GREMLIN Database
RAPA - Response regulator aspartate phosphatase A
UniProt: Q00828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (319)
Sequences: 1386 (1261)
Seq/√Len: 70.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
237_E240_K5.3421.00
229_G245_F4.9801.00
276_N279_E4.9471.00
108_G124_Y4.8791.00
189_A205_L4.8211.00
197_Y200_R4.4321.00
116_M119_S3.4931.00
302_L306_L3.4871.00
351_Q354_K3.3991.00
225_L244_Y3.2451.00
193_D205_L2.9271.00
104_N126_R2.8971.00
144_A163_Y2.7871.00
347_I360_E2.7131.00
188_I192_Y2.6651.00
148_A164_A2.5601.00
268_T284_Y2.4901.00
202_L231_C2.4621.00
202_L228_L2.4481.00
267_L271_L2.3921.00
264_I283_K2.3701.00
245_F266_S2.3631.00
107_R111_E2.3401.00
225_L247_K2.2341.00
242_A274_Q2.1941.00
242_A270_V2.1741.00
279_E282_K2.1591.00
232_Y240_K2.1371.00
339_A358_F2.1251.00
104_N123_Y2.1111.00
343_A359_Y2.0861.00
242_A271_L2.0671.00
246_G267_L2.0281.00
185_E204_H2.0161.00
342_A346_Y2.0101.00
147_M151_F1.9881.00
229_G244_Y1.9681.00
267_L283_K1.9481.00
226_Y266_S1.9431.00
242_A267_L1.9311.00
202_L235_M1.9121.00
242_A246_G1.8801.00
319_V322_T1.8771.00
303_F310_Y1.8551.00
202_L232_Y1.8271.00
354_K357_S1.8161.00
39_E42_I1.7911.00
209_L221_I1.7651.00
200_R203_P1.7541.00
166_Q169_E1.7461.00
315_D318_S1.7451.00
111_E119_S1.7221.00
238_L270_V1.7191.00
272_Y284_Y1.6931.00
339_A361_K1.6911.00
161_M188_I1.6871.00
36_L40_R1.6851.00
226_Y229_G1.6751.00
119_S122_M1.6721.00
205_L227_N1.6661.00
186_F227_N1.6651.00
327_E361_K1.6530.99
338_L342_A1.5840.99
132_A140_K1.5620.99
240_K243_E1.5610.99
249_V264_I1.5390.99
109_M124_Y1.5110.99
182_I208_A1.5060.99
157_T160_S1.5010.99
271_L276_N1.4900.99
310_Y315_D1.4840.99
35_K39_E1.4790.99
271_L279_E1.4660.99
35_K42_I1.4580.99
124_Y146_K1.4520.99
268_T287_G1.4450.99
359_Y363_V1.4240.98
270_V274_Q1.4240.98
190_G205_L1.4190.98
101_Y127_A1.3970.98
229_G241_A1.3940.98
33_R36_L1.3800.98
108_G280_A1.3700.98
222_S248_S1.3560.98
59_E63_R1.3430.98
108_G127_A1.3430.98
248_S263_S1.3140.97
49_Q52_L1.3030.97
170_T174_Y1.2900.97
40_R46_E1.2830.97
302_L334_Y1.2820.97
156_Q159_V1.2760.97
57_L62_H1.2570.97
126_R129_K1.2560.97
145_F187_V1.2360.96
335_I339_A1.2340.96
266_S269_Q1.2120.96
313_N318_S1.2010.96
302_L305_F1.2000.96
303_F306_L1.1980.95
230_N245_F1.1930.95
189_A208_A1.1660.95
206_E228_L1.1480.94
140_K144_A1.1350.94
346_Y354_K1.1350.94
189_A201_A1.1230.94
314_I318_S1.1220.94
48_D51_L1.1200.94
207_L210_D1.1180.93
357_S361_K1.1140.93
192_Y200_R1.1070.93
246_G283_K1.1000.93
233_E238_L1.0980.93
131_L143_F1.0950.93
186_F224_A1.0910.93
