P5CR3 - BACSU - GREMLIN Contacts

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P5CR3 - Pyrroline-5-carboxylate reductase 3

UniProt:	Q00777	Sequences: MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRALMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPLRLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKESNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKNMSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (260)
Sequences:	5202 (3895)
Seq/√Len:	241.5

ECOLI - P5CR
BACSU - P5CR3 P5CR2 COMER P5CR1
SULSO - Q97ZT3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_G	141_K	3.260	1.00
76_V	97_A	2.805	1.00
126_A	212_K	2.788	1.00
219_M	227_R	2.688	1.00
116_V	129_S	2.527	1.00
212_K	216_E	2.505	1.00
177_I	207_L	2.477	1.00
180_I	250_F	2.433	1.00
181_F	214_L	2.412	1.00
5_G	60_W	2.233	1.00
34_E	57_L	2.182	1.00
154_R	201_D	2.161	1.00
178_A	210_T	2.092	1.00
106_E	134_S	2.073	1.00
195_S	198_E	2.050	1.00
146_N	157_E	2.044	1.00
185_A	200_F	2.007	1.00
128_I	154_R	2.006	1.00
146_N	150_S	1.952	1.00
142_K	157_E	1.936	1.00
208_Y	212_K	1.935	1.00
156_R	201_D	1.903	1.00
212_K	215_I	1.877	1.00
9_Y	33_I	1.875	1.00
88_N	91_T	1.856	1.00
173_A	206_S	1.849	1.00
38_K	43_R	1.815	1.00
121_T	127_G	1.797	1.00
219_M	223_E	1.785	1.00
184_L	254_F	1.765	1.00
176_F	238_G	1.757	1.00
223_E	227_R	1.750	1.00
243_H	247_P	1.738	1.00
133_H	142_K	1.733	1.00
180_I	246_V	1.731	1.00
150_S	155_V	1.729	1.00
130_L	166_A	1.720	1.00
189_V	196_K	1.697	1.00
16_I	152_F	1.635	1.00
138_A	141_K	1.631	1.00
5_G	64_C	1.623	1.00
236_G	240_E	1.589	1.00
3_Q	30_E	1.581	1.00
94_V	145_L	1.580	1.00
260_K	263_L	1.554	1.00
35_T	41_R	1.554	1.00
131_V	157_E	1.546	1.00
159_K	162_N	1.542	1.00
93_I	109_T	1.533	1.00
164_D	261_Y	1.521	1.00
204_I	215_I	1.519	1.00
66_L	92_H	1.518	1.00
126_A	208_Y	1.517	1.00
12_M	96_I	1.487	1.00
246_V	249_V	1.482	1.00
32_F	52_V	1.480	1.00
43_R	47_S	1.478	1.00
223_E	226_E	1.477	1.00
229_A	236_G	1.477	1.00
36_R	75_H	1.468	1.00
32_F	54_A	1.466	1.00
80_M	109_T	1.459	1.00
244_A	252_E	1.444	1.00
33_I	51_N	1.443	1.00
56_P	59_N	1.436	1.00
139_A	143_E	1.436	1.00
77_I	108_E	1.426	1.00
77_I	104_L	1.422	1.00
95_S	105_L	1.418	1.00
192_S	255_E	1.411	1.00
186_L	196_K	1.399	1.00
205_H	208_Y	1.385	1.00
14_D	41_R	1.384	1.00
181_F	207_L	1.360	1.00
41_R	44_A	1.354	1.00
190_R	255_E	1.348	1.00
158_I	163_L	1.343	1.00
128_I	205_H	1.333	1.00
182_E	225_L	1.329	1.00
114_S	145_L	1.328	1.00
101_P	104_L	1.327	1.00
18_R	48_D	1.325	1.00
241_V	244_A	1.323	1.00
