GREMLIN Database
CAPA - PGA biosynthesis protein CapA
UniProt: P96738 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (303)
Sequences: 2241 (1785)
Seq/√Len: 102.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_A169_I3.9921.00
263_S287_T3.6971.00
194_A230_A3.5151.00
64_V101_G3.3341.00
275_P292_S3.2941.00
194_A234_A3.0701.00
142_S172_A3.0301.00
290_F311_V2.7621.00
62_S96_S2.7331.00
93_F99_V2.7091.00
198_F226_M2.5561.00
239_V267_A2.5301.00
240_Q273_H2.5141.00
67_I101_G2.5011.00
284_Y289_I2.4571.00
269_I313_Y2.3961.00
230_A234_A2.3531.00
174_Y178_D2.3251.00
243_W259_A2.3121.00
63_F271_V2.3071.00
108_T157_D2.2681.00
101_G137_F2.2501.00
260_R264_D2.2291.00
308_S328_I2.1821.00
141_N197_G2.1821.00
61_A238_V2.1761.00
264_D284_Y2.1731.00
261_A265_A2.0871.00
338_V346_K2.0661.00
220_P261_A2.0661.00
60_S314_H2.0431.00
259_A289_I1.9951.00
187_K192_T1.9861.00
102_N144_N1.9821.00
278_L309_A1.9681.00
64_V296_F1.9631.00
231_K237_V1.9611.00
260_R282_E1.9371.00
99_V138_T1.9321.00
268_D287_T1.9301.00
103_F162_F1.9231.00
101_G140_L1.8981.00
194_A237_V1.8291.00
234_A237_V1.8271.00
100_A240_Q1.8241.00
147_A172_A1.8191.00
64_V137_F1.7951.00
59_L189_N1.7761.00
260_R284_Y1.7751.00
163_A174_Y1.7701.00
107_V129_V1.7431.00
90_E94_R1.7151.00
108_T154_G1.7011.00
60_S312_Q1.6661.00
192_T235_D1.6491.00
93_F137_F1.6381.00
83_D134_D1.6291.00
64_V310_L1.6251.00
236_I269_I1.6221.00
129_V161_E1.6211.00
170_V197_G1.6201.00
139_V195_T1.6181.00
227_I262_M1.5681.00
185_Y234_A1.5661.00
104_E145_N1.5641.00
241_S262_M1.5571.00
176_L180_K1.5431.00
96_S99_V1.5321.00
224_I228_S1.5091.00
62_S310_L1.4891.00
175_S178_D1.4891.00
185_Y192_T1.4811.00
245_Q252_N1.4711.00
198_F223_F1.4691.00
130_K165_Q1.4681.00
62_S312_Q1.4601.00
260_R289_I1.4591.00
129_V165_Q1.4551.00
96_S138_T1.4531.00
263_S284_Y1.4451.00
162_F167_L1.4441.00
263_S289_I1.4411.00
137_F140_L1.4411.00
243_W255_Q1.4391.00
264_D285_N1.4271.00
62_S99_V1.4161.00
145_N276_H1.4101.00
152_V156_K1.3941.00
197_G240_Q1.3901.00
141_N240_Q1.3861.00
100_A195_T1.3620.99
236_I315_L1.3610.99
249_N304_R1.3480.99
139_V170_V1.3450.99
312_Q324_E1.3430.99
309_A325_V1.3360.99
131_V135_M1.3310.99
283_V288_V1.3310.99
168_D186_Q1.3270.99
105_N124_T1.3260.99
148_M155_M1.3260.99
160_G174_Y1.3190.99
59_L193_I1.3130.99
159_L169_I1.2970.99
100_A139_V1.2940.99
312_Q326_T1.2810.99
185_Y194_A1.2810.99
185_Y230_A1.2780.99
256_R260_R1.2770.99
224_I265_A1.2560.99
129_V162_F1.2530.99
