GREMLIN Database
YWQF - UDP-glucose 6-dehydrogenase YwqF
UniProt: P96718 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (404)
Sequences: 8471 (5119)
Seq/√Len: 254.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_D198_R4.9451.00
33_A37_D4.7961.00
348_Y389_I4.2341.00
300_A381_M3.3771.00
2_N25_H3.2971.00
311_T344_R3.2971.00
322_N387_A3.2851.00
174_D177_T3.1791.00
311_T346_R3.1441.00
38_E43_I2.9971.00
301_L341_L2.9161.00
147_A181_L2.8691.00
195_T234_A2.6631.00
300_A379_A2.6361.00
313_A377_S2.6171.00
131_N146_V2.6091.00
104_K133_L2.5681.00
21_E57_K2.5261.00
145_S174_D2.5141.00
100_T129_L2.5041.00
314_L335_A2.4481.00
4_T77_A2.4101.00
294_A337_R2.4021.00
40_R66_F2.3721.00
226_E299_K2.3181.00
280_E287_K2.2901.00
196_D199_S2.2821.00
37_D41_K2.2651.00
334_I383_L2.2011.00
318_S352_A2.1881.00
378_D402_E2.1771.00
111_K114_T2.1381.00
231_D234_A2.1281.00
25_H65_N2.0871.00
160_Y164_H2.0481.00
79_I184_L2.0371.00
24_H187_P1.9771.00
104_K136_E1.9751.00
312_I343_A1.9711.00
346_R377_S1.9671.00
8_T28_C1.9591.00
33_A68_T1.9481.00
207_S239_M1.9461.00
369_T372_E1.9201.00
70_Y105_R1.9101.00
195_T203_I1.9051.00
209_A217_F1.8891.00
25_H63_R1.8681.00
228_V275_V1.8611.00
139_A142_V1.8471.00
374_V397_Y1.8271.00
34_H37_D1.8221.00
89_K93_H1.8151.00
273_G283_K1.8121.00
80_I114_T1.8101.00
116_V134_I1.8091.00
44_S55_M1.7931.00
398_Q404_P1.7931.00
382_I412_C1.7821.00
371_E396_A1.7781.00
178_A182_E1.7601.00
213_T285_V1.7501.00
178_A194_Q1.7361.00
202_M225_C1.7341.00
346_R367_K1.7291.00
71_E109_H1.7271.00
101_D104_K1.7191.00
71_E75_A1.7091.00
393_P396_A1.6941.00
313_A373_A1.6911.00
100_T104_K1.6851.00
32_D35_K1.6401.00
179_N183_E1.6241.00
17_V55_M1.6211.00
175_E179_N1.6181.00
278_D283_K1.6181.00
3_I184_L1.5941.00
37_D40_R1.5871.00
2_N76_Q1.5821.00
210_F214_K1.5691.00
103_A130_I1.5601.00
115_V180_T1.5371.00
295_M299_K1.5321.00
337_R340_A1.5211.00
17_V64_L1.5181.00
30_D36_I1.4981.00
4_T80_I1.4971.00
131_N135_T1.4961.00
39_M66_F1.4861.00
19_L184_L1.4781.00
182_E194_Q1.4641.00
269_V283_K1.4621.00
321_P385_D1.4611.00
300_A407_F1.4581.00
18_S21_E1.4551.00
387_A390_K1.4511.00
283_K287_K1.4351.00
17_V54_L1.4321.00
317_L347_A1.4241.00
210_F248_Q1.4181.00
226_E295_M1.4141.00
38_E45_P1.4141.00
338_L343_A1.4111.00
100_T133_L1.3991.00
223_N295_M1.3941.00
179_N193_Y1.3931.00
129_L132_G1.3831.00
29_I70_Y1.3791.00
224_I279_F1.3711.00
254_I409_G1.3641.00
337_R341_L1.3561.00
52_E56_R1.3511.00
36_I68_T1.3511.00
223_N292_Q1.3321.00
183_E186_R1.3311.00
79_I115_V1.3311.00
50_G53_E1.3201.00
53_E57_K1.3191.00
