GREMLIN Database
MINC - Septum site-determining protein MinC
UniProt: Q01463 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (198)
Sequences: 1568 (1170)
Seq/√Len: 83.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_I152_A6.4221.00
148_L152_A5.3191.00
137_R156_F3.9811.00
126_L136_V2.9791.00
174_L196_A2.9661.00
64_Y67_Q2.8521.00
136_V144_V2.6681.00
82_F85_S2.5141.00
105_I125_L2.4511.00
121_K139_G2.3201.00
120_V124_L2.1901.00
128_G146_G2.1131.00
67_Q70_Q2.0571.00
8_Y34_G2.0521.00
163_V195_C2.0511.00
151_I173_Q2.0251.00
112_V134_G2.0081.00
80_D84_H1.9881.00
80_D85_S1.9371.00
139_G157_N1.9121.00
153_H175_R1.9001.00
151_I175_R1.8911.00
105_I122_G1.8791.00
124_L136_V1.8581.00
160_N178_H1.8511.00
160_N177_N1.8321.00
112_V118_L1.8241.00
160_N202_G1.8201.00
111_I128_G1.7861.00
110_K128_G1.7201.00
184_P194_E1.7081.00
106_I122_G1.6691.00
82_F86_I1.6551.00
13_G17_G1.6441.00
145_L165_A1.6151.00
107_S127_I1.5731.00
179_V198_L1.5431.00
129_D171_P1.5331.00
197_Y207_E1.4990.99
36_Q40_S1.4730.99
89_E92_T1.4550.99
122_G138_A1.4180.99
166_A169_M1.4010.99
32_L74_L1.3940.99
129_D146_G1.3790.99
11_I15_K1.3750.99
173_Q180_L1.3510.99
153_H156_F1.3280.99
32_L70_Q1.3270.99
96_A99_I1.3050.98
199_D205_V1.3030.98
130_V134_G1.2990.98
69_E73_E1.2990.98
92_T97_Q1.2840.98
177_N198_L1.2750.98
151_I172_T1.2700.98
113_R131_N1.2610.98
95_E99_I1.2340.98
117_V135_T1.2290.98
176_I204_M1.2170.98
119_Q139_G1.2170.98
27_S30_E1.2140.97
90_V93_K1.1940.97
123_D140_G1.1910.97
54_V88_S1.1860.97
60_N75_I1.1780.97
97_Q100_R1.1650.97
124_L130_V1.1360.96
194_E206_I1.1300.96
166_A171_P1.1270.96
171_P183_S1.1050.96
167_S171_P1.1050.96
159_N162_A1.0930.95
76_A82_F1.0890.95
130_V152_A1.0810.95
112_V124_L1.0760.95
126_L198_L1.0750.95
79_K85_S1.0660.95
127_I136_V1.0590.94
129_D147_S1.0590.94
28_F67_Q1.0580.94
29_D70_Q1.0530.94
79_K82_F1.0510.94
108_V118_L1.0510.94
114_S148_L1.0490.94
122_G139_G1.0370.94
135_T151_I1.0340.94
39_L42_E1.0300.94
164_I174_L1.0290.94
181_N206_I1.0260.93
95_E98_Q1.0240.93
183_S186_H1.0240.93
33_D37_N1.0200.93
80_D86_I1.0180.93
159_N177_N1.0150.93
72_T76_A1.0100.93
73_E77_S1.0060.93
92_T96_A1.0050.93
94_K98_Q0.9980.92
119_Q156_F0.9950.92
182_R185_D0.9900.92
70_Q74_L0.9800.92
17_G185_D0.9790.92
28_F74_L0.9760.92
81_L85_S0.9620.91
92_T100_R0.9610.91
203_N207_E0.9600.91
169_M174_L0.9520.91
42_E45_T0.9480.90
42_E46_D0.9460.90
38_M74_L0.9410.90
138_A142_I0.9390.90
11_I43_Q0.9380.90
131_N166_A0.9380.90
149_K170_L0.9330.90
91_I97_Q0.9290.89
175_R180_L0.9290.89
77_S161_Q0.9290.89
47_G51_K0.9230.89
148_L166_A0.9230.89
113_R116_Q0.9230.89
41_I112_V0.9220.89
110_K136_V0.9210.89
120_V139_G0.9210.89
130_V148_L0.9110.89
136_V148_L0.9100.88
139_G175_R0.9090.88
123_D141_N0.9090.88
55_H85_S0.9060.88
132_P183_S0.9020.88
32_L36_Q0.8960.88
16_N20_L0.8940.88
153_H173_Q0.8920.87
91_I95_E0.8880.87
181_N204_M0.8830.87
36_Q77_S0.8810.87
139_G156_F0.8760.87
84_H87_D0.8740.86
60_N89_E0.8720.86
181_N194_E0.8720.86
148_L164_I0.8550.85
109_S127_I0.8540.85
112_V197_Y0.8530.85
197_Y205_V0.8520.85
131_N185_D0.8500.85
134_G197_Y0.8480.85
131_N144_V0.8380.84
147_S168_E0.8380.84
172_T182_R0.8370.84
167_S193_M0.8350.84
127_I146_G0.8220.83
166_A194_E0.8150.82
47_G80_D0.8150.82
194_E204_M0.8140.82
33_D36_Q0.8040.81
