GREMLIN Database
CAPB - PGA synthase CapB
UniProt: P96736 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (375)
Sequences: 193 (143)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_A235_M4.2060.97
29_L33_V4.1660.97
167_L187_T3.9160.96
52_L109_V3.7980.95
49_T61_G3.0700.87
33_V97_M2.7620.80
47_L265_A2.7350.79
68_A221_A2.7080.78
370_G374_G2.6530.77
212_D220_V2.6460.77
219_G222_Q2.5980.75
33_V384_H2.5840.75
166_H188_K2.5750.75
93_Q113_M2.5710.75
205_F235_M2.4520.71
222_Q354_M2.3960.69
128_L367_Y2.3580.68
93_Q112_C2.3110.66
169_I175_T2.3070.66
71_I241_D2.3040.66
88_P189_V2.2960.65
35_I48_T2.2840.65
37_G41_K2.1940.62
37_G40_G2.1940.62
20_R24_K2.1800.61
26_I97_M2.1370.60
66_T120_Q2.0410.56
265_A374_G2.0310.56
36_N112_C2.0270.55
147_G295_R2.0100.55
32_R131_N2.0040.54
205_F231_A1.9970.54
164_N186_N1.9890.54
180_Q249_P1.9780.53
168_V184_E1.9520.52
168_V219_G1.9330.52
226_I232_F1.9330.52
221_A226_I1.9220.51
66_T242_P1.9010.50
13_V276_K1.8520.48
263_F368_G1.8470.48
62_K113_M1.8450.48
168_V216_L1.8150.47
173_E309_V1.8000.46
122_I187_T1.8000.46
114_A162_P1.7800.46
183_K212_D1.7650.45
34_N136_V1.7650.45
66_T89_N1.7570.45
213_N241_D1.7460.44
38_I150_L1.7370.44
6_I349_S1.6980.42
153_I325_T1.6700.41
36_N120_Q1.6580.41
17_L98_R1.6500.41
36_N93_Q1.6390.40
80_P149_T1.6370.40
30_P265_A1.6350.40
210_F213_N1.6220.40
29_L153_I1.6210.40
290_I369_V1.6080.39
147_G297_D1.6000.39
175_T191_I1.5970.39
80_P153_I1.5910.38
130_A211_P1.5840.38
138_V323_E1.5800.38
117_P213_N1.5700.38
7_A11_I1.5620.37
90_I119_Y1.5620.37
153_I190_I1.5600.37
12_L16_I1.5460.37
6_I9_A1.5460.37
139_L170_T1.5360.36
11_I155_E1.5160.36
31_V249_P1.5120.36
43_T143_M1.5110.35
9_A253_P1.5090.35
157_F302_T1.5010.35
215_S247_I1.4830.34
98_R178_F1.4820.34
60_V254_S1.4690.34
221_A373_H1.4560.34
223_A278_V1.4450.33
43_T160_T1.4400.33
214_A309_V1.4280.33
351_D357_L1.4210.32
243_G264_A1.4100.32
113_M213_N1.4030.32
33_V132_I1.3990.32
39_R42_S1.3880.31
37_G42_S1.3880.31
259_F374_G1.3840.31
63_T243_G1.3830.31
25_N144_D1.3760.31
209_V302_T1.3670.30
228_E232_F1.3640.30
356_L363_N1.3610.30
339_A342_L1.3600.30
259_F370_G1.3560.30
68_A189_V1.3540.30
9_A76_P1.3500.30
54_E291_I1.3490.30
289_I316_S1.3490.30
144_D197_I1.3460.30
22_H26_I1.3450.30
155_E181_K1.3410.30
35_I85_P1.3400.30
71_I85_P1.3290.29
34_N139_L1.3270.29
68_A243_G1.3270.29
51_I216_L1.3220.29
114_A120_Q1.2940.28
221_A305_F1.2800.28
7_A360_R1.2790.28
36_N130_A1.2740.27
74_D212_D1.2720.27
245_M368_G1.2720.27
210_F302_T1.2660.27
90_I187_T1.2650.27
97_M106_N1.2640.27
181_K184_E1.2520.27
24_K206_E1.2490.27
80_P271_T1.2430.26
110_S139_L1.2410.26
57_Y107_A1.2410.26
38_I59_T1.2360.26
30_P127_L1.2330.26
66_T113_M1.2290.26
158_T178_F1.2190.26
155_E278_V1.2180.26
48_T365_V1.2100.25
23_Q27_D1.2080.25
44_V214_A1.2000.25
48_T134_V1.1890.25
43_T209_V1.1830.25
214_A220_V1.1780.25
63_T112_C1.1760.24
294_C325_T1.1760.24
148_P152_E1.1700.24
29_L182_A1.1640.24
