GREMLIN Database
YWTE - Putative phosphatase YwtE
UniProt: P96741 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (253)
Sequences: 10666 (8731)
Seq/√Len: 548.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_K275_Y4.2211.00
15_K269_D3.5551.00
230_A244_A3.1151.00
267_S270_E2.8981.00
241_F247_R2.7811.00
20_S271_N2.7501.00
22_E271_N2.5711.00
218_A228_I2.5221.00
255_D259_E2.4631.00
14_N18_V2.4431.00
6_I37_V2.4171.00
242_E260_K2.3891.00
215_T243_V2.3291.00
22_E278_D2.3091.00
41_T48_V2.3051.00
225_T243_V2.0751.00
209_G239_S2.0341.00
2_K227_D2.0071.00
21_A25_E1.9801.00
29_R32_D1.9401.00
235_P256_E1.8981.00
76_S216_K1.8951.00
238_L257_L1.8831.00
238_L260_K1.8461.00
247_R262_T1.8441.00
249_A261_S1.8241.00
27_I37_V1.8211.00
30_A35_I1.7951.00
235_P254_I1.7901.00
29_R278_D1.7801.00
3_C38_T1.7481.00
255_D258_K1.7461.00
81_D84_A1.7391.00
266_K270_E1.7371.00
224_E227_D1.7371.00
29_R33_A1.6961.00
246_H263_F1.6931.00
24_R54_D1.6861.00
215_T219_D1.6721.00
216_K220_I1.6581.00
5_A214_L1.6501.00
246_H262_T1.6501.00
69_D73_R1.6291.00
216_K219_D1.6251.00
211_G243_V1.5931.00
154_H157_S1.5891.00
248_I276_F1.5881.00
212_R215_T1.5831.00
214_L240_M1.5701.00
78_T216_K1.5671.00
257_L260_K1.5591.00
92_L170_C1.5581.00
36_L221_Y1.5551.00
8_L13_L1.5491.00
84_A190_K1.5371.00
6_I231_I1.5211.00
20_S23_N1.5181.00
263_F280_L1.5111.00
263_F276_F1.4801.00
23_N271_N1.4661.00
25_E29_R1.4621.00
182_K186_K1.4601.00
93_L110_P1.4451.00
226_Q245_G1.4441.00
230_A240_M1.4441.00
231_I273_V1.4371.00
87_A190_K1.4131.00
22_E275_Y1.3701.00
231_I276_F1.3611.00
26_A274_A1.3491.00
24_R28_K1.3391.00
95_K184_E1.3041.00
74_L77_R1.2971.00
84_A87_A1.2941.00
241_F257_L1.2931.00
5_A40_C1.2931.00
249_A253_A1.2911.00
251_E267_S1.2781.00
77_R164_N1.2751.00
26_A278_D1.2721.00
263_F279_Q1.2621.00
78_T205_P1.2621.00
238_L242_E1.2571.00
192_A239_S1.2441.00
82_Q86_K1.2431.00
28_K32_D1.2431.00
225_T228_I1.2421.00
91_Y95_K1.2391.00
258_K264_V1.2291.00
177_K180_Q1.2271.00
218_A225_T1.2041.00
77_R166_Y1.2031.00
229_Y280_L1.1991.00
66_T74_L1.1871.00
256_E259_E1.1841.00
84_A191_L1.1841.00
3_C223_I1.1711.00
14_N269_D1.1671.00
276_F280_L1.1661.00
273_V277_I1.1641.00
15_K268_N1.1641.00
228_I244_A1.1641.00
179_K195_S1.1511.00
38_T217_L1.1481.00
4_I277_I1.1441.00
4_I30_A1.1391.00
4_I35_I1.1321.00
22_E26_A1.1311.00
265_T276_F1.1161.00
60_I213_A1.1091.00
252_N268_N1.1011.00
179_K183_E1.1001.00
67_I216_K1.0971.00
192_A207_S1.0841.00
248_I265_T1.0821.00
229_Y246_H1.0811.00
274_A278_D1.0771.00
230_A241_F1.0761.00
225_T245_G1.0691.00
3_C218_A1.0661.00
254_I257_L1.0591.00
190_K206_A1.0491.00
90_D94_S1.0491.00
250_M272_G1.0451.00
8_L51_L1.0451.00
5_A228_I1.0441.00
21_A24_R1.0431.00
194_T204_L1.0421.00