54_Y61_R1.0910.93
96_T150_I1.0840.92
228_L232_Y1.0770.92
81_F84_L1.0750.92
54_Y57_L1.0690.92
292_R297_E1.0680.92
34_V39_E1.0680.92
236_G273_K1.0610.92
122_M216_G1.0600.92
192_Y204_H1.0560.91
301_E350_G1.0560.91
182_I212_A1.0530.91
239_Q274_Q1.0520.91
47_E50_D1.0280.90
343_A347_I1.0270.90
158_Y162_S1.0210.90
326_L338_L1.0210.90
158_Y192_Y1.0180.90
40_R43_E1.0180.90
72_F78_Q1.0130.90
51_L55_Y1.0130.90
129_K132_A1.0100.89
113_K117_F1.0090.89
33_R44_D1.0070.89
33_R41_E1.0040.89
300_V304_Q1.0040.89
54_Y60_F1.0030.89
190_G227_N0.9960.89
108_G123_Y0.9940.89
229_G263_S0.9920.89
121_M154_L0.9910.89
42_I45_M0.9840.88
249_V267_L0.9840.88
146_K149_E0.9830.88
38_V41_E0.9760.88
33_R42_I0.9750.88
33_R45_M0.9650.87
105_F124_Y0.9620.87
168_L185_E0.9510.86
172_Q188_I0.9440.86
248_S251_I0.9410.86
205_L228_L0.9370.86
112_F117_F0.9340.85
84_L87_D0.9310.85
46_E49_Q0.9310.85
116_M123_Y0.9300.85
111_E123_Y0.9290.85
145_F148_A0.9270.85
246_G279_E0.9260.85
181_R184_C0.9250.85
189_A204_H0.9200.85
37_E40_R0.9140.84
36_L39_E0.9110.84
199_E235_M0.9100.84
228_L244_Y0.9100.84
242_A287_G0.9040.83
41_E45_M0.9010.83
209_L225_L0.9000.83
265_Y269_Q0.8980.83
233_E270_V0.8910.83
209_L228_L0.8880.82
304_Q307_H0.8860.82
299_F302_L0.8830.82
56_S59_E0.8820.82
65_M71_P0.8820.82
53_L58_M0.8780.82
233_E266_S0.8740.81
300_V303_F0.8740.81
52_L56_S0.8730.81
230_N266_S0.8720.81
43_E46_E0.8660.81
185_E225_L0.8560.80
212_A221_I0.8530.80
102_Y106_F0.8520.80
42_I47_E0.8520.80
345_F349_N0.8490.79
111_E116_M0.8480.79
249_V263_S0.8470.79
117_F229_G0.8470.79
283_K287_G0.8390.79
39_E43_E0.8380.79
139_E143_F0.8340.78
324_Q327_E0.8300.78
280_A284_Y0.8250.77
193_D231_C0.8200.77
206_E244_Y0.8190.77
163_Y166_Q0.8180.77
214_K258_D0.8180.77
339_A342_A0.8140.76
352_P355_A0.8130.76
352_P357_S0.8110.76
134_V137_D0.8100.76
345_F353_E0.8090.76
218_P221_I0.8090.76
301_E305_F0.8080.76
42_I52_L0.8070.76
55_Y62_H0.8000.75
217_N220_L0.7990.75
355_A359_Y0.7970.75
338_L358_F0.7960.75
231_C235_M0.7950.75
350_G357_S0.7930.75
189_A231_C0.7890.74
202_L206_E0.7890.74
247_K251_I0.7870.74
247_K250_S0.7870.74
127_A131_L0.7850.74
346_Y358_F0.7800.73
206_E247_K0.7800.73
149_E171_Y0.7800.73
150_I154_L0.7800.73
360_E363_V0.7790.73
264_I287_G0.7780.73
232_Y237_E0.7770.73
236_G350_G0.7770.73
101_Y131_L0.7760.73
185_E207_L0.7760.73
124_Y128_E0.7730.73
271_L274_Q0.7730.73
353_E363_V0.7720.73
34_V37_E0.7720.73
265_Y268_T0.7650.72
129_K311_G0.7640.72
38_V42_I0.7640.72
340_H363_V0.7620.72
213_K221_I0.7600.71
37_E46_E0.7590.71
54_Y59_E0.7590.71
122_M126_R0.7570.71
