MINC - BACSU - GREMLIN Contacts

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MINC - Septum site-determining protein MinC

UniProt:	Q01463	Sequences: MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQYTDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREEAEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNNQAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPDLTRLEGGM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	226 (198)
Sequences:	1568 (1170)
Seq/√Len:	83.2

ECOLI - MINC
BACSU - MINC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
142_I	152_A	6.422	1.00
148_L	152_A	5.319	1.00
137_R	156_F	3.981	1.00
126_L	136_V	2.979	1.00
174_L	196_A	2.966	1.00
64_Y	67_Q	2.852	1.00
136_V	144_V	2.668	1.00
82_F	85_S	2.514	1.00
105_I	125_L	2.451	1.00
121_K	139_G	2.320	1.00
120_V	124_L	2.190	1.00
128_G	146_G	2.113	1.00
67_Q	70_Q	2.057	1.00
8_Y	34_G	2.052	1.00
163_V	195_C	2.051	1.00
151_I	173_Q	2.025	1.00
112_V	134_G	2.008	1.00
80_D	84_H	1.988	1.00
80_D	85_S	1.937	1.00
139_G	157_N	1.912	1.00
153_H	175_R	1.900	1.00
151_I	175_R	1.891	1.00
105_I	122_G	1.879	1.00
124_L	136_V	1.858	1.00
160_N	178_H	1.851	1.00
160_N	177_N	1.832	1.00
112_V	118_L	1.824	1.00
160_N	202_G	1.820	1.00
111_I	128_G	1.786	1.00
110_K	128_G	1.720	1.00
184_P	194_E	1.708	1.00
106_I	122_G	1.669	1.00
82_F	86_I	1.655	1.00
13_G	17_G	1.644	1.00
145_L	165_A	1.615	1.00
107_S	127_I	1.573	1.00
179_V	198_L	1.543	1.00
129_D	171_P	1.533	1.00
197_Y	207_E	1.499	0.99
36_Q	40_S	1.473	0.99
89_E	92_T	1.455	0.99
122_G	138_A	1.418	0.99
166_A	169_M	1.401	0.99
32_L	74_L	1.394	0.99
129_D	146_G	1.379	0.99
11_I	15_K	1.375	0.99
173_Q	180_L	1.351	0.99
153_H	156_F	1.328	0.99
32_L	70_Q	1.327	0.99
96_A	99_I	1.305	0.98
199_D	205_V	1.303	0.98
130_V	134_G	1.299	0.98
69_E	73_E	1.299	0.98
92_T	97_Q	1.284	0.98
177_N	198_L	1.275	0.98
151_I	172_T	1.270	0.98
113_R	131_N	1.261	0.98
95_E	99_I	1.234	0.98
117_V	135_T	1.229	0.98
176_I	204_M	1.217	0.98
119_Q	139_G	1.217	0.98
27_S	30_E	1.214	0.97
90_V	93_K	1.194	0.97
123_D	140_G	1.191	0.97
54_V	88_S	1.186	0.97
60_N	75_I	1.178	0.97
97_Q	100_R	1.165	0.97
124_L	130_V	1.136	0.96
194_E	206_I	1.130	0.96
166_A	171_P	1.127	0.96
171_P	183_S	1.105	0.96
167_S	171_P	1.105	0.96
159_N	162_A	1.093	0.95
76_A	82_F	1.089	0.95
130_V	152_A	1.081	0.95
112_V	124_L	1.076	0.95
126_L	198_L	1.075	0.95
79_K	85_S	1.066	0.95
127_I	136_V	1.059	0.94
129_D	147_S	1.059	0.94
28_F	67_Q	1.058	0.94
29_D	70_Q	1.053	0.94
79_K	82_F	1.051	0.94
108_V	118_L	1.051	0.94
114_S	148_L	1.049	0.94
122_G	139_G	1.037	0.94
135_T	151_I	1.034	0.94
39_L	42_E	1.030	0.94
