GREMLIN Database
SP5B - Stage V sporulation protein B
UniProt: Q00758 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 518 (453)
Sequences: 16851 (14376)
Seq/√Len: 675.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
312_K315_V4.9361.00
230_T234_S3.4521.00
106_F109_V3.1981.00
149_N152_P3.1131.00
44_M280_G3.1121.00
356_A360_K2.9671.00
384_L387_A2.9301.00
350_Y353_S2.7991.00
148_Q306_E2.7101.00
339_F360_K2.6751.00
384_L439_V2.6691.00
386_G390_M2.6041.00
447_K451_L2.5521.00
253_E278_L2.4261.00
342_A356_A2.3431.00
69_V146_G2.3191.00
104_L125_L2.3101.00
351_G354_G2.2951.00
253_E403_I2.1711.00
342_A360_K2.1691.00
448_E451_L2.1641.00
361_V415_M2.1531.00
395_G428_V2.1481.00
343_D347_R2.1271.00
368_L426_V2.1131.00
241_G389_M2.0811.00
402_L420_A2.0701.00
358_F414_I2.0431.00
36_G39_G2.0421.00
183_A186_G2.0401.00
306_E310_Q2.0301.00
307_G315_V2.0221.00
256_V407_A2.0031.00
67_K71_E1.9941.00
12_I151_N1.9901.00
337_I341_F1.9871.00
121_L125_L1.9611.00
257_V261_L1.9591.00
318_Y322_Q1.9401.00
462_I490_I1.9261.00
412_L419_L1.9231.00
459_C463_S1.9131.00
341_F344_E1.9091.00
68_L235_V1.8911.00
407_A417_A1.8901.00
83_N225_G1.8741.00
391_N431_L1.8671.00
361_V422_V1.8661.00
226_K230_T1.8441.00
103_F128_T1.8341.00
108_P121_L1.7961.00
253_E421_I1.7631.00
313_L317_E1.7621.00
331_G370_Y1.7411.00
256_V403_I1.7271.00
336_V460_G1.7221.00
308_M382_L1.7191.00
350_Y354_G1.7061.00
488_A492_M1.7001.00
337_I484_I1.6951.00
107_A125_L1.6801.00
33_R351_G1.6721.00
261_L274_Q1.6691.00
406_L412_L1.6681.00
413_G416_G1.6501.00
320_L378_V1.6411.00
315_V318_Y1.6321.00
80_K83_N1.6291.00
261_L414_I1.6281.00
430_L434_A1.6271.00
262_A274_Q1.6221.00
407_A410_P1.6211.00
406_L420_A1.6151.00
344_E347_R1.6141.00
416_G420_A1.6091.00
32_A281_F1.6021.00
346_M355_A1.5971.00
357_V415_M1.5891.00
403_I407_A1.5881.00
43_Y47_A1.5821.00
163_V197_A1.5781.00
463_S487_S1.5781.00
225_G228_T1.5781.00
346_M359_I1.5751.00
45_M258_A1.5721.00
245_I393_L1.5701.00
149_N209_K1.5561.00
368_L429_T1.5551.00
143_Y147_K1.5521.00
361_V419_L1.5451.00
398_V427_L1.5391.00
304_I316_V1.5391.00
365_F422_V1.5341.00
459_C487_S1.5211.00
343_D360_K1.5211.00
335_V367_L1.5101.00
317_E321_E1.5101.00
85_L143_Y1.5051.00
361_V418_A1.4981.00
343_D356_A1.4981.00
341_F345_L1.4941.00
420_A424_G1.4851.00
148_Q303_A1.4771.00
314_Q318_Y1.4771.00
316_V378_V1.4711.00
186_G190_S1.4701.00
82_K86_V1.4621.00