71_R299_D1.2440.99
316_K321_G1.2370.99
246_E274_H1.2360.99
160_G164_K1.2340.99
227_I265_A1.2260.99
230_A237_V1.2160.99
59_L191_V1.2130.99
227_I237_V1.2070.99
99_V137_F1.2000.99
196_L226_M1.1900.99
243_W272_G1.1850.99
253_D257_Q1.1850.99
59_L188_V1.1800.98
109_Y126_K1.1690.98
293_L311_V1.1620.98
278_L308_S1.1440.98
126_K157_D1.1430.98
156_K174_Y1.1390.98
89_V296_F1.1220.98
145_N242_H1.1200.98
104_E242_H1.1130.98
92_I310_L1.1060.98
185_Y233_H1.1030.98
122_L246_E1.0940.98
173_G179_A1.0890.97
104_E276_H1.0880.97
262_M270_I1.0800.97
247_Y305_T1.0700.97
185_Y229_E1.0660.97
63_F240_Q1.0600.97
144_N242_H1.0550.97
106_P150_Y1.0410.97
251_P280_P1.0400.97
157_D161_E1.0360.97
66_D276_H1.0240.96
47_E51_V1.0200.96
247_Y300_Q1.0080.96
282_E291_Y1.0060.96
199_T202_S1.0060.96
108_T123_Q1.0050.96
282_E289_I0.9950.96
231_K268_D0.9920.96
100_A141_N0.9890.95
146_H149_D0.9890.95
66_D242_H0.9870.95
187_K190_G0.9830.95
273_H293_L0.9750.95
191_V317_K0.9530.94
227_I267_A0.9490.94
263_S285_N0.9460.94
238_V269_I0.9360.94
162_F169_I0.9340.94
142_S147_A0.9330.94
195_T240_Q0.9290.94
288_V313_Y0.9280.94
180_K216_L0.9270.94
58_V314_H0.9270.94
223_F226_M0.9230.93
155_M172_A0.9210.93
159_L174_Y0.9200.93
193_I315_L0.9150.93
198_F241_S0.9130.93
224_I261_A0.9090.93
273_H292_S0.9030.93
110_Q157_D0.8980.93
295_N300_Q0.8920.92
106_P158_T0.8910.92
239_V270_I0.8890.92
205_G209_K0.8890.92
257_Q261_A0.8880.92
89_V310_L0.8860.92
269_I315_L0.8850.92
66_D145_N0.8840.92
342_S345_Q0.8840.92
161_E164_K0.8820.92
102_N242_H0.8790.92
67_I132_L0.8720.91
123_Q150_Y0.8670.91
142_S169_I0.8630.91
239_V262_M0.8620.91
66_D102_N0.8620.91
290_F293_L0.8560.91
220_P258_L0.8540.91
69_M128_S0.8540.91
264_D289_I0.8490.90
220_P257_Q0.8480.90
229_E233_H0.8470.90
242_H274_H0.8430.90
269_I288_V0.8430.90
243_W279_E0.8410.90
340_K343_L0.8370.90
252_N255_Q0.8340.89
170_V195_T0.8290.89
255_Q279_E0.8280.89
276_H295_N0.8220.89
70_G119_E0.8220.89
67_I86_F0.8170.89
58_V316_K0.8120.88
195_T238_V0.8090.88
196_L239_V0.8080.88
91_P94_R0.8060.88
334_T338_V0.8030.88
256_R282_E0.8010.88
270_I287_T0.7980.87
182_K230_A0.7970.87
213_P216_L0.7930.87
99_V136_N0.7920.87
175_S214_G0.7920.87
62_S93_F0.7920.87
109_Y157_D0.7910.87
87_Q90_E0.7880.87
70_G122_L0.7860.87
155_M173_G0.7820.86
221_E225_P0.7750.86
49_P52_K0.7690.85
152_V212_T0.7670.85
302_W305_T0.7640.85
72_Y299_D0.7630.85
223_F262_M0.7590.85
133_K167_L0.7560.84
146_H276_H0.7550.84
46_A50_K0.7530.84