164_I	174_L	1.029	0.94
181_N	206_I	1.026	0.93
95_E	98_Q	1.024	0.93
183_S	186_H	1.024	0.93
33_D	37_N	1.020	0.93
80_D	86_I	1.018	0.93
159_N	177_N	1.015	0.93
72_T	76_A	1.010	0.93
73_E	77_S	1.006	0.93
92_T	96_A	1.005	0.93
94_K	98_Q	0.998	0.92
119_Q	156_F	0.995	0.92
182_R	185_D	0.990	0.92
70_Q	74_L	0.980	0.92
17_G	185_D	0.979	0.92
28_F	74_L	0.976	0.92
81_L	85_S	0.962	0.91
92_T	100_R	0.961	0.91
203_N	207_E	0.960	0.91
169_M	174_L	0.952	0.91
42_E	45_T	0.948	0.90
42_E	46_D	0.946	0.90
38_M	74_L	0.941	0.90
138_A	142_I	0.939	0.90
11_I	43_Q	0.938	0.90
131_N	166_A	0.938	0.90
149_K	170_L	0.933	0.90
91_I	97_Q	0.929	0.89
175_R	180_L	0.929	0.89
77_S	161_Q	0.929	0.89
47_G	51_K	0.923	0.89
148_L	166_A	0.923	0.89
113_R	116_Q	0.923	0.89
41_I	112_V	0.922	0.89
110_K	136_V	0.921	0.89
120_V	139_G	0.921	0.89
130_V	148_L	0.911	0.89
136_V	148_L	0.910	0.88
139_G	175_R	0.909	0.88
123_D	141_N	0.909	0.88
55_H	85_S	0.906	0.88
132_P	183_S	0.902	0.88
32_L	36_Q	0.896	0.88
16_N	20_L	0.894	0.88
153_H	173_Q	0.892	0.87
91_I	95_E	0.888	0.87
181_N	204_M	0.883	0.87
36_Q	77_S	0.881	0.87
139_G	156_F	0.876	0.87
84_H	87_D	0.874	0.86
60_N	89_E	0.872	0.86
181_N	194_E	0.872	0.86
148_L	164_I	0.855	0.85
109_S	127_I	0.854	0.85
112_V	197_Y	0.853	0.85
197_Y	205_V	0.852	0.85
131_N	185_D	0.850	0.85
134_G	197_Y	0.848	0.85
131_N	144_V	0.838	0.84
147_S	168_E	0.838	0.84
172_T	182_R	0.837	0.84
167_S	193_M	0.835	0.84
127_I	146_G	0.822	0.83
166_A	194_E	0.815	0.82
47_G	80_D	0.815	0.82
194_E	204_M	0.814	0.82
33_D	36_Q	0.804	0.81
15_K	19_T	0.801	0.81
39_L	75_I	0.799	0.81
80_D	87_D	0.798	0.81
110_K	207_E	0.797	0.81
118_L	180_L	0.795	0.81
147_S	171_P	0.793	0.81
173_Q	182_R	0.792	0.80
124_L	139_G	0.785	0.80
14_T	17_G	0.768	0.78
23_D	26_C	0.768	0.78
28_F	71_L	0.766	0.78
43_Q	166_A	0.756	0.77
56_V	163_V	0.755	0.77
91_I	99_I	0.752	0.77
28_F	70_Q	0.750	0.77
47_G	209_L	0.748	0.77
82_F	87_D	0.740	0.76
151_I	180_L	0.732	0.75
108_V	130_V	0.727	0.75
92_T	95_E	0.726	0.74
144_V	201_D	0.726	0.74
13_G	20_L	0.717	0.73
10_T	38_M	0.712	0.73
177_N	191_N	0.710	0.73
56_V	101_E	0.710	0.73
62_F	71_L	0.709	0.73
168_E	191_N	0.705	0.72
12_K	18_L	0.702	0.72
32_L	77_S	0.701	0.72
91_I	94_K	0.700	0.72
8_Y	31_L	0.699	0.72
116_Q	135_T	0.698	0.71
11_I	38_M	0.694	0.71
90_V	97_Q	0.693	0.71
144_V	148_L	0.692	0.71
90_V	94_K	0.691	0.71
7_Q	54_V	0.690	0.71
160_N	179_V	0.687	0.70
37_N	41_I	0.686	0.70
22_L	31_L	0.685	0.70
37_N	40_S	0.684	0.70
169_M	183_S	0.682	0.70
93_K	98_Q	0.680	0.69
158_G	175_R	0.678	0.69
126_L	130_V	0.678	0.69
12_K	38_M	0.676	0.69
182_R	194_E	0.674	0.69
131_N	149_K	0.673	0.69
103_A	159_N	0.673	0.69