227_K277_H1.3191.00
129_L133_L1.3181.00
36_I66_F1.3131.00
110_V114_T1.3131.00
73_G76_Q1.3031.00
172_T178_A1.3001.00
332_I336_D1.2901.00
213_T217_F1.2901.00
297_V334_I1.2871.00
18_S163_F1.2841.00
180_T183_E1.2831.00
69_S73_G1.2761.00
34_H38_E1.2671.00
65_N73_G1.2421.00
234_A237_Y1.2331.00
54_L159_I1.2241.00
75_A111_K1.2211.00
303_R407_F1.2121.00
299_K407_F1.2111.00
281_L284_S1.2091.00
113_D145_S1.2061.00
351_I388_D1.1891.00
21_E163_F1.1871.00
27_T77_A1.1851.00
223_N227_K1.1851.00
218_I236_A1.1841.00
213_T281_L1.1741.00
225_C232_I1.1691.00
145_S176_K1.1691.00
313_A380_V1.1661.00
40_R65_N1.1661.00
97_E101_D1.1641.00
157_S160_Y1.1581.00
203_I238_G1.1531.00
27_T65_N1.1521.00
56_R60_A1.1501.00
315_L392_F1.1481.00
79_I180_T1.1471.00
27_T76_Q1.1471.00
311_T376_G1.1461.00
38_E41_K1.1461.00
145_S177_T1.1421.00
103_A133_L1.1361.00
374_V380_V1.1351.00
2_N27_T1.1281.00
406_I413_Y1.1251.00
281_L288_V1.1231.00
39_M64_L1.1181.00
256_Y286_I1.1161.00
317_L357_K1.1141.00
149_N185_F1.1041.00
297_V337_R1.1031.00
196_D234_A1.1011.00
103_A107_A1.0991.00
206_A221_I1.0931.00
6_I102_A1.0921.00
382_I406_I1.0821.00
107_A134_I1.0811.00
35_K45_P1.0811.00
312_I379_A1.0801.00
177_T181_L1.0801.00
104_K108_K1.0801.00
118_T130_I1.0751.00
333_V336_D1.0651.00
313_A346_R1.0631.00
199_S230_A1.0631.00
221_I232_I1.0591.00
344_R365_E1.0581.00
54_L57_K1.0571.00
176_K180_T1.0551.00
6_I80_I1.0521.00
380_V401_M1.0521.00
243_K248_Q1.0521.00
294_A298_D1.0501.00
70_Y109_H1.0481.00
8_T16_G1.0481.00
76_Q111_K1.0321.00
172_T177_T1.0321.00
182_E186_R1.0281.00
36_I40_R1.0221.00
161_D164_H1.0211.00
115_V147_A1.0211.00
113_D143_S1.0201.00
27_T67_E1.0171.00
175_E178_A1.0151.00
233_E251_K1.0131.00
280_E291_N1.0121.00
335_A339_A1.0091.00
87_P95_N1.0021.00
78_D114_T1.0021.00
118_T127_N0.9981.00
387_A391_Q0.9961.00
170_I181_L0.9891.00
382_I413_Y0.9881.00
186_R191_P0.9831.00
233_E237_Y0.9801.00
307_V343_A0.9771.00
16_G28_C0.9691.00
301_L343_A0.9691.00
271_I274_N0.9681.00
336_D339_A0.9671.00
143_S176_K0.9621.00
225_C235_V0.9621.00
3_I19_L0.9581.00
230_A235_V0.9521.00
237_Y247_S0.9511.00
300_A409_G0.9511.00
112_R143_S0.9501.00
16_G64_L0.9481.00
21_E53_E0.9481.00
352_A366_Y0.9421.00
4_T29_I0.9411.00
212_A286_I0.9411.00
333_V337_R0.9331.00
101_D105_R0.9321.00
128_D197_I0.9321.00
94_A123_P0.9311.00
199_S235_V0.9291.00
182_E193_Y0.9291.00
317_L329_A0.9261.00
301_L307_V0.9241.00
82_I106_I0.9241.00
128_D132_G0.9231.00
105_R108_K0.9221.00
223_N291_N0.9211.00
51_L55_M0.9141.00
131_N197_I0.9101.00
4_T27_T0.9071.00
315_L380_V0.9031.00