321_G327_P0.7480.84
69_M73_V0.7480.84
244_G274_H0.7470.84
251_P279_E0.7470.84
259_A291_Y0.7460.84
139_V183_I0.7450.83
198_F239_V0.7440.83
242_H276_H0.7430.83
98_Y186_Q0.7400.83
145_N295_N0.7400.83
259_A270_I0.7340.83
104_E146_H0.7340.83
96_S312_Q0.7330.82
182_K194_A0.7310.82
106_P154_G0.7290.82
183_I186_Q0.7270.82
263_S282_E0.7250.82
47_E52_K0.7240.82
344_K347_T0.7230.82
107_V167_L0.7230.82
122_L277_V0.7220.82
68_M73_V0.7210.81
45_K48_T0.7160.81
259_A272_G0.7160.81
146_H242_H0.7160.81
202_S206_F0.7150.81
262_M267_A0.7130.81
142_S158_T0.7110.81
70_G120_I0.7110.81
243_W262_M0.7030.80
307_D345_Q0.7010.80
212_T217_P0.7010.80
267_A287_T0.6980.79
331_H336_A0.6920.79
214_G217_P0.6920.79
275_P279_E0.6920.79
199_T215_V0.6910.79
88_Y91_P0.6900.79
59_L315_L0.6890.78
141_N170_V0.6880.78
47_E50_K0.6870.78
247_Y295_N0.6870.78
66_D104_E0.6870.78
48_T52_K0.6850.78
45_K53_T0.6820.78
260_R263_S0.6820.78
70_G300_Q0.6810.78
246_E295_N0.6800.78
77_T85_I0.6800.78
48_T54_Y0.6730.77
85_I297_V0.6720.77
105_N144_N0.6700.76
200_D254_R0.6700.76
92_I95_A0.6690.76
180_K226_M0.6670.76
48_T51_V0.6620.76
227_I231_K0.6620.76
120_I300_Q0.6610.76
122_L276_H0.6600.75
226_M229_E0.6570.75
154_G158_T0.6570.75
90_E134_D0.6550.75
50_K53_T0.6540.75
46_A49_P0.6510.74
77_T82_A0.6500.74
113_Y116_A0.6480.74
237_V268_D0.6450.74
103_F106_P0.6430.74
300_Q305_T0.6390.73
142_S162_F0.6370.73
196_L230_A0.6370.73
53_T56_D0.6360.73
161_E165_Q0.6360.73
323_F327_P0.6350.73
277_V292_S0.6350.73
98_Y188_V0.6350.73
49_P53_T0.6340.72
220_P224_I0.6320.72
46_A52_K0.6320.72
98_Y139_V0.6300.72
126_K164_K0.6300.72
104_E274_H0.6300.72
122_L145_N0.6290.72
93_F96_S0.6270.72
192_T233_H0.6260.72
109_Y125_N0.6250.71
243_W270_I0.6210.71
316_K320_T0.6200.71
102_N246_E0.6200.71
255_Q272_G0.6190.71
248_D279_E0.6170.70
68_M71_R0.6140.70
164_K232_K0.6140.70
129_V167_L0.6130.70
56_D316_K0.6110.70
347_T350_R0.6100.70
328_I335_P0.6080.69
142_S155_M0.6070.69
46_A54_Y0.6060.69
61_A313_Y0.6050.69
104_E295_N0.6050.69
140_L162_F0.6040.69
222_I225_P0.6040.69
241_S270_I0.6020.69
49_P54_Y0.6020.69
310_L328_I0.5980.68
45_K52_K0.5960.68
175_S211_N0.5960.68
103_F107_V0.5960.68
144_N246_E0.5940.68
103_F132_L0.5940.68
274_H298_F0.5910.67
121_H206_F0.5910.67
211_N214_G0.5900.67
102_N275_P0.5890.67
247_Y308_S0.5890.67
83_D164_K0.5870.67
144_N273_H0.5860.67
274_H295_N0.5860.67
140_L167_L0.5850.66
106_P124_T0.5840.66
47_E54_Y0.5830.66
226_M230_A0.5830.66
168_D183_I0.5800.66
