GREMLIN Database
CAPC - PGA biosynthesis protein CapC
UniProt: P96737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (137)
Sequences: 194 (137)
Seq/√Len: 11.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_P128_T2.8500.94
77_F118_N2.6430.91
59_V64_G2.6300.91
52_L56_L2.4960.88
76_K107_G2.4920.88
29_A128_T2.3890.86
25_G115_L2.3020.83
58_Y116_I2.2680.82
16_L41_F2.1950.80
61_V80_M2.1060.77
105_F118_N2.0280.75
111_I115_L1.8820.69
19_I52_L1.8660.68
59_V141_A1.8640.68
48_L84_G1.8260.66
23_K81_L1.8240.66
73_G117_A1.8190.66
82_I143_M1.8170.66
86_V89_I1.8030.65
29_A113_P1.8000.65
17_S84_G1.7900.65
120_I129_F1.7820.64
47_I94_L1.7790.64
21_A32_V1.7000.60
88_K107_G1.6450.58
9_A143_M1.6180.57
22_E108_I1.6040.56
51_L129_F1.6030.56
65_L69_M1.5910.55
50_V108_I1.5470.53
11_I93_F1.5090.51
33_V36_Y1.5050.51
31_L110_I1.5000.51
76_K112_V1.5000.51
22_E33_V1.4920.50
37_L136_S1.4880.50
64_G68_F1.4870.50
97_I100_F1.4430.48
73_G115_L1.4180.47
13_G109_G1.3710.44
35_G124_G1.3350.43
35_G116_I1.2980.41
10_L17_S1.2790.40
123_Q128_T1.2690.39
60_I64_G1.2540.39
113_P123_Q1.2420.38
86_V133_L1.2410.38
60_I67_K1.2260.37
62_K83_T1.2230.37
48_L83_T1.2200.37
61_V83_T1.2130.37
87_L131_S1.2010.36
89_I133_L1.1910.36
7_Y88_K1.1830.35
64_G142_I1.1780.35
71_L79_A1.1750.35
58_Y77_F1.1650.35
48_L56_L1.1540.34
127_I132_T1.1520.34
56_L97_I1.1400.34
34_P109_G1.1260.33
114_G123_Q1.1090.32
67_K138_A1.1060.32
58_Y79_A1.1020.32
85_I119_T1.0980.32
48_L94_L1.0910.31
41_F119_T1.0830.31
32_V35_G1.0590.30
32_V75_R1.0360.29
12_L102_I1.0220.29
72_Y114_G1.0100.28
38_G75_R1.0100.28
55_L60_I1.0040.28
34_P117_A0.9980.28
105_F133_L0.9820.27
108_I134_L0.9780.27
18_L21_A0.9730.27
95_Y100_F0.9730.27
65_L125_L0.9710.27
29_A139_T0.9710.27
28_P131_S0.9540.26
33_V108_I0.9340.25
116_I131_S0.9300.25
86_V129_F0.9280.25
78_A139_T0.9210.25
54_S112_V0.9130.24
52_L98_V0.9120.24
8_I81_L0.9080.24
13_G72_Y0.9030.24
71_L77_F0.8930.24
65_L86_V0.8930.24
132_T140_F0.8920.24
17_S114_G0.8890.23
19_I83_T0.8870.23
121_Q139_T0.8820.23
65_L68_F0.8740.23
15_L51_L0.8690.23
13_G27_V0.8680.23
16_L98_V0.8400.22
28_P77_F0.8380.22
34_P73_G0.8360.22
20_F124_G0.8150.21
38_G136_S0.8130.21
12_L20_F0.8090.21
51_L55_L0.8080.21
98_V102_I0.7940.20
45_V60_I0.7910.20
44_P51_L0.7890.20
12_L48_L0.7880.20
57_T83_T0.7860.20
14_V120_I0.7850.20
35_G111_I0.7840.20
112_V123_Q0.7820.20
97_I126_T0.7770.20
25_G118_N0.7770.20
36_Y108_I0.7670.19
75_R114_G0.7660.19
26_I53_V0.7660.19
31_L117_A0.7600.19
60_I83_T0.7570.19
52_L90_A0.7510.19
74_R92_D0.7470.19
16_L93_F0.7410.19
15_L52_L0.7400.19
51_L67_K0.7400.19
52_L126_T0.7380.19
22_E119_T0.7340.18
130_G138_A0.7280.18
41_F136_S0.7250.18
12_L133_L0.7240.18
50_V85_I0.7140.18
28_P72_Y0.7100.18
49_L67_K0.7000.17
39_L75_R0.6950.17
61_V74_R0.6940.17
29_A119_T0.6860.17
24_T82_I0.6790.17
38_G130_G0.6760.17
90_A129_F0.6740.17
60_I101_E0.6740.17
17_S135_L0.6730.17
84_G101_E0.6710.17
26_I122_K0.6610.16
44_P56_L0.6580.16
15_L44_P0.6520.16
17_S70_I0.6480.16
62_K141_A0.6440.16
15_L126_T0.6430.16
60_I133_L0.6420.16
57_T87_L0.6410.16
49_L74_R0.6390.16
20_F32_V0.6380.16
28_P119_T0.6360.16
87_L90_A0.6350.16
32_V42_N0.6280.15
69_M86_V0.6250.15
21_A29_A0.6240.15
44_P98_V0.6230.15
83_T127_I0.6220.15
8_I98_V0.6200.15
44_P109_G0.6190.15
13_G122_K0.6160.15
72_Y78_A0.6100.15
59_V93_F0.6060.15
12_L143_M0.6060.15
85_I111_I0.6040.15
120_I138_A0.6020.15
40_V103_A0.6010.15
17_S116_I0.5990.15
25_G117_A0.5970.15
51_L62_K0.5970.15
73_G76_K0.5960.15
24_T112_V0.5950.15
19_I97_I0.5930.15
88_K99_P0.5890.14
124_G128_T0.5890.14
22_E95_Y0.5860.14
56_L103_A0.5850.14
20_F127_I0.5770.14
32_V81_L0.5730.14
70_I75_R0.5730.14
32_V84_G0.5720.14
91_F116_I0.5690.14
90_A142_I0.5660.14
12_L50_V0.5590.14
81_L115_L0.5590.14
14_V24_T0.5520.14
48_L81_L0.5510.14
8_I142_I0.5510.14
67_K112_V0.5480.14
20_F44_P0.5450.13
76_K134_L0.5430.13
84_G88_K0.5410.13
132_T135_L0.5380.13
115_L132_T0.5340.13
41_F137_G0.5340.13
13_G114_G0.5340.13
16_L34_P0.5240.13
130_G137_G0.5220.13
39_L73_G0.5200.13
56_L126_T0.5150.13
60_I94_L0.5120.13
9_A139_T0.5050.13
121_Q132_T0.5050.13
58_Y96_P0.5030.13
32_V129_F0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.9329 12.4 0.936 Contact Map
4j05A 3 0.9597 4.8 0.947 Contact Map
4tphA 2 0.9463 4.8 0.947 Contact Map
3wdoA 1 0.9799 4.1 0.949 Contact Map
1pw4A 1 0.9866 3.9 0.95 Contact Map
4pypA 1 0.9396 3.3 0.951 Contact Map
3o7qA 1 0.9664 3.2 0.951 Contact Map
4gc0A 1 0.9597 2.4 0.954 Contact Map
4ldsA 2 0.9195 2.4 0.954 Contact Map
4cadC 1 0.4899 2.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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