GREMLIN Database
YWQE - Tyrosine-protein phosphatase YwqE
UniProt: P96717 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (232)
Sequences: 1383 (1179)
Seq/√Len: 77.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_S62_L4.4191.00
154_V189_H4.1161.00
26_A66_L3.5411.00
18_D21_D3.3031.00
36_T74_H2.9361.00
109_F118_A2.8921.00
16_A22_S2.6561.00
105_I130_Y2.6391.00
38_I99_L2.6121.00
65_R68_K2.5141.00
30_V72_P2.5101.00
8_I39_A2.4601.00
36_T76_L2.4361.00
43_H79_Q2.3241.00
30_V73_L2.2951.00
92_A128_K2.2771.00
26_A73_L2.2581.00
26_A37_I2.1871.00
30_V71_I2.1771.00
17_G21_D2.1541.00
19_S65_R2.1221.00
107_I122_F2.0841.00
190_F231_L2.0831.00
65_R69_E2.0141.00
63_N67_I1.9871.00
162_I188_I1.9701.00
59_A63_N1.9591.00
27_R69_E1.9441.00
58_A61_Q1.8981.00
29_A34_I1.8691.00
59_A77_P1.8661.00
4_I38_I1.8391.00
213_E218_S1.7351.00
39_A75_V1.7071.00
119_E152_H1.7051.00
80_E135_A1.6801.00
16_A21_D1.6491.00
32_Q206_Q1.6371.00
55_V77_P1.6091.00
42_H196_H1.5981.00
134_I158_A1.5680.99
159_A190_F1.5650.99
10_P58_A1.5580.99
78_G98_S1.5460.99
160_S188_I1.5440.99
106_L135_A1.5410.99
169_G172_G1.5380.99
25_M195_A1.5130.99
136_H196_H1.4650.99
197_N200_T1.4560.99
222_Y226_E1.4360.99
133_V231_L1.4070.99
229_E233_R1.4040.99
4_I192_A1.4020.99
186_N220_L1.3870.99
9_L58_A1.3860.99
14_D194_D1.3850.99
66_L71_I1.3770.99
6_C195_A1.3750.99
4_I190_F1.3670.99
42_H136_H1.3420.98
123_Y127_L1.3300.98
11_A18_D1.3180.98
12_M55_V1.3120.98
76_L232_L1.3100.98
89_Q93_K1.3050.98
181_R185_A1.2970.98
182_L188_I1.2930.98
42_H194_D1.2840.98
108_E136_H1.2770.98
98_S130_Y1.2740.98
133_V190_F1.2510.97
12_M77_P1.2170.97
28_A31_R1.2020.97
38_I190_F1.2000.97
23_I27_R1.1980.97
154_V187_L1.1960.97
81_I87_V1.1890.96
29_A37_I1.1870.96
205_T209_L1.1770.96
81_I96_L1.1740.96
123_Y126_Q1.1720.96
180_L211_V1.1640.96
30_V35_R1.1630.96
51_E54_A1.1520.96
108_E196_H1.1510.96
218_S222_Y1.1500.96
223_M228_A1.1480.96
42_H80_E1.1480.96
113_H142_E1.1470.96
137_P160_S1.1390.95
91_L130_Y1.1350.95
66_L75_V1.1270.95
34_I193_S1.1270.95
140_N163_T1.1200.95
217_G220_L1.1070.95
124_D127_L1.1040.95
28_A203_F1.1030.95
14_D196_H1.1020.94
162_I179_S1.1000.94
63_N74_H1.0920.94
80_E196_H1.0910.94
38_I100_N1.0850.94
23_I69_E1.0790.94
154_V160_S1.0730.94
118_A153_L1.0720.94
114_V140_N1.0720.94
12_M58_A1.0670.93
171_F201_R1.0660.93
52_P56_R1.0660.93
104_Y132_P1.0630.93
26_A71_I1.0570.93
42_H108_E1.0550.93
82_R163_T1.0540.93
150_L160_S1.0520.93
13_D196_H1.0520.93
212_L224_L1.0460.93
136_H194_D1.0430.93