357_V360_K1.4601.00
338_L363_A1.4561.00
182_Y186_G1.4551.00
257_V275_Y1.4531.00
256_V404_F1.4501.00
65_I88_S1.4421.00
460_G464_S1.4311.00
274_Q414_I1.4291.00
455_V459_C1.4211.00
164_R194_G1.4191.00
405_V410_P1.4141.00
151_N155_M1.4131.00
337_I459_C1.4001.00
167_L190_S1.3961.00
321_E325_R1.3931.00
401_G405_V1.3871.00
46_A127_I1.3851.00
434_A438_K1.3781.00
300_L323_A1.3731.00
123_P188_M1.3661.00
399_K403_I1.3581.00
71_E383_N1.3551.00
390_M394_I1.3551.00
364_P422_V1.3511.00
73_S81_T1.3501.00
286_L362_M1.3491.00
37_E277_E1.3491.00
44_M276_G1.3421.00
315_V319_R1.3391.00
252_F400_T1.3241.00
28_R284_T1.3041.00
257_V417_A1.3031.00
37_E276_G1.2931.00
406_L411_S1.2921.00
18_M22_M1.2921.00
391_N435_T1.2901.00
358_F418_A1.2841.00
238_P389_M1.2811.00
406_L410_P1.2771.00
405_V411_S1.2681.00
257_V278_L1.2641.00
87_M229_F1.2621.00
29_V33_R1.2571.00
282_A358_F1.2481.00
399_K421_I1.2471.00
465_A469_Y1.2381.00
307_G319_R1.2371.00
277_E355_A1.2301.00
108_P125_L1.2261.00
156_S201_Y1.2211.00
25_F29_V1.2191.00
88_S232_L1.2151.00
170_V174_I1.2151.00
465_A468_Q1.2151.00
169_A173_T1.2131.00
19_V158_V1.2071.00
40_V44_M1.2061.00
132_P135_A1.2021.00
415_M418_A1.1991.00
320_L375_L1.1921.00
456_I460_G1.1901.00
346_M356_A1.1881.00
332_G456_I1.1861.00
107_A121_L1.1821.00
402_L406_L1.1791.00
399_K424_G1.1791.00
282_A355_A1.1721.00
403_I421_I1.1691.00
238_P386_G1.1591.00
70_A146_G1.1571.00
16_A154_A1.1551.00
308_M316_V1.1541.00
72_A80_K1.1531.00
398_V402_L1.1371.00
156_S202_L1.1351.00
251_F254_P1.1301.00
328_L332_G1.1261.00
166_S170_V1.1251.00
20_T161_Q1.1251.00
237_L241_G1.1211.00
105_F108_P1.1211.00
391_N432_H1.1181.00
375_L433_A1.1171.00
27_N165_I1.1151.00
43_Y187_A1.1151.00
335_V339_F1.1101.00
22_M26_V1.1091.00
412_L416_G1.1091.00
464_S467_K1.1071.00
111_A120_T1.1041.00
358_F415_M1.1011.00
313_L382_L1.0981.00
133_I199_L1.0951.00
64_A235_V1.0941.00
393_L397_L1.0881.00
133_I196_L1.0861.00
248_L396_A1.0851.00
253_E399_K1.0851.00
245_I389_M1.0821.00
167_L171_C1.0781.00
245_I396_A1.0761.00
231_Q383_N1.0751.00
58_Q62_P1.0751.00
91_I229_F1.0741.00
68_L231_Q1.0721.00
301_V305_S1.0701.00
150_M299_A1.0651.00
94_V98_I1.0641.00
365_F418_A1.0601.00
36_G353_S1.0561.00
378_V436_V1.0531.00
129_P192_V1.0521.00
69_V81_T1.0451.00
108_P112_E1.0361.00
260_S407_A1.0351.00
375_L432_H1.0331.00
39_G42_L1.0331.00
129_P132_P1.0321.00
31_I187_A1.0271.00