127_L152_E1.1440.24
373_H377_E1.1440.24
194_N215_S1.1410.23
123_F128_L1.1380.23
8_C16_I1.1310.23
36_N89_N1.1310.23
14_I35_I1.1270.23
213_N293_N1.1270.23
119_Y145_V1.1210.23
9_A186_N1.1210.23
100_T158_T1.1150.23
227_D366_I1.1140.23
38_I209_V1.1120.23
120_Q263_F1.1040.22
210_F226_I1.1030.22
36_N66_T1.1010.22
19_K23_Q1.0990.22
214_A341_K1.0930.22
9_A192_A1.0920.22
130_A270_S1.0710.22
38_I138_V1.0680.21
250_L307_N1.0670.21
178_F274_I1.0670.21
140_E150_L1.0660.21
265_A274_I1.0640.21
10_V183_K1.0620.21
145_V302_T1.0580.21
52_L107_A1.0510.21
115_V145_V1.0460.21
254_S340_D1.0420.21
55_A305_F1.0410.21
138_V153_I1.0390.21
90_I93_Q1.0370.21
362_H366_I1.0360.21
65_G266_N1.0340.21
65_G92_E1.0340.21
65_G142_H1.0340.21
298_R301_R1.0340.21
64_T142_H1.0340.21
64_T266_N1.0340.21
64_T92_E1.0340.21
64_T298_R1.0340.21
64_T83_R1.0340.21
65_G83_R1.0340.21
64_T111_E1.0340.21
65_G111_E1.0340.21
64_T301_R1.0340.21
65_G298_R1.0340.21
111_E266_N1.0340.21
111_E298_R1.0340.21
111_E301_R1.0340.21
92_E301_R1.0340.21
92_E298_R1.0340.21
92_E266_N1.0340.21
92_E142_H1.0340.21
92_E111_E1.0340.21
83_R301_R1.0340.21
83_R298_R1.0340.21
83_R266_N1.0340.21
83_R142_H1.0340.21
83_R92_E1.0340.21
142_H266_N1.0340.21
142_H298_R1.0340.21
142_H301_R1.0340.21
83_R111_E1.0340.21
111_E142_H1.0340.21
266_N298_R1.0340.21
266_N301_R1.0340.21
65_G301_R1.0340.21
68_A373_H1.0320.21
24_K183_K1.0300.20
179_K362_H1.0270.20
149_T238_A1.0260.20
73_W105_A1.0250.20
119_Y302_T1.0230.20
360_R364_R1.0190.20
34_N267_D1.0180.20
17_L250_L1.0150.20
57_Y106_N0.9930.20
148_P325_T0.9870.19
80_P183_K0.9870.19
45_T205_F0.9830.19
44_V346_E0.9820.19
36_N113_M0.9810.19
28_A307_N0.9810.19
169_I198_T0.9800.19
18_E374_G0.9790.19
171_D175_T0.9780.19
34_N85_P0.9670.19
58_K135_I0.9670.19
93_Q213_N0.9660.19
18_E47_L0.9620.19
26_I122_I0.9600.19
23_Q129_Q0.9580.19
114_A165_G0.9570.19
6_I11_I0.9530.19
154_A261_N0.9480.18
97_M108_I0.9460.18
351_D381_E0.9450.18
100_T268_A0.9450.18
185_R325_T0.9440.18
46_R117_P0.9400.18
72_Y135_I0.9390.18
268_A304_Q0.9390.18
192_A195_S0.9370.18
260_V289_I0.9360.18
129_Q252_S0.9310.18
134_V167_L0.9290.18
136_V209_V0.9270.18
220_V234_G0.9240.18
237_N247_I0.9220.18
78_E207_Y0.9160.18
145_V275_W0.9110.18
115_V132_I0.9090.18
42_S107_A0.9070.17
78_E241_D0.9050.17
168_V328_I0.9030.17
38_I146_M0.9010.17
234_G263_F0.9010.17
113_M117_P0.8980.17
71_I108_I0.8980.17
130_A269_S0.8940.17
20_R254_S0.8940.17
136_V144_D0.8900.17
156_A262_G0.8870.17
45_T274_I0.8870.17
90_I113_M0.8850.17
52_L59_T0.8850.17
350_T353_I0.8820.17
45_T185_R0.8810.17
6_I186_N0.8750.17
207_Y240_P0.8730.17
29_L179_K0.8730.17
119_Y161_I0.8730.17
124_Q221_A0.8720.17
22_H61_G0.8700.17
115_V120_Q0.8650.17
54_E233_K0.8640.17
41_K46_R0.8590.16
39_R46_R0.8590.16
40_G46_R0.8590.16
37_G46_R0.8590.16
21_R33_V0.8580.16
115_V275_W0.8550.16
38_I152_E0.8540.16
23_Q276_K0.8520.16
112_C130_A0.8520.16
112_C117_P0.8440.16
168_V305_F0.8430.16
