YWTE - BACSU - GREMLIN Contacts

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YWTE - Putative phosphatase YwtE

UniProt:	P96741	Sequences: MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRATFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVYTDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFDGGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLADIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYFIDQLLSGQYA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	286 (253)
Sequences:	10666 (8731)
Seq/√Len:	548.9

ECOLI - YBHA YIDA YBJI YIGL SUPH COF MPGP
BACSU - YWTE YWPJ YXEH YHAX YKRA YITU YCSE NTDB
HALSA - PGP
SULSO - PGP1 PGP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
266_K	275_Y	4.221	1.00
15_K	269_D	3.555	1.00
230_A	244_A	3.115	1.00
267_S	270_E	2.898	1.00
241_F	247_R	2.781	1.00
20_S	271_N	2.750	1.00
22_E	271_N	2.571	1.00
218_A	228_I	2.522	1.00
255_D	259_E	2.463	1.00
14_N	18_V	2.443	1.00
6_I	37_V	2.417	1.00
242_E	260_K	2.389	1.00
215_T	243_V	2.329	1.00
22_E	278_D	2.309	1.00
41_T	48_V	2.305	1.00
225_T	243_V	2.075	1.00
209_G	239_S	2.034	1.00
2_K	227_D	2.007	1.00
21_A	25_E	1.980	1.00
29_R	32_D	1.940	1.00
235_P	256_E	1.898	1.00
76_S	216_K	1.895	1.00
238_L	257_L	1.883	1.00
238_L	260_K	1.846	1.00
247_R	262_T	1.844	1.00
249_A	261_S	1.824	1.00
27_I	37_V	1.821	1.00
30_A	35_I	1.795	1.00
235_P	254_I	1.790	1.00
29_R	278_D	1.780	1.00
3_C	38_T	1.748	1.00
255_D	258_K	1.746	1.00
81_D	84_A	1.739	1.00
266_K	270_E	1.737	1.00
224_E	227_D	1.737	1.00
29_R	33_A	1.696	1.00
246_H	263_F	1.693	1.00
24_R	54_D	1.686	1.00
215_T	219_D	1.672	1.00
216_K	220_I	1.658	1.00
5_A	214_L	1.650	1.00
246_H	262_T	1.650	1.00
69_D	73_R	1.629	1.00
216_K	219_D	1.625	1.00
211_G	243_V	1.593	1.00
154_H	157_S	1.589	1.00
248_I	276_F	1.588	1.00
212_R	215_T	1.583	1.00
214_L	240_M	1.570	1.00
78_T	216_K	1.567	1.00
257_L	260_K	1.559	1.00
92_L	170_C	1.558	1.00
36_L	221_Y	1.555	1.00
8_L	13_L	1.549	1.00
84_A	190_K	1.537	1.00
6_I	231_I	1.521	1.00
20_S	23_N	1.518	1.00
263_F	280_L	1.511	1.00
263_F	276_F	1.480	1.00
23_N	271_N	1.466	1.00
25_E	29_R	1.462	1.00
182_K	186_K	1.460	1.00
93_L	110_P	1.445	1.00
226_Q	245_G	1.444	1.00
230_A	240_M	1.444	1.00
231_I	273_V	1.437	1.00
87_A	190_K	1.413	1.00
22_E	275_Y	1.370	1.00
231_I	276_F	1.361	1.00
26_A	274_A	1.349	1.00
24_R	28_K	1.339	1.00
95_K	184_E	1.304	1.00
74_L	77_R	1.297	1.00
84_A	87_A	1.294	1.00
241_F	257_L	1.293	1.00
5_A	40_C	1.293	1.00
249_A	253_A	1.291	1.00
