SP3AA - BACSU - GREMLIN Contacts

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SP3AA - Stage III sporulation protein AA

UniProt:	Q01367	Sequences: MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRGQPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGGVKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLSSTGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSPEVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYLELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	307 (271)
Sequences:	786 (562)
Seq/√Len:	34.2

BACSU - SP3AA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_A	222_I	5.772	1.00
174_I	193_F	4.719	1.00
157_A	174_I	4.475	1.00
124_A	159_L	4.117	1.00
173_G	212_M	3.814	1.00
143_G	147_T	3.814	1.00
175_V	212_M	3.296	1.00
160_S	220_V	3.240	1.00
125_E	159_L	3.152	1.00
283_G	286_T	3.124	1.00
182_A	199_V	3.079	1.00
264_K	268_E	3.038	1.00
32_I	53_G	2.989	1.00
170_V	219_E	2.847	1.00
38_V	53_G	2.657	1.00
99_E	104_K	2.604	1.00
58_A	112_F	2.497	1.00
283_G	288_S	2.440	1.00
9_P	61_I	2.417	1.00
140_L	247_V	2.399	0.99
226_I	235_L	2.393	0.99
222_I	246_I	2.378	0.99
51_Y	57_D	2.303	0.99
235_L	245_V	2.220	0.99
212_M	216_M	2.204	0.99
32_I	61_I	2.188	0.99
171_K	217_S	2.183	0.99
65_L	90_V	2.161	0.99
182_A	193_F	2.141	0.99
8_L	16_L	2.126	0.99
213_I	238_A	2.120	0.99
229_M	233_D	2.082	0.99
179_S	201_D	2.059	0.98
279_S	288_S	2.055	0.98
96_V	106_L	2.019	0.98
279_S	283_G	2.007	0.98
251_G	257_L	2.001	0.98
11_S	57_D	1.965	0.98
84_I	90_V	1.922	0.98
36_R	193_F	1.906	0.97
146_Q	171_K	1.832	0.97
142_I	275_Y	1.801	0.96
209_L	234_A	1.800	0.96
174_I	182_A	1.758	0.96
124_A	155_D	1.757	0.96
103_V	211_M	1.752	0.96
209_L	238_A	1.707	0.95
65_L	82_V	1.661	0.94
212_M	221_M	1.656	0.94
38_V	49_L	1.616	0.93
157_A	212_M	1.611	0.93
279_S	286_T	1.579	0.92
128_L	156_L	1.578	0.92
36_R	189_P	1.571	0.92
136_W	143_G	1.567	0.92
174_I	222_I	1.557	0.92
249_A	260_R	1.539	0.91
131_L	156_L	1.536	0.91
46_P	143_G	1.529	0.91
140_L	275_Y	1.509	0.91
7_V	84_I	1.504	0.90
121_L	192_Q	1.500	0.90
93_A	111_S	1.497	0.90
281_A	288_S	1.495	0.90
162_T	192_Q	1.469	0.89
284_P	287_V	1.467	0.89
27_I	40_L	1.467	0.89
163_G	196_R	1.451	0.89
141_I	248_S	1.447	0.89
8_L	114_I	1.446	0.89
95_R	108_D	1.432	0.88
88_H	117_A	1.432	0.88
142_I	257_L	1.395	0.87
193_F	197_I	1.381	0.86
235_L	267_W	1.376	0.86
60_L	64_R	1.369	0.86
138_N	244_S	1.345	0.85
162_T	195_Q	1.325	0.84
244_S	273_D	1.316	0.83
128_L	159_L	1.293	0.82
277_E	291_Y	1.274	0.81
171_K	219_E	1.232	0.79
161_S	222_I	1.221	0.78
237_E	241_A	1.216	0.78
61_I	112_F	1.208	0.78
39_E	46_P	1.202	0.77
213_I	221_M	1.183	0.76