209_V328_I0.8400.16
208_M214_A0.8380.16
62_K93_Q0.8380.16
38_I210_F0.8310.16
117_P293_N0.8290.16
47_L140_E0.8250.16
34_N130_A0.8220.16
122_I182_A0.8210.16
72_Y129_Q0.8210.16
22_H127_L0.8140.15
68_A124_Q0.8140.15
246_R292_M0.8120.15
122_I135_I0.8100.15
93_Q119_Y0.8020.15
62_K66_T0.7990.15
19_K126_E0.7950.15
152_E376_A0.7950.15
89_N238_A0.7940.15
51_I274_I0.7940.15
257_G383_I0.7920.15
76_P184_E0.7910.15
267_D368_G0.7890.15
246_R381_E0.7880.15
20_R79_K0.7810.15
320_L342_L0.7780.15
44_V267_D0.7770.15
139_L267_D0.7760.15
329_V342_L0.7720.15
71_I134_V0.7700.15
276_K349_S0.7700.15
198_T254_S0.7680.15
88_P267_D0.7660.15
93_Q372_I0.7610.14
102_E186_N0.7600.14
213_N264_A0.7580.14
38_I115_V0.7570.14
35_I116_N0.7570.14
49_T71_I0.7540.14
144_D171_D0.7510.14
148_P153_I0.7500.14
69_R264_A0.7500.14
98_R317_E0.7500.14
115_V302_T0.7480.14
35_I109_V0.7450.14
70_M274_I0.7440.14
186_N353_I0.7430.14
50_G221_A0.7430.14
32_R69_R0.7420.14
109_V194_N0.7390.14
214_A228_E0.7360.14
171_D354_M0.7350.14
63_T113_M0.7350.14
9_A97_M0.7320.14
139_L157_F0.7300.14
135_I191_I0.7290.14
29_L127_L0.7280.14
72_Y156_A0.7270.14
152_E159_A0.7270.14
262_G367_Y0.7240.14
76_P342_L0.7230.14
71_I154_A0.7230.14
15_G148_P0.7210.14
112_C213_N0.7200.14
126_E224_L0.7190.14
150_L283_Y0.7170.14
179_K225_G0.7140.14
68_A168_V0.7140.14
263_F293_N0.7130.14
186_N251_I0.7110.13
355_E362_H0.7100.13
75_T136_V0.7080.13
56_G59_T0.7070.13
135_I244_A0.7060.13
181_K187_T0.7060.13
36_N160_T0.7040.13
96_V232_F0.7030.13
87_G263_F0.7000.13
14_I267_D0.6990.13
97_M316_S0.6980.13
32_R264_A0.6980.13
33_V192_A0.6980.13
22_H45_T0.6970.13
25_N366_I0.6930.13
201_Y211_P0.6930.13
35_I134_V0.6920.13
210_F218_L0.6920.13
144_D279_K0.6920.13
245_M309_V0.6910.13
162_P165_G0.6900.13
90_I260_V0.6890.13
89_N93_Q0.6830.13
140_E143_M0.6830.13
161_I184_E0.6820.13
146_M315_A0.6790.13
26_I32_R0.6780.13
129_Q186_N0.6770.13
180_Q286_D0.6730.13
101_V282_G0.6720.13
27_D200_E0.6720.13
375_A380_I0.6710.13
113_M243_G0.6710.13
108_I368_G0.6690.13
120_Q134_V0.6680.13
23_Q102_E0.6650.13
46_R213_N0.6640.13
109_V270_S0.6640.13
210_F299_V0.6630.13
54_E238_A0.6560.12
190_I353_I0.6540.12
30_P131_N0.6500.12
148_P243_G0.6470.12
18_E217_A0.6460.12
20_R176_E0.6450.12
157_F170_T0.6440.12
176_E228_E0.6430.12
191_I238_A0.6430.12
342_L350_T0.6420.12
34_N124_Q0.6390.12
332_Y336_K0.6360.12
110_S170_T0.6350.12
135_I161_I0.6340.12
63_T68_A0.6340.12
355_E359_K0.6310.12
64_T141_D0.6260.12
141_D266_N0.6260.12
111_E141_D0.6260.12
141_D301_R0.6260.12
65_G141_D0.6260.12
141_D298_R0.6260.12
83_R141_D0.6260.12
92_E141_D0.6260.12
147_G261_N0.6230.12
94_K244_A0.6200.12
94_K215_S0.6200.12
134_V168_V0.6180.12
45_T207_Y0.6150.12
143_M268_A0.6140.12
112_C182_A0.6120.12
340_D384_H0.6120.12
259_F265_A0.6120.12
49_T171_D0.6100.12
260_V274_I0.6090.12
213_N243_G0.6070.12
9_A201_Y0.6060.12
220_V238_A0.6040.12
8_C76_P0.6040.12
125_E279_K0.6030.12
10_V355_E0.6020.12
158_T203_R0.6010.12