291_N294_A0.9031.00
106_I116_V0.9001.00
279_F282_L0.8981.00
311_T377_S0.8941.00
336_D340_A0.8931.00
254_I383_L0.8901.00
127_N197_I0.8891.00
293_Q333_V0.8881.00
110_V144_I0.8851.00
310_K378_D0.8841.00
18_S162_T0.8791.00
8_T64_L0.8771.00
379_A405_L0.8761.00
298_D302_N0.8761.00
179_N182_E0.8731.00
29_I73_G0.8721.00
312_I381_M0.8711.00
326_M357_K0.8711.00
67_E73_G0.8701.00
113_D176_K0.8691.00
367_K373_A0.8661.00
304_L310_K0.8641.00
367_K372_E0.8621.00
29_I67_E0.8610.99
346_R365_E0.8580.99
117_V181_L0.8570.99
331_S383_L0.8550.99
23_G187_P0.8540.99
115_V177_T0.8530.99
135_T144_I0.8520.99
79_I117_V0.8490.99
303_R405_L0.8440.99
82_I99_I0.8410.99
15_T162_T0.8400.99
315_L389_I0.8400.99
55_M64_L0.8390.99
372_E375_K0.8360.99
309_G344_R0.8360.99
179_N194_Q0.8300.99
214_K250_L0.8300.99
299_K302_N0.8210.99
103_A118_T0.8210.99
182_E191_P0.8200.99
270_Q274_N0.8190.99
140_E172_T0.8180.99
313_A374_V0.8180.99
3_I24_H0.8170.99
256_Y265_T0.8160.99
31_I105_R0.8150.99
133_L136_E0.8130.99
317_L326_M0.8100.99
266_N286_I0.8040.99
394_L413_Y0.8040.99
296_L409_G0.7990.99
376_G402_E0.7950.99
269_V282_L0.7930.99
300_A312_I0.7920.99
326_M356_A0.7920.99
79_I181_L0.7910.99
224_I268_L0.7890.99
339_A363_A0.7890.99
4_T74_L0.7870.99
321_P387_A0.7830.99
300_A338_L0.7830.99
272_A279_F0.7810.99
370_I374_V0.7790.99
134_I146_V0.7780.99
70_Y108_K0.7770.99
224_I277_H0.7730.99
297_V341_L0.7670.99
317_L335_A0.7660.99
270_Q273_G0.7650.99
329_A332_I0.7640.99
315_L374_V0.7630.99
385_D410_R0.7600.99
370_I388_D0.7580.99
353_V366_Y0.7580.99
339_A364_V0.7570.99
291_N298_D0.7550.99
117_V184_L0.7530.99
290_N333_V0.7530.99
240_G249_F0.7520.99
138_L141_P0.7510.99
346_R376_G0.7510.99
132_G136_E0.7480.99
326_M352_A0.7450.99
78_D180_T0.7450.99
126_T130_I0.7450.99
135_T140_E0.7410.98
269_V286_I0.7410.98
113_D144_I0.7410.98
166_D243_K0.7400.98
210_F250_L0.7400.98
94_A267_A0.7370.98
138_L142_V0.7370.98
326_M332_I0.7350.98
5_V16_G0.7340.98
305_G310_K0.7320.98
339_A345_I0.7320.98
153_L162_T0.7270.98
119_K185_F0.7250.98
22_I188_F0.7230.98
27_T73_G0.7230.98
29_I68_T0.7220.98
178_A193_Y0.7180.98
147_A172_T0.7160.98
296_L407_F0.7100.98
335_A347_A0.7100.98
15_T167_R0.7060.98
191_P241_Q0.7010.98
193_Y241_Q0.7010.98
15_T19_L0.7010.98
315_L382_I0.7000.98
29_I105_R0.6990.98
214_K218_I0.6980.98
107_A144_I0.6970.98
106_I109_H0.6970.98
18_S159_I0.6910.98
10_Y327_R0.6890.98
209_A282_L0.6870.98
74_L80_I0.6870.98
4_T73_G0.6860.98
82_I116_V0.6860.98
232_I236_A0.6830.97
128_D131_N0.6820.97
80_I106_I0.6820.97
385_D390_K0.6800.97
294_A333_V0.6800.97