345_L349_M1.0201.00
28_R350_Y1.0191.00
41_G276_G1.0161.00
282_A362_M1.0151.00
371_F429_T1.0141.00
66_S142_G1.0111.00
64_A232_L1.0101.00
189_L193_A1.0091.00
190_S194_G1.0081.00
452_S456_I1.0061.00
203_F207_K1.0061.00
342_A359_I1.0051.00
304_I381_A1.0051.00
100_T104_L1.0041.00
344_E467_K1.0031.00
437_S440_L1.0031.00
257_V414_I1.0021.00
200_L204_V1.0021.00
314_Q317_E1.0021.00
452_S455_V0.9981.00
45_M275_Y0.9971.00
434_A437_S0.9971.00
64_A236_S0.9971.00
281_F350_Y0.9941.00
13_L299_A0.9911.00
431_L434_A0.9841.00
90_T94_V0.9821.00
32_A350_Y0.9821.00
167_L193_A0.9821.00
338_L359_I0.9801.00
235_V385_A0.9781.00
339_F342_A0.9771.00
100_T103_F0.9731.00
256_V260_S0.9721.00
397_L401_G0.9711.00
479_N483_W0.9701.00
107_A111_A0.9701.00
249_S399_K0.9651.00
387_A435_T0.9621.00
83_N87_M0.9611.00
422_V425_M0.9571.00
68_L71_E0.9571.00
484_I488_A0.9561.00
102_L106_F0.9541.00
390_M393_L0.9521.00
10_T299_A0.9461.00
10_T296_L0.9451.00
453_F456_I0.9441.00
61_L88_S0.9431.00
450_A454_A0.9361.00
104_L108_P0.9361.00
37_E353_S0.9351.00
67_K383_N0.9331.00
107_A128_T0.9331.00
404_F410_P0.9311.00
128_T132_P0.9311.00
379_L435_T0.9311.00
484_I487_S0.9271.00
427_L431_L0.9261.00
262_A275_Y0.9251.00
125_L129_P0.9241.00
34_F173_T0.9221.00
403_I406_L0.9201.00
242_S388_A0.9191.00
40_V276_G0.9181.00
451_L455_V0.9171.00
307_G312_K0.9151.00
29_V350_Y0.9141.00
5_T8_K0.9111.00
339_F364_P0.9101.00
483_W487_S0.9091.00
86_V90_T0.9081.00
170_V173_T0.9071.00
14_I295_S0.9061.00
17_G21_R0.9051.00
204_V208_Y0.9051.00
419_L423_T0.9011.00
89_L140_L0.9011.00
365_F368_L0.8981.00
30_V34_F0.8941.00
227_Q230_T0.8931.00
194_G198_S0.8921.00
224_N229_F0.8911.00
431_L435_T0.8901.00
23_L165_I0.8891.00
411_S415_M0.8881.00
481_A485_A0.8831.00
94_V97_L0.8831.00
122_Y185_A0.8831.00
13_L154_A0.8821.00
303_A306_E0.8821.00
152_P205_C0.8821.00
46_A123_P0.8791.00
79_Q83_N0.8781.00
100_T132_P0.8781.00
360_K364_P0.8781.00
74_A310_Q0.8781.00
105_F109_V0.8771.00
69_V147_K0.8761.00
346_M350_Y0.8731.00
464_S468_Q0.8731.00
254_P275_Y0.8681.00
80_K228_T0.8671.00
362_M418_A0.8621.00
64_A68_L0.8621.00
355_A358_F0.8621.00
238_P385_A0.8611.00
348_V480_L0.8611.00
185_A188_M0.8611.00
51_F55_T0.8591.00
456_I459_C0.8581.00
280_G284_T0.8561.00
282_A359_I0.8541.00
316_V382_L0.8511.00
29_V32_A0.8501.00
380_Q388_A0.8481.00
81_T147_K0.8481.00
71_E231_Q0.8471.00
339_F343_D0.8471.00
6_F10_T0.8421.00
