00
7_I19_T0.9021.00
72_Q75_V0.8971.00
177_R186_T0.8961.00
228_A231_A0.8961.00
8_T129_Y0.8941.00
37_V119_I0.8931.00
154_D195_H0.8931.00
173_V176_I0.8861.00
60_L63_V0.8851.00
4_A111_K0.8851.00
18_T214_S0.8831.00
41_I128_G0.8831.00
63_V73_A0.8821.00
174_N232_Y0.8811.00
224_P229_S0.8791.00
93_S99_A0.8751.00
106_M109_E0.8701.00
25_T221_A0.8701.00
71_H75_V0.8621.00
221_A233_R0.8511.00
29_I221_A0.8491.00
141_V157_I0.8481.00
73_A87_M0.8451.00
5_I239_I0.8381.00
207_D227_R0.8351.00
158_G161_E0.8341.00
229_S233_R0.8331.00
235_I239_I0.8321.00
91_Q96_T0.8271.00
94_D98_V0.8261.00
105_N109_E0.8261.00
103_I107_V0.8231.00
221_A229_S0.8161.00
220_I229_S0.8101.00
130_K159_L0.8081.00
37_V117_V0.8051.00
26_A29_I0.8041.00
14_V149_A0.8031.00
93_S97_A0.8031.00
97_A101_E0.8011.00
3_E169_P0.8011.00
28_A82_D0.8011.00
204_V231_A0.8011.00
94_D102_Q0.8001.00
39_T128_G0.7981.00
5_I138_K0.7981.00
91_Q100_P0.7951.00
91_Q99_A0.7921.00
42_G126_E0.7811.00
7_I118_I0.7751.00
216_H222_M0.7701.00
145_P176_I0.7691.00
144_T149_A0.7691.00
48_V147_I0.7651.00
10_G159_L0.7641.00
24_G84_L0.7631.00
141_V153_A0.7581.00
34_V116_Y0.7571.00
189_I193_V0.7561.00
45_N151_R0.7531.00
25_T219_P0.7471.00
180_L185_D0.7421.00
4_A137_D0.7411.00
94_D99_A0.7361.00
183_N186_T0.7351.00
173_V203_I0.7311.00
44_R89_A0.7281.00
193_V202_G0.7281.00
36_L50_M0.7271.00
227_R230_I0.7211.00
94_D100_P0.7201.00
72_Q76_K0.7101.00
114_F117_V0.7021.00
201_L238_R0.6961.00
154_D158_G0.6951.00
22_N232_Y0.6931.00
26_A232_Y0.6931.00
169_P201_L0.6901.00
19_T142_V0.6891.00
111_K137_D0.6891.00
132_A136_A0.6881.00
170_R199_D0.6881.00
69_K109_E0.6861.00
121_C129_Y0.6841.00
101_E104_K0.6821.00
230_I234_N0.6801.00
81_D84_L0.6741.00
65_E69_K0.6721.00
140_I239_I0.6671.00
95_K102_Q0.6671.00
91_Q98_V0.6611.00
180_L208_D0.6531.00
77_D80_F0.6501.00
106_M110_L0.6481.00
92_T97_A0.6451.00
223_D226_N0.6431.00
143_T171_L0.6431.00
141_V156_I0.6391.00
22_N219_P0.6391.00
74_L78_K0.6371.00
35_C74_L0.6351.00
39_T103_I0.6341.00
126_E129_Y0.6331.00
73_A76_K0.6331.00
232_Y235_I0.6321.00
20_S46_L0.6311.00
225_K230_I0.6301.00
199_D238_R0.6271.00
34_V118_I0.6231.00
190_D193_V0.6221.00
84_L89_A0.6211.00
118_I239_I0.6191.00
62_D68_C0.6181.00
220_I228_A0.6171.00
93_S98_V0.6161.00
34_V115_D0.6121.00
157_I161_E0.6121.00
97_A102_Q0.6111.00
72_Q77_D0.6111.00
74_L85_Y0.6101.00
60_L87_M0.6071.00
3_E32_K0.6061.00
11_K148_S0.6061.00
16_K123_A0.6051.00
193_V203_I0.6041.00
227_R231_A0.6031.00
9_S14_V0.6031.00
58_Y73_A0.6021.00
11_K16_K0.6021.00
70_M73_A0.6021.00
59_D90_A0.6011.00
95_K101_E0.6011.00
238_R241_G0.6011.00
62_D67_R0.5981.00
63_V66_G0.5961.00
19_T204_V0.5951.00
119_I132_A0.5941.00
80_F85_Y0.5941.00
52_L86_L0.5941.00
147_I151_R0.5921.00
31_G82_D0.5921.00
47_D84_L0.5891.00
93_S102_Q0.5881.00
92_T100_P0.5881.00
95_K98_V0.5871.00
192_I195_H0.5841.00
5_I169_P0.5831.00
84_L90_A0.5811.00
26_A229_S0.5801.00
62_D65_E0.5761.00
66_G69_K0.5741.00
171_L193_V0.5741.00
82_D85_Y0.5741.00
108_Q111_K0.5741.00
158_G162_Q0.5731.00
212_K222_M0.5721.00
68_C73_A0.5701.00
155_R158_G0.5681.00
211_I214_S0.5661.00
213_A220_I0.5651.00
125_I159_L0.5631.00
81_D85_Y0.5631.00
45_N48_V0.5611.00
205_A227_R0.5611.00
236_A240_L0.5541.00
186_T190_D0.5541.00
44_R90_A0.5511.00
133_V139_A0.5471.00
49_V214_S0.5461.00
99_A128_G0.5431.00
92_T102_Q0.5431.00
21_A36_L0.5421.00
75_V78_K0.5411.00
96_T99_A0.5401.00
208_D211_I0.5401.00
147_I215_N0.5371.00
138_K168_P0.5371.00
11_K14_V0.5361.00
23_L235_I0.5361.00
25_T28_A0.5351.00
179_H186_T0.5341.00
6_V132_A0.5341.00
77_D81_D0.5331.00
184_G189_I0.5271.00
137_D165_N0.5271.00
62_D66_G0.5251.00
97_A100_P0.5221.00
63_V106_M0.5221.00
87_M90_A0.5201.00
47_D88_P0.5191.00
213_A219_P0.5161.00
28_A34_V0.5161.00
100_P131_N0.5161.00
183_N189_I0.5141.00
33_R114_F0.5141.00
187_M190_D0.5131.00
4_A136_A0.5121.00
29_I224_P0.5121.00
143_T153_A0.5081.00
101_E105_N0.5061.00
48_V148_S0.5061.00
131_N134_S0.5051.00
104_K135_G0.5040.99
96_T102_Q0.5040.99
154_D196_L0.5040.99
22_N220_I0.5030.99
176_I186_T0.5030.99
209_E226_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hyqA 1 0.8582 100 0.295 Contact Map
3q9lA 2 0.9291 100 0.298 Contact Map
4v03A 2 0.8769 100 0.299 Contact Map
4pfsA 1 0.8657 100 0.3 Contact Map
4rz3A 2 0.8806 100 0.307 Contact Map
1g3qA 1 0.8769 100 0.315 Contact Map
3fwyA 2 0.9291 100 0.335 Contact Map
3ea0A 2 0.8657 100 0.337 Contact Map
3pg5A 2 0.806 100 0.339 Contact Map
1wcv1 2 0.8657 100 0.341 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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