YWQE - BACSU - GREMLIN Contacts

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YWQE - Tyrosine-protein phosphatase YwqE

UniProt:	P96717	Sequences: MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHNNGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDTKYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAASQITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGSELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	254 (232)
Sequences:	1383 (1179)
Seq/√Len:	77.4

BACSU - YWQE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_S	62_L	4.419	1.00
154_V	189_H	4.116	1.00
26_A	66_L	3.541	1.00
18_D	21_D	3.303	1.00
36_T	74_H	2.936	1.00
109_F	118_A	2.892	1.00
16_A	22_S	2.656	1.00
105_I	130_Y	2.639	1.00
38_I	99_L	2.612	1.00
65_R	68_K	2.514	1.00
30_V	72_P	2.510	1.00
8_I	39_A	2.460	1.00
36_T	76_L	2.436	1.00
43_H	79_Q	2.324	1.00
30_V	73_L	2.295	1.00
92_A	128_K	2.277	1.00
26_A	73_L	2.258	1.00
26_A	37_I	2.187	1.00
30_V	71_I	2.177	1.00
17_G	21_D	2.154	1.00
19_S	65_R	2.122	1.00
107_I	122_F	2.084	1.00
190_F	231_L	2.083	1.00
65_R	69_E	2.014	1.00
63_N	67_I	1.987	1.00
162_I	188_I	1.970	1.00
59_A	63_N	1.959	1.00
27_R	69_E	1.944	1.00
58_A	61_Q	1.898	1.00
29_A	34_I	1.869	1.00
59_A	77_P	1.866	1.00
4_I	38_I	1.839	1.00
213_E	218_S	1.735	1.00
39_A	75_V	1.707	1.00
119_E	152_H	1.705	1.00
80_E	135_A	1.680	1.00
16_A	21_D	1.649	1.00
32_Q	206_Q	1.637	1.00
55_V	77_P	1.609	1.00
42_H	196_H	1.598	1.00
134_I	158_A	1.568	0.99
159_A	190_F	1.565	0.99
10_P	58_A	1.558	0.99
78_G	98_S	1.546	0.99
160_S	188_I	1.544	0.99
106_L	135_A	1.541	0.99
169_G	172_G	1.538	0.99
25_M	195_A	1.513	0.99
136_H	196_H	1.465	0.99
197_N	200_T	1.456	0.99
222_Y	226_E	1.436	0.99
133_V	231_L	1.407	0.99
229_E	233_R	1.404	0.99
4_I	192_A	1.402	0.99
186_N	220_L	1.387	0.99
9_L	58_A	1.386	0.99
14_D	194_D	1.385	0.99
66_L	71_I	1.377	0.99
6_C	195_A	1.375	0.99
4_I	190_F	1.367	0.99
42_H	136_H	1.342	0.98
123_Y	127_L	1.330	0.98
11_A	18_D	1.318	0.98
12_M	55_V	1.312	0.98
76_L	232_L	1.310	0.98
89_Q	93_K	1.305	0.98
181_R	185_A	1.297	0.98
182_L	188_I	1.293	0.98
42_H	194_D	1.284	0.98
108_E	136_H	1.277	0.98
98_S	130_Y	1.274	0.98
133_V	190_F	1.251	0.97
12_M	77_P	1.217	0.97
28_A	31_R	1.202	0.97
38_I	190_F	1.200	0.97
23_I	27_R	1.198	0.97
154_V	187_L	1.196	0.97
81_I	87_V	1.189	0.96
29_A	37_I	1.187	0.96
205_T	209_L	1.177	0.96
81_I	96_L	1.174	0.96
123_Y	126_Q	1.172	0.96
180_L	211_V	1.164	0.96
30_V	35_R	1.163	0.96
51_E	54_A	1.152	0.96
108_E	196_H	1.151	0.96
218_S	222_Y	1.150	0.96
223_M	228_A	1.148	0.96
42_H	80_E	1.148	0.96
113_H	142_E	1.147	0.96
137_P	160_S	1.139	0.95
91_L	130_Y	1.135	0.95
66_L	75_V	1.127	0.95
34_I	193_S	1.127	0.95
140_N	163_T	1.120	0.95
217_G	220_L	1.107	0.95
124_D	127_L	1.104	0.95
28_A	203_F	1.103	0.95
14_D	196_H	1.102	0.94
162_I	179_S	1.100	0.94
63_N	74_H	1.092	0.94
80_E	196_H	1.091	0.94
38_I	100_N	1.085	0.94
23_I	69_E	1.079	0.94
154_V	160_S	1.073	0.94
118_A	153_L	1.072	0.94
114_V	140_N	1.072	0.94
12_M	58_A	1.067	0.93
