GREMLIN Database
YWQG - Uncharacterized protein YwqG
UniProt: P96719 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 261 (237)
Sequences: 599 (525)
Seq/√Len: 34.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_H224_D4.1611.00
25_L146_P3.7591.00
85_F109_V3.6601.00
151_E194_K3.5031.00
35_Y44_Y3.0921.00
217_M220_Q3.0861.00
86_Y112_F3.0681.00
242_T245_D3.0641.00
85_F239_F2.8451.00
223_S231_W2.7721.00
241_I246_L2.5731.00
245_D250_D2.5591.00
238_N259_D2.5491.00
36_D70_H2.5311.00
113_E249_K2.5071.00
84_Q112_F2.4741.00
45_F49_E2.4581.00
51_Y86_Y2.4131.00
245_D253_N2.4061.00
54_D88_S2.3310.99
18_S153_V2.2910.99
77_Y196_G2.2440.99
25_L39_I2.2340.99
63_L239_F2.2150.99
67_N70_H2.1990.99
215_T242_T2.1950.99
217_M238_N2.1250.99
63_L221_I2.0820.99
202_T259_D2.0560.98
22_Y194_K1.9420.98
37_S65_Q1.9130.97
223_S233_D1.8960.97
44_Y84_Q1.8630.97
104_Q108_R1.8510.97
232_G260_C1.7890.96
37_S146_P1.7800.96
230_M233_D1.7800.96
74_L77_Y1.7770.96
203_Q235_G1.7620.96
69_S80_S1.7500.96
230_M234_V1.7490.96
39_I221_I1.7080.95
33_G36_D1.6660.94
214_H253_N1.6480.94
27_V144_V1.6450.94
60_M108_R1.6120.93
66_I195_I1.5900.93
222_D236_I1.5730.92
223_S230_M1.5630.92
68_F71_I1.5590.92
39_I144_V1.5560.92
19_A150_S1.5300.91
203_Q260_C1.5210.91
111_Y249_K1.5130.91
216_I243_P1.5040.90
51_Y59_P1.5020.90
68_F111_Y1.4830.90
201_F205_D1.4620.89
51_Y123_V1.4530.89
12_R16_E1.4470.89
22_Y149_S1.4460.89
27_V39_I1.4320.88
97_N101_R1.4200.88
222_D235_G1.3900.87
63_L233_D1.3860.86
65_Q84_Q1.3840.86
45_F112_F1.3820.86
246_L251_F1.3790.86
45_F51_Y1.3690.86
220_Q232_G1.3510.85
72_P196_G1.3470.85
64_A85_F1.3340.84
74_L196_G1.3250.84
38_K44_Y1.3230.84
142_A227_I1.3180.83
67_N82_I1.3010.83
68_F86_Y1.2900.82
199_A205_D1.2850.82
250_D253_N1.2810.82
46_P68_F1.2770.81
193_H220_Q1.2610.81
44_Y65_Q1.2360.79
87_I259_D1.2310.79
66_I146_P1.2260.79
54_D58_Q1.2170.78
68_F85_F1.2090.78
43_P86_Y1.1990.77
203_Q220_Q1.1930.77
95_G256_Y1.1610.75
21_E75_D1.1280.73
215_T243_P1.1100.71
178_D184_N1.1050.71
194_K217_M1.0980.70
240_F259_D1.0930.70
96_L258_W1.0880.70
65_Q219_L1.0870.70
20_K198_Y1.0820.69
202_T238_N1.0770.69
87_I238_N1.0750.69
63_L87_I1.0650.68
22_Y151_E1.0640.68
255_L258_W1.0620.68
71_I248_K1.0530.67
84_Q115_I1.0520.67
144_V195_I1.0490.67
46_P112_F1.0490.67
21_E148_K1.0470.67
231_W237_A1.0390.66
40_A77_Y1.0380.66
192_G222_D1.0360.66
84_Q196_G1.0340.66
230_M260_C1.0330.66
27_V221_I1.0290.65
40_A48_H1.0190.65
23_V195_I1.0170.64
203_Q259_D1.0160.64
40_A199_A1.0150.64
66_I71_I1.0140.64
44_Y67_N1.0130.64
64_A220_Q1.0050.64
