GREMLIN Database
SP3AA - Stage III sporulation protein AA
UniProt: Q01367 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (271)
Sequences: 786 (562)
Seq/√Len: 34.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_A222_I5.7721.00
174_I193_F4.7191.00
157_A174_I4.4751.00
124_A159_L4.1171.00
173_G212_M3.8141.00
143_G147_T3.8141.00
175_V212_M3.2961.00
160_S220_V3.2401.00
125_E159_L3.1521.00
283_G286_T3.1241.00
182_A199_V3.0791.00
264_K268_E3.0381.00
32_I53_G2.9891.00
170_V219_E2.8471.00
38_V53_G2.6571.00
99_E104_K2.6041.00
58_A112_F2.4971.00
283_G288_S2.4401.00
9_P61_I2.4171.00
140_L247_V2.3990.99
226_I235_L2.3930.99
222_I246_I2.3780.99
51_Y57_D2.3030.99
235_L245_V2.2200.99
212_M216_M2.2040.99
32_I61_I2.1880.99
171_K217_S2.1830.99
65_L90_V2.1610.99
182_A193_F2.1410.99
8_L16_L2.1260.99
213_I238_A2.1200.99
229_M233_D2.0820.99
179_S201_D2.0590.98
279_S288_S2.0550.98
96_V106_L2.0190.98
279_S283_G2.0070.98
251_G257_L2.0010.98
11_S57_D1.9650.98
84_I90_V1.9220.98
36_R193_F1.9060.97
146_Q171_K1.8320.97
142_I275_Y1.8010.96
209_L234_A1.8000.96
174_I182_A1.7580.96
124_A155_D1.7570.96
103_V211_M1.7520.96
209_L238_A1.7070.95
65_L82_V1.6610.94
212_M221_M1.6560.94
38_V49_L1.6160.93
157_A212_M1.6110.93
279_S286_T1.5790.92
128_L156_L1.5780.92
36_R189_P1.5710.92
136_W143_G1.5670.92
174_I222_I1.5570.92
249_A260_R1.5390.91
131_L156_L1.5360.91
46_P143_G1.5290.91
140_L275_Y1.5090.91
7_V84_I1.5040.90
121_L192_Q1.5000.90
93_A111_S1.4970.90
281_A288_S1.4950.90
162_T192_Q1.4690.89
284_P287_V1.4670.89
27_I40_L1.4670.89
163_G196_R1.4510.89
141_I248_S1.4470.89
8_L114_I1.4460.89
95_R108_D1.4320.88
88_H117_A1.4320.88
142_I257_L1.3950.87
193_F197_I1.3810.86
235_L267_W1.3760.86
60_L64_R1.3690.86
138_N244_S1.3450.85
162_T195_Q1.3250.84
244_S273_D1.3160.83
128_L159_L1.2930.82
277_E291_Y1.2740.81
171_K219_E1.2320.79
161_S222_I1.2210.78
237_E241_A1.2160.78
61_I112_F1.2080.78
39_E46_P1.2020.77
213_I221_M1.1830.76
30_V227_G1.1570.75
157_A193_F1.1540.74
16_L30_V1.1430.74
131_L276_L1.1420.74
18_E25_L1.1370.73
223_V247_V1.1330.73
160_S172_T1.1180.72
137_L273_D1.1160.72
7_V114_I1.1080.71
183_G213_I1.1080.71
237_E260_R1.1070.71
4_I8_L1.1010.71
119_Q192_Q1.0920.70
157_A248_S1.0880.70
249_A263_L1.0880.70
118_R243_V1.0810.69
65_L267_W1.0690.68
275_Y295_G1.0630.68
105_G262_S1.0620.68
86_G201_D1.0610.68
26_E43_R1.0590.68
174_I181_I1.0590.68
146_Q217_S1.0540.67
171_K247_V1.0500.67
119_Q191_H1.0460.67
48_Y84_I1.0450.67
171_K238_A1.0380.66
236_L265_R1.0350.66
181_I193_F1.0170.65
236_L269_E1.0130.64
50_S125_E0.9920.63
111_S181_I0.9890.62
172_T220_V0.9860.62
136_W246_I0.9780.61
113_N227_G0.9690.61
16_L271_A0.9670.61
104_K181_I0.9620.60
251_G256_D0.9600.60
143_G197_I0.9560.60
117_A183_G0.9540.60
35_N290_I0.9530.59
11_S15_A0.9480.59
111_S223_V0.9460.59
13_K182_A0.9400.58
228_R241_A0.9270.57
252_W256_D0.9260.57
145_P205_K0.9220.57
85_R183_G0.9210.57