171_F	201_R	1.066	0.93
52_P	56_R	1.066	0.93
104_Y	132_P	1.063	0.93
26_A	71_I	1.057	0.93
42_H	108_E	1.055	0.93
82_R	163_T	1.054	0.93
150_L	160_S	1.052	0.93
13_D	196_H	1.052	0.93
212_L	224_L	1.046	0.93
136_H	194_D	1.043	0.93
192_A	228_A	1.040	0.93
119_E	156_K	1.038	0.93
122_F	158_A	1.038	0.93
13_D	42_H	1.037	0.92
178_F	182_L	1.035	0.92
7_H	14_D	1.032	0.92
211_V	215_E	1.029	0.92
144_R	178_F	1.029	0.92
151_Y	187_L	1.028	0.92
160_S	189_H	1.027	0.92
108_E	194_D	1.026	0.92
2_I	36_T	1.022	0.92
5_H	42_H	1.019	0.92
83_I	118_A	1.012	0.92
32_Q	204_H	1.008	0.91
164_S	191_V	1.005	0.91
7_H	80_E	0.994	0.91
144_R	175_L	0.989	0.91
80_E	194_D	0.987	0.91
82_R	140_N	0.986	0.90
7_H	13_D	0.973	0.90
80_E	136_H	0.971	0.90
7_H	42_H	0.970	0.90
63_N	75_V	0.966	0.90
14_D	42_H	0.940	0.88
126_Q	156_K	0.935	0.88
61_Q	64_K	0.933	0.88
104_Y	131_I	0.920	0.87
111_F	163_T	0.919	0.87
41_P	55_V	0.909	0.87
9_L	12_M	0.901	0.86
176_K	180_L	0.899	0.86
103_K	131_I	0.897	0.86
135_A	196_H	0.894	0.86
147_P	185_A	0.888	0.85
5_H	14_D	0.884	0.85
84_Y	90_D	0.883	0.85
5_H	15_G	0.882	0.85
24_E	27_R	0.867	0.84
10_P	16_A	0.859	0.83
83_I	109_F	0.848	0.82
227_N	230_L	0.848	0.82
5_H	196_H	0.841	0.82
42_H	139_R	0.841	0.82
55_V	79_Q	0.841	0.82
79_Q	97_L	0.841	0.82
66_L	73_L	0.831	0.81
54_A	58_A	0.830	0.81
76_L	100_N	0.829	0.81
184_E	216_F	0.827	0.81
5_H	13_D	0.820	0.80
78_G	100_N	0.819	0.80
60_D	64_K	0.817	0.80
143_I	178_F	0.816	0.80
7_H	194_D	0.806	0.79
7_H	196_H	0.790	0.78
191_V	224_L	0.790	0.78
34_I	164_S	0.790	0.78
99_L	135_A	0.789	0.78
25_M	197_N	0.787	0.77
205_T	212_L	0.787	0.77
133_V	159_A	0.786	0.77
135_A	194_D	0.782	0.77
82_R	111_F	0.781	0.77
166_S	172_G	0.777	0.77
180_L	216_F	0.774	0.76
109_F	122_F	0.772	0.76
221_P	228_A	0.762	0.75
64_K	68_K	0.759	0.75
14_D	139_R	0.759	0.75
62_L	75_V	0.757	0.75
27_R	31_R	0.755	0.75
28_A	32_Q	0.754	0.74
163_T	201_R	0.745	0.74
39_A	59_A	0.744	0.73
35_R	72_P	0.738	0.73
213_E	221_P	0.735	0.73
80_E	108_E	0.730	0.72
77_P	97_L	0.729	0.72
81_I	130_Y	0.728	0.72
35_R	74_H	0.727	0.72
80_E	139_R	0.724	0.71
13_D	194_D	0.723	0.71
87_V	96_L	0.720	0.71
191_V	209_L	0.718	0.71
212_L	217_G	0.717	0.71
42_H	135_A	0.715	0.70
16_A	25_M	0.715	0.70
67_I	74_H	0.714	0.70
114_V	142_E	0.712	0.70
23_I	71_I	0.710	0.70
91_L	96_L	0.704	0.69
147_P	178_F	0.704	0.69
217_G	221_P	0.701	0.69
27_R	71_I	0.699	0.69
230_L	233_R	0.699	0.69
139_R	196_H	0.699	0.69
23_I	65_R	0.696	0.68
83_I	121_L	0.690	0.68
209_L	212_L	0.689	0.68
139_R	194_D	0.687	0.67
160_S	187_L	0.684	0.67
61_Q	65_R	0.681	0.67
226_E	230_L	0.679	0.66
66_L	69_E	0.678	0.66
14_D	80_E	0.677	0.66
87_V	107_I	0.674	0.66
25_M	29_A	0.669	0.65
228_A	231_L	0.667	0.65
23_I	66_L	0.664	0.65
43_H	50_N	0.662	0.65
8_I	26_A	0.662	0.65
177_A	181_R	0.660	0.64
24_E	198_V	0.658	0.64
51_E	95_Q	0.655	0.64
169_G	176_K	0.653	0.63
204_H	207_E	0.652	0.63
137_P	169_G	0.652	0.63
15_G	136_H	0.652	0.63
81_I	98_S	0.651	0.63
99_L	133_V	0.650	0.63
119_E	153_L	0.647	0.63
