GREMLIN Database
QUEG - Epoxyqueuosine reductase
UniProt: P97030 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (337)
Sequences: 2038 (1224)
Seq/√Len: 66.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
279_S282_E4.7711.00
13_Y16_S4.2311.00
231_T342_K3.4121.00
10_L120_L3.3301.00
138_L173_I3.2611.00
9_E123_K3.2431.00
156_C209_L3.1561.00
160_T167_V3.1491.00
192_T196_D2.9831.00
298_K329_R2.9011.00
237_L307_A2.8221.00
11_I24_F2.7351.00
311_F343_I2.5681.00
195_L203_L2.5681.00
7_K11_I2.5561.00
238_Y295_R2.4911.00
305_I320_L2.4831.00
141_R157_M2.4661.00
317_L340_I2.4461.00
229_F232_K2.4381.00
73_I170_A2.3701.00
68_K177_P2.3521.00
117_E129_T2.3511.00
197_A246_V2.3311.00
39_L43_L2.3261.00
71_V174_T2.3031.00
24_F69_S2.2661.00
38_I42_S2.2311.00
72_A171_E2.2211.00
297_K301_Q2.2111.00
7_K24_F2.1681.00
324_M337_A2.1001.00
17_I116_L2.0761.00
97_C168_Y2.0721.00
103_K289_H2.0531.00
11_I181_D2.0351.00
69_S180_P2.0261.00
26_T146_R1.9891.00
74_A169_L1.9781.00
45_Y208_Q1.9741.00
13_Y119_F1.9731.00
59_T62_L1.9711.00
7_K179_E1.9681.00
163_Y167_V1.9521.00
128_R175_N1.9381.00
213_R229_F1.9371.00
333_R337_A1.9361.00
276_L308_L1.9351.00
285_E288_G1.9251.00
203_L209_L1.9131.00
237_L304_A1.8471.00
295_R299_P1.8461.00
21_K160_T1.7801.00
14_A22_I1.7701.00
152_S158_I1.7501.00
224_F334_G1.7211.00
222_K299_P1.6870.99
53_D56_K1.6810.99
125_E175_N1.6810.99
67_A173_I1.6540.99
48_G221_T1.6470.99
320_L324_M1.6430.99
26_T69_S1.6370.99
308_L316_A1.5900.99
10_L24_F1.5890.99
186_D207_G1.5570.99
132_M136_G1.5520.99
85_P246_V1.5410.99
34_K59_T1.5270.99
213_R228_E1.5130.99
141_R152_S1.5010.99
72_A147_A1.4880.99
327_D333_R1.4860.99
7_K181_D1.4750.99
328_P336_A1.4720.98
22_I73_I1.4720.98
236_R242_T1.4670.98
70_I143_V1.4640.98
118_D121_K1.4480.98
98_R245_T1.4460.98
70_I173_I1.4310.98
192_T195_L1.4280.98
271_L274_P1.4270.98
41_E54_I1.4090.98
149_I158_I1.4020.98
111_E115_L1.3950.98
13_Y17_I1.3780.98
21_K162_E1.3720.98
334_G337_A1.3700.98
98_R101_W1.3610.97
47_S212_Q1.3530.97
74_A167_V1.3370.97
38_I58_V1.3240.97
327_D332_I1.3230.97
10_L22_I1.3210.97
321_T324_M1.3170.97
225_L306_L1.3130.97
117_E172_M1.3060.97
280_N284_K1.3010.97
131_S172_M1.2650.96
34_K58_V1.2610.96
259_P262_E1.2510.96
80_R262_E1.2500.96
305_I336_A1.2470.96
94_G272_L1.2470.96
93_R271_L1.2450.96
20_D76_A1.2440.96
320_L323_L1.2410.96
327_D336_A1.2390.96
37_L50_E1.2380.96
55_E58_V1.2340.95
118_D122_S1.2330.95
304_A308_L1.2310.95
27_A67_A1.2290.95
161_P184_I1.2150.95
184_I187_M1.2110.95
140_D169_L1.2050.95
337_A341_G1.1980.95
210_N213_R1.1930.95
284_K287_F1.1920.95
277_A319_E1.1770.94
329_R333_R1.1680.94
226_P229_F1.1570.94
11_I15_K1.1560.94
25_T143_V1.1540.94
