GREMLIN Database
P5CR3 - Pyrroline-5-carboxylate reductase 3
UniProt: Q00777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (260)
Sequences: 5202 (3895)
Seq/√Len: 241.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_G141_K3.2601.00
76_V97_A2.8051.00
126_A212_K2.7881.00
219_M227_R2.6881.00
116_V129_S2.5271.00
212_K216_E2.5051.00
177_I207_L2.4771.00
180_I250_F2.4331.00
181_F214_L2.4121.00
5_G60_W2.2331.00
34_E57_L2.1821.00
154_R201_D2.1611.00
178_A210_T2.0921.00
106_E134_S2.0731.00
195_S198_E2.0501.00
146_N157_E2.0441.00
185_A200_F2.0071.00
128_I154_R2.0061.00
146_N150_S1.9521.00
142_K157_E1.9361.00
208_Y212_K1.9351.00
156_R201_D1.9031.00
212_K215_I1.8771.00
9_Y33_I1.8751.00
88_N91_T1.8561.00
173_A206_S1.8491.00
38_K43_R1.8151.00
121_T127_G1.7971.00
219_M223_E1.7851.00
184_L254_F1.7651.00
176_F238_G1.7571.00
223_E227_R1.7501.00
243_H247_P1.7381.00
133_H142_K1.7331.00
180_I246_V1.7311.00
150_S155_V1.7291.00
130_L166_A1.7201.00
189_V196_K1.6971.00
16_I152_F1.6351.00
138_A141_K1.6311.00
5_G64_C1.6231.00
236_G240_E1.5891.00
3_Q30_E1.5811.00
94_V145_L1.5801.00
260_K263_L1.5541.00
35_T41_R1.5541.00
131_V157_E1.5461.00
159_K162_N1.5421.00
93_I109_T1.5331.00
164_D261_Y1.5211.00
204_I215_I1.5191.00
66_L92_H1.5181.00
126_A208_Y1.5171.00
12_M96_I1.4871.00
246_V249_V1.4821.00
32_F52_V1.4801.00
43_R47_S1.4781.00
223_E226_E1.4771.00
229_A236_G1.4771.00
36_R75_H1.4681.00
32_F54_A1.4661.00
80_M109_T1.4591.00
244_A252_E1.4441.00
33_I51_N1.4431.00
56_P59_N1.4361.00
139_A143_E1.4361.00
77_I108_E1.4261.00
77_I104_L1.4221.00
95_S105_L1.4181.00
192_S255_E1.4111.00
186_L196_K1.3991.00
205_H208_Y1.3851.00
14_D41_R1.3841.00
181_F207_L1.3601.00
41_R44_A1.3541.00
190_R255_E1.3481.00
158_I163_L1.3431.00
128_I205_H1.3331.00
182_E225_L1.3291.00
114_S145_L1.3281.00
101_P104_L1.3271.00
18_R48_D1.3251.00
241_V244_A1.3231.00
190_R251_D1.3181.00
177_I180_I1.3041.00
6_L13_A1.3001.00
248_D252_E1.2961.00
255_E259_R1.2941.00
246_V250_F1.2931.00
172_S234_I1.2811.00
220_S223_E1.2791.00
186_L247_P1.2601.00
37_T40_E1.2561.00
258_L262_E1.2451.00
44_A48_D1.2251.00
70_C96_I1.2171.00
6_L17_A1.2161.00
76_V100_V1.2151.00
97_A100_V1.2031.00
104_L108_E1.1981.00
168_N254_F1.1931.00
182_E222_E1.1881.00
131_V155_V1.1741.00
122_S127_G1.1731.00
238_G253_V1.1721.00
146_N155_V1.1501.00
242_I253_V1.1471.00
106_E135_E1.1421.00
188_A194_L1.1381.00
16_I20_L1.1321.00
66_L144_R1.1311.00
126_A205_H1.1311.00
87_V93_I1.1251.00
43_R46_M1.1181.00
60_W64_C1.1151.00
27_K30_E1.1151.00
32_F63_T1.1141.00
143_E147_E1.1061.00
6_L68_L1.1051.00
240_E244_A1.1001.00
229_A239_A1.0991.00
102_L132_V1.0971.00
131_V149_L1.0921.00
237_E240_E1.0911.00
13_A17_A1.0871.00
137_L141_K1.0861.00
106_E136_A1.0821.00
102_L113_I1.0781.00
103_R107_A1.0761.00