190_R	251_D	1.318	1.00
177_I	180_I	1.304	1.00
6_L	13_A	1.300	1.00
248_D	252_E	1.296	1.00
255_E	259_R	1.294	1.00
246_V	250_F	1.293	1.00
172_S	234_I	1.281	1.00
220_S	223_E	1.279	1.00
186_L	247_P	1.260	1.00
37_T	40_E	1.256	1.00
258_L	262_E	1.245	1.00
44_A	48_D	1.225	1.00
70_C	96_I	1.217	1.00
6_L	17_A	1.216	1.00
76_V	100_V	1.215	1.00
97_A	100_V	1.203	1.00
104_L	108_E	1.198	1.00
168_N	254_F	1.193	1.00
182_E	222_E	1.188	1.00
131_V	155_V	1.174	1.00
122_S	127_G	1.173	1.00
238_G	253_V	1.172	1.00
146_N	155_V	1.150	1.00
242_I	253_V	1.147	1.00
106_E	135_E	1.142	1.00
188_A	194_L	1.138	1.00
16_I	20_L	1.132	1.00
66_L	144_R	1.131	1.00
126_A	205_H	1.131	1.00
87_V	93_I	1.125	1.00
43_R	46_M	1.118	1.00
60_W	64_C	1.115	1.00
27_K	30_E	1.115	1.00
32_F	63_T	1.114	1.00
143_E	147_E	1.106	1.00
6_L	68_L	1.105	1.00
240_E	244_A	1.100	1.00
229_A	239_A	1.099	1.00
102_L	132_V	1.097	1.00
131_V	149_L	1.092	1.00
237_E	240_E	1.091	1.00
13_A	17_A	1.087	1.00
137_L	141_K	1.086	1.00
106_E	136_A	1.082	1.00
102_L	113_I	1.078	1.00
103_R	107_A	1.076	1.00
3_Q	32_F	1.076	1.00
37_T	41_R	1.075	1.00
158_I	166_A	1.069	1.00
181_F	203_L	1.055	1.00
192_S	258_L	1.055	1.00
128_I	156_R	1.049	1.00
131_V	146_N	1.039	1.00
71_V	97_A	1.039	1.00
225_L	229_A	1.034	1.00
92_H	141_K	1.032	1.00
66_L	94_V	1.021	1.00
102_L	105_L	1.021	1.00
14_D	49_Y	1.021	1.00
169_L	254_F	1.020	1.00
242_I	250_F	1.020	1.00
58_E	82_R	1.019	1.00
69_I	76_V	1.017	1.00
164_D	262_E	1.014	1.00
116_V	149_L	1.013	1.00
156_R	198_E	1.006	1.00
16_I	96_I	1.004	1.00
11_S	227_R	1.003	1.00
22_K	125_E	0.993	1.00
166_A	202_F	0.986	1.00
208_Y	215_I	0.977	1.00
178_A	213_M	0.977	1.00
241_V	252_E	0.975	1.00
20_L	148_L	0.973	1.00
170_T	202_F	0.964	1.00
18_R	49_Y	0.963	1.00
133_H	157_E	0.961	1.00
179_A	239_A	0.959	1.00
154_R	205_H	0.956	1.00
40_E	43_R	0.955	1.00
75_H	79_T	0.949	1.00
166_A	170_T	0.945	1.00
17_A	33_I	0.944	1.00
241_V	256_R	0.944	1.00
59_N	63_T	0.942	1.00
19_Q	152_F	0.939	1.00
77_I	81_R	0.933	1.00
75_H	78_E	0.928	1.00
132_V	163_L	0.927	1.00
67_I	91_T	0.927	1.00
237_E	260_K	0.926	1.00
104_L	107_A	0.920	1.00
214_L	221_F	0.914	1.00
68_L	94_V	0.913	1.00
58_E	62_N	0.906	1.00
100_V	104_L	0.903	1.00
245_S	249_V	0.903	1.00
186_L	189_V	0.898	1.00
165_V	194_L	0.897	1.00
256_R	259_R	0.894	1.00
245_S	248_D	0.894	1.00
197_E	201_D	0.892	1.00
204_I	211_G	0.882	0.99
35_T	42_L	0.881	0.99
179_A	243_H	0.881	0.99
105_L	113_I	0.879	0.99
42_L	55_D	0.876	0.99
42_L	53_S	0.876	0.99
198_E	201_D	0.873	0.99