333_R336_A1.1540.94
297_K327_D1.1490.93
151_F187_M1.1470.93
322_E326_K1.1420.93
218_L229_F1.1360.93
9_E119_F1.1330.93
319_E322_E1.1310.93
205_N208_Q1.1300.93
64_L67_A1.1220.93
95_I101_W1.1160.92
313_D343_I1.1150.92
316_A320_L1.1140.92
87_S95_I1.1080.92
306_L335_T1.1080.92
141_R158_I1.1050.92
318_P321_T1.1050.92
75_L112_K1.1030.92
326_K333_R1.0940.92
20_D257_L1.0900.91
112_K258_H1.0900.91
94_G270_P1.0860.91
5_Q9_E1.0840.91
284_K293_S1.0810.91
103_K260_E1.0790.91
73_I172_M1.0670.91
195_L206_P1.0590.90
6_L124_H1.0520.90
256_H262_E1.0490.90
316_A323_L1.0490.90
17_I115_L1.0400.89
22_I71_V1.0390.89
63_L136_G1.0360.89
316_A321_T1.0340.89
121_K126_D1.0310.89
316_A343_I1.0270.89
249_L252_G1.0210.89
238_Y290_V1.0210.89
141_R207_G1.0200.88
288_G293_S1.0140.88
69_S177_P1.0120.88
51_E56_K1.0060.88
127_I174_T1.0040.88
276_L304_A1.0040.88
220_Q294_W1.0000.87
21_K74_A0.9950.87
64_L132_M0.9850.87
224_F335_T0.9810.86
111_E118_D0.9760.86
8_E12_E0.9710.86
312_K343_I0.9680.86
98_R166_Y0.9660.86
39_L42_S0.9600.85
331_V334_G0.9590.85
26_T180_P0.9570.85
11_I22_I0.9560.85
16_S119_F0.9560.85
35_D39_L0.9530.85
33_L145_E0.9500.85
55_E62_L0.9410.84
301_Q323_L0.9410.84
47_S221_T0.9350.84
141_R155_N0.9330.84
215_I218_L0.9330.84
278_I282_E0.9320.83
238_Y292_G0.9320.83
37_L49_F0.9280.83
152_S155_N0.9270.83
87_S93_R0.9210.83
205_N216_S0.9190.83
125_E128_R0.9140.82
311_F316_A0.9130.82
154_K192_T0.9060.82
56_K138_L0.9000.81
154_K189_G0.9000.81
277_A322_E0.8940.81
54_I59_T0.8940.81
317_L321_T0.8940.81
62_L65_P0.8920.81
156_C203_L0.8890.80
159_T165_S0.8890.80
299_P302_R0.8810.80
151_F159_T0.8770.80
64_L173_I0.8770.80
155_N165_S0.8760.80
73_I109_L0.8750.79
74_A163_Y0.8700.79
282_E285_E0.8690.79
326_K337_A0.8680.79
204_V210_N0.8580.78
56_K173_I0.8570.78
142_A152_S0.8570.78
34_K55_E0.8560.78
88_T95_I0.8500.77
124_H127_I0.8500.77
9_E13_Y0.8480.77
165_S244_Q0.8470.77
45_Y204_V0.8450.77
11_I14_A0.8420.77
260_E263_P0.8410.77
30_F33_L0.8380.76
300_I304_A0.8370.76
283_F292_G0.8350.76
242_T246_V0.8340.76
315_S321_T0.8340.76
215_I219_T0.8290.76
227_D334_G0.8280.76
238_Y299_P0.8250.75
84_A87_S0.8240.75
41_E46_L0.8210.75
304_A307_A0.8210.75
94_G304_A0.8200.75
324_M334_G0.8180.75
167_V258_H0.8150.74
161_P187_M0.8130.74
151_F249_L0.8090.74
84_A95_I0.8080.74
40_Q50_E0.8070.74
14_A73_I0.8070.74
90_T93_R0.8060.74
140_D157_M0.8020.73
94_G237_L0.8000.73
34_K54_I0.7990.73
56_K62_L0.7980.73
290_V293_S0.7960.73
63_L132_M0.7930.72
283_F291_S0.7910.72
67_A70_I0.7870.72
274_P286_K0.7860.72
12_E15_K0.7860.72
230_R338_W0.7840.72
152_S157_M0.7840.72
110_R132_M0.7830.71
155_N207_G0.7830.71
85_P197_A0.7820.71
34_K62_L0.7820.71
156_C206_P0.7790.71
43_L208_Q0.7760.71