239_T385_A0.8411.00
34_F172_T0.8391.00
9_G148_Q0.8381.00
468_Q471_S0.8361.00
278_L362_M0.8361.00
341_F483_W0.8331.00
449_Y452_S0.8331.00
140_L203_F0.8311.00
402_L423_T0.8301.00
97_L101_P0.8291.00
171_C182_Y0.8291.00
122_Y125_L0.8261.00
98_I102_L0.8251.00
379_L388_A0.8201.00
168_V190_S0.8191.00
133_I192_V0.8181.00
419_L422_V0.8171.00
111_A121_L0.8161.00
322_Q325_R0.8161.00
189_L192_V0.8151.00
10_T14_I0.8151.00
476_E479_N0.8141.00
400_T404_F0.8121.00
228_T231_Q0.8101.00
23_L27_N0.8101.00
160_E164_R0.8101.00
394_I431_L0.8081.00
303_A307_G0.8071.00
233_M236_S0.8061.00
325_R329_L0.8061.00
467_K483_W0.8051.00
333_I491_Y0.8021.00
258_A275_Y0.8021.00
281_F284_T0.8001.00
164_R168_V0.7981.00
348_V477_A0.7971.00
86_V222_I0.7961.00
364_P368_L0.7931.00
389_M393_L0.7931.00
11_L15_A0.7891.00
130_V195_E0.7891.00
336_V456_I0.7871.00
286_L366_F0.7841.00
403_I417_A0.7841.00
299_A302_P0.7831.00
319_R323_A0.7801.00
284_T288_L0.7781.00
327_C370_Y0.7761.00
364_P367_L0.7741.00
402_L405_V0.7741.00
336_V340_V0.7741.00
65_I69_V0.7741.00
435_T438_K0.7711.00
387_A390_M0.7711.00
93_G97_L0.7691.00
460_G463_S0.7681.00
31_I168_V0.7681.00
234_S237_L0.7671.00
233_M237_L0.7661.00
388_A392_S0.7651.00
192_V196_L0.7641.00
461_F465_A0.7621.00
333_I336_V0.7611.00
96_S135_A0.7591.00
8_K151_N0.7571.00
276_G281_F0.7551.00
12_I16_A0.7541.00
108_P111_A0.7541.00
276_G280_G0.7531.00
307_G310_Q0.7521.00
162_V166_S0.7491.00
35_I39_G0.7481.00
174_I182_Y0.7461.00
245_I392_S0.7431.00
101_P105_F0.7421.00
204_V207_K0.7411.00
247_N251_F0.7411.00
293_T297_S0.7411.00
65_I84_I0.7401.00
48_P254_P0.7401.00
126_A192_V0.7381.00
333_I456_I0.7381.00
191_S195_E0.7381.00
339_F363_A0.7381.00
30_V169_A0.7371.00
285_L350_Y0.7351.00
47_A51_F0.7351.00
286_L289_P0.7341.00
144_F206_F0.7341.00
340_V460_G0.7321.00
125_L128_T0.7311.00
28_R32_A0.7311.00
43_Y184_A0.7301.00
15_A19_V0.7301.00
141_R145_Q0.7291.00
73_S147_K0.7291.00
29_V349_M0.7261.00
283_M287_T0.7261.00
391_N395_G0.7241.00
40_V281_F0.7231.00
375_L429_T0.7231.00
84_I88_S0.7221.00
7_L11_L0.7221.00
365_F421_I0.7161.00
435_T439_V0.7161.00
37_E354_G0.7121.00
60_G236_S0.7121.00
234_S386_G0.7101.00
87_M224_N0.7091.00
54_T58_Q0.7091.00
58_Q92_T0.7081.00
109_V112_E0.7051.00
165_I169_A0.7011.00
50_F131_V0.6991.00
254_P280_G0.6981.00
192_V195_E0.6961.00
67_K385_A0.6961.00
466_I469_Y0.6921.00
252_F256_V0.6921.00
137_S199_L0.6911.00