192_A228_A1.0400.93
119_E156_K1.0380.93
122_F158_A1.0380.93
13_D42_H1.0370.92
178_F182_L1.0350.92
7_H14_D1.0320.92
211_V215_E1.0290.92
144_R178_F1.0290.92
151_Y187_L1.0280.92
160_S189_H1.0270.92
108_E194_D1.0260.92
2_I36_T1.0220.92
5_H42_H1.0190.92
83_I118_A1.0120.92
32_Q204_H1.0080.91
164_S191_V1.0050.91
7_H80_E0.9940.91
144_R175_L0.9890.91
80_E194_D0.9870.91
82_R140_N0.9860.90
7_H13_D0.9730.90
80_E136_H0.9710.90
7_H42_H0.9700.90
63_N75_V0.9660.90
14_D42_H0.9400.88
126_Q156_K0.9350.88
61_Q64_K0.9330.88
104_Y131_I0.9200.87
111_F163_T0.9190.87
41_P55_V0.9090.87
9_L12_M0.9010.86
176_K180_L0.8990.86
103_K131_I0.8970.86
135_A196_H0.8940.86
147_P185_A0.8880.85
5_H14_D0.8840.85
84_Y90_D0.8830.85
5_H15_G0.8820.85
24_E27_R0.8670.84
10_P16_A0.8590.83
83_I109_F0.8480.82
227_N230_L0.8480.82
5_H196_H0.8410.82
42_H139_R0.8410.82
55_V79_Q0.8410.82
79_Q97_L0.8410.82
66_L73_L0.8310.81
54_A58_A0.8300.81
76_L100_N0.8290.81
184_E216_F0.8270.81
5_H13_D0.8200.80
78_G100_N0.8190.80
60_D64_K0.8170.80
143_I178_F0.8160.80
7_H194_D0.8060.79
7_H196_H0.7900.78
191_V224_L0.7900.78
34_I164_S0.7900.78
99_L135_A0.7890.78
25_M197_N0.7870.77
205_T212_L0.7870.77
133_V159_A0.7860.77
135_A194_D0.7820.77
82_R111_F0.7810.77
166_S172_G0.7770.77
180_L216_F0.7740.76
109_F122_F0.7720.76
221_P228_A0.7620.75
64_K68_K0.7590.75
14_D139_R0.7590.75
62_L75_V0.7570.75
27_R31_R0.7550.75
28_A32_Q0.7540.74
163_T201_R0.7450.74
39_A59_A0.7440.73
35_R72_P0.7380.73
213_E221_P0.7350.73
80_E108_E0.7300.72
77_P97_L0.7290.72
81_I130_Y0.7280.72
35_R74_H0.7270.72
80_E139_R0.7240.71
13_D194_D0.7230.71
87_V96_L0.7200.71
191_V209_L0.7180.71
212_L217_G0.7170.71
42_H135_A0.7150.70
16_A25_M0.7150.70
67_I74_H0.7140.70
114_V142_E0.7120.70
23_I71_I0.7100.70
91_L96_L0.7040.69
147_P178_F0.7040.69
217_G221_P0.7010.69
27_R71_I0.6990.69
230_L233_R0.6990.69
139_R196_H0.6990.69
23_I65_R0.6960.68
83_I121_L0.6900.68
209_L212_L0.6890.68
139_R194_D0.6870.67
160_S187_L0.6840.67
61_Q65_R0.6810.67
226_E230_L0.6790.66
66_L69_E0.6780.66
14_D80_E0.6770.66
87_V107_I0.6740.66
25_M29_A0.6690.65
228_A231_L0.6670.65
23_I66_L0.6640.65
43_H50_N0.6620.65
8_I26_A0.6620.65
177_A181_R0.6600.64
24_E198_V0.6580.64
51_E95_Q0.6550.64
169_G176_K0.6530.63
204_H207_E0.6520.63
137_P169_G0.6520.63
15_G136_H0.6520.63
81_I98_S0.6510.63
99_L133_V0.6500.63
119_E153_L0.6470.63
32_Q195_A0.6460.63
136_H139_R0.6440.62
193_S201_R0.6440.62
39_A62_L0.6430.62
23_I62_L0.6420.62
13_D108_E0.6400.62
21_D197_N0.6390.62