24_F178_F0.7730.70
264_D267_I0.7720.70
296_G299_P0.7700.70
66_K128_R0.7700.70
48_G223_G0.7680.70
103_K107_D0.7640.70
287_F293_S0.7630.69
120_L176_I0.7610.69
197_A201_G0.7610.69
139_S142_A0.7610.69
121_K128_R0.7590.69
328_P333_R0.7560.69
276_L320_L0.7550.69
23_G147_A0.7510.68
33_L142_A0.7490.68
317_L320_L0.7460.68
91_E197_A0.7460.68
282_E286_K0.7460.68
113_L170_A0.7440.68
6_L120_L0.7440.68
97_C216_S0.7430.67
215_I225_L0.7410.67
95_I236_R0.7390.67
27_A70_I0.7380.67
112_K115_L0.7370.67
226_P230_R0.7340.66
145_E186_D0.7330.66
38_I54_I0.7320.66
55_E59_T0.7310.66
71_V172_M0.7270.66
150_G158_I0.7250.66
27_A146_R0.7240.65
222_K331_V0.7240.65
28_D146_R0.7220.65
102_G266_E0.7180.65
330_P341_G0.7150.64
37_L58_V0.7130.64
40_Q46_L0.7100.64
69_S178_F0.7070.64
156_C208_Q0.7030.63
13_Y123_K0.7020.63
25_T180_P0.7020.63
266_E286_K0.6970.62
308_L320_L0.6960.62
227_D342_K0.6950.62
324_M336_A0.6950.62
94_G268_A0.6940.62
117_E127_I0.6930.62
100_S290_V0.6910.62
107_D289_H0.6900.62
38_I55_E0.6890.62
75_L109_L0.6890.62
149_I169_L0.6890.62
319_E323_L0.6860.61
318_P322_E0.6860.61
221_T229_F0.6850.61
145_E152_S0.6800.61
124_H128_R0.6800.61
281_R296_G0.6780.60
156_C207_G0.6770.60
35_D38_I0.6770.60
314_A317_L0.6760.60
265_P268_A0.6740.60
227_D337_A0.6720.60
301_Q327_D0.6710.60
334_G341_G0.6710.60
330_P334_G0.6700.59
97_C295_R0.6690.59
24_F71_V0.6690.59
46_L51_E0.6690.59
228_E232_K0.6690.59
5_Q8_E0.6660.59
221_T306_L0.6660.59
333_R340_I0.6640.59
201_G232_K0.6630.59
189_G249_L0.6620.58
193_K246_V0.6620.58
218_L221_T0.6600.58
324_M340_I0.6570.58
301_Q304_A0.6560.58
7_K69_S0.6520.57
273_K308_L0.6490.57
317_L324_M0.6490.57
54_I62_L0.6470.57
76_A258_H0.6470.57
278_I287_F0.6470.57
40_Q47_S0.6460.57
33_L139_S0.6450.57
114_D131_S0.6440.56
280_N297_K0.6390.56
119_F123_K0.6360.55
315_S318_P0.6360.55
297_K304_A0.6340.55
305_I332_I0.6330.55
110_R136_G0.6330.55
229_F233_I0.6320.55
34_K50_E0.6310.55
155_N203_L0.6290.55
35_D58_V0.6290.55
140_D220_Q0.6280.55
154_K195_L0.6280.55
317_L341_G0.6270.54
50_E53_D0.6220.54
116_L172_M0.6220.54
130_K137_E0.6200.54
63_L110_R0.6190.53
166_Y245_T0.6190.53
7_K180_P0.6180.53
314_A321_T0.6180.53
278_I300_I0.6160.53
273_K319_E0.6140.53
220_Q295_R0.6110.53
8_E11_I0.6110.53
227_D230_R0.6100.52
111_E119_F0.6050.52
142_A145_E0.6040.52
92_R228_E0.6030.52
313_D316_A0.6030.52
98_R251_K0.6020.51
305_I309_A0.6020.51
224_F306_L0.6000.51
151_F186_D0.5990.51
25_T147_A0.5980.51
121_K127_I0.5970.51
23_G173_I0.5960.51
326_K342_K0.5950.51
10_L176_I0.5900.50
20_D163_Y0.5900.50
13_Y115_L0.5900.50
64_L175_N0.5880.50
108_V112_K0.5880.50
97_C157_M0.5880.50
131_S170_A0.5850.49
273_K343_I0.5830.49
331_V337_A0.5830.49
