GREMLIN Database
NFI - Endonuclease V
UniProt: P96724 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (207)
Sequences: 1032 (695)
Seq/√Len: 48.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_P197_D4.5531.00
125_H173_E3.8041.00
66_D69_T3.5041.00
155_F189_F2.9481.00
30_L192_C2.9381.00
223_D227_H2.9361.00
159_E164_A2.7091.00
45_V99_I2.6981.00
126_M130_T2.6771.00
32_P200_S2.5961.00
177_R202_Y2.5641.00
41_T73_I2.5071.00
197_D200_S2.2461.00
137_G195_Y2.2081.00
75_K225_E2.2071.00
103_A136_L2.1681.00
120_Y192_C2.1121.00
181_T209_I2.1051.00
118_N121_L2.0961.00
112_V204_I2.0851.00
113_F140_T2.0841.00
120_Y130_T2.0441.00
114_L219_V2.0161.00
22_F25_K1.9780.99
141_I205_T1.9590.99
192_C198_L1.9380.99
181_T188_I1.9140.99
24_L126_M1.8700.99
28_I134_F1.8580.99
74_E107_E1.8560.99
58_G82_I1.8350.99
64_V108_T1.8130.99
161_E164_A1.7880.99
161_E183_R1.7720.99
103_A113_F1.7430.99
49_Y82_I1.7310.98
18_L90_F1.7270.98
63_I72_V1.7120.98
165_Y177_R1.6920.98
43_A64_V1.6900.98
174_V177_R1.6830.98
48_A226_T1.6690.98
58_G98_L1.6580.98
227_H230_R1.6530.98
114_L205_T1.6410.98
80_G98_L1.6320.98
147_Y178_A1.6250.98
96_L132_A1.6060.97
223_D226_T1.5560.97
43_A62_I1.5370.97
65_I70_K1.5310.97
155_F158_P1.4930.96
61_C226_T1.4690.96
178_A189_F1.4670.96
33_T195_Y1.4440.95
158_P166_T1.4180.95
68_D208_L1.3720.94
168_I178_A1.3630.94
170_I175_Y1.3590.93
177_R198_L1.3480.93
47_L99_I1.3410.93
147_Y168_I1.3380.93
115_F132_A1.3330.93
66_D71_E1.3250.93
84_V223_D1.3240.93
217_I220_R1.2890.92
80_G101_E1.2800.91
114_L208_L1.2680.91
101_E104_K1.2590.91
48_A227_H1.2440.90
62_I103_A1.2390.90
132_A136_L1.2230.89
218_P221_L1.2160.89
179_L206_M1.2040.88
64_V107_E1.1980.88
48_A59_V1.1600.86
125_H170_I1.1590.86
23_N27_R1.1470.86
115_F218_P1.1350.85
32_P195_Y1.1350.85
114_L143_I1.1310.85
17_F84_V1.1250.85
192_C201_S1.1170.84
160_I184_D1.1150.84
162_V212_E1.1110.84
155_F166_T1.0940.83
63_I221_L1.0840.82
74_E108_T1.0720.82
18_L22_F1.0670.81
45_V132_A1.0630.81
144_A221_L1.0520.81
29_N33_T1.0510.80
163_G206_M1.0390.80
92_A131_H1.0330.79
167_D177_R1.0320.79
118_N146_T1.0280.79
39_I204_I1.0280.79
28_I130_T1.0200.78
118_N144_A1.0140.78
121_L176_G1.0090.78
64_V106_L1.0010.77
45_V91_L0.9890.76
165_Y202_Y0.9700.75
20_V23_N0.9650.74
113_F138_K0.9630.74
102_A106_L0.9600.74
67_A207_S0.9570.74
59_V227_H0.9540.74
187_P220_R0.9520.73
204_I218_P0.9500.73
118_N148_L0.9450.73
182_R185_V0.9440.73
158_P164_A0.9400.73
20_V90_F0.9330.72
179_L209_I0.9320.72
47_L58_G0.9300.72
33_T197_D0.9260.71
28_I120_Y0.9160.71
174_V198_L0.9130.70
43_A111_D0.9100.70
160_I164_A0.8980.69
39_I111_D0.8920.68
149_K175_Y0.8900.68
103_A132_A0.8860.68
130_T140_T0.8850.68
204_I207_S0.8810.68
203_Q207_S0.8760.67
179_L202_Y0.8710.67
141_I204_I0.8690.66
144_A175_Y0.8680.66
187_P214_R0.8660.66
182_R209_I0.8500.65
99_I115_F0.8480.65
90_F134_F0.8440.64
25_K28_I0.8420.64
128_V148_L0.8410.64
169_I172_G0.8380.64
214_R220_R0.8320.63
62_I102_A0.8270.63
170_I173_E0.8260.62
44_G219_V0.8080.61
113_F132_A0.8080.61
16_D20_V0.8070.61
164_A180_R0.8060.61
58_G128_V0.8060.61
76_V105_K0.8000.60
93_F131_H0.7990.60
65_I219_V0.7950.60
167_D174_V0.7890.59
100_I136_L0.7850.59
205_T214_R0.7820.58
50_W59_V0.7780.58
16_D87_V0.7720.57
41_T108_T0.7640.56
134_F194_N0.7590.56
174_V190_L0.7580.56
61_C77_H0.7560.56
29_N195_Y0.7560.56
34_I200_S0.7510.55
106_L110_P0.7480.55
157_T160_I0.7470.55
45_V115_F0.7410.54