220_L223_M0.6390.62
13_D136_H0.6380.62
5_H40_T0.6370.62
208_A211_V0.6320.61
7_H136_H0.6310.61
82_R109_F0.6290.61
216_F224_L0.6270.60
99_L231_L0.6270.60
42_H201_R0.6230.60
104_Y190_F0.6220.60
55_V59_A0.6190.59
212_L221_P0.6170.59
37_I203_F0.6160.59
167_L183_V0.6150.59
5_H136_H0.6100.58
209_L224_L0.6050.58
108_E201_R0.5990.57
208_A212_L0.5990.57
108_E139_R0.5980.57
25_M28_A0.5980.57
13_D80_E0.5970.57
14_D136_H0.5950.56
90_D95_Q0.5940.56
153_L160_S0.5940.56
7_H15_G0.5920.56
21_D198_V0.5900.56
209_L225_T0.5880.56
191_V212_L0.5870.55
151_Y155_E0.5870.55
39_A77_P0.5860.55
120_Q123_Y0.5820.55
114_V163_T0.5810.55
7_H40_T0.5810.55
14_D108_E0.5780.54
194_D201_R0.5760.54
143_I149_L0.5740.54
120_Q124_D0.5740.54
172_G176_K0.5730.54
172_G175_L0.5710.53
162_I167_L0.5710.53
164_S208_A0.5690.53
44_N47_V0.5690.53
137_P171_F0.5690.53
164_S192_A0.5690.53
125_L130_Y0.5650.53
137_P179_S0.5610.52
210_Y213_E0.5590.52
110_P140_N0.5580.52
32_Q201_R0.5560.51
104_Y133_V0.5550.51
22_S233_R0.5550.51
43_H55_V0.5530.51
56_R77_P0.5530.51
209_L221_P0.5490.51
15_G196_H0.5480.50
196_H201_R0.5480.50
109_F142_E0.5480.50
129_G150_L0.5470.50
10_P19_S0.5470.50
51_E55_V0.5460.50
216_F220_L0.5450.50
25_M202_N0.5440.50
180_L215_E0.5430.50
195_A203_F0.5410.50
126_Q132_P0.5380.49
5_H194_D0.5380.49
110_P114_V0.5370.49
59_A71_I0.5350.49
5_H139_R0.5340.49
99_L102_T0.5340.49
6_C37_I0.5340.49
163_T196_H0.5330.49
148_S185_A0.5330.49
98_S101_D0.5320.48
60_D63_N0.5310.48
165_G192_A0.5300.48
225_T228_A0.5240.47
48_Y163_T0.5220.47
63_N124_D0.5210.47
221_P225_T0.5190.47
136_H163_T0.5180.47
59_A75_V0.5170.46
44_N48_Y0.5170.46
52_P97_L0.5150.46
79_Q228_A0.5140.46
108_E135_A0.5140.46
225_T229_E0.5130.46
165_G170_I0.5130.46
5_H80_E0.5130.46
219_E229_E0.5110.46
43_H78_G0.5110.46
49_K193_S0.5070.45
36_T229_E0.5050.45
193_S224_L0.5040.45
165_G171_F0.5040.45
15_G42_H0.5040.45
222_Y225_T0.5020.45
105_I125_L0.5010.44
195_A201_R0.5000.44
26_A69_E0.5000.44
215_E220_L0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qy7A 1 0.9724 100 0.399 Contact Map
2wjeA 1 0.9331 100 0.468 Contact Map
4gc3A 1 0.878 100 0.634 Contact Map
2yxoA 3 0.9016 100 0.645 Contact Map
1m65A 3 0.8701 100 0.649 Contact Map
3dcpA 1 0.8228 100 0.661 Contact Map
3b0xA 1 0.8937 100 0.678 Contact Map
2yb1A 1 0.8268 99.9 0.686 Contact Map
2w9mA 1 0.8858 99.9 0.686 Contact Map
2anuA 5 0.7913 99.9 0.707 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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