66_S146_G0.6911.00
410_P417_A0.6881.00
284_T287_T0.6861.00
323_A374_P0.6861.00
477_A484_I0.6841.00
301_V381_A0.6841.00
301_V377_A0.6821.00
305_S309_E0.6811.00
333_I459_C0.6801.00
327_C374_P0.6801.00
415_M419_L0.6761.00
477_A481_A0.6751.00
13_L150_M0.6751.00
126_A189_L0.6711.00
171_C174_I0.6691.00
281_F355_A0.6691.00
377_A380_Q0.6671.00
398_V401_G0.6671.00
122_Y126_A0.6661.00
406_L416_G0.6661.00
134_I195_E0.6651.00
205_C209_K0.6631.00
244_F248_L0.6621.00
79_Q82_K0.6611.00
161_Q164_R0.6581.00
253_E283_M0.6541.00
124_L128_T0.6531.00
7_L10_T0.6531.00
51_F54_T0.6531.00
255_I259_Q0.6491.00
251_F255_I0.6461.00
35_I184_A0.6441.00
466_I486_A0.6441.00
457_V461_F0.6431.00
487_S491_Y0.6421.00
433_A437_S0.6421.00
136_I199_L0.6421.00
459_C462_I0.6411.00
342_A363_A0.6401.00
167_L170_V0.6391.00
480_L484_I0.6391.00
187_A191_S0.6391.00
19_V23_L0.6391.00
227_Q231_Q0.6381.00
485_A489_A0.6381.00
9_G299_A0.6361.00
198_S202_L0.6361.00
160_E198_S0.6361.00
71_E309_E0.6361.00
379_L436_V0.6351.00
103_F124_L0.6351.00
461_F464_S0.6341.00
307_G316_V0.6341.00
467_K470_I0.6331.00
16_A158_V0.6321.00
426_V430_L0.6301.00
96_S100_T0.6291.00
377_A381_A0.6291.00
201_Y205_C0.6281.00
418_A422_V0.6281.00
337_I488_A0.6271.00
144_F152_P0.6261.00
66_S70_A0.6221.00
67_K381_A0.6211.00
249_S396_A0.6211.00
50_F54_T0.6211.00
45_M48_P0.6211.00
107_A124_L0.6211.00
347_R350_Y0.6191.00
296_L300_L0.6171.00
394_I397_L0.6161.00
156_S198_S0.6161.00
31_I40_V0.6161.00
385_A388_A0.6161.00
319_R322_Q0.6161.00
100_T128_T0.6151.00
475_S479_N0.6141.00
28_R40_V0.6131.00
103_F107_A0.6131.00
399_K420_A0.6131.00
344_E483_W0.6121.00
126_A188_M0.6111.00
86_V89_L0.6101.00
232_L236_S0.6091.00
446_I450_A0.6081.00
152_P155_M0.6081.00
133_I136_I0.6081.00
334_S338_L0.6061.00
284_T350_Y0.6051.00
477_A480_L0.6041.00
35_I40_V0.6041.00
375_L436_V0.6041.00
239_T380_Q0.6031.00
329_L333_I0.6031.00
475_S478_V0.6011.00
91_I95_L0.6001.00
369_Y373_G0.5991.00
43_Y188_M0.5981.00
421_I424_G0.5951.00
155_M159_L0.5951.00
30_V173_T0.5911.00
164_R190_S0.5901.00
140_L202_L0.5901.00
145_Q153_L0.5891.00
83_N228_T0.5871.00
448_E452_S0.5841.00
365_F425_M0.5841.00
11_L18_M0.5831.00
14_I18_M0.5831.00
156_S160_E0.5821.00
84_I228_T0.5821.00
174_I181_E0.5821.00
335_V363_A0.5801.00
463_S467_K0.5781.00
62_P142_G0.5781.00
393_L396_A0.5771.00
437_S441_P0.5771.00
479_N482_G0.5761.00
422_V426_V0.5731.00
