GREMLIN Database
SP3AB - Stage III sporulation protein AB
UniProt: Q01368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (169)
Sequences: 509 (452)
Seq/√Len: 34.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_L56_A5.7571.00
90_W115_G4.9021.00
38_A72_F3.1841.00
28_R107_E2.9721.00
11_V167_I2.5881.00
36_R138_E2.5521.00
148_Q152_E2.4761.00
44_A121_H2.4171.00
146_Q150_K2.3871.00
44_A125_S2.3821.00
7_A167_I2.2650.99
78_Q92_Q2.2480.99
119_G126_Q2.2020.99
89_A93_S2.1270.99
43_E131_K2.0560.98
14_T163_G2.0370.98
6_G13_A1.9550.98
85_S88_T1.9530.98
53_L56_A1.9030.97
33_R145_E1.8160.97
78_Q93_S1.8010.96
121_H125_S1.7290.96
6_G9_F1.7050.95
135_T138_E1.7020.95
61_A73_S1.6720.95
33_R43_E1.6660.95
32_I107_E1.6270.94
47_M127_Q1.6130.94
157_S161_L1.5950.93
98_W101_L1.5300.92
36_R141_E1.5240.91
57_S75_F1.5110.91
11_V164_L1.5030.91
107_E140_S1.4910.90
75_F86_A1.4770.90
110_V133_A1.4710.90
28_R159_G1.4590.89
38_A43_E1.4450.89
86_A89_A1.4160.88
43_E128_K1.3770.87
98_W107_E1.3730.86
27_E30_R1.3730.86
91_E112_K1.3560.86
71_L75_F1.3550.86
75_F93_S1.3150.84
141_E152_E1.3030.83
19_F31_Q1.2840.82
28_R144_A1.2630.81
31_Q67_P1.2450.80
120_I125_S1.2440.80
36_R134_L1.2430.80
78_Q96_K1.2420.80
68_V71_L1.2410.80
9_F81_K1.2270.79
49_G114_F1.2090.78
114_F130_I1.2080.78
161_L165_L1.2080.78
128_K132_L1.1960.78
4_L7_A1.1910.77
11_V14_T1.1860.77
4_L8_V1.1510.75
40_Q132_L1.1500.75
147_A151_N1.1460.74
64_L85_S1.1350.74
35_L71_L1.1330.74
13_A16_W1.1310.73
29_P33_R1.1270.73
15_T19_F1.1200.73
44_A129_H1.1180.73
33_R136_H1.1180.73
54_H79_L1.1090.72
23_K26_T1.0980.71
36_R90_W1.0930.71
66_Q70_T1.0910.71
115_G164_L1.0780.70
153_K169_L1.0740.70
91_E95_K1.0700.69
74_A96_K1.0680.69
32_I103_L1.0660.69
125_S129_H1.0590.68
51_T54_H1.0560.68
105_K147_A1.0500.68
22_A118_L1.0260.66
39_L90_W1.0160.65
26_T148_Q1.0160.65
139_A143_D1.0140.65
68_V72_F1.0080.65
66_Q69_S0.9990.64
61_A69_S0.9910.63
95_K108_Y0.9800.62
95_K112_K0.9770.62
38_A117_T0.9750.62
13_A103_L0.9580.61
130_I134_L0.9530.60
73_S77_D0.9520.60
63_Q110_V0.9500.60
2_L109_E0.9470.60
72_F86_A0.9460.60
88_T92_Q0.9400.59
21_M41_S0.9400.59
15_T167_I0.9190.57
14_T73_S0.9130.57
76_S80_D0.9130.57
58_Q80_D0.9000.56
151_N154_M0.8990.56
111_L135_T0.8960.55
42_L123_R0.8960.55
43_E134_L0.8940.55
165_L169_L0.8930.55
50_H123_R0.8930.55
22_A159_G0.8870.55
137_L170_L0.8810.54
34_Q37_A0.8750.54
2_L92_Q0.8740.54
15_T118_L0.8720.53
51_T56_A0.8710.53
15_T159_G0.8680.53
164_L168_L0.8670.53
72_F118_L0.8610.52
79_L135_T0.8550.52
90_W111_L0.8510.52
152_E161_L0.8470.51
34_Q68_V0.8340.50
10_I66_Q0.8210.49
49_G107_E0.8200.49
103_L138_E0.8160.49
29_P141_E0.8150.48
69_S102_S0.8110.48
74_A78_Q0.8040.48
75_F89_A0.8010.47
136_H139_A0.7980.47
27_E31_Q0.7960.47
85_S154_M0.7940.47
53_L86_A0.7930.47
103_L108_Y0.7920.47