30_V	227_G	1.157	0.75
157_A	193_F	1.154	0.74
16_L	30_V	1.143	0.74
131_L	276_L	1.142	0.74
18_E	25_L	1.137	0.73
223_V	247_V	1.133	0.73
160_S	172_T	1.118	0.72
137_L	273_D	1.116	0.72
7_V	114_I	1.108	0.71
183_G	213_I	1.108	0.71
237_E	260_R	1.107	0.71
4_I	8_L	1.101	0.71
119_Q	192_Q	1.092	0.70
157_A	248_S	1.088	0.70
249_A	263_L	1.088	0.70
118_R	243_V	1.081	0.69
65_L	267_W	1.069	0.68
275_Y	295_G	1.063	0.68
105_G	262_S	1.062	0.68
86_G	201_D	1.061	0.68
26_E	43_R	1.059	0.68
174_I	181_I	1.059	0.68
146_Q	217_S	1.054	0.67
171_K	247_V	1.050	0.67
119_Q	191_H	1.046	0.67
48_Y	84_I	1.045	0.67
171_K	238_A	1.038	0.66
236_L	265_R	1.035	0.66
181_I	193_F	1.017	0.65
236_L	269_E	1.013	0.64
50_S	125_E	0.992	0.63
111_S	181_I	0.989	0.62
172_T	220_V	0.986	0.62
136_W	246_I	0.978	0.61
113_N	227_G	0.969	0.61
16_L	271_A	0.967	0.61
104_K	181_I	0.962	0.60
251_G	256_D	0.960	0.60
143_G	197_I	0.956	0.60
117_A	183_G	0.954	0.60
35_N	290_I	0.953	0.59
11_S	15_A	0.948	0.59
111_S	223_V	0.946	0.59
13_K	182_A	0.940	0.58
228_R	241_A	0.927	0.57
252_W	256_D	0.926	0.57
145_P	205_K	0.922	0.57
85_R	183_G	0.921	0.57
142_I	277_E	0.921	0.57
222_I	248_S	0.919	0.57
66_S	249_A	0.910	0.56
267_W	275_Y	0.905	0.55
20_P	118_R	0.896	0.55
93_A	209_L	0.892	0.54
268_E	271_A	0.892	0.54
39_E	195_Q	0.891	0.54
189_P	193_F	0.890	0.54
34_I	58_A	0.887	0.54
279_S	282_K	0.885	0.54
179_S	184_C	0.882	0.54
147_T	288_S	0.881	0.53
137_L	274_R	0.877	0.53
123_I	237_E	0.876	0.53
143_G	157_A	0.875	0.53
97_I	105_G	0.875	0.53
10_E	38_V	0.871	0.53
253_S	277_E	0.869	0.52
62_L	112_F	0.863	0.52
15_A	51_Y	0.862	0.52
63_S	247_V	0.859	0.52
292_D	295_G	0.857	0.51
210_M	241_A	0.854	0.51
28_E	223_V	0.849	0.51
66_S	203_C	0.847	0.51
258_M	268_E	0.844	0.50
241_A	260_R	0.842	0.50
62_L	109_I	0.842	0.50
201_D	204_P	0.841	0.50
200_L	204_P	0.841	0.50
291_Y	295_G	0.835	0.50
27_I	42_R	0.834	0.49
240_H	260_R	0.830	0.49
275_Y	292_D	0.830	0.49
104_K	184_C	0.830	0.49
38_V	57_D	0.825	0.49
264_K	295_G	0.824	0.49
33_R	198_D	0.818	0.48
275_Y	293_K	0.813	0.48
231_D	272_F	0.809	0.47
43_R	118_R	0.799	0.47
256_D	280_R	0.797	0.46
68_Y	223_V	0.796	0.46
238_A	245_V	0.787	0.45
103_V	106_L	0.786	0.45
98_T	219_E	0.786	0.45
239_L	271_A	0.782	0.45
94_G	201_D	0.776	0.45
206_A	230_E	0.774	0.44
204_P	261_P	0.774	0.44
13_K	61_I	0.773	0.44
212_M	223_V	0.773	0.44
36_R	53_G	0.768	0.44
115_R	250_H	0.767	0.44
123_I	141_I	0.766	0.44
175_V	208_G	0.763	0.43
15_A	49_L	0.762	0.43
92_L	112_F	0.760	0.43
65_L	271_A	0.760	0.43
280_R	288_S	0.760	0.43
145_P	227_G	0.756	0.43
32_I	38_V	0.756	0.43
4_I	116_I	0.755	0.43
88_H	208_G	0.753	0.43