52_Q56_P0.7370.54
41_T64_V0.7360.54
116_D145_K0.7310.53
16_D19_Q0.7290.53
46_D145_K0.7280.53
25_K126_M0.7270.53
149_K170_I0.7250.53
45_V113_F0.7230.52
118_N150_I0.7200.52
39_I113_F0.7180.52
147_Y150_I0.7170.52
213_S220_R0.7160.52
223_D230_R0.7160.52
24_L27_R0.7140.51
42_C71_E0.7140.51
103_A109_E0.7110.51
114_L136_L0.7090.51
60_C214_R0.7050.51
17_F90_F0.7030.50
169_I174_V0.7020.50
59_V226_T0.6980.50
121_L147_Y0.6970.50
47_L98_L0.6960.50
202_Y206_M0.6950.50
114_L141_I0.6950.50
42_C45_V0.6920.49
48_A230_R0.6890.49
78_S105_K0.6860.49
65_I72_V0.6850.49
74_E105_K0.6840.48
133_A194_N0.6830.48
162_V206_M0.6820.48
78_S102_A0.6800.48
188_I205_T0.6770.48
182_R218_P0.6750.48
50_W53_D0.6680.47
42_C141_I0.6670.47
50_W79_M0.6670.47
48_A223_D0.6660.47
109_E138_K0.6600.46
59_V229_L0.6600.46
42_C140_T0.6590.46
181_T206_M0.6570.46
49_Y91_L0.6530.45
192_C195_Y0.6520.45
143_I226_T0.6510.45
77_H225_E0.6500.45
89_G223_D0.6450.45
100_I104_K0.6440.44
121_L175_Y0.6370.44
90_F202_Y0.6340.43
47_L56_P0.6300.43
120_Y126_M0.6250.43
84_V227_H0.6250.43
177_R192_C0.6250.43
82_I98_L0.6240.42
206_M209_I0.6200.42
19_Q22_F0.6170.42
28_I126_M0.6150.42
159_E166_T0.6140.41
39_I146_T0.6140.41
196_I200_S0.6120.41
121_L191_S0.6100.41
91_L118_N0.6100.41
65_I221_L0.6030.40
86_Y94_R0.6030.40
86_Y91_L0.6000.40
19_Q23_N0.6000.40
29_N34_I0.5990.40
84_V90_F0.5970.40
180_R214_R0.5970.40
164_A184_D0.5970.40
139_P201_S0.5960.40
60_C102_A0.5930.39
46_D191_S0.5900.39
92_A227_H0.5890.39
221_L224_L0.5870.39
224_L228_V0.5860.39
72_V221_L0.5860.39
92_A118_N0.5840.39
45_V140_T0.5840.39
90_F121_L0.5830.38
143_I205_T0.5820.38
23_N151_K0.5800.38
157_T189_F0.5760.38
133_A195_Y0.5750.38
59_V230_R0.5740.38
33_T200_S0.5740.38
76_V106_L0.5730.38
129_A142_G0.5700.37
226_T230_R0.5690.37
121_L168_I0.5680.37
78_S101_E0.5640.37
118_N147_Y0.5620.37
214_R217_I0.5610.36
40_N66_D0.5610.36
201_S209_I0.5580.36
15_Q31_S0.5570.36
77_H229_L0.5530.36
31_S69_T0.5530.36
39_I196_I0.5530.36
215_L218_P0.5530.36
212_E224_L0.5520.36
213_S217_I0.5520.36
213_S219_V0.5500.35
221_L225_E0.5480.35
49_Y59_V0.5460.35
20_V27_R0.5450.35
29_N32_P0.5450.35
15_Q207_S0.5450.35
47_L128_V0.5440.35
23_N26_N0.5420.35
27_R31_S0.5420.35
45_V143_I0.5390.34
53_D63_I0.5370.34
86_Y95_E0.5360.34
144_A219_V0.5360.34
58_G63_I0.5360.34
158_P180_R0.5300.34
121_L225_E0.5300.34
132_A138_K0.5300.34
87_V178_A0.5290.33
51_E59_V0.5250.33
42_C114_L0.5250.33
62_I106_L0.5250.33
51_E189_F0.5250.33
92_A171_D0.5250.33
73_I140_T0.5240.33
181_T187_P0.5230.33
145_K191_S0.5210.33
17_F130_T0.5200.33
44_G64_V0.5190.33
45_V103_A0.5190.33
147_Y189_F0.5180.32
150_I215_L0.5170.32
58_G91_L0.5160.32
44_G65_I0.5130.32
20_V93_F0.5130.32
158_P186_K0.5130.32
53_D79_M0.5100.32
84_V128_V0.5090.32
20_V228_V0.5090.32
99_I132_A0.5070.32
162_V209_I0.5040.31
76_V107_E0.5020.31
84_V87_V0.5000.31
41_T111_D0.5000.31
49_Y182_R0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ga2A 1 0.9958 100 0.151 Contact Map
4nspA 1 0.916 100 0.231 Contact Map
2w36A 1 0.9328 100 0.278 Contact Map
3gocA 2 0.9538 100 0.316 Contact Map
2qh9A 2 0.7269 100 0.501 Contact Map
2nrrA 1 0.5798 97.5 0.906 Contact Map
2ygkA 2 0.9454 97.2 0.909 Contact Map
2nrtA 1 0.6807 96.9 0.914 Contact Map
3c65A 1 0.6092 96.6 0.917 Contact Map
1yvuA 1 0.8613 81.5 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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