59_P108_R0.9870.62
36_D67_N0.9710.61
220_Q239_F0.9680.61
34_R199_A0.9640.60
45_F70_H0.9530.59
169_M173_G0.9470.59
59_P86_Y0.9390.58
49_E112_F0.9290.57
26_N145_E0.9200.57
178_D185_E0.9170.56
243_P247_R0.9110.56
229_S237_A0.9090.56
12_R20_K0.8990.55
217_M222_D0.8980.55
35_Y84_Q0.8920.54
217_M240_F0.8900.54
43_P62_L0.8880.54
220_Q235_G0.8840.54
223_S235_G0.8830.54
248_K252_S0.8810.53
118_N121_E0.8810.53
62_L65_Q0.8780.53
174_Q185_E0.8760.53
37_S70_H0.8740.53
201_F207_R0.8730.53
46_P110_I0.8680.52
241_I251_F0.8630.52
156_T188_E0.8630.52
245_D252_S0.8550.51
68_F77_Y0.8510.51
45_F86_Y0.8480.51
151_E154_L0.8470.50
233_D260_C0.8470.50
183_Y188_E0.8460.50
48_H247_R0.8380.50
220_Q260_C0.8340.49
71_I146_P0.8300.49
143_A146_P0.8290.49
32_T38_K0.8260.49
13_D244_E0.8230.48
203_Q217_M0.8220.48
68_F107_F0.8190.48
66_I219_L0.8180.48
35_Y86_Y0.8170.48
83_L86_Y0.8160.48
84_Q201_F0.8150.48
69_S250_D0.8120.48
89_V138_I0.8080.47
93_V96_L0.7960.46
77_Y215_T0.7910.46
239_F254_V0.7800.45
25_L165_G0.7770.45
13_D169_M0.7730.44
25_L71_I0.7630.43
234_V260_C0.7630.43
223_S232_G0.7520.43
82_I112_F0.7460.42
71_I97_N0.7430.42
145_E163_Y0.7390.41
54_D106_N0.7380.41
15_L24_K0.7320.41
199_A259_D0.7300.41
37_S219_L0.7290.41
80_S113_E0.7290.41
29_K113_E0.7280.41
76_G243_P0.7230.40
201_F238_N0.7190.40
77_Y216_I0.7180.40
55_E106_N0.7150.39
69_S178_D0.7110.39
167_E185_E0.7110.39
17_K221_I0.7100.39
118_N254_V0.7100.39
240_F257_N0.7100.39
160_F203_Q0.7090.39
85_F230_M0.7090.39
138_I142_A0.7080.39
74_L86_Y0.7070.39
45_F61_K0.7060.39
97_N103_E0.7060.39
136_F159_Q0.7000.38
25_L32_T0.6990.38
56_N105_K0.6980.38
240_F256_Y0.6970.38
72_P77_Y0.6960.38
44_Y115_I0.6940.38
50_T120_D0.6940.38
162_Q184_N0.6930.38
87_I237_A0.6910.38
104_Q107_F0.6910.38
39_I216_I0.6880.37
44_Y112_F0.6880.37
60_M250_D0.6870.37
220_Q238_N0.6790.37
68_F196_G0.6750.36
215_T245_D0.6710.36
24_K149_S0.6680.36
54_D237_A0.6670.36
238_N251_F0.6650.36
74_L111_Y0.6640.35
15_L37_S0.6600.35
161_E186_L0.6600.35
23_V46_P0.6580.35
92_D260_C0.6550.35
11_Y15_L0.6530.35
241_I244_E0.6520.35
49_E110_I0.6510.34
34_R159_Q0.6490.34
77_Y153_V0.6460.34
27_V224_D0.6440.34
202_T205_D0.6430.34
50_T176_G0.6420.34
69_S72_P0.6390.34
186_L244_E0.6380.33
236_I257_N0.6360.33
212_K215_T0.6350.33
41_G52_P0.6340.33
60_M135_D0.6310.33
197_G220_Q0.6310.33
88_S106_N0.6290.33
43_P118_N0.6280.33
80_S115_I0.6240.32
47_K121_E0.6230.32
116_V141_E0.6200.32
112_F115_I0.6190.32
118_N225_D0.6190.32
38_K198_Y0.6180.32
199_A217_M0.6160.32
27_V193_H0.6150.32
38_K141_E0.6140.32
83_L112_F0.6130.32