154_R157_S0.6760.97
47_F351_I0.6760.97
359_V365_E0.6740.97
24_H79_I0.6740.97
25_H76_Q0.6740.97
127_N148_S0.6720.97
181_L185_F0.6710.97
126_T129_L0.6710.97
35_K39_M0.6700.97
314_L381_M0.6680.97
99_I126_T0.6660.97
81_F184_L0.6640.97
35_K38_E0.6640.97
227_K278_D0.6630.97
169_V203_I0.6630.97
138_L143_S0.6620.97
217_F221_I0.6610.97
107_A116_V0.6600.97
356_A360_L0.6590.97
8_T30_D0.6570.97
224_I272_A0.6570.97
380_V389_I0.6550.97
199_S234_A0.6550.97
172_T194_Q0.6550.97
6_I70_Y0.6540.97
169_V182_E0.6530.97
369_T396_A0.6520.97
290_N293_Q0.6520.97
99_I103_A0.6510.97
5_V15_T0.6500.97
155_E319_F0.6500.97
112_R142_V0.6480.96
357_K366_Y0.6470.96
171_G178_A0.6470.96
269_V279_F0.6470.96
254_I296_L0.6450.96
43_I56_R0.6440.96
360_L364_V0.6440.96
352_A356_A0.6400.96
304_L405_L0.6400.96
315_L370_I0.6400.96
153_L158_A0.6400.96
360_L363_A0.6390.96
212_A256_Y0.6390.96
221_I268_L0.6370.96
347_A364_V0.6370.96
233_E411_N0.6360.96
361_P366_Y0.6340.96
53_E56_R0.6330.96
71_E108_K0.6330.96
236_A240_G0.6320.96
265_T286_I0.6290.96
121_T264_D0.6280.96
269_V273_G0.6270.96
118_T134_I0.6270.96
220_E288_V0.6260.96
110_V134_I0.6260.96
237_Y240_G0.6250.96
169_V191_P0.6250.96
62_G65_N0.6250.96
394_L406_I0.6240.96
78_D112_R0.6240.96
43_I52_E0.6230.96
168_I203_I0.6230.96
82_I118_T0.6220.96
208_N264_D0.6210.96
31_I98_Q0.6210.96
354_S357_K0.6200.96
43_I51_L0.6190.95
350_P389_I0.6190.95
22_I163_F0.6170.95
71_E105_R0.6170.95
304_L312_I0.6150.95
82_I130_I0.6140.95
347_A366_Y0.6130.95
292_Q295_M0.6120.95
52_E55_M0.6120.95
380_V397_Y0.6110.95
119_K149_N0.6110.95
304_L379_A0.6100.95
195_T199_S0.6090.95
88_Q266_N0.6080.95
273_G280_E0.6080.95
140_E144_I0.6080.95
99_I118_T0.6080.95
401_M404_P0.6070.95
29_I102_A0.6050.95
8_T39_M0.6030.95
178_A181_L0.6030.95
20_S63_R0.6020.95
74_L114_T0.6020.95
336_D359_V0.6000.95
121_T260_C0.5990.95
6_I74_L0.5990.95
182_E192_I0.5980.95
259_S263_K0.5970.95
86_T120_S0.5960.94
368_E372_E0.5950.94
96_L100_T0.5940.94
236_A252_A0.5940.94
347_A353_V0.5930.94
147_A170_I0.5930.94
21_E54_L0.5920.94
370_I392_F0.5920.94
88_Q92_G0.5910.94
271_I275_V0.5910.94
80_I109_H0.5900.94
105_R109_H0.5900.94
89_K100_T0.5900.94
218_I221_I0.5900.94
30_D68_T0.5900.94
266_N290_N0.5900.94
236_A251_K0.5890.94
177_T180_T0.5880.94
145_S180_T0.5880.94
240_G245_I0.5850.94
132_G135_T0.5850.94
293_Q334_I0.5830.94
284_S287_K0.5830.94
326_M331_S0.5820.94
297_V301_L0.5820.94
299_K303_R0.5820.94
247_S251_K0.5810.94
293_Q330_P0.5800.94
119_K263_K0.5800.94
335_A364_V0.5800.94
119_K155_E0.5790.94
305_G308_T0.5780.94