97_L132_P0.5731.00
347_R351_G0.5721.00
126_A185_A0.5721.00
229_F233_M0.5721.00
368_L422_V0.5711.00
45_M254_P0.5711.00
458_I461_F0.5701.00
87_M91_I0.5691.00
52_L247_N0.5691.00
278_L283_M0.5681.00
235_V239_T0.5671.00
90_T93_G0.5651.00
347_R352_S0.5651.00
344_E348_V0.5651.00
38_E42_L0.5631.00
234_S238_P0.5631.00
425_M429_T0.5611.00
31_I35_I0.5601.00
111_A124_L0.5601.00
13_L17_G0.5581.00
104_L107_A0.5581.00
325_R448_E0.5581.00
337_I487_S0.5571.00
242_S246_G0.5551.00
106_F110_M0.5551.00
260_S404_F0.5551.00
68_L72_A0.5541.00
163_V194_G0.5541.00
72_A228_T0.5531.00
242_S392_S0.5521.00
73_S148_Q0.5521.00
398_V424_G0.5511.00
334_S337_I0.5501.00
90_T224_N0.5481.00
399_K402_L0.5461.00
161_Q165_I0.5461.00
24_G28_R0.5441.00
300_L304_I0.5431.00
107_A110_M0.5431.00
49_T53_A0.5431.00
42_L123_P0.5411.00
454_A457_V0.5411.00
303_A319_R0.5411.00
347_R356_A0.5401.00
68_L84_I0.5381.00
249_S252_F0.5361.00
207_K211_T0.5351.00
142_G146_G0.5351.00
183_A190_S0.5351.00
89_L92_T0.5341.00
330_S334_S0.5341.00
72_A81_T0.5341.00
462_I465_A0.5321.00
295_S298_T0.5311.00
384_L388_A0.5291.00
341_F487_S0.5291.00
481_A484_I0.5291.00
36_G354_G0.5291.00
332_G367_L0.5281.00
41_G275_Y0.5271.00
128_T131_V0.5261.00
159_L163_V0.5251.00
69_V85_L0.5251.00
160_E194_G0.5251.00
403_I420_A0.5241.00
231_Q235_V0.5241.00
476_E480_L0.5230.99
480_L483_W0.5230.99
252_F399_K0.5220.99
87_M226_K0.5220.99
168_V172_T0.5220.99
251_F287_T0.5220.99
357_V361_V0.5200.99
141_R157_Q0.5200.99
346_M354_G0.5190.99
294_Y298_T0.5190.99
463_S466_I0.5190.99
186_G189_L0.5180.99
328_L367_L0.5150.99
150_M154_A0.5150.99
145_Q150_M0.5150.99
19_V22_M0.5140.99
185_A189_L0.5140.99
316_V319_R0.5140.99
242_S389_M0.5130.99
466_I470_I0.5110.99
338_L345_L0.5110.99
395_G424_G0.5110.99
308_M381_A0.5100.99
39_G184_A0.5080.99
98_I101_P0.5070.99
278_L418_A0.5060.99
207_K210_K0.5020.99
344_E479_N0.5000.99
5_T148_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8224 100 0.374 Contact Map
3w4tA 1 0.8166 100 0.394 Contact Map
4humA 1 0.8436 100 0.397 Contact Map
3mktA 1 0.8398 100 0.413 Contact Map
4q65A 1 0.6931 20.2 0.954 Contact Map
2cfqA 1 0.7568 18.8 0.954 Contact Map
1pw4A 1 0.3764 15.6 0.956 Contact Map
3dl8G 1 0.6815 11.2 0.959 Contact Map
3wdoA 1 0.3726 9.9 0.96 Contact Map
2kluA 1 0.0965 6.3 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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