169_M175_F0.6120.32
47_K125_D0.6070.31
92_D96_L0.6040.31
110_I211_Y0.6030.31
15_L59_P0.6030.31
202_T220_Q0.6020.31
214_H255_L0.6010.31
43_P65_Q0.5990.31
243_P252_S0.5970.30
193_H227_I0.5960.30
46_P78_P0.5940.30
23_V196_G0.5940.30
65_Q70_H0.5920.30
60_M88_S0.5900.30
80_S111_Y0.5900.30
28_R143_A0.5890.30
77_Y195_I0.5870.30
253_N257_N0.5850.30
21_E150_S0.5850.30
235_G238_N0.5850.30
163_Y186_L0.5840.30
45_F237_A0.5800.29
11_Y97_N0.5800.29
103_E252_S0.5780.29
65_Q82_I0.5760.29
95_G101_R0.5760.29
238_N258_W0.5740.29
68_F246_L0.5740.29
29_K79_S0.5730.29
141_E248_K0.5730.29
111_Y239_F0.5720.29
96_L101_R0.5720.29
14_L165_G0.5700.29
238_N257_N0.5630.28
109_V239_F0.5620.28
201_F206_P0.5620.28
14_L17_K0.5610.28
86_Y123_V0.5590.28
84_Q114_N0.5590.28
107_F239_F0.5570.28
21_E72_P0.5570.28
202_T236_I0.5560.28
64_A251_F0.5560.28
144_V219_L0.5540.27
237_A254_V0.5540.27
193_H221_I0.5520.27
201_F240_F0.5500.27
176_G181_D0.5470.27
220_Q240_F0.5460.27
238_N260_C0.5450.27
110_I219_L0.5450.27
64_A239_F0.5420.27
51_Y61_K0.5420.27
48_H121_E0.5410.27
12_R23_V0.5410.27
257_N260_C0.5410.27
86_Y173_G0.5410.27
56_N156_T0.5400.27
77_Y152_W0.5400.27
77_Y226_D0.5400.27
57_G85_F0.5390.26
241_I245_D0.5380.26
51_Y62_L0.5370.26
55_E213_E0.5360.26
31_K55_E0.5350.26
76_G247_R0.5350.26
207_R232_G0.5330.26
103_E164_T0.5330.26
219_L250_D0.5330.26
224_D227_I0.5320.26
229_S260_C0.5300.26
28_R162_Q0.5300.26
82_I103_E0.5290.26
53_T59_P0.5270.26
39_I142_A0.5250.26
203_Q232_G0.5250.26
43_P146_P0.5250.26
43_P84_Q0.5240.25
179_E182_I0.5240.25
236_I240_F0.5230.25
39_I226_D0.5230.25
47_K118_N0.5220.25
51_Y68_F0.5200.25
16_E30_G0.5180.25
108_R169_M0.5180.25
16_E194_K0.5170.25
218_L246_L0.5170.25
236_I259_D0.5170.25
66_I186_L0.5140.25
35_Y118_N0.5140.25
37_S68_F0.5100.25
65_Q111_Y0.5100.25
206_P210_A0.5090.25
178_D183_Y0.5090.25
202_T235_G0.5080.24
45_F59_P0.5080.24
37_S67_N0.5080.24
151_E199_A0.5060.24
63_L231_W0.5040.24
223_S234_V0.5040.24
80_S226_D0.5030.24
201_F256_Y0.5030.24
164_T256_Y0.5010.24
32_T72_P0.5000.24
244_E247_R0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pv5A 1 0.9962 100 0.149 Contact Map
1j8bA 2 0.1533 8.9 0.962 Contact Map
3s9gA 2 0.1111 4.7 0.967 Contact Map
4lh9A 4 0.1533 4.2 0.967 Contact Map
2js3A 2 0.2797 4.1 0.968 Contact Map
4c1aA 2 0.1264 3.2 0.969 Contact Map
3m1fV 1 0.0843 3 0.97 Contact Map
1z8uA 1 0.0958 2.3 0.971 Contact Map
1mz9A 3 0.1341 2.2 0.972 Contact Map
3h6pC 1 0.0536 2.1 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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