28_K31_V1.0331.00
218_A243_V1.0181.00
205_P208_S1.0181.00
91_Y94_S1.0171.00
248_I263_F1.0121.00
167_K202_E1.0121.00
234_S254_I1.0121.00
209_G212_R1.0021.00
244_A247_R1.0021.00
265_T272_G1.0021.00
77_R104_D0.9881.00
253_A258_K0.9861.00
218_A223_I0.9861.00
79_L164_N0.9791.00
229_Y276_F0.9761.00
251_E258_K0.9731.00
276_F279_Q0.9701.00
249_A257_L0.9661.00
214_L244_A0.9621.00
266_K272_G0.9591.00
215_T225_T0.9541.00
3_C228_I0.9531.00
12_L23_N0.9521.00
183_E186_K0.9511.00
172_S177_K0.9501.00
217_L221_Y0.9501.00
86_K90_D0.9501.00
78_T207_S0.9501.00
211_G239_S0.9461.00
275_Y279_Q0.9441.00
6_I273_V0.9431.00
65_G208_S0.9431.00
67_I76_S0.9431.00
28_K56_D0.9401.00
12_L27_I0.9391.00
67_I213_A0.9381.00
45_T61_A0.9381.00
229_Y248_I0.9371.00
235_P238_L0.9351.00
49_K72_Y0.9231.00
25_E28_K0.9201.00
49_K53_D0.9141.00
90_D156_E0.9111.00
275_Y278_D0.9071.00
35_I229_Y0.9051.00
250_M265_T0.9041.00
180_Q184_E0.8991.00
38_T58_P0.8981.00
30_A37_V0.8941.00
23_N274_A0.8931.00
87_A90_D0.8921.00
106_H150_K0.8891.00
251_E266_K0.8871.00
75_I220_I0.8861.00
172_S178_L0.8841.00
41_T61_A0.8831.00
68_H72_Y0.8791.00
61_A66_T0.8791.00
228_I245_G0.8771.00
218_A245_G0.8771.00
251_E270_E0.8741.00
175_M179_K0.8621.00
5_A38_T0.8601.00
180_Q183_E0.8541.00
60_I217_L0.8521.00
83_E87_A0.8521.00
179_K182_K0.8491.00
204_L209_G0.8471.00
68_H74_L0.8451.00
23_N26_A0.8441.00
256_E260_K0.8371.00
14_N20_S0.8351.00
79_L166_Y0.8251.00
45_T68_H0.8241.00
94_S184_E0.8221.00
40_C60_I0.8221.00
6_I12_L0.8201.00
241_F260_K0.8151.00
4_I229_Y0.8121.00
91_Y184_E0.8091.00
245_G262_T0.8081.00
8_L39_I0.7991.00
87_A91_Y0.7991.00
80_M205_P0.7991.00
228_I243_V0.7951.00
61_A68_H0.7941.00
230_A247_R0.7881.00
44_A62_A0.7871.00
30_A277_I0.7861.00
22_E274_A0.7851.00
266_K279_Q0.7821.00
36_L58_P0.7801.00
250_M253_A0.7791.00
193_Q203_I0.7731.00
241_F261_S0.7711.00
26_A29_R0.7671.00
12_L19_I0.7541.00
35_I227_D0.7511.00
95_K180_Q0.7431.00
214_L230_A0.7411.00
58_P221_Y0.7391.00
82_Q164_N0.7361.00
14_N268_N0.7351.00
192_A206_A0.7341.00
212_R216_K0.7331.00
114_E118_H0.7321.00
86_K156_E0.7311.00
89_A93_L0.7311.00
182_K195_S0.7271.00
253_A257_L0.7271.00
227_D245_G0.7221.00
174_D177_K0.7201.00
73_R220_I0.7141.00
48_V59_I0.7101.00
65_G205_P0.7091.00
10_G250_M0.7051.00
153_P157_S0.7041.00
233_D253_A0.6991.00
263_F275_Y0.6941.00
215_T218_A0.6931.00
239_S242_E0.6891.00
93_L156_E0.6861.00
246_H276_F0.6851.00
103_T163_E0.6841.00
208_S212_R0.6831.00
63_N202_E0.6811.00
16_E269_D0.6801.00
48_V61_A0.6751.00
39_I48_V0.6751.00
59_I70_T0.6711.00
263_F266_K0.6651.00
85_G165_I0.6641.00
40_C240_M0.6621.00
83_E86_K0.6621.00
12_L268_N0.6561.00
155_I158_V0.6551.00
231_I248_I0.6551.00
247_R257_L0.6541.00
153_P156_E0.6481.00
192_A209_G0.6471.00