14_N	134_N	0.747	0.42
68_Y	132_Y	0.740	0.42
15_A	38_V	0.739	0.42
155_D	201_D	0.736	0.41
62_L	66_S	0.736	0.41
56_E	60_L	0.735	0.41
38_V	51_Y	0.734	0.41
67_N	221_M	0.733	0.41
20_P	23_Q	0.732	0.41
82_V	105_G	0.729	0.41
246_I	276_L	0.724	0.40
217_S	246_I	0.724	0.40
87_G	178_R	0.723	0.40
127_L	276_L	0.722	0.40
178_R	214_R	0.720	0.40
109_I	152_L	0.714	0.39
27_I	220_V	0.710	0.39
118_R	222_I	0.704	0.39
243_V	266_L	0.703	0.39
42_R	118_R	0.701	0.38
5_A	27_I	0.699	0.38
66_S	251_G	0.697	0.38
117_A	208_G	0.695	0.38
254_I	277_E	0.695	0.38
31_R	187_G	0.693	0.38
95_R	202_A	0.689	0.37
163_G	238_A	0.689	0.37
12_M	285_G	0.687	0.37
31_R	198_D	0.686	0.37
235_L	272_F	0.686	0.37
10_E	13_K	0.685	0.37
122_G	125_E	0.680	0.37
222_I	285_G	0.679	0.37
54_T	131_L	0.678	0.37
226_I	262_S	0.677	0.37
122_G	155_D	0.674	0.36
118_R	241_A	0.673	0.36
155_D	163_G	0.673	0.36
87_G	205_K	0.671	0.36
260_R	288_S	0.669	0.36
209_L	221_M	0.665	0.36
125_E	128_L	0.665	0.36
102_G	207_E	0.665	0.36
28_E	280_R	0.664	0.35
203_C	211_M	0.661	0.35
204_P	207_E	0.661	0.35
95_R	146_Q	0.660	0.35
191_H	260_R	0.659	0.35
92_L	188_I	0.659	0.35
88_H	227_G	0.658	0.35
27_I	153_L	0.657	0.35
187_G	198_D	0.653	0.35
87_G	113_N	0.653	0.35
34_I	62_L	0.652	0.35
156_L	276_L	0.650	0.34
175_V	261_P	0.648	0.34
30_V	181_I	0.648	0.34
204_P	210_M	0.644	0.34
7_V	290_I	0.642	0.34
139_T	163_G	0.640	0.34
180_E	250_H	0.639	0.34
174_I	197_I	0.639	0.34
267_W	282_K	0.637	0.33
6_E	182_A	0.636	0.33
204_P	241_A	0.636	0.33
39_E	189_P	0.636	0.33
146_Q	241_A	0.634	0.33
138_N	273_D	0.634	0.33
84_I	186_R	0.633	0.33
26_E	102_G	0.628	0.33
18_E	188_I	0.626	0.33
144_P	147_T	0.625	0.33
173_G	216_M	0.625	0.33
148_G	224_D	0.624	0.32
98_T	199_V	0.624	0.32
56_E	59_H	0.623	0.32
87_G	214_R	0.623	0.32
100_N	121_L	0.621	0.32
89_R	250_H	0.621	0.32
35_N	271_A	0.617	0.32
183_G	189_P	0.616	0.32
31_R	87_G	0.612	0.32
64_R	127_L	0.609	0.31
91_G	250_H	0.606	0.31
216_M	223_V	0.605	0.31
177_E	198_D	0.604	0.31
243_V	273_D	0.604	0.31
55_A	186_R	0.602	0.31
33_R	187_G	0.602	0.31
160_S	241_A	0.600	0.31
109_I	127_L	0.599	0.31
12_M	32_I	0.598	0.31
127_L	152_L	0.598	0.31
156_L	246_I	0.597	0.30
10_E	60_L	0.597	0.30
66_S	257_L	0.595	0.30
148_G	151_T	0.594	0.30
121_L	159_L	0.594	0.30
53_G	58_A	0.593	0.30
88_H	179_S	0.593	0.30
231_D	266_L	0.592	0.30
192_Q	197_I	0.589	0.30
132_Y	223_V	0.588	0.30
113_N	215_S	0.587	0.30
34_I	38_V	0.586	0.30
9_P	199_V	0.585	0.30
108_D	171_K	0.585	0.30
37_P	163_G	0.584	0.30
83_T	117_A	0.583	0.29
89_R	115_R	0.582	0.29
86_G	161_S	0.582	0.29
87_G	177_E	0.581	0.29
91_G	145_P	0.581	0.29
282_K	288_S	0.580	0.29
42_R	47_V	0.580	0.29