142_I277_E0.9210.57
222_I248_S0.9190.57
66_S249_A0.9100.56
267_W275_Y0.9050.55
20_P118_R0.8960.55
93_A209_L0.8920.54
268_E271_A0.8920.54
39_E195_Q0.8910.54
189_P193_F0.8900.54
34_I58_A0.8870.54
279_S282_K0.8850.54
179_S184_C0.8820.54
147_T288_S0.8810.53
137_L274_R0.8770.53
123_I237_E0.8760.53
143_G157_A0.8750.53
97_I105_G0.8750.53
10_E38_V0.8710.53
253_S277_E0.8690.52
62_L112_F0.8630.52
15_A51_Y0.8620.52
63_S247_V0.8590.52
292_D295_G0.8570.51
210_M241_A0.8540.51
28_E223_V0.8490.51
66_S203_C0.8470.51
258_M268_E0.8440.50
241_A260_R0.8420.50
62_L109_I0.8420.50
201_D204_P0.8410.50
200_L204_P0.8410.50
291_Y295_G0.8350.50
27_I42_R0.8340.49
240_H260_R0.8300.49
275_Y292_D0.8300.49
104_K184_C0.8300.49
38_V57_D0.8250.49
264_K295_G0.8240.49
33_R198_D0.8180.48
275_Y293_K0.8130.48
231_D272_F0.8090.47
43_R118_R0.7990.47
256_D280_R0.7970.46
68_Y223_V0.7960.46
238_A245_V0.7870.45
103_V106_L0.7860.45
98_T219_E0.7860.45
239_L271_A0.7820.45
94_G201_D0.7760.45
206_A230_E0.7740.44
204_P261_P0.7740.44
13_K61_I0.7730.44
212_M223_V0.7730.44
36_R53_G0.7680.44
115_R250_H0.7670.44
123_I141_I0.7660.44
175_V208_G0.7630.43
15_A49_L0.7620.43
92_L112_F0.7600.43
65_L271_A0.7600.43
280_R288_S0.7600.43
145_P227_G0.7560.43
32_I38_V0.7560.43
4_I116_I0.7550.43
88_H208_G0.7530.43
14_N134_N0.7470.42
68_Y132_Y0.7400.42
15_A38_V0.7390.42
155_D201_D0.7360.41
62_L66_S0.7360.41
56_E60_L0.7350.41
38_V51_Y0.7340.41
67_N221_M0.7330.41
20_P23_Q0.7320.41
82_V105_G0.7290.41
246_I276_L0.7240.40
217_S246_I0.7240.40
87_G178_R0.7230.40
127_L276_L0.7220.40
178_R214_R0.7200.40
109_I152_L0.7140.39
27_I220_V0.7100.39
118_R222_I0.7040.39
243_V266_L0.7030.39
42_R118_R0.7010.38
5_A27_I0.6990.38
66_S251_G0.6970.38
117_A208_G0.6950.38
254_I277_E0.6950.38
31_R187_G0.6930.38
95_R202_A0.6890.37
163_G238_A0.6890.37
12_M285_G0.6870.37
31_R198_D0.6860.37
235_L272_F0.6860.37
10_E13_K0.6850.37
122_G125_E0.6800.37
222_I285_G0.6790.37
54_T131_L0.6780.37
226_I262_S0.6770.37
122_G155_D0.6740.36
118_R241_A0.6730.36
155_D163_G0.6730.36
87_G205_K0.6710.36
260_R288_S0.6690.36
209_L221_M0.6650.36
125_E128_L0.6650.36
102_G207_E0.6650.36
28_E280_R0.6640.35
203_C211_M0.6610.35
204_P207_E0.6610.35
95_R146_Q0.6600.35
191_H260_R0.6590.35
92_L188_I0.6590.35
88_H227_G0.6580.35
27_I153_L0.6570.35
187_G198_D0.6530.35
87_G113_N0.6530.35
34_I62_L0.6520.35
156_L276_L0.6500.34
175_V261_P0.6480.34
30_V181_I0.6480.34
204_P210_M0.6440.34
7_V290_I0.6420.34
139_T163_G0.6400.34
180_E250_H0.6390.34
174_I197_I0.6390.34
267_W282_K0.6370.33
6_E182_A0.6360.33
204_P241_A0.6360.33
39_E189_P0.6360.33
146_Q241_A0.6340.33
138_N273_D0.6340.33
84_I186_R0.6330.33
26_E102_G0.6280.33
18_E188_I0.6260.33
144_P147_T0.6250.33
173_G216_M0.6250.33
148_G224_D0.6240.32
98_T199_V0.6240.32
56_E59_H0.6230.32
87_G214_R0.6230.32
100_N121_L0.6210.32
89_R250_H0.6210.32
35_N271_A0.6170.32
183_G189_P0.6160.32
31_R87_G0.6120.32