27_S	32_L	0.672	0.69
105_I	123_D	0.670	0.68
65_K	69_E	0.670	0.68
29_D	32_L	0.667	0.68
106_I	112_V	0.667	0.68
60_N	208_R	0.658	0.67
115_G	149_K	0.657	0.67
39_L	81_L	0.651	0.66
90_V	96_A	0.647	0.66
26_C	128_G	0.641	0.65
142_I	164_I	0.639	0.65
38_M	159_N	0.638	0.65
40_S	189_K	0.637	0.64
86_I	100_R	0.635	0.64
24_D	31_L	0.629	0.64
25_A	31_L	0.627	0.63
148_L	170_L	0.627	0.63
83_V	86_I	0.625	0.63
80_D	83_V	0.624	0.63
192_E	208_R	0.622	0.63
114_S	131_N	0.620	0.62
93_K	96_A	0.620	0.62
135_T	156_F	0.619	0.62
158_G	198_L	0.617	0.62
12_K	140_G	0.616	0.62
109_S	124_L	0.616	0.62
55_H	135_T	0.614	0.62
174_L	206_I	0.610	0.61
129_D	174_L	0.610	0.61
144_V	165_A	0.609	0.61
70_Q	73_E	0.606	0.61
170_L	190_G	0.606	0.61
43_Q	46_D	0.605	0.61
38_M	206_I	0.600	0.60
175_R	182_R	0.598	0.60
126_L	134_G	0.594	0.59
132_P	172_T	0.593	0.59
127_I	195_C	0.591	0.59
20_L	54_V	0.589	0.58
29_D	101_E	0.586	0.58
150_G	155_G	0.584	0.58
93_K	100_R	0.582	0.58
36_Q	79_K	0.581	0.57
123_D	143_F	0.580	0.57
193_M	208_R	0.580	0.57
26_C	31_L	0.580	0.57
175_R	184_P	0.578	0.57
175_R	178_H	0.573	0.56
40_S	101_E	0.571	0.56
90_V	95_E	0.566	0.55
93_K	97_Q	0.565	0.55
56_V	75_I	0.563	0.55
19_T	208_R	0.559	0.55
56_V	68_E	0.557	0.54
41_I	126_L	0.555	0.54
61_R	66_E	0.553	0.54
201_D	205_V	0.552	0.54
196_A	204_M	0.550	0.53
9_V	17_G	0.549	0.53
199_D	203_N	0.548	0.53
117_V	120_V	0.547	0.53
119_Q	137_R	0.544	0.53
121_K	151_I	0.537	0.52
107_S	141_N	0.536	0.52
13_G	38_M	0.535	0.51
17_G	146_G	0.534	0.51
30_E	102_E	0.532	0.51
16_N	27_S	0.530	0.51
126_L	144_V	0.529	0.51
136_V	164_I	0.529	0.51
143_F	165_A	0.528	0.50
18_L	31_L	0.528	0.50
72_T	83_V	0.527	0.50
17_G	39_L	0.525	0.50
28_F	174_L	0.524	0.50
30_E	206_I	0.524	0.50
30_E	33_D	0.523	0.50
45_T	169_M	0.522	0.50
19_T	117_V	0.519	0.49
11_I	191_N	0.517	0.49
170_L	191_N	0.516	0.49
51_K	80_D	0.516	0.49
38_M	169_M	0.509	0.48
38_M	42_E	0.507	0.48
14_T	20_L	0.506	0.48
28_F	64_Y	0.505	0.47
164_I	198_L	0.504	0.47
136_V	171_P	0.503	0.47
115_G	131_N	0.503	0.47
59_G	89_E	0.503	0.47
11_I	114_S	0.502	0.47
66_E	94_K	0.501	0.47
181_N	184_P	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hf2A	2	0.885	100	0.171	Contact Map
4v02C	2	0.531	100	0.413	Contact Map
2m4iA	1	0.4381	99.6	0.727	Contact Map
3ghfA	2	0.4204	99.1	0.797	Contact Map
1pqsA	1	0.3009	45.3	0.942	Contact Map
1q1oA	1	0.3407	19.6	0.952	Contact Map
2pfuA	1	0.3805	16.8	0.953	Contact Map
1nktA	3	0.8628	16.7	0.953	Contact Map
1vd2A	1	0.354	14.3	0.955	Contact Map
1wj6A	1	0.385	14.1	0.955	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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