32_Q	195_A	0.646	0.63
136_H	139_R	0.644	0.62
193_S	201_R	0.644	0.62
39_A	62_L	0.643	0.62
23_I	62_L	0.642	0.62
13_D	108_E	0.640	0.62
21_D	197_N	0.639	0.62
220_L	223_M	0.639	0.62
13_D	136_H	0.638	0.62
5_H	40_T	0.637	0.62
208_A	211_V	0.632	0.61
7_H	136_H	0.631	0.61
82_R	109_F	0.629	0.61
216_F	224_L	0.627	0.60
99_L	231_L	0.627	0.60
42_H	201_R	0.623	0.60
104_Y	190_F	0.622	0.60
55_V	59_A	0.619	0.59
212_L	221_P	0.617	0.59
37_I	203_F	0.616	0.59
167_L	183_V	0.615	0.59
5_H	136_H	0.610	0.58
209_L	224_L	0.605	0.58
108_E	201_R	0.599	0.57
208_A	212_L	0.599	0.57
108_E	139_R	0.598	0.57
25_M	28_A	0.598	0.57
13_D	80_E	0.597	0.57
14_D	136_H	0.595	0.56
90_D	95_Q	0.594	0.56
153_L	160_S	0.594	0.56
7_H	15_G	0.592	0.56
21_D	198_V	0.590	0.56
209_L	225_T	0.588	0.56
191_V	212_L	0.587	0.55
151_Y	155_E	0.587	0.55
39_A	77_P	0.586	0.55
120_Q	123_Y	0.582	0.55
114_V	163_T	0.581	0.55
7_H	40_T	0.581	0.55
14_D	108_E	0.578	0.54
194_D	201_R	0.576	0.54
143_I	149_L	0.574	0.54
120_Q	124_D	0.574	0.54
172_G	176_K	0.573	0.54
172_G	175_L	0.571	0.53
162_I	167_L	0.571	0.53
164_S	208_A	0.569	0.53
44_N	47_V	0.569	0.53
137_P	171_F	0.569	0.53
164_S	192_A	0.569	0.53
125_L	130_Y	0.565	0.53
137_P	179_S	0.561	0.52
210_Y	213_E	0.559	0.52
110_P	140_N	0.558	0.52
32_Q	201_R	0.556	0.51
104_Y	133_V	0.555	0.51
22_S	233_R	0.555	0.51
43_H	55_V	0.553	0.51
56_R	77_P	0.553	0.51
209_L	221_P	0.549	0.51
15_G	196_H	0.548	0.50
196_H	201_R	0.548	0.50
109_F	142_E	0.548	0.50
129_G	150_L	0.547	0.50
10_P	19_S	0.547	0.50
51_E	55_V	0.546	0.50
216_F	220_L	0.545	0.50
25_M	202_N	0.544	0.50
180_L	215_E	0.543	0.50
195_A	203_F	0.541	0.50
126_Q	132_P	0.538	0.49
5_H	194_D	0.538	0.49
110_P	114_V	0.537	0.49
59_A	71_I	0.535	0.49
5_H	139_R	0.534	0.49
99_L	102_T	0.534	0.49
6_C	37_I	0.534	0.49
163_T	196_H	0.533	0.49
148_S	185_A	0.533	0.49
98_S	101_D	0.532	0.48
60_D	63_N	0.531	0.48
165_G	192_A	0.530	0.48
225_T	228_A	0.524	0.47
48_Y	163_T	0.522	0.47
63_N	124_D	0.521	0.47
221_P	225_T	0.519	0.47
136_H	163_T	0.518	0.47
59_A	75_V	0.517	0.46
44_N	48_Y	0.517	0.46
52_P	97_L	0.515	0.46
79_Q	228_A	0.514	0.46
108_E	135_A	0.514	0.46
225_T	229_E	0.513	0.46
165_G	170_I	0.513	0.46
5_H	80_E	0.513	0.46
219_E	229_E	0.511	0.46
43_H	78_G	0.511	0.46
49_K	193_S	0.507	0.45
36_T	229_E	0.505	0.45
193_S	224_L	0.504	0.45
165_G	171_F	0.504	0.45
15_G	42_H	0.504	0.45
222_Y	225_T	0.502	0.45
105_I	125_L	0.501	0.44
195_A	201_R	0.500	0.44
26_A	69_E	0.500	0.44
215_E	220_L	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qy7A	1	0.9724	100	0.399	Contact Map
2wjeA	1	0.9331	100	0.468	Contact Map
4gc3A	1	0.878	100	0.634	Contact Map
2yxoA	3	0.9016	100	0.645	Contact Map
1m65A	3	0.8701	100	0.649	Contact Map
3dcpA	1	0.8228	100	0.661	Contact Map
3b0xA	1	0.8937	100	0.678	Contact Map
2yb1A	1	0.8268	99.9	0.686	Contact Map
2w9mA	1	0.8858	99.9	0.686	Contact Map
2anuA	5	0.7913	99.9	0.707	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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