46_P	197_I	0.580	0.29
209_L	256_D	0.579	0.29
182_A	249_A	0.578	0.29
33_R	216_M	0.578	0.29
8_L	44_G	0.576	0.29
209_L	223_V	0.576	0.29
180_E	224_D	0.573	0.29
99_E	109_I	0.573	0.29
93_A	107_R	0.573	0.29
201_D	231_D	0.571	0.29
39_E	116_I	0.570	0.29
183_G	245_V	0.570	0.29
126_P	290_I	0.570	0.29
146_Q	222_I	0.567	0.28
90_V	112_F	0.564	0.28
120_K	233_D	0.562	0.28
221_M	245_V	0.562	0.28
212_M	275_Y	0.562	0.28
170_V	220_V	0.562	0.28
64_R	123_I	0.562	0.28
191_H	236_L	0.562	0.28
83_T	113_N	0.561	0.28
199_V	268_E	0.561	0.28
67_N	156_L	0.560	0.28
171_K	237_E	0.560	0.28
93_A	216_M	0.559	0.28
87_G	198_D	0.557	0.28
12_M	53_G	0.557	0.28
148_G	180_E	0.555	0.28
62_L	272_F	0.553	0.27
40_L	95_R	0.552	0.27
10_E	14_N	0.552	0.27
109_I	227_G	0.552	0.27
10_E	17_S	0.551	0.27
123_I	159_L	0.550	0.27
64_R	118_R	0.548	0.27
109_I	215_S	0.547	0.27
178_R	198_D	0.544	0.27
158_R	194_G	0.542	0.27
113_N	208_G	0.541	0.27
10_E	175_V	0.540	0.27
262_S	265_R	0.540	0.27
231_D	249_A	0.538	0.26
177_E	205_K	0.538	0.26
198_D	214_R	0.534	0.26
32_I	164_K	0.534	0.26
196_R	209_L	0.534	0.26
116_I	207_E	0.534	0.26
111_S	118_R	0.532	0.26
112_F	174_I	0.531	0.26
26_E	120_K	0.531	0.26
91_G	150_T	0.530	0.26
39_E	171_K	0.529	0.26
200_L	203_C	0.529	0.26
177_E	214_R	0.528	0.26
53_G	153_L	0.527	0.26
8_L	233_D	0.527	0.26
142_I	251_G	0.525	0.26
65_L	112_F	0.525	0.26
141_I	152_L	0.524	0.26
63_S	223_V	0.523	0.25
9_P	146_Q	0.522	0.25
100_N	268_E	0.520	0.25
143_G	222_I	0.520	0.25
163_G	173_G	0.519	0.25
141_I	253_S	0.519	0.25
84_I	251_G	0.519	0.25
120_K	123_I	0.519	0.25
191_H	243_V	0.519	0.25
26_E	263_L	0.518	0.25
20_P	24_W	0.516	0.25
28_E	190_Q	0.514	0.25
221_M	260_R	0.513	0.25
40_L	188_I	0.513	0.25
10_E	65_L	0.512	0.25
85_R	190_Q	0.512	0.25
96_V	103_V	0.512	0.25
16_L	38_V	0.512	0.25
19_I	125_E	0.511	0.25
49_L	183_G	0.509	0.25
111_S	222_I	0.509	0.25
152_L	156_L	0.508	0.24
124_A	158_R	0.506	0.24
9_P	284_P	0.505	0.24
65_L	84_I	0.505	0.24
98_T	204_P	0.504	0.24
15_A	57_D	0.503	0.24
84_I	269_E	0.502	0.24
89_R	180_E	0.501	0.24
245_V	257_L	0.500	0.24
90_V	255_S	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ewvA	3	0.9121	99.9	0.792	Contact Map
2oap1	3	0.9446	99.9	0.793	Contact Map
3jvvA	3	0.9121	99.9	0.793	Contact Map
4ihqA	3	0.9577	99.9	0.795	Contact Map
2gzaA	3	0.8697	99.7	0.833	Contact Map
2pt7A	3	0.9121	99.4	0.863	Contact Map
2eyuA	1	0.5831	99.4	0.866	Contact Map
2r8rA	1	0.5472	99.3	0.873	Contact Map
4ksrA	3	0.8599	99.2	0.877	Contact Map
2orwA	3	0.5016	99	0.885	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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