GREMLIN Database
YWQN - Putative NAD(P)H-dependent FMN-containing oxidoreductase YwqN
UniProt: P96726 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (167)
Sequences: 3105 (2527)
Seq/√Len: 195.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_E65_R5.1471.00
22_K25_Q3.5161.00
85_G89_L2.9521.00
2_K28_D2.9481.00
88_K92_D2.8441.00
5_V24_V2.7991.00
76_T84_S2.5431.00
74_F87_L2.3491.00
21_E31_H2.3121.00
26_G175_L2.1501.00
22_K172_S2.0341.00
41_P89_L1.9721.00
16_T75_A1.9371.00
4_A69_C1.8951.00
82_G135_Q1.8771.00
64_E68_Q1.8361.00
5_V20_A1.7581.00
13_G17_D1.7281.00
2_K68_Q1.7161.00
37_Y61_S1.7031.00
169_S173_R1.6991.00
8_G87_L1.6791.00
45_L53_R1.6731.00
3_I71_I1.6611.00
23_A118_I1.6421.00
23_A73_I1.6271.00
59_Y63_I1.6231.00
12_S36_K1.6211.00
83_M135_Q1.6011.00
115_A140_F1.5931.00
24_V29_A1.5721.00
48_A53_R1.5501.00
22_K168_L1.5401.00
114_Q146_S1.5361.00
34_L90_F1.5341.00
134_Q138_H1.4811.00
32_I65_R1.4541.00
47_H50_G1.4321.00
42_I53_R1.4291.00
76_T83_M1.4141.00
37_Y58_D1.4131.00
24_V31_H1.3971.00
33_Y36_K1.3921.00
26_G172_S1.3731.00
173_R176_K1.3701.00
116_Y174_L1.3621.00
45_L48_A1.3461.00
25_Q172_S1.3431.00
43_E55_V1.3251.00
17_D21_E1.3101.00
32_I62_I1.2991.00
20_A75_A1.2751.00
57_D93_R1.2621.00
66_I72_L1.2481.00
18_V162_L1.2411.00
85_G92_D1.2401.00
17_D31_H1.2321.00
169_S172_S1.2161.00
19_L171_A1.2151.00
60_D63_I1.2051.00
42_I45_L1.1991.00
76_T119_A1.1951.00
7_N20_A1.1791.00
83_M88_K1.1501.00
15_N159_G1.1391.00
41_P86_T1.1311.00
42_I48_A1.1171.00
3_I27_F1.1171.00
38_P58_D1.1151.00
164_D167_A1.1041.00
16_T20_A1.0961.00
26_G176_K1.0911.00
6_I62_I1.0811.00
23_A175_L1.0751.00
56_Q60_D1.0711.00
151_V173_R1.0641.00
40_Q43_E1.0531.00
5_V29_A1.0511.00
40_Q55_V1.0501.00
47_H54_P1.0441.00
71_I114_Q1.0411.00
14_G17_D1.0301.00
86_T89_L1.0281.00
137_E150_Y1.0241.00
170_A173_R1.0211.00
23_A27_F1.0211.00
78_I132_L1.0191.00
64_E67_L1.0121.00
80_W95_S1.0081.00
62_I90_F1.0081.00
117_V136_F1.0031.00
71_I116_Y1.0011.00
17_D33_Y0.9991.00
160_D163_R0.9981.00
114_Q148_K0.9881.00
7_N31_H0.9820.99
66_I90_F0.9770.99
63_I97_T0.9750.99
173_R177_R0.9680.99
165_H169_S0.9630.99
20_A24_V0.9610.99
83_M87_L0.9500.99
44_D79_Y0.9350.99
157_R160_D0.9350.99
37_Y62_I0.9340.99
166_Q170_A0.9330.99
75_A118_I0.9320.99
46_R95_S0.9300.99
61_S65_R0.9210.99
21_E25_Q0.9200.99
61_S64_E0.9120.99
130_L134_Q0.9100.99
83_M132_L0.9090.99
156_N160_D0.9020.99
7_N33_Y0.8910.99
167_A170_A0.8820.99
32_I37_Y0.8700.99
82_G88_K0.8660.99
6_I90_F0.8600.99
8_G84_S0.8580.99
11_R15_N0.8570.99
4_A65_R0.8490.98
4_A32_I0.8440.98
39_I89_L0.8440.98
72_L115_A0.8340.98
58_D61_S0.8340.98
171_A175_L0.8290.98
74_F136_F0.8280.98
18_V22_K0.8270.98
110_M113_K0.8260.98
88_K135_Q0.8240.98
69_C72_L0.8140.98
27_F175_L0.8120.98