251_E	267_S	1.278	1.00
77_R	164_N	1.275	1.00
26_A	278_D	1.272	1.00
263_F	279_Q	1.262	1.00
78_T	205_P	1.262	1.00
238_L	242_E	1.257	1.00
192_A	239_S	1.244	1.00
82_Q	86_K	1.243	1.00
28_K	32_D	1.243	1.00
225_T	228_I	1.242	1.00
91_Y	95_K	1.239	1.00
258_K	264_V	1.229	1.00
177_K	180_Q	1.227	1.00
218_A	225_T	1.204	1.00
77_R	166_Y	1.203	1.00
229_Y	280_L	1.199	1.00
66_T	74_L	1.187	1.00
256_E	259_E	1.184	1.00
84_A	191_L	1.184	1.00
3_C	223_I	1.171	1.00
14_N	269_D	1.167	1.00
276_F	280_L	1.166	1.00
273_V	277_I	1.164	1.00
15_K	268_N	1.164	1.00
228_I	244_A	1.164	1.00
179_K	195_S	1.151	1.00
38_T	217_L	1.148	1.00
4_I	277_I	1.144	1.00
4_I	30_A	1.139	1.00
4_I	35_I	1.132	1.00
22_E	26_A	1.131	1.00
265_T	276_F	1.116	1.00
60_I	213_A	1.109	1.00
252_N	268_N	1.101	1.00
179_K	183_E	1.100	1.00
67_I	216_K	1.097	1.00
192_A	207_S	1.084	1.00
248_I	265_T	1.082	1.00
229_Y	246_H	1.081	1.00
274_A	278_D	1.077	1.00
230_A	241_F	1.076	1.00
225_T	245_G	1.069	1.00
3_C	218_A	1.066	1.00
254_I	257_L	1.059	1.00
190_K	206_A	1.049	1.00
90_D	94_S	1.049	1.00
250_M	272_G	1.045	1.00
8_L	51_L	1.045	1.00
5_A	228_I	1.044	1.00
21_A	24_R	1.043	1.00
194_T	204_L	1.042	1.00
28_K	31_V	1.033	1.00
218_A	243_V	1.018	1.00
205_P	208_S	1.018	1.00
91_Y	94_S	1.017	1.00
248_I	263_F	1.012	1.00
167_K	202_E	1.012	1.00
234_S	254_I	1.012	1.00
209_G	212_R	1.002	1.00
244_A	247_R	1.002	1.00
265_T	272_G	1.002	1.00
77_R	104_D	0.988	1.00
253_A	258_K	0.986	1.00
218_A	223_I	0.986	1.00
79_L	164_N	0.979	1.00
229_Y	276_F	0.976	1.00
251_E	258_K	0.973	1.00
276_F	279_Q	0.970	1.00
249_A	257_L	0.966	1.00
214_L	244_A	0.962	1.00
266_K	272_G	0.959	1.00
215_T	225_T	0.954	1.00
3_C	228_I	0.953	1.00
12_L	23_N	0.952	1.00
183_E	186_K	0.951	1.00
172_S	177_K	0.950	1.00
217_L	221_Y	0.950	1.00
86_K	90_D	0.950	1.00
78_T	207_S	0.950	1.00
211_G	239_S	0.946	1.00
275_Y	279_Q	0.944	1.00
6_I	273_V	0.943	1.00
65_G	208_S	0.943	1.00
67_I	76_S	0.943	1.00
28_K	56_D	0.940	1.00
12_L	27_I	0.939	1.00
67_I	213_A	0.938	1.00
45_T	61_A	0.938	1.00
229_Y	248_I	0.937	1.00
235_P	238_L	0.935	1.00
49_K	72_Y	0.923	1.00
25_E	28_K	0.920	1.00
49_K	53_D	0.914	1.00
90_D	156_E	0.911	1.00
275_Y	278_D	0.907	1.00
35_I	229_Y	0.905	1.00
250_M	265_T	0.904	1.00
180_Q	184_E	0.899	1.00
38_T	58_P	0.898	1.00
30_A	37_V	0.894	1.00
23_N	274_A	0.893	1.00
87_A	90_D	0.892	1.00
106_H	150_K	0.889	1.00
251_E	266_K	0.887	1.00
75_I	220_I	0.886	1.00
172_S	178_L	0.884	1.00
41_T	61_A	0.883	1.00
68_H	72_Y	0.879	1.00
