GREMLIN Database
YWQK - Putative antitoxin YwqK
UniProt: P96723 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (119)
Sequences: 317 (297)
Seq/√Len: 27.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_I105_E3.0841.00
58_T69_T2.9881.00
69_T93_S2.6970.99
92_I105_E2.6770.99
46_Y57_F2.6560.99
56_Y69_T2.6040.99
69_T80_S2.5810.99
82_K93_S2.5760.99
106_Q116_E2.4830.99
80_S93_S2.2520.98
65_A84_Y2.1680.98
81_E94_I2.1420.97
41_F63_G2.1100.97
25_V28_E1.8960.95
66_H85_R1.8360.94
104_S116_E1.8120.93
69_T82_K1.8000.93
21_W24_S1.7860.93
56_Y80_S1.7560.92
91_G115_S1.7230.91
93_S106_Q1.7210.91
70_C78_K1.7170.91
72_F96_W1.7010.91
34_E45_A1.6540.89
102_K108_Y1.6060.88
45_A69_T1.5970.88
58_T82_K1.5850.87
94_I102_K1.5640.87
69_T84_Y1.5380.86
56_Y93_S1.4170.81
105_E117_K1.3830.79
112_I133_T1.3710.78
96_W119_W1.3650.78
68_L81_E1.3560.77
58_T80_S1.3470.77
97_F113_L1.3060.75
119_W125_L1.2650.72
50_P78_K1.2640.72
69_T116_E1.2530.72
57_F72_F1.2320.70
52_G76_G1.2180.69
66_H83_E1.2010.68
93_S116_E1.1900.68
57_F70_C1.1770.67
58_T93_S1.1590.65
17_F20_L1.1450.64
93_S108_Y1.1400.64
117_K125_L1.1300.63
58_T65_A1.1280.63
77_N95_I1.1220.63
100_G122_E1.1200.63
97_F108_Y1.1130.62
81_E105_E1.0990.61
58_T71_E1.0910.61
58_T106_Q1.0640.59
82_K106_Q1.0500.58
82_K95_I1.0230.56
116_E126_L1.0050.54
56_Y106_Q0.9900.53
26_S64_L0.9860.53
60_Y84_Y0.9420.50
17_F23_S0.9360.49
77_N98_E0.9350.49
52_G87_G0.9310.49
95_I108_Y0.9220.48
69_T106_Q0.9210.48
16_D19_D0.9200.48
130_E135_S0.9090.47
84_Y93_S0.9020.47
57_F85_R0.8990.46
100_G123_G0.8980.46
81_E123_G0.8850.45
27_D36_E0.8850.45
65_A87_G0.8770.45
93_S102_K0.8760.45
73_Y108_Y0.8680.44
26_S66_H0.8660.44
16_D21_W0.8630.44
65_A71_E0.8630.44
33_P70_C0.8590.43
132_D135_S0.8520.43
23_S38_G0.8490.43
120_D126_L0.8480.42
120_D124_N0.8390.42
18_E23_S0.8370.42
36_E63_G0.8330.41
53_Q108_Y0.8280.41
82_K116_E0.8260.41
73_Y79_K0.8170.40
64_L111_S0.8130.40
118_N128_K0.8060.39
16_D20_L0.8000.39
18_E30_L0.7980.39
60_Y65_A0.7860.38
16_D23_S0.7840.38
30_L120_D0.7710.37
23_S31_D0.7530.36
58_T130_E0.7520.36
56_Y82_K0.7490.35
72_F119_W0.7440.35
101_R111_S0.7310.34
43_G60_Y0.7310.34
83_E86_Y0.7280.34
115_S123_G0.7230.34
131_I134_D0.7110.33
99_N109_E0.7070.33
30_L87_G0.7010.32
89_L93_S0.6960.32
52_G67_G0.6940.32
48_L96_W0.6930.32
38_G105_E0.6890.31
80_S116_E0.6890.31
41_F66_H0.6850.31
129_Y135_S0.6820.31
45_A111_S0.6760.31
35_D87_G0.6610.30
53_Q104_S0.6560.29
43_G59_K0.6510.29
18_E81_E0.6490.29
72_F78_K0.6480.29
91_G125_L0.6460.29
57_F96_W0.6420.28
74_E122_E0.6390.28
99_N121_E0.6390.28
33_P39_Q0.6370.28
71_E106_Q0.6340.28
127_N135_S0.6290.28
130_E133_T0.6280.28
32_N45_A0.6270.27
49_Y128_K0.6260.27
74_E124_N0.6260.27
68_L96_W0.6180.27
22_F90_H0.6150.27
53_Q121_E0.6140.27
78_K96_W0.6130.27
80_S108_Y0.6060.26
97_F123_G0.6050.26
34_E43_G0.5940.26
84_Y108_Y0.5940.26
51_N83_E0.5890.25
57_F104_S0.5890.25
113_L124_N0.5840.25
97_F101_R0.5810.25
45_A56_Y0.5810.25
37_N111_S0.5790.25
79_K103_K0.5790.25
87_G107_Q0.5760.24
21_W25_V0.5740.24
73_Y97_F0.5720.24
16_D24_S0.5710.24
59_K66_H0.5710.24
120_D128_K0.5640.24
45_A93_S0.5630.24
98_E119_W0.5610.24
20_L23_S0.5590.24
42_T62_N0.5560.23
118_N134_D0.5530.23
80_S106_Q0.5520.23
40_P86_Y0.5500.23
63_G67_G0.5490.23
57_F98_E0.5440.23
96_W102_K0.5420.23
43_G125_L0.5390.22
34_E40_P0.5370.22
83_E88_Q0.5320.22
22_F48_L0.5290.22
130_E134_D0.5220.22
44_L63_G0.5190.21
20_L119_W0.5180.21
22_F26_S0.5140.21
120_D130_E0.5140.21
20_L31_D0.5110.21
53_Q77_N0.5100.21
91_G127_N0.5080.21
33_P36_E0.5060.21
96_W121_E0.5050.21
82_K89_L0.5030.21
49_Y123_G0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h3iA 1 0.8312 99.7 0.38 Contact Map
2f69A 1 0.5714 98.9 0.609 Contact Map
4ld1A 1 0.7662 97.7 0.716 Contact Map
4by2A 1 0.6234 94.9 0.791 Contact Map
3hiaA 3 0.539 49.6 0.874 Contact Map
2ww5A 1 0.7338 22.1 0.896 Contact Map
4x36A 2 0.8377 17.8 0.9 Contact Map
2bibA 1 0.7597 16.9 0.902 Contact Map
3klkA 1 0.7662 14.7 0.904 Contact Map
4cnlA 1 0.8117 9.1 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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