125_K129_K0.7570.71
111_E271_L0.7560.71
42_I46_E0.7540.71
39_E46_E0.7490.70
226_Y252_C0.7480.70
174_Y177_Y0.7480.70
81_F85_L0.7480.70
34_V41_E0.7470.70
218_P251_I0.7450.70
112_F245_F0.7440.70
33_R40_R0.7420.70
38_V66_L0.7390.69
354_K358_F0.7370.69
218_P361_K0.7360.69
86_E90_G0.7360.69
62_H68_Y0.7360.69
185_E192_Y0.7360.69
301_E306_L0.7340.69
268_T283_K0.7300.68
39_E44_D0.7300.68
301_E304_Q0.7280.68
303_F325_F0.7280.68
188_I204_H0.7250.68
310_Y322_T0.7240.68
213_K292_R0.7240.68
282_K286_E0.7240.68
284_Y359_Y0.7220.68
56_S63_R0.7220.68
220_L223_S0.7210.67
232_Y242_A0.7180.67
33_R47_E0.7160.67
285_R289_E0.7130.67
313_N354_K0.7130.67
287_G290_I0.7120.66
206_E240_K0.7120.66
101_Y105_F0.7050.66
40_R63_R0.7040.66
79_L84_L0.7040.66
108_G112_F0.7040.66
252_C260_L0.7020.65
37_E41_E0.6990.65
301_E308_A0.6990.65
274_Q283_K0.6990.65
38_V43_E0.6980.65
226_Y263_S0.6940.64
313_N316_T0.6900.64
36_L42_I0.6860.64
34_V45_M0.6850.63
225_L243_E0.6850.63
40_R44_D0.6830.63
145_F184_C0.6790.63
307_H323_F0.6780.63
69_I73_G0.6750.62
303_F319_V0.6740.62
192_Y203_P0.6720.62
208_A287_G0.6710.62
62_H66_L0.6710.62
358_F361_K0.6680.61
173_M176_T0.6680.61
35_K41_E0.6650.61
40_R51_L0.6650.61
112_F150_I0.6650.61
37_E43_E0.6650.61
356_L359_Y0.6650.61
71_P85_L0.6640.61
33_R50_D0.6630.61
336_E343_A0.6620.61
61_R67_D0.6620.61
41_E47_E0.6610.61
342_A354_K0.6600.61
302_L310_Y0.6600.61
206_E283_K0.6570.60
346_Y351_Q0.6560.60
53_L59_E0.6540.60
261_P291_A0.6540.60
37_E42_I0.6530.60
61_R284_Y0.6520.60
47_E56_S0.6520.60
356_L360_E0.6520.60
222_S252_C0.6520.60
326_L329_H0.6500.59
39_E51_L0.6490.59
124_Y127_A0.6480.59
299_F304_Q0.6480.59
53_L60_F0.6450.59
340_H344_Q0.6440.59
186_F208_A0.6420.58
108_G296_D0.6420.58
350_G353_E0.6410.58
225_L248_S0.6400.58
225_L264_I0.6400.58
43_E50_D0.6390.58
299_F303_F0.6390.58
168_L191_N0.6380.58
33_R38_V0.6380.58
100_E130_N0.6360.58
186_F205_L0.6360.58
105_F143_F0.6320.57
353_E357_S0.6310.57
252_C263_S0.6300.57
99_L102_Y0.6210.56
261_P268_T0.6180.56
241_A304_Q0.6180.56
112_F124_Y0.6170.55
183_Q186_F0.6170.55
177_Y181_R0.6160.55
202_L242_A0.6160.55
67_D70_K0.6150.55
318_S321_H0.6120.55
208_A222_S0.6100.55
105_F152_Y0.6100.55
164_A303_F0.6090.55
289_E292_R0.6090.55
141_A145_F0.6060.54
169_E172_Q0.6060.54
164_A321_H0.6060.54
41_E50_D0.6050.54
266_S270_V0.6050.54
50_D53_L0.6040.54
351_Q358_F0.6020.54
141_A167_A0.6010.54
60_F63_R0.6010.54
208_A224_A0.5990.53
33_R39_E0.5970.53
54_Y58_M0.5950.53
80_E83_E0.5910.52
51_L57_L0.5900.52
160_S191_N0.5890.52
333_P337_E0.5890.52
60_F268_T0.5870.52