175_M198_K0.6421.00
93_L99_F0.6411.00
66_T166_Y0.6411.00
152_I155_I0.6411.00
89_A101_V0.6391.00
271_N274_A0.6381.00
8_L48_V0.6361.00
22_E25_E0.6361.00
183_E187_H0.6311.00
247_R261_S0.6281.00
238_L241_F0.6281.00
82_Q162_G0.6261.00
169_L202_E0.6251.00
252_N258_K0.6231.00
104_D164_N0.6221.00
45_T49_K0.6191.00
189_K206_A0.6191.00
101_V165_I0.6181.00
20_S274_A0.6151.00
112_D151_P0.6141.00
52_L59_I0.6111.00
193_Q201_I0.6111.00
96_N177_K0.6081.00
19_I24_R0.6041.00
211_G215_T0.6031.00
231_I265_T0.6031.00
235_P257_L0.6011.00
257_L261_S0.5991.00
197_G234_S0.5991.00
192_A204_L0.5981.00
150_K153_P0.5971.00
4_I231_I0.5951.00
252_N267_S0.5941.00
111_F153_P0.5941.00
233_D250_M0.5931.00
3_C217_L0.5911.00
167_K196_S0.5891.00
58_P69_D0.5881.00
249_A260_K0.5861.00
74_L104_D0.5861.00
274_A277_I0.5861.00
66_T104_D0.5851.00
62_A166_Y0.5851.00
184_E187_H0.5841.00
103_T165_I0.5820.99
8_L12_L0.5810.99
169_L200_I0.5790.99
13_L268_N0.5780.99
223_I228_I0.5780.99
104_D166_Y0.5750.99
104_D163_E0.5750.99
91_Y185_L0.5750.99
69_D220_I0.5730.99
207_S212_R0.5710.99
31_V37_V0.5680.99
100_E169_L0.5670.99
48_V51_L0.5660.99
26_A30_A0.5650.99
85_G89_A0.5640.99
67_I217_L0.5620.99
23_N27_I0.5610.99
250_M268_N0.5590.99
30_A274_A0.5580.99
175_M195_S0.5510.99
223_I227_D0.5500.99
25_E278_D0.5480.99
58_P217_L0.5480.99
265_T275_Y0.5460.99
171_F200_I0.5460.99
97_I181_A0.5450.99
67_I220_I0.5430.99
178_L201_I0.5420.99
62_A65_G0.5410.99
62_A200_I0.5410.99
246_H280_L0.5390.99
50_A53_D0.5380.99
42_G236_N0.5380.99
176_D180_Q0.5370.99
170_C203_I0.5350.99
225_T244_A0.5350.99
271_N275_Y0.5320.99
223_I245_G0.5310.99
49_K52_L0.5300.99
89_A99_F0.5270.99
39_I52_L0.5270.99
211_G228_I0.5250.99
31_V56_D0.5240.99
248_I262_T0.5230.99
36_L223_I0.5200.99
78_T208_S0.5200.99
88_I203_I0.5180.99
254_I258_K0.5150.99
81_D190_K0.5150.99
62_A202_E0.5140.99
251_E264_V0.5130.99
144_F149_I0.5120.99
172_S181_A0.5100.99
178_L195_S0.5100.99
97_I170_C0.5090.99
151_P154_H0.5090.99
69_D75_I0.5090.99
100_E107_L0.5090.99
27_I31_V0.5080.99
14_N271_N0.5080.99
85_G101_V0.5020.99
6_I30_A0.5020.99
62_A169_L0.5020.99
178_L182_K0.5020.99
62_A102_Y0.5010.99
103_T106_H0.5010.99
88_I168_L0.5010.99
40_C63_N0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nrwA 1 0.9825 100 0.209 Contact Map
3pgvA 3 0.8881 100 0.25 Contact Map
2b30A 2 0.9091 100 0.262 Contact Map
1nf2A 4 0.9126 100 0.269 Contact Map
1rkqA 1 0.9091 100 0.273 Contact Map
3l7yA 1 0.8986 100 0.273 Contact Map
4qjbA 1 0.8986 100 0.274 Contact Map
2rbkA 1 0.8881 100 0.279 Contact Map
3daoA 1 0.8951 100 0.281 Contact Map
3dnpA 2 0.9406 100 0.288 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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