22_K26_G0.8110.98
10_T86_T0.8110.98
21_E24_V0.8070.98
6_I34_L0.8020.98
87_L90_F0.7960.98
41_P85_G0.7910.98
117_V137_E0.7900.98
86_T92_D0.7880.98
131_P134_Q0.7850.97
132_L136_F0.7730.97
66_I94_W0.7680.97
67_L97_T0.7600.97
18_V21_E0.7570.97
39_I90_F0.7480.97
23_A75_A0.7460.97
133_I137_E0.7450.97
94_W139_I0.7380.96
15_N161_I0.7340.96
19_L153_G0.7310.96
121_G126_K0.7220.96
172_S176_K0.7190.96
82_G131_P0.7170.96
59_Y94_W0.7150.96
23_A116_Y0.7110.96
131_P135_Q0.7090.95
155_G160_D0.6950.95
91_I139_I0.6950.95
146_S149_G0.6950.95
43_E47_H0.6930.95
39_I59_Y0.6910.95
168_L172_S0.6890.95
83_M91_I0.6860.95
147_F150_Y0.6830.94
140_F145_M0.6820.94
4_A66_I0.6810.94
13_G21_E0.6770.94
149_G174_L0.6750.94
91_I95_S0.6750.94
12_S33_Y0.6740.94
172_S175_L0.6740.94
162_L168_L0.6650.94
19_L118_I0.6640.94
34_L86_T0.6630.94
7_N17_D0.6610.93
35_Q43_E0.6600.93
65_R68_Q0.6570.93
60_D64_E0.6560.93
46_R96_Q0.6540.93
76_T87_L0.6460.93
59_Y96_Q0.6430.92
81_F142_F0.6420.92
136_F147_F0.6380.92
63_I67_L0.6380.92
5_V73_I0.6360.92
146_S151_V0.6340.92
23_A71_I0.6250.91
41_P72_L0.6210.91
116_Y148_K0.6190.91
151_V174_L0.6070.90
81_F138_H0.6040.90
58_D93_R0.6030.90
133_I150_Y0.6030.90
108_Q111_S0.5990.90
115_A145_M0.5980.90
139_I143_M0.5950.89
73_I116_Y0.5940.89
82_G132_L0.5870.89
85_G94_W0.5840.88
63_I94_W0.5830.88
23_A26_G0.5820.88
16_T76_T0.5800.88
30_E69_C0.5780.88
155_G161_I0.5780.88
80_W143_M0.5760.88
133_I141_H0.5730.87
138_H141_H0.5720.87
80_W94_W0.5720.87
7_N75_A0.5700.87
137_E141_H0.5700.87
16_T120_V0.5690.87
159_G163_R0.5660.87
66_I110_M0.5660.87
87_L136_F0.5660.87
74_F115_A0.5640.87
141_H147_F0.5620.86
19_L120_V0.5610.86
39_I58_D0.5580.86
135_Q139_I0.5530.86
45_L54_P0.5500.85
116_Y149_G0.5490.85
63_I80_W0.5460.85
43_E54_P0.5410.84
18_V159_G0.5400.84
55_V58_D0.5370.84
165_H168_L0.5330.83
35_Q86_T0.5320.83
119_A152_L0.5290.83
153_G167_A0.5290.83
134_Q137_E0.5270.83
8_G76_T0.5270.83
21_E68_Q0.5230.82
50_G54_P0.5220.82
7_N16_T0.5180.82
77_P84_S0.5180.82
151_V171_A0.5140.81
27_F172_S0.5130.81
94_W143_M0.5120.81
158_P162_L0.5080.80
78_I121_G0.5080.80
17_D35_Q0.5080.80
5_V31_H0.5070.80
80_W98_L0.5060.80
115_A139_I0.5040.80
5_V27_F0.5010.80
158_P161_I0.5010.80
14_G33_Y0.5000.79
81_F123_D0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rliA 3 0.9448 100 0.312 Contact Map
3lcmA 2 1 100 0.398 Contact Map
1sqsA 2 0.9116 100 0.406 Contact Map
4r81A 4 0.989 100 0.408 Contact Map
3k1yA 4 0.895 100 0.417 Contact Map
4c0xA 2 0.9834 100 0.418 Contact Map
3u7iA 2 0.9834 100 0.419 Contact Map
2hpvA 2 0.9834 100 0.421 Contact Map
3w7aA 2 0.989 100 0.423 Contact Map
1t5bA 2 0.9945 100 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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