3_Q32_F1.0761.00
37_T41_R1.0751.00
158_I166_A1.0691.00
181_F203_L1.0551.00
192_S258_L1.0551.00
128_I156_R1.0491.00
131_V146_N1.0391.00
71_V97_A1.0391.00
225_L229_A1.0341.00
92_H141_K1.0321.00
66_L94_V1.0211.00
102_L105_L1.0211.00
14_D49_Y1.0211.00
169_L254_F1.0201.00
242_I250_F1.0201.00
58_E82_R1.0191.00
69_I76_V1.0171.00
164_D262_E1.0141.00
116_V149_L1.0131.00
156_R198_E1.0061.00
16_I96_I1.0041.00
11_S227_R1.0031.00
22_K125_E0.9931.00
166_A202_F0.9861.00
208_Y215_I0.9771.00
178_A213_M0.9771.00
241_V252_E0.9751.00
20_L148_L0.9731.00
170_T202_F0.9641.00
18_R49_Y0.9631.00
133_H157_E0.9611.00
179_A239_A0.9591.00
154_R205_H0.9561.00
40_E43_R0.9551.00
75_H79_T0.9491.00
166_A170_T0.9451.00
17_A33_I0.9441.00
241_V256_R0.9441.00
59_N63_T0.9421.00
19_Q152_F0.9391.00
77_I81_R0.9331.00
75_H78_E0.9281.00
132_V163_L0.9271.00
67_I91_T0.9271.00
237_E260_K0.9261.00
104_L107_A0.9201.00
214_L221_F0.9141.00
68_L94_V0.9131.00
58_E62_N0.9061.00
100_V104_L0.9031.00
245_S249_V0.9031.00
186_L189_V0.8981.00
165_V194_L0.8971.00
256_R259_R0.8941.00
245_S248_D0.8941.00
197_E201_D0.8921.00
204_I211_G0.8820.99
35_T42_L0.8810.99
179_A243_H0.8810.99
105_L113_I0.8790.99
42_L55_D0.8760.99
42_L53_S0.8760.99
198_E201_D0.8730.99
14_D48_D0.8700.99
185_A189_V0.8630.99
220_S226_E0.8600.99
9_Y45_L0.8590.99
226_E236_G0.8540.99
5_G34_E0.8470.99
169_L188_A0.8420.99
18_R123_E0.8410.99
140_E143_E0.8390.99
44_A47_S0.8380.99
76_V80_M0.8340.99
128_I202_F0.8320.99
58_E86_Y0.8310.99
114_S133_H0.8300.99
7_I79_T0.8280.99
234_I261_Y0.8250.99
4_I20_L0.8240.99
21_L28_E0.8220.99
65_Q91_T0.8160.99
61_A67_I0.8160.99
259_R263_L0.8150.99
192_S254_F0.8130.99
62_N86_Y0.8120.99
11_S230_T0.7980.99
122_S152_F0.7960.99
168_N258_L0.7940.99
132_V159_K0.7940.99
200_F204_I0.7930.99
41_R45_L0.7910.99
81_R108_E0.7900.99
183_E247_P0.7810.99
3_Q63_T0.7800.99
222_E226_E0.7790.99
35_T38_K0.7780.99
237_E241_V0.7730.99
92_H145_L0.7720.99
32_F64_C0.7690.99
238_G241_V0.7640.99
34_E54_A0.7630.99
57_L82_R0.7620.98
81_R84_Y0.7570.98
137_L142_K0.7560.98
133_H137_L0.7550.98
38_K42_L0.7550.98
188_A203_L0.7540.98
115_R160_E0.7530.98
3_Q65_Q0.7510.98
239_A243_H0.7500.98
76_V95_S0.7480.98
208_Y211_G0.7440.98
238_G257_T0.7430.98
17_A31_L0.7400.98
17_A45_L0.7350.98
77_I100_V0.7330.98
96_I116_V0.7300.98
26_I30_E0.7280.98
240_E252_E0.7280.98
190_R240_E0.7220.98
14_D44_A0.7220.98
194_L202_F0.7200.98
204_I214_L0.7190.98
164_D265_T0.7150.98
133_H139_A0.7150.98
61_A83_L0.7140.98
80_M97_A0.7120.98
67_I93_I0.7120.98
59_N62_N0.7110.98
52_V63_T0.7100.98
13_A70_C0.7100.98
147_E150_S0.7090.98
167_S173_A0.7080.98
182_E186_L0.7060.98
172_S257_T0.7020.97
42_L46_M0.7010.97
170_T206_S0.7010.97
186_L190_R0.6990.97
143_E146_N0.6990.97
162_N165_V0.6980.97
14_D18_R0.6980.97
128_I201_D0.6950.97