265_T282_L0.5780.94
392_F397_Y0.5750.93
151_E260_C0.5730.93
379_A407_F0.5720.93
135_T143_S0.5710.93
348_Y370_I0.5710.93
354_S368_E0.5700.93
395_A398_Q0.5680.93
75_A109_H0.5680.93
167_R185_F0.5680.93
98_Q102_A0.5680.93
254_I321_P0.5660.93
183_E187_P0.5650.93
223_N226_E0.5640.93
169_V178_A0.5620.93
172_T197_I0.5610.92
117_V147_A0.5610.92
298_D341_L0.5610.92
281_L285_V0.5590.92
300_A307_V0.5590.92
152_F207_S0.5580.92
116_V144_I0.5580.92
394_L397_Y0.5560.92
264_D327_R0.5550.92
280_E284_S0.5550.92
167_R207_S0.5540.92
155_E263_K0.5540.92
242_D245_I0.5540.92
282_L285_V0.5500.92
297_V307_V0.5480.92
202_M221_I0.5470.92
24_H184_L0.5460.91
39_M45_P0.5460.91
36_I39_M0.5460.91
50_G54_L0.5450.91
365_E376_G0.5440.91
398_Q406_I0.5440.91
339_A344_R0.5440.91
176_K179_N0.5430.91
81_F185_F0.5430.91
277_H288_V0.5420.91
206_A209_A0.5420.91
210_F218_I0.5420.91
279_F283_K0.5410.91
96_L129_L0.5400.91
317_L331_S0.5400.91
222_S292_Q0.5400.91
208_N320_K0.5400.91
166_D244_R0.5390.91
119_K167_R0.5380.91
50_G159_I0.5370.91
174_D178_A0.5360.91
240_G248_Q0.5360.91
44_S52_E0.5340.91
224_I228_V0.5330.90
70_Y74_L0.5330.90
221_I225_C0.5330.90
162_T188_F0.5320.90
85_G263_K0.5320.90
233_E252_A0.5310.90
23_G63_R0.5310.90
223_N277_H0.5310.90
108_K112_R0.5300.90
260_C263_K0.5300.90
254_I334_I0.5300.90
199_S203_I0.5290.90
131_N172_T0.5270.90
84_V98_Q0.5250.90
57_K60_A0.5250.90
87_P325_D0.5230.90
11_V327_R0.5220.90
338_L345_I0.5220.90
374_V377_S0.5170.89
161_D165_G0.5170.89
372_E376_G0.5160.89
77_A80_I0.5150.89
172_T175_E0.5150.89
280_E283_K0.5150.89
371_E375_K0.5150.89
317_L332_I0.5150.89
194_Q238_G0.5140.89
304_L307_V0.5140.89
256_Y285_V0.5140.89
393_P397_Y0.5140.89
226_E292_Q0.5130.89
216_S281_L0.5130.89
296_L334_I0.5130.89
11_V259_S0.5120.89
374_V401_M0.5120.89
109_H114_T0.5120.89
9_G12_G0.5100.88
65_N76_Q0.5100.88
97_E100_T0.5090.88
208_N260_C0.5090.88
304_L403_T0.5090.88
335_A383_L0.5080.88
170_I192_I0.5070.88
336_D360_L0.5070.88
26_V64_L0.5020.88
87_P328_E0.5020.88
180_T187_P0.5020.88
297_V300_A0.5010.88
303_R379_A0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9955 100 0.24 Contact Map
3gg2A 3 0.9636 100 0.256 Contact Map
2q3eA 5 0.9795 100 0.257 Contact Map
2o3jA 4 0.975 100 0.258 Contact Map
4a7pA 2 0.9682 100 0.276 Contact Map
3g79A 2 0.9773 100 0.278 Contact Map
3ojoA 2 0.9364 100 0.28 Contact Map
3vtfA 2 0.95 100 0.299 Contact Map
4xr9A 2 0.9682 100 0.305 Contact Map
1mv8A 2 0.9477 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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