61_A	66_T	0.879	1.00
228_I	245_G	0.877	1.00
218_A	245_G	0.877	1.00
251_E	270_E	0.874	1.00
175_M	179_K	0.862	1.00
5_A	38_T	0.860	1.00
180_Q	183_E	0.854	1.00
60_I	217_L	0.852	1.00
83_E	87_A	0.852	1.00
179_K	182_K	0.849	1.00
204_L	209_G	0.847	1.00
68_H	74_L	0.845	1.00
23_N	26_A	0.844	1.00
256_E	260_K	0.837	1.00
14_N	20_S	0.835	1.00
79_L	166_Y	0.825	1.00
45_T	68_H	0.824	1.00
94_S	184_E	0.822	1.00
40_C	60_I	0.822	1.00
6_I	12_L	0.820	1.00
241_F	260_K	0.815	1.00
4_I	229_Y	0.812	1.00
91_Y	184_E	0.809	1.00
245_G	262_T	0.808	1.00
8_L	39_I	0.799	1.00
87_A	91_Y	0.799	1.00
80_M	205_P	0.799	1.00
228_I	243_V	0.795	1.00
61_A	68_H	0.794	1.00
230_A	247_R	0.788	1.00
44_A	62_A	0.787	1.00
30_A	277_I	0.786	1.00
22_E	274_A	0.785	1.00
266_K	279_Q	0.782	1.00
36_L	58_P	0.780	1.00
250_M	253_A	0.779	1.00
193_Q	203_I	0.773	1.00
241_F	261_S	0.771	1.00
26_A	29_R	0.767	1.00
12_L	19_I	0.754	1.00
35_I	227_D	0.751	1.00
95_K	180_Q	0.743	1.00
214_L	230_A	0.741	1.00
58_P	221_Y	0.739	1.00
82_Q	164_N	0.736	1.00
14_N	268_N	0.735	1.00
192_A	206_A	0.734	1.00
212_R	216_K	0.733	1.00
114_E	118_H	0.732	1.00
86_K	156_E	0.731	1.00
89_A	93_L	0.731	1.00
182_K	195_S	0.727	1.00
253_A	257_L	0.727	1.00
227_D	245_G	0.722	1.00
174_D	177_K	0.720	1.00
73_R	220_I	0.714	1.00
48_V	59_I	0.710	1.00
65_G	205_P	0.709	1.00
10_G	250_M	0.705	1.00
153_P	157_S	0.704	1.00
233_D	253_A	0.699	1.00
263_F	275_Y	0.694	1.00
215_T	218_A	0.693	1.00
239_S	242_E	0.689	1.00
93_L	156_E	0.686	1.00
246_H	276_F	0.685	1.00
103_T	163_E	0.684	1.00
208_S	212_R	0.683	1.00
63_N	202_E	0.681	1.00
16_E	269_D	0.680	1.00
48_V	61_A	0.675	1.00
39_I	48_V	0.675	1.00
59_I	70_T	0.671	1.00
263_F	266_K	0.665	1.00
85_G	165_I	0.664	1.00
40_C	240_M	0.662	1.00
83_E	86_K	0.662	1.00
12_L	268_N	0.656	1.00
155_I	158_V	0.655	1.00
231_I	248_I	0.655	1.00
247_R	257_L	0.654	1.00
153_P	156_E	0.648	1.00
192_A	209_G	0.647	1.00
175_M	198_K	0.642	1.00
93_L	99_F	0.641	1.00
66_T	166_Y	0.641	1.00
152_I	155_I	0.641	1.00
89_A	101_V	0.639	1.00
271_N	274_A	0.638	1.00
8_L	48_V	0.636	1.00
22_E	25_E	0.636	1.00
183_E	187_H	0.631	1.00
247_R	261_S	0.628	1.00
238_L	241_F	0.628	1.00
82_Q	162_G	0.626	1.00
169_L	202_E	0.625	1.00
252_N	258_K	0.623	1.00
104_D	164_N	0.622	1.00
45_T	49_K	0.619	1.00
189_K	206_A	0.619	1.00
101_V	165_I	0.618	1.00
20_S	274_A	0.615	1.00
112_D	151_P	0.614	1.00
52_L	59_I	0.611	1.00
193_Q	201_I	0.611	1.00
96_N	177_K	0.608	1.00
19_I	24_R	0.604	1.00
211_G	215_T	0.603	1.00
231_I	265_T	0.603	1.00