15_K19_T0.8010.81
39_L75_I0.7990.81
80_D87_D0.7980.81
110_K207_E0.7970.81
118_L180_L0.7950.81
147_S171_P0.7930.81
173_Q182_R0.7920.80
124_L139_G0.7850.80
14_T17_G0.7680.78
23_D26_C0.7680.78
28_F71_L0.7660.78
43_Q166_A0.7560.77
56_V163_V0.7550.77
91_I99_I0.7520.77
28_F70_Q0.7500.77
47_G209_L0.7480.77
82_F87_D0.7400.76
151_I180_L0.7320.75
108_V130_V0.7270.75
92_T95_E0.7260.74
144_V201_D0.7260.74
13_G20_L0.7170.73
10_T38_M0.7120.73
177_N191_N0.7100.73
56_V101_E0.7100.73
62_F71_L0.7090.73
168_E191_N0.7050.72
12_K18_L0.7020.72
32_L77_S0.7010.72
91_I94_K0.7000.72
8_Y31_L0.6990.72
116_Q135_T0.6980.71
11_I38_M0.6940.71
90_V97_Q0.6930.71
144_V148_L0.6920.71
90_V94_K0.6910.71
7_Q54_V0.6900.71
160_N179_V0.6870.70
37_N41_I0.6860.70
22_L31_L0.6850.70
37_N40_S0.6840.70
169_M183_S0.6820.70
93_K98_Q0.6800.69
158_G175_R0.6780.69
126_L130_V0.6780.69
12_K38_M0.6760.69
182_R194_E0.6740.69
131_N149_K0.6730.69
103_A159_N0.6730.69
27_S32_L0.6720.69
105_I123_D0.6700.68
65_K69_E0.6700.68
29_D32_L0.6670.68
106_I112_V0.6670.68
60_N208_R0.6580.67
115_G149_K0.6570.67
39_L81_L0.6510.66
90_V96_A0.6470.66
26_C128_G0.6410.65
142_I164_I0.6390.65
38_M159_N0.6380.65
40_S189_K0.6370.64
86_I100_R0.6350.64
24_D31_L0.6290.64
25_A31_L0.6270.63
148_L170_L0.6270.63
83_V86_I0.6250.63
80_D83_V0.6240.63
192_E208_R0.6220.63
114_S131_N0.6200.62
93_K96_A0.6200.62
135_T156_F0.6190.62
158_G198_L0.6170.62
12_K140_G0.6160.62
109_S124_L0.6160.62
55_H135_T0.6140.62
174_L206_I0.6100.61
129_D174_L0.6100.61
144_V165_A0.6090.61
70_Q73_E0.6060.61
170_L190_G0.6060.61
43_Q46_D0.6050.61
38_M206_I0.6000.60
175_R182_R0.5980.60
126_L134_G0.5940.59
132_P172_T0.5930.59
127_I195_C0.5910.59
20_L54_V0.5890.58
29_D101_E0.5860.58
150_G155_G0.5840.58
93_K100_R0.5820.58
36_Q79_K0.5810.57
123_D143_F0.5800.57
193_M208_R0.5800.57
26_C31_L0.5800.57
175_R184_P0.5780.57
175_R178_H0.5730.56
40_S101_E0.5710.56
90_V95_E0.5660.55
93_K97_Q0.5650.55
56_V75_I0.5630.55
19_T208_R0.5590.55
56_V68_E0.5570.54
41_I126_L0.5550.54
61_R66_E0.5530.54
201_D205_V0.5520.54
196_A204_M0.5500.53
9_V17_G0.5490.53
199_D203_N0.5480.53
117_V120_V0.5470.53
119_Q137_R0.5440.53
121_K151_I0.5370.52
107_S141_N0.5360.52
13_G38_M0.5350.51
17_G146_G0.5340.51
30_E102_E0.5320.51
16_N27_S0.5300.51
126_L144_V0.5290.51
136_V164_I0.5290.51
143_F165_A0.5280.50
18_L31_L0.5280.50
72_T83_V0.5270.50
17_G39_L0.5250.50
28_F174_L0.5240.50
30_E206_I0.5240.50
30_E33_D0.5230.50
45_T169_M0.5220.50
19_T117_V0.5190.49
11_I191_N0.5170.49
170_L191_N0.5160.49
51_K80_D0.5160.49
38_M169_M0.5090.48
38_M42_E0.5070.48
14_T20_L0.5060.48
28_F64_Y0.5050.47
164_I198_L0.5040.47
136_V171_P0.5030.47
115_G131_N0.5030.47
59_G89_E0.5030.47
11_I114_S0.5020.47
66_E94_K0.5010.47
181_N184_P0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hf2A 2 0.885 100 0.171 Contact Map
4v02C 2 0.531 100 0.413 Contact Map
2m4iA 1 0.4381 99.6 0.727 Contact Map
3ghfA 2 0.4204 99.1 0.797 Contact Map
1pqsA 1 0.3009 45.3 0.942 Contact Map
1q1oA 1 0.3407 19.6 0.952 Contact Map
2pfuA 1 0.3805 16.8 0.953 Contact Map
1nktA 3 0.8628 16.7 0.953 Contact Map
1vd2A 1 0.354 14.3 0.955 Contact Map
1wj6A 1 0.385 14.1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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