132_M296_G0.5820.49
295_R300_I0.5810.49
276_L301_Q0.5810.49
9_E12_E0.5810.49
270_P275_L0.5800.49
306_L310_H0.5800.49
102_G267_I0.5800.49
298_K301_Q0.5780.49
108_V260_E0.5770.49
29_T146_R0.5770.49
306_L334_G0.5760.48
24_F180_P0.5760.48
155_N244_Q0.5750.48
315_S330_P0.5740.48
20_D258_H0.5720.48
225_L229_F0.5710.48
96_F292_G0.5690.48
329_R334_G0.5690.48
100_S291_S0.5690.48
121_K129_T0.5690.48
323_L327_D0.5690.48
331_V335_T0.5680.47
204_V209_L0.5670.47
69_S179_E0.5660.47
187_M249_L0.5650.47
7_K22_I0.5650.47
195_L204_V0.5650.47
31_D146_R0.5620.47
56_K59_T0.5620.47
23_G31_D0.5620.47
57_R283_F0.5610.47
159_T162_E0.5610.47
321_T326_K0.5610.47
104_D219_T0.5600.47
323_L332_I0.5590.46
7_K178_F0.5590.46
272_L275_L0.5580.46
102_G291_S0.5570.46
103_K293_S0.5570.46
15_K22_I0.5560.46
25_T146_R0.5560.46
154_K206_P0.5550.46
107_D293_S0.5520.46
103_K264_D0.5520.46
232_K342_K0.5500.45
317_L323_L0.5490.45
43_L115_L0.5480.45
127_I176_I0.5480.45
329_R337_A0.5480.45
266_E270_P0.5470.45
120_L183_P0.5460.45
323_L336_A0.5460.45
284_K288_G0.5460.45
47_S211_A0.5440.45
160_T163_Y0.5420.44
99_A220_Q0.5410.44
328_P337_A0.5400.44
106_H134_D0.5390.44
21_K163_Y0.5390.44
60_P136_G0.5370.44
278_I286_K0.5360.44
187_M252_G0.5340.43
96_F190_S0.5310.43
36_R39_L0.5310.43
36_R152_S0.5300.43
126_D175_N0.5290.43
42_S55_E0.5290.43
114_D118_D0.5270.43
333_R341_G0.5270.43
117_E121_K0.5260.43
161_P180_P0.5260.43
330_P337_A0.5250.42
155_N197_A0.5230.42
223_G226_P0.5210.42
234_G242_T0.5210.42
86_R89_R0.5200.42
122_S257_L0.5190.42
9_E195_L0.5190.42
27_A173_I0.5190.42
19_V73_I0.5180.42
273_K316_A0.5180.42
66_K175_N0.5170.41
212_Q279_S0.5160.41
41_E47_S0.5160.41
312_K321_T0.5160.41
228_E231_T0.5160.41
86_R315_S0.5160.41
314_A341_G0.5150.41
216_S339_A0.5140.41
76_A163_Y0.5130.41
37_L142_A0.5120.41
281_R285_E0.5120.41
38_I282_E0.5120.41
12_E254_D0.5100.41
114_D129_T0.5100.41
120_L127_I0.5090.41
100_S292_G0.5080.40
24_F181_D0.5080.40
142_A157_M0.5060.40
34_K38_I0.5040.40
33_L141_R0.5030.40
298_K327_D0.5030.40
71_V178_F0.5030.40
49_F166_Y0.5020.40
165_S250_N0.5010.40
117_E174_T0.5010.40
278_I301_Q0.5010.40
114_D117_E0.5010.40
321_T341_G0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rasA 2 0.8135 100 0.607 Contact Map
4uquA 2 0.7098 100 0.709 Contact Map
2bs2B 1 0.5855 99.4 0.899 Contact Map
4jw2A 1 0.1891 99.1 0.91 Contact Map
3i9v9 1 0.3161 98.9 0.917 Contact Map
1te4A 1 0.2876 98.7 0.923 Contact Map
4jw3C 1 0.2513 98.7 0.924 Contact Map
3ltmA 1 0.3109 98.4 0.93 Contact Map
3ltjA 2 0.3238 98.4 0.931 Contact Map
4d4zA 1 0.329 98.1 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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