34_V40_R0.5870.52
54_Y103_F0.5860.52
125_K204_H0.5850.52
258_D281_Q0.5840.51
181_R185_E0.5830.51
311_G314_I0.5810.51
320_S324_Q0.5800.51
316_T320_S0.5800.51
201_A231_C0.5790.51
55_Y61_R0.5770.51
170_T232_Y0.5760.50
41_E59_E0.5750.50
214_K232_Y0.5740.50
37_E65_M0.5730.50
344_Q348_E0.5720.50
38_V48_D0.5710.50
336_E340_H0.5710.50
145_F149_E0.5700.50
42_I292_R0.5690.50
212_A224_A0.5690.50
306_L310_Y0.5670.49
33_R43_E0.5670.49
347_I359_Y0.5660.49
162_S286_E0.5660.49
96_T100_E0.5660.49
345_F362_M0.5650.49
53_L71_P0.5640.49
208_A248_S0.5640.49
286_E290_I0.5610.49
121_M151_F0.5610.49
324_Q351_Q0.5610.49
47_E59_E0.5600.49
226_Y231_C0.5590.48
55_Y58_M0.5580.48
143_F146_K0.5580.48
86_E89_E0.5560.48
52_L58_M0.5560.48
229_G267_L0.5540.48
325_F329_H0.5530.48
79_L108_G0.5530.48
67_D81_F0.5530.48
83_E87_D0.5520.48
102_Y105_F0.5520.48
262_H265_Y0.5500.47
287_G303_F0.5500.47
121_M125_K0.5500.47
114_Q346_Y0.5500.47
157_T161_M0.5490.47
128_E241_A0.5490.47
111_E114_Q0.5470.47
49_Q59_E0.5470.47
327_E335_I0.5460.47
35_K45_M0.5460.47
155_K160_S0.5450.47
56_S65_M0.5430.46
128_E143_F0.5400.46
105_F146_K0.5400.46
356_L361_K0.5390.46
41_E44_D0.5380.46
57_L60_F0.5370.46
317_E352_P0.5360.46
34_V52_L0.5360.46
48_D54_Y0.5350.46
287_G297_E0.5340.45
103_F107_R0.5340.45
189_A248_S0.5340.45
122_M199_E0.5320.45
245_F263_S0.5320.45
39_E55_Y0.5320.45
245_F270_V0.5320.45
126_R178_T0.5300.45
62_H72_F0.5280.45
110_Y146_K0.5280.45
33_R37_E0.5260.44
333_P338_L0.5260.44
34_V46_E0.5260.44
348_E362_M0.5240.44
45_M50_D0.5230.44
35_K56_S0.5230.44
139_E208_A0.5200.44
109_M171_Y0.5180.43
34_V42_I0.5170.43
128_E163_Y0.5170.43
142_E146_K0.5160.43
191_N195_M0.5150.43
173_M344_Q0.5150.43
90_G93_Y0.5150.43
68_Y71_P0.5130.43
252_C291_A0.5130.43
36_L43_E0.5120.43
357_S360_E0.5120.43
230_N233_E0.5120.43
141_A182_I0.5110.43
110_Y172_Q0.5090.42
233_E245_F0.5070.42
312_K346_Y0.5070.42
92_Q286_E0.5050.42
112_F146_K0.5040.42
278_A281_Q0.5010.41
124_Y265_Y0.5010.41
37_E45_M0.5010.41
217_N221_I0.5000.41
339_A346_Y0.5000.41
147_M154_L0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gyoA 2 0.9524 100 0.252 Contact Map
3q15A 2 0.9656 100 0.253 Contact Map
4i1aA 2 0.9471 100 0.255 Contact Map
3ulqA 1 0.9815 100 0.266 Contact Map
4gpkA 3 0.9101 100 0.325 Contact Map
1w3bA 2 0.8122 100 0.418 Contact Map
3q7aA 1 0.7328 100 0.425 Contact Map
4ui9C 2 0.9286 100 0.43 Contact Map
3sf4A 1 0.8386 100 0.432 Contact Map
4l9pA 1 0.7513 100 0.436 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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