14_D	48_D	0.870	0.99
185_A	189_V	0.863	0.99
220_S	226_E	0.860	0.99
9_Y	45_L	0.859	0.99
226_E	236_G	0.854	0.99
5_G	34_E	0.847	0.99
169_L	188_A	0.842	0.99
18_R	123_E	0.841	0.99
140_E	143_E	0.839	0.99
44_A	47_S	0.838	0.99
76_V	80_M	0.834	0.99
128_I	202_F	0.832	0.99
58_E	86_Y	0.831	0.99
114_S	133_H	0.830	0.99
7_I	79_T	0.828	0.99
234_I	261_Y	0.825	0.99
4_I	20_L	0.824	0.99
21_L	28_E	0.822	0.99
65_Q	91_T	0.816	0.99
61_A	67_I	0.816	0.99
259_R	263_L	0.815	0.99
192_S	254_F	0.813	0.99
62_N	86_Y	0.812	0.99
11_S	230_T	0.798	0.99
122_S	152_F	0.796	0.99
168_N	258_L	0.794	0.99
132_V	159_K	0.794	0.99
200_F	204_I	0.793	0.99
41_R	45_L	0.791	0.99
81_R	108_E	0.790	0.99
183_E	247_P	0.781	0.99
3_Q	63_T	0.780	0.99
222_E	226_E	0.779	0.99
35_T	38_K	0.778	0.99
237_E	241_V	0.773	0.99
92_H	145_L	0.772	0.99
32_F	64_C	0.769	0.99
238_G	241_V	0.764	0.99
34_E	54_A	0.763	0.99
57_L	82_R	0.762	0.98
81_R	84_Y	0.757	0.98
137_L	142_K	0.756	0.98
133_H	137_L	0.755	0.98
38_K	42_L	0.755	0.98
188_A	203_L	0.754	0.98
115_R	160_E	0.753	0.98
3_Q	65_Q	0.751	0.98
239_A	243_H	0.750	0.98
76_V	95_S	0.748	0.98
208_Y	211_G	0.744	0.98
238_G	257_T	0.743	0.98
17_A	31_L	0.740	0.98
17_A	45_L	0.735	0.98
77_I	100_V	0.733	0.98
96_I	116_V	0.730	0.98
26_I	30_E	0.728	0.98
240_E	252_E	0.728	0.98
190_R	240_E	0.722	0.98
14_D	44_A	0.722	0.98
194_L	202_F	0.720	0.98
204_I	214_L	0.719	0.98
164_D	265_T	0.715	0.98
133_H	139_A	0.715	0.98
61_A	83_L	0.714	0.98
80_M	97_A	0.712	0.98
67_I	93_I	0.712	0.98
59_N	62_N	0.711	0.98
52_V	63_T	0.710	0.98
13_A	70_C	0.710	0.98
147_E	150_S	0.709	0.98
167_S	173_A	0.708	0.98
182_E	186_L	0.706	0.98
172_S	257_T	0.702	0.97
42_L	46_M	0.701	0.97
170_T	206_S	0.701	0.97
186_L	190_R	0.699	0.97
143_E	146_N	0.699	0.97
162_N	165_V	0.698	0.97
14_D	18_R	0.698	0.97
128_I	201_D	0.695	0.97
179_A	247_P	0.694	0.97
259_R	262_E	0.693	0.97
124_A	212_K	0.692	0.97
46_M	53_S	0.688	0.97
163_L	261_Y	0.685	0.97
17_A	51_N	0.684	0.97
98_A	234_I	0.681	0.97
130_L	163_L	0.681	0.97
78_E	81_R	0.679	0.97
167_S	261_Y	0.679	0.97
102_L	134_S	0.675	0.97
84_Y	110_E	0.674	0.97
4_I	26_I	0.674	0.97
45_L	49_Y	0.671	0.97
117_I	171_S	0.668	0.97
68_L	149_L	0.668	0.97
98_A	264_L	0.661	0.96
196_K	200_F	0.657	0.96
240_E	243_H	0.656	0.96
188_A	199_A	0.654	0.96
112_G	137_L	0.653	0.96
102_L	106_E	0.652	0.96
134_S	137_L	0.651	0.96
126_A	154_R	0.651	0.96
144_R	147_E	0.646	0.96
222_E	225_L	0.645	0.96
101_P	265_T	0.641	0.96
34_E	56_P	0.638	0.96
32_F	60_W	0.635	0.95
78_E	82_R	0.633	0.95
254_F	257_T	0.624	0.95