64_R127_L0.6090.31
91_G250_H0.6060.31
216_M223_V0.6050.31
177_E198_D0.6040.31
243_V273_D0.6040.31
55_A186_R0.6020.31
33_R187_G0.6020.31
160_S241_A0.6000.31
109_I127_L0.5990.31
12_M32_I0.5980.31
127_L152_L0.5980.31
156_L246_I0.5970.30
10_E60_L0.5970.30
66_S257_L0.5950.30
148_G151_T0.5940.30
121_L159_L0.5940.30
53_G58_A0.5930.30
88_H179_S0.5930.30
231_D266_L0.5920.30
192_Q197_I0.5890.30
132_Y223_V0.5880.30
113_N215_S0.5870.30
34_I38_V0.5860.30
9_P199_V0.5850.30
108_D171_K0.5850.30
37_P163_G0.5840.30
83_T117_A0.5830.29
89_R115_R0.5820.29
86_G161_S0.5820.29
87_G177_E0.5810.29
91_G145_P0.5810.29
282_K288_S0.5800.29
42_R47_V0.5800.29
46_P197_I0.5800.29
209_L256_D0.5790.29
182_A249_A0.5780.29
33_R216_M0.5780.29
8_L44_G0.5760.29
209_L223_V0.5760.29
180_E224_D0.5730.29
99_E109_I0.5730.29
93_A107_R0.5730.29
201_D231_D0.5710.29
39_E116_I0.5700.29
183_G245_V0.5700.29
126_P290_I0.5700.29
146_Q222_I0.5670.28
90_V112_F0.5640.28
120_K233_D0.5620.28
221_M245_V0.5620.28
212_M275_Y0.5620.28
170_V220_V0.5620.28
64_R123_I0.5620.28
191_H236_L0.5620.28
83_T113_N0.5610.28
199_V268_E0.5610.28
67_N156_L0.5600.28
171_K237_E0.5600.28
93_A216_M0.5590.28
87_G198_D0.5570.28
12_M53_G0.5570.28
148_G180_E0.5550.28
62_L272_F0.5530.27
40_L95_R0.5520.27
10_E14_N0.5520.27
109_I227_G0.5520.27
10_E17_S0.5510.27
123_I159_L0.5500.27
64_R118_R0.5480.27
109_I215_S0.5470.27
178_R198_D0.5440.27
158_R194_G0.5420.27
113_N208_G0.5410.27
10_E175_V0.5400.27
262_S265_R0.5400.27
231_D249_A0.5380.26
177_E205_K0.5380.26
198_D214_R0.5340.26
32_I164_K0.5340.26
196_R209_L0.5340.26
116_I207_E0.5340.26
111_S118_R0.5320.26
112_F174_I0.5310.26
26_E120_K0.5310.26
91_G150_T0.5300.26
39_E171_K0.5290.26
200_L203_C0.5290.26
177_E214_R0.5280.26
53_G153_L0.5270.26
8_L233_D0.5270.26
142_I251_G0.5250.26
65_L112_F0.5250.26
141_I152_L0.5240.26
63_S223_V0.5230.25
9_P146_Q0.5220.25
100_N268_E0.5200.25
143_G222_I0.5200.25
163_G173_G0.5190.25
141_I253_S0.5190.25
84_I251_G0.5190.25
120_K123_I0.5190.25
191_H243_V0.5190.25
26_E263_L0.5180.25
20_P24_W0.5160.25
28_E190_Q0.5140.25
221_M260_R0.5130.25
40_L188_I0.5130.25
10_E65_L0.5120.25
85_R190_Q0.5120.25
96_V103_V0.5120.25
16_L38_V0.5120.25
19_I125_E0.5110.25
49_L183_G0.5090.25
111_S222_I0.5090.25
152_L156_L0.5080.24
124_A158_R0.5060.24
9_P284_P0.5050.24
65_L84_I0.5050.24
98_T204_P0.5040.24
15_A57_D0.5030.24
84_I269_E0.5020.24
89_R180_E0.5010.24
245_V257_L0.5000.24
90_V255_S0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ewvA 3 0.9121 99.9 0.792 Contact Map
2oap1 3 0.9446 99.9 0.793 Contact Map
3jvvA 3 0.9121 99.9 0.793 Contact Map
4ihqA 3 0.9577 99.9 0.795 Contact Map
2gzaA 3 0.8697 99.7 0.833 Contact Map
2pt7A 3 0.9121 99.4 0.863 Contact Map
2eyuA 1 0.5831 99.4 0.866 Contact Map
2r8rA 1 0.5472 99.3 0.873 Contact Map
4ksrA 3 0.8599 99.2 0.877 Contact Map
2orwA 3 0.5016 99 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.