179_A247_P0.6940.97
259_R262_E0.6930.97
124_A212_K0.6920.97
46_M53_S0.6880.97
163_L261_Y0.6850.97
17_A51_N0.6840.97
98_A234_I0.6810.97
130_L163_L0.6810.97
78_E81_R0.6790.97
167_S261_Y0.6790.97
102_L134_S0.6750.97
84_Y110_E0.6740.97
4_I26_I0.6740.97
45_L49_Y0.6710.97
117_I171_S0.6680.97
68_L149_L0.6680.97
98_A264_L0.6610.96
196_K200_F0.6570.96
240_E243_H0.6560.96
188_A199_A0.6540.96
112_G137_L0.6530.96
102_L106_E0.6520.96
134_S137_L0.6510.96
126_A154_R0.6510.96
144_R147_E0.6460.96
222_E225_L0.6450.96
101_P265_T0.6410.96
34_E56_P0.6380.96
32_F60_W0.6350.95
78_E82_R0.6330.95
254_F257_T0.6240.95
165_V192_S0.6200.95
79_T82_R0.6190.95
112_G134_S0.6170.95
5_G67_I0.6140.95
169_L184_L0.6130.94
141_K144_R0.6100.94
187_S254_F0.6090.94
35_T96_I0.6090.94
54_A60_W0.6050.94
185_A203_L0.6050.94
185_A221_F0.6050.94
178_A224_T0.6050.94
114_S137_L0.6030.94
34_E60_W0.6010.94
130_L156_R0.5970.94
72_P230_T0.5970.94
15_M19_Q0.5970.94
248_D251_D0.5960.94
57_L60_W0.5960.94
106_E113_I0.5930.93
162_N198_E0.5910.93
5_G32_F0.5910.93
33_I45_L0.5880.93
92_H114_S0.5860.93
129_S153_S0.5860.93
113_I134_S0.5850.93
178_A214_L0.5840.93
129_S152_F0.5840.93
255_E258_L0.5810.93
66_L148_L0.5790.93
236_G239_A0.5790.93
154_R215_I0.5760.92
175_G235_T0.5760.92
167_S172_S0.5740.92
57_L61_A0.5710.92
121_T174_P0.5700.92
173_A257_T0.5690.92
250_F254_F0.5690.92
230_T234_I0.5670.92
165_V188_A0.5630.92
61_A86_Y0.5630.92
21_L24_E0.5590.91
11_S72_P0.5580.91
130_L170_T0.5580.91
207_L246_V0.5560.91
175_G238_G0.5540.91
55_D59_N0.5540.91
242_I246_V0.5530.91
163_L166_A0.5520.91
61_A91_T0.5520.91
69_I97_A0.5490.91
124_A213_M0.5470.90
125_E152_F0.5470.90
87_V109_T0.5450.90
173_A254_F0.5440.90
132_V160_E0.5410.90
149_L152_F0.5410.90
162_N195_S0.5400.90
117_I163_L0.5390.90
176_F257_T0.5380.90
109_T113_I0.5380.90
114_S142_K0.5340.89
36_R42_L0.5330.89
83_L87_V0.5280.89
187_S251_D0.5280.89
240_E251_D0.5260.89
120_I227_R0.5250.89
40_E44_A0.5250.89
171_S234_I0.5230.88
64_C91_T0.5220.88
69_I83_L0.5210.88
86_Y91_T0.5210.88
23_H125_E0.5200.88
9_Y17_A0.5160.88
183_E250_F0.5160.88
92_H112_G0.5150.88
16_I149_L0.5150.88
185_A188_A0.5140.88
119_A171_S0.5140.88
22_K216_E0.5120.87
112_G138_A0.5110.87
7_I34_E0.5090.87
61_A64_C0.5040.86
139_A142_K0.5030.86
181_F221_F0.5010.86
181_F211_G0.5000.86
179_A246_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2izzA 5 0.9853 100 0.373 Contact Map
2rcyA 5 0.9412 100 0.386 Contact Map
2ahrA 5 0.9338 100 0.399 Contact Map
1yqgA 2 0.9522 100 0.405 Contact Map
3triA 2 0.9779 100 0.406 Contact Map
3gt0A 3 0.7868 100 0.445 Contact Map
4kqwA 2 0.9559 100 0.46 Contact Map
4wjiA 2 0.9522 100 0.503 Contact Map
3fr7A 2 0.9412 100 0.518 Contact Map
2i76A 2 0.8493 100 0.562 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.