52_P158_L0.7920.47
42_L53_L0.7900.46
18_G119_G0.7820.46
15_T32_I0.7790.45
70_T100_T0.7740.45
152_E156_K0.7720.45
53_L57_S0.7660.44
138_E150_K0.7660.44
119_G159_G0.7650.44
37_A139_A0.7590.44
88_T95_K0.7580.44
36_R148_Q0.7580.44
75_F78_Q0.7480.43
86_A90_W0.7460.43
24_I61_A0.7400.42
11_V140_S0.7240.41
147_A150_K0.7230.41
114_F150_K0.7220.41
2_L8_V0.7200.40
87_K94_L0.7180.40
90_W136_H0.7160.40
124_I127_Q0.7160.40
94_L111_L0.7150.40
16_W63_Q0.7110.40
18_G126_Q0.7000.39
13_A68_V0.6950.38
4_L101_L0.6950.38
63_Q139_A0.6940.38
110_V140_S0.6930.38
55_T95_K0.6900.38
74_A104_K0.6890.38
73_S80_D0.6830.37
83_S135_T0.6820.37
137_L146_Q0.6800.37
88_T169_L0.6780.37
106_S140_S0.6740.37
45_E59_Q0.6690.36
56_A110_V0.6680.36
44_A165_L0.6670.36
49_G167_I0.6670.36
11_V99_D0.6600.36
38_A68_V0.6550.35
98_W108_Y0.6510.35
125_S155_I0.6500.35
59_Q145_E0.6490.35
56_A166_L0.6430.34
155_I169_L0.6420.34
6_G45_E0.6290.33
95_K167_I0.6280.33
21_M155_I0.6250.33
121_H126_Q0.6240.33
116_E140_S0.6120.32
9_F46_I0.6120.32
39_L114_F0.6110.32
84_D89_A0.6100.32
100_T112_K0.6080.32
41_S164_L0.6050.31
114_F168_L0.6000.31
49_G141_E0.5950.31
12_V62_K0.5950.31
2_L30_R0.5910.30
13_A90_W0.5900.30
77_D94_L0.5900.30
69_S79_L0.5880.30
83_S105_K0.5810.30
28_R32_I0.5810.30
17_T160_F0.5810.30
36_R122_D0.5800.30
97_V168_L0.5790.30
31_Q102_S0.5780.30
52_P123_R0.5780.30
29_P144_A0.5770.29
76_S146_Q0.5770.29
19_F51_T0.5740.29
45_E60_I0.5690.29
33_R166_L0.5680.29
3_K73_S0.5680.29
78_Q170_L0.5670.29
46_I126_Q0.5660.29
107_E144_A0.5640.29
29_P36_R0.5620.28
93_S101_L0.5610.28
116_E170_L0.5590.28
3_K39_L0.5580.28
51_T61_A0.5540.28
16_W127_Q0.5500.28
151_N165_L0.5470.27
114_F124_I0.5450.27
131_K142_A0.5430.27
59_Q168_L0.5410.27
4_L11_V0.5390.27
9_F36_R0.5380.27
35_L101_L0.5310.26
4_L19_F0.5300.26
34_Q65_A0.5290.26
99_D166_L0.5270.26
81_K133_A0.5270.26
116_E120_I0.5270.26
72_F154_M0.5260.26
86_A165_L0.5260.26
118_L132_L0.5250.26
9_F104_K0.5240.26
40_Q43_E0.5230.26
141_E161_L0.5220.26
113_Q161_L0.5210.26
63_Q103_L0.5200.26
98_W103_L0.5180.25
58_Q76_S0.5150.25
163_G170_L0.5120.25
19_F159_G0.5100.25
110_V144_A0.5100.25
61_A109_E0.5090.25
77_D108_Y0.5080.25
95_K145_E0.5070.25
54_H107_E0.5060.25
2_L24_I0.5060.25
154_M159_G0.5050.25
49_G128_K0.5020.24
101_L167_I0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ykeB 1 0.6784 17.8 0.935 Contact Map
2jxuA 1 0.7485 17 0.936 Contact Map
4hkrA 3 0.2807 14.8 0.937 Contact Map
2whnA 1 0.6374 13.7 0.938 Contact Map
2j69A 1 0.7544 10.8 0.941 Contact Map
3c1qA 2 0.6901 7.1 0.946 Contact Map
4hhxA 1 0.5731 6.9 0.946 Contact Map
1ykhB 1 0.6608 6.3 0.947 Contact Map
1gotG 1 0.3275 5.7 0.948 Contact Map
4cq4A 4 0.4854 5.4 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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