153_Q156_K0.5790.66
69_M105_N0.5790.66
98_Y138_T0.5780.65
177_S232_K0.5770.65
314_H322_R0.5770.65
134_D177_S0.5770.65
100_A197_G0.5720.65
290_F323_F0.5710.65
46_A53_T0.5710.65
170_V173_G0.5690.64
48_T53_T0.5680.64
73_V85_I0.5680.64
180_K222_I0.5660.64
236_I268_D0.5660.64
141_N242_H0.5650.64
74_E82_A0.5650.64
274_H293_L0.5630.63
245_Q248_D0.5630.63
214_G218_A0.5620.63
45_K282_E0.5610.63
303_T306_R0.5610.63
110_Q123_Q0.5600.63
251_P256_R0.5590.63
173_G214_G0.5580.63
46_A51_V0.5570.63
345_Q348_I0.5570.63
225_P228_S0.5570.63
234_A267_A0.5560.62
117_D120_I0.5550.62
325_V329_D0.5550.62
68_M144_N0.5550.62
148_M202_S0.5540.62
340_K345_Q0.5530.62
66_D274_H0.5530.62
119_E200_D0.5520.62
159_L163_A0.5470.61
237_V267_A0.5470.61
270_I284_Y0.5460.61
253_D256_R0.5460.61
278_L293_L0.5450.61
246_E277_V0.5440.61
187_K193_I0.5430.61
45_K54_Y0.5420.61
191_V194_A0.5410.60
145_N149_D0.5400.60
104_E122_L0.5400.60
231_K234_A0.5390.60
212_T218_A0.5370.60
278_L294_G0.5370.60
316_K319_G0.5370.60
63_F293_L0.5370.60
335_P338_V0.5360.60
93_F101_G0.5350.60
329_D342_S0.5330.59
119_E308_S0.5330.59
245_Q254_R0.5320.59
89_V328_I0.5310.59
45_K50_K0.5290.59
68_M298_F0.5280.59
45_K51_V0.5270.58
66_D146_H0.5260.58
194_A233_H0.5260.58
68_M122_L0.5260.58
170_V240_Q0.5250.58
260_R291_Y0.5220.58
71_R75_K0.5210.58
337_P341_D0.5210.58
68_M297_V0.5210.58
295_N298_F0.5200.57
57_D317_K0.5190.57
145_N274_H0.5180.57
175_S209_K0.5180.57
158_T162_F0.5170.57
288_V323_F0.5170.57
204_K207_A0.5170.57
170_V183_I0.5150.57
150_Y154_G0.5150.57
69_M297_V0.5130.56
92_I337_P0.5120.56
67_I140_L0.5120.56
182_K185_Y0.5110.56
69_M132_L0.5100.56
343_L349_I0.5100.56
164_K322_R0.5100.56
281_I290_F0.5090.56
278_L346_K0.5080.56
107_V128_S0.5070.56
122_L125_N0.5070.56
128_S131_V0.5060.55
148_M206_F0.5060.55
98_Y195_T0.5050.55
102_N273_H0.5050.55
274_H300_Q0.5020.55
273_H281_I0.5020.55
255_Q259_A0.5020.55
68_M300_Q0.5000.55
246_E276_H0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t70A 2 0.6395 100 0.726 Contact Map
2z06A 4 0.6263 100 0.732 Contact Map
4b2oA 4 0.6237 100 0.737 Contact Map
1t71A 2 0.7 99.9 0.763 Contact Map
3gveA 2 0.7421 99.9 0.768 Contact Map
3c9fA 2 0.7789 99.9 0.778 Contact Map
3jyfA 2 0.7711 99.9 0.779 Contact Map
4q7fA 1 0.7579 99.9 0.789 Contact Map
1hp1A 1 0.8026 99.9 0.791 Contact Map
2z1aA 1 0.7684 99.9 0.794 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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