165_V	192_S	0.620	0.95
79_T	82_R	0.619	0.95
112_G	134_S	0.617	0.95
5_G	67_I	0.614	0.95
169_L	184_L	0.613	0.94
141_K	144_R	0.610	0.94
187_S	254_F	0.609	0.94
35_T	96_I	0.609	0.94
54_A	60_W	0.605	0.94
185_A	203_L	0.605	0.94
185_A	221_F	0.605	0.94
178_A	224_T	0.605	0.94
114_S	137_L	0.603	0.94
34_E	60_W	0.601	0.94
130_L	156_R	0.597	0.94
72_P	230_T	0.597	0.94
15_M	19_Q	0.597	0.94
248_D	251_D	0.596	0.94
57_L	60_W	0.596	0.94
106_E	113_I	0.593	0.93
162_N	198_E	0.591	0.93
5_G	32_F	0.591	0.93
33_I	45_L	0.588	0.93
92_H	114_S	0.586	0.93
129_S	153_S	0.586	0.93
113_I	134_S	0.585	0.93
178_A	214_L	0.584	0.93
129_S	152_F	0.584	0.93
255_E	258_L	0.581	0.93
66_L	148_L	0.579	0.93
236_G	239_A	0.579	0.93
154_R	215_I	0.576	0.92
175_G	235_T	0.576	0.92
167_S	172_S	0.574	0.92
57_L	61_A	0.571	0.92
121_T	174_P	0.570	0.92
173_A	257_T	0.569	0.92
250_F	254_F	0.569	0.92
230_T	234_I	0.567	0.92
165_V	188_A	0.563	0.92
61_A	86_Y	0.563	0.92
21_L	24_E	0.559	0.91
11_S	72_P	0.558	0.91
130_L	170_T	0.558	0.91
207_L	246_V	0.556	0.91
175_G	238_G	0.554	0.91
55_D	59_N	0.554	0.91
242_I	246_V	0.553	0.91
163_L	166_A	0.552	0.91
61_A	91_T	0.552	0.91
69_I	97_A	0.549	0.91
124_A	213_M	0.547	0.90
125_E	152_F	0.547	0.90
87_V	109_T	0.545	0.90
173_A	254_F	0.544	0.90
132_V	160_E	0.541	0.90
149_L	152_F	0.541	0.90
162_N	195_S	0.540	0.90
117_I	163_L	0.539	0.90
176_F	257_T	0.538	0.90
109_T	113_I	0.538	0.90
114_S	142_K	0.534	0.89
36_R	42_L	0.533	0.89
83_L	87_V	0.528	0.89
187_S	251_D	0.528	0.89
240_E	251_D	0.526	0.89
120_I	227_R	0.525	0.89
40_E	44_A	0.525	0.89
171_S	234_I	0.523	0.88
64_C	91_T	0.522	0.88
69_I	83_L	0.521	0.88
86_Y	91_T	0.521	0.88
23_H	125_E	0.520	0.88
9_Y	17_A	0.516	0.88
183_E	250_F	0.516	0.88
92_H	112_G	0.515	0.88
16_I	149_L	0.515	0.88
185_A	188_A	0.514	0.88
119_A	171_S	0.514	0.88
22_K	216_E	0.512	0.87
112_G	138_A	0.511	0.87
7_I	34_E	0.509	0.87
61_A	64_C	0.504	0.86
139_A	142_K	0.503	0.86
181_F	221_F	0.501	0.86
181_F	211_G	0.500	0.86
179_A	246_V	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2izzA	5	0.9853	100	0.373	Contact Map
2rcyA	5	0.9412	100	0.386	Contact Map
2ahrA	5	0.9338	100	0.399	Contact Map
1yqgA	2	0.9522	100	0.405	Contact Map
3triA	2	0.9779	100	0.406	Contact Map
3gt0A	3	0.7868	100	0.445	Contact Map
4kqwA	2	0.9559	100	0.46	Contact Map
4wjiA	2	0.9522	100	0.503	Contact Map
3fr7A	2	0.9412	100	0.518	Contact Map
2i76A	2	0.8493	100	0.562	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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