GREMLIN Database
YWQD - Tyrosine-protein kinase YwqD
UniProt: P96716 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (185)
Sequences: 14999 (10269)
Seq/√Len: 755.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_D155_Y4.3271.00
186_S216_G4.2851.00
63_A159_I3.7941.00
70_F157_M3.3001.00
75_K157_M3.1801.00
49_M178_A3.0541.00
47_S152_C2.6811.00
49_M162_T2.6031.00
117_A124_D2.5621.00
78_L155_Y2.3481.00
180_G210_L2.2841.00
76_K156_D2.1071.00
71_A123_L2.1061.00
62_T213_I2.0491.00
63_A79_L2.0441.00
145_K177_V2.0341.00
104_V114_A2.0321.00
82_A160_F1.9961.00
75_K156_D1.9811.00
187_S214_M1.9721.00
112_E154_A1.9531.00
110_S113_Q1.9411.00
46_K180_G1.8961.00
50_I66_L1.8621.00
64_A89_V1.8511.00
64_A93_F1.8381.00
79_L89_V1.7591.00
82_A101_L1.7381.00
47_S160_F1.7061.00
109_S114_A1.6821.00
92_A190_T1.6651.00
78_L151_A1.6461.00
80_I160_F1.6111.00
62_T215_N1.6021.00
58_G215_N1.6011.00
214_M228_Y1.5921.00
70_F159_I1.5631.00
183_L198_A1.5631.00
148_A160_F1.5481.00
95_L125_V1.5291.00
199_K203_A1.4761.00
67_A159_I1.4391.00
70_F77_V1.4241.00
182_V213_I1.4211.00
103_S130_P1.4211.00
180_G211_G1.4161.00
64_A92_A1.4091.00
67_A79_L1.3661.00
50_I182_V1.3651.00
100_G129_G1.3611.00
147_L151_A1.3521.00
152_C179_D1.3461.00
65_N68_V1.3371.00
184_V215_N1.3361.00
52_S57_E1.3111.00
60_S89_V1.3091.00
109_S113_Q1.3001.00
114_A126_L1.2961.00
100_G103_S1.2601.00
68_V72_Q1.2591.00
115_V124_D1.2521.00
71_A122_H1.2401.00
50_I63_A1.2371.00
116_Q127_T1.2341.00
52_S59_K1.2031.00
47_S178_A1.2021.00
145_K149_Y1.1941.00
99_V109_S1.1831.00
150_E154_A1.1811.00
104_V147_L1.1621.00
144_M147_L1.1341.00
99_V103_S1.1181.00
76_K154_A1.1181.00
186_S189_K1.1151.00
137_E141_S1.1121.00
93_F123_L1.1111.00
62_T184_V1.1091.00
187_S217_K1.0881.00
54_C57_E1.0631.00
102_T106_L1.0621.00
67_A123_L1.0471.00
146_E150_E1.0471.00
60_S161_D1.0431.00
87_P90_H1.0291.00
90_H127_T1.0221.00
191_E194_Q1.0171.00
59_K83_D1.0111.00
165_I198_A1.0041.00
53_A57_E0.9991.00
202_L207_S0.9941.00
78_L158_V0.9931.00
185_I195_A0.9841.00
180_G208_K0.9791.00
88_T92_A0.9771.00
54_C194_Q0.9681.00
188_G191_E0.9651.00
82_A173_I0.9551.00
143_W146_E0.9501.00
84_L169_A0.9481.00
104_V126_L0.9451.00
221_K224_E0.9441.00
111_M126_L0.9411.00
144_M148_A0.9381.00
84_L102_T0.9351.00
138_L142_K0.9261.00
62_T66_L0.9081.00
53_A183_L0.8981.00
90_H97_N0.8971.00
46_K179_D0.8951.00
89_V125_V0.8951.00
49_M174_L0.8891.00
81_D90_H0.8821.00
89_V92_A0.8791.00
149_Y152_C0.8751.00
111_M115_V0.8741.00
67_A89_V0.8721.00
50_I62_T0.8701.00
99_V114_A0.8651.00
74_G122_H0.8601.00
112_E150_E0.8591.00
138_L141_S0.8581.00
181_S207_S0.8571.00
139_L142_K0.8511.00
82_A144_M0.8491.00
48_V157_M0.8361.00
51_T198_A0.8301.00
160_F178_A0.8271.00
69_V73_Q0.8201.00
47_S148_A0.8161.00
115_V155_Y0.8161.00
103_S108_K0.8131.00
120_E123_L0.8121.00
185_I212_A0.8081.00
46_K152_C0.8001.00
68_V123_L0.7971.00
111_M114_A0.7951.00
68_V120_E0.7931.00
115_V126_L0.7901.00
181_S202_L0.7861.00
175_G207_S0.7801.00
124_D127_T0.7791.00
51_T170_D0.7791.00
162_T173_I0.7781.00