235_P	257_L	0.601	1.00
257_L	261_S	0.599	1.00
197_G	234_S	0.599	1.00
192_A	204_L	0.598	1.00
150_K	153_P	0.597	1.00
4_I	231_I	0.595	1.00
252_N	267_S	0.594	1.00
111_F	153_P	0.594	1.00
233_D	250_M	0.593	1.00
3_C	217_L	0.591	1.00
167_K	196_S	0.589	1.00
58_P	69_D	0.588	1.00
249_A	260_K	0.586	1.00
74_L	104_D	0.586	1.00
274_A	277_I	0.586	1.00
66_T	104_D	0.585	1.00
62_A	166_Y	0.585	1.00
184_E	187_H	0.584	1.00
103_T	165_I	0.582	0.99
8_L	12_L	0.581	0.99
169_L	200_I	0.579	0.99
13_L	268_N	0.578	0.99
223_I	228_I	0.578	0.99
104_D	166_Y	0.575	0.99
104_D	163_E	0.575	0.99
91_Y	185_L	0.575	0.99
69_D	220_I	0.573	0.99
207_S	212_R	0.571	0.99
31_V	37_V	0.568	0.99
100_E	169_L	0.567	0.99
48_V	51_L	0.566	0.99
26_A	30_A	0.565	0.99
85_G	89_A	0.564	0.99
67_I	217_L	0.562	0.99
23_N	27_I	0.561	0.99
250_M	268_N	0.559	0.99
30_A	274_A	0.558	0.99
175_M	195_S	0.551	0.99
223_I	227_D	0.550	0.99
25_E	278_D	0.548	0.99
58_P	217_L	0.548	0.99
265_T	275_Y	0.546	0.99
171_F	200_I	0.546	0.99
97_I	181_A	0.545	0.99
67_I	220_I	0.543	0.99
178_L	201_I	0.542	0.99
62_A	65_G	0.541	0.99
62_A	200_I	0.541	0.99
246_H	280_L	0.539	0.99
50_A	53_D	0.538	0.99
42_G	236_N	0.538	0.99
176_D	180_Q	0.537	0.99
170_C	203_I	0.535	0.99
225_T	244_A	0.535	0.99
271_N	275_Y	0.532	0.99
223_I	245_G	0.531	0.99
49_K	52_L	0.530	0.99
89_A	99_F	0.527	0.99
39_I	52_L	0.527	0.99
211_G	228_I	0.525	0.99
31_V	56_D	0.524	0.99
248_I	262_T	0.523	0.99
36_L	223_I	0.520	0.99
78_T	208_S	0.520	0.99
88_I	203_I	0.518	0.99
254_I	258_K	0.515	0.99
81_D	190_K	0.515	0.99
62_A	202_E	0.514	0.99
251_E	264_V	0.513	0.99
144_F	149_I	0.512	0.99
172_S	181_A	0.510	0.99
178_L	195_S	0.510	0.99
97_I	170_C	0.509	0.99
151_P	154_H	0.509	0.99
69_D	75_I	0.509	0.99
100_E	107_L	0.509	0.99
27_I	31_V	0.508	0.99
14_N	271_N	0.508	0.99
85_G	101_V	0.502	0.99
6_I	30_A	0.502	0.99
62_A	169_L	0.502	0.99
178_L	182_K	0.502	0.99
62_A	102_Y	0.501	0.99
103_T	106_H	0.501	0.99
88_I	168_L	0.501	0.99
40_C	63_N	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nrwA	1	0.9825	100	0.209	Contact Map
3pgvA	3	0.8881	100	0.25	Contact Map
2b30A	2	0.9091	100	0.262	Contact Map
1nf2A	4	0.9126	100	0.269	Contact Map
1rkqA	1	0.9091	100	0.273	Contact Map
3l7yA	1	0.8986	100	0.273	Contact Map
4qjbA	1	0.8986	100	0.274	Contact Map
2rbkA	1	0.8881	100	0.279	Contact Map
3daoA	1	0.8951	100	0.281	Contact Map
3dnpA	2	0.9406	100	0.288	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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