122_I369_V0.6000.12
62_K153_I0.6000.12
75_T157_F0.5970.12
94_K127_L0.5950.11
100_T105_A0.5950.11
66_T372_I0.5930.11
36_N263_F0.5920.11
114_A234_G0.5910.11
72_Y193_D0.5870.11
183_K349_S0.5830.11
9_A280_E0.5830.11
29_L101_V0.5820.11
74_D254_S0.5820.11
24_K256_P0.5820.11
12_L95_E0.5800.11
156_A179_K0.5780.11
66_T93_Q0.5780.11
186_N285_T0.5780.11
93_Q117_P0.5770.11
47_L374_G0.5770.11
175_T190_I0.5760.11
188_K195_S0.5750.11
36_N165_G0.5740.11
36_N45_T0.5720.11
35_I123_F0.5710.11
89_N112_C0.5670.11
177_F320_L0.5650.11
212_D222_Q0.5630.11
13_V254_S0.5620.11
53_I201_Y0.5600.11
229_E326_E0.5550.11
46_R241_D0.5510.11
93_Q120_Q0.5500.11
120_Q264_A0.5490.11
101_V182_A0.5490.11
218_L231_A0.5490.11
121_I133_G0.5480.11
35_I270_S0.5480.11
131_N238_A0.5470.11
92_E295_R0.5460.11
83_R295_R0.5460.11
64_T295_R0.5460.11
65_G295_R0.5460.11
266_N295_R0.5460.11
295_R298_R0.5460.11
142_H295_R0.5460.11
111_E295_R0.5460.11
295_R301_R0.5460.11
207_Y243_G0.5450.11
360_R382_K0.5420.11
61_G73_W0.5410.11
8_C354_M0.5400.11
40_G301_R0.5400.11
40_G298_R0.5400.11
40_G266_N0.5400.11
40_G142_H0.5400.11
41_K64_T0.5400.11
41_K65_G0.5400.11
41_K83_R0.5400.11
41_K92_E0.5400.11
41_K111_E0.5400.11
41_K142_H0.5400.11
41_K266_N0.5400.11
41_K298_R0.5400.11
41_K301_R0.5400.11
40_G92_E0.5400.11
40_G83_R0.5400.11
39_R64_T0.5400.11
37_G301_R0.5400.11
37_G298_R0.5400.11
37_G266_N0.5400.11
37_G142_H0.5400.11
37_G111_E0.5400.11
37_G92_E0.5400.11
37_G83_R0.5400.11
39_R65_G0.5400.11
39_R83_R0.5400.11
40_G65_G0.5400.11
40_G64_T0.5400.11
39_R301_R0.5400.11
39_R298_R0.5400.11
39_R266_N0.5400.11
39_R142_H0.5400.11
39_R111_E0.5400.11
39_R92_E0.5400.11
37_G65_G0.5400.11
37_G64_T0.5400.11
40_G111_E0.5400.11
375_A378_P0.5400.11
59_T269_S0.5400.11
129_Q230_T0.5380.11
147_G322_G0.5380.11
95_E267_D0.5380.11
145_V216_L0.5340.11
19_K101_V0.5330.11
316_S328_I0.5330.11
208_M309_V0.5310.10
133_G165_G0.5290.10
205_F213_N0.5270.10
210_F243_G0.5240.10
59_T356_L0.5230.10
205_F238_A0.5210.10
229_E233_K0.5200.10
119_Y207_Y0.5190.10
154_A197_I0.5180.10
128_L344_D0.5170.10
7_A17_L0.5170.10
27_D362_H0.5160.10
69_R148_P0.5160.10
173_E296_A0.5150.10
188_K311_P0.5150.10
89_N220_V0.5110.10
174_Y178_F0.5110.10
215_S357_L0.5080.10
96_V238_A0.5070.10
10_V178_F0.5050.10
148_P294_C0.5050.10
48_T155_E0.5030.10
97_M128_L0.5030.10
318_L369_V0.5020.10
154_A158_T0.5020.10
99_E107_A0.5020.10
209_V221_A0.5010.10
267_D342_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qdiA 1 0.8677 100 0.789 Contact Map
1w78A 1 0.9084 100 0.797 Contact Map
1o5zA 1 0.888 100 0.798 Contact Map
1gg4A 1 0.8321 100 0.8 Contact Map
4cvkA 1 0.8295 100 0.8 Contact Map
3zm6A 1 0.8728 100 0.805 Contact Map
1jbwA 1 0.8575 100 0.805 Contact Map
4hv4A 1 0.8753 100 0.807 Contact Map
2vosA 1 0.9008 100 0.808 Contact Map
1p3dA 1 0.8601 100 0.808 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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