147_L150_E0.7771.00
110_S150_E0.7691.00
78_L115_V0.7631.00
137_E140_S0.7631.00
81_D87_P0.7631.00
77_V156_D0.7621.00
146_E149_Y0.7601.00
118_S121_K0.7591.00
76_K124_D0.7591.00
183_L209_L0.7561.00
69_V72_Q0.7561.00
83_D86_K0.7551.00
47_S158_V0.7531.00
222_H226_G0.7521.00
112_E116_Q0.7501.00
101_L126_L0.7481.00
51_T181_S0.7481.00
77_V159_I0.7471.00
49_M181_S0.7431.00
126_L147_L0.7381.00
151_A154_A0.7321.00
99_V113_Q0.7251.00
200_E203_A0.7231.00
111_M150_E0.7211.00
101_L104_V0.7211.00
77_V157_M0.7201.00
113_Q116_Q0.7131.00
162_T174_L0.7091.00
197_K200_E0.7081.00
88_T190_T0.7051.00
48_V159_I0.7041.00
222_H225_Y0.7041.00
83_D164_P0.7031.00
55_P167_A0.6981.00
79_L123_L0.6981.00
51_T162_T0.6931.00
115_V118_S0.6911.00
60_S88_T0.6901.00
85_R170_D0.6881.00
196_A200_E0.6861.00
80_I158_V0.6791.00
200_E204_T0.6771.00
214_M217_K0.6771.00
53_A198_A0.6751.00
169_A173_I0.6741.00
172_Q175_G0.6711.00
119_N122_H0.6671.00
71_A77_V0.6651.00
47_S179_D0.6631.00
103_S106_L0.6611.00
134_N137_E0.6591.00
76_K122_H0.6531.00
190_T195_A0.6461.00
77_V123_L0.6451.00
91_T193_E0.6441.00
88_T91_T0.6441.00
89_V93_F0.6401.00
79_L159_I0.6401.00
102_T138_L0.6391.00
180_G209_L0.6371.00
142_K146_E0.6341.00
186_S190_T0.6281.00
78_L126_L0.6271.00
58_G161_D0.6221.00
198_A202_L0.6211.00
118_S125_V0.6201.00
223_S227_Y0.6181.00
142_K145_K0.6091.00
59_K161_D0.6081.00
70_F73_Q0.6081.00
104_V111_M0.6011.00
219_L222_H0.5981.00
155_Y158_V0.5931.00
68_V71_A0.5931.00
57_E190_T0.5921.00
166_L194_Q0.5891.00
114_A118_S0.5891.00
152_C158_V0.5881.00
64_A79_L0.5861.00
93_F125_V0.5851.00
185_I214_M0.5841.00
187_S224_E0.5831.00
53_A201_A0.5831.00
66_L182_V0.5831.00
104_V107_K0.5811.00
76_K155_Y0.5811.00
54_C190_T0.5781.00
192_K196_A0.5771.00
137_E142_K0.5761.00
55_P86_K0.5751.00
46_K210_L0.5711.00
148_A177_V0.5691.00
50_I159_I0.5691.00
88_T194_Q0.5681.00
102_T134_N0.5661.00
65_N69_V0.5611.00
144_M174_L0.5601.00
148_A151_A0.5581.00
169_A172_Q0.5521.00
131_I134_N0.5501.00
103_S107_K0.5491.00
87_P128_S0.5471.00
45_M179_D0.5451.00
115_V151_A0.5441.00
132_P135_P0.5431.00
201_A204_T0.5431.00
172_Q201_A0.5421.00
45_M158_V0.5411.00
137_E168_V0.5401.00
53_A166_L0.5381.00
171_A201_A0.5381.00
102_T129_G0.5371.00
111_M151_A0.5361.00
183_L199_K0.5341.00
196_A199_K0.5321.00
60_S64_A0.5311.00
111_M154_A0.5261.00
195_A199_K0.5261.00
124_D154_A0.5251.00
168_V171_A0.5241.00
48_V180_G0.5211.00
136_A167_A0.5211.00
116_Q125_V0.5191.00
81_D89_V0.5161.00
78_L124_D0.5151.00
162_T170_D0.5121.00
53_A190_T0.5101.00
150_E153_A0.5091.00
225_Y228_Y0.5091.00
99_V116_Q0.5081.00
56_G86_K0.5081.00
141_S144_M0.5071.00
91_T189_K0.5031.00
87_P131_I0.5021.00
57_E87_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cioA 2 0.9747 100 0.179 Contact Map
3la6A 4 0.9789 100 0.179 Contact Map
4jlvA 1 0.8608 100 0.202 Contact Map
4jmpA 1 0.8861 100 0.203 Contact Map
4rz3A 2 0.8101 100 0.324 Contact Map
4pfsA 1 0.8059 100 0.336 Contact Map
3pg5A 2 0.7848 100 0.337 Contact Map
1g3qA 1 0.8017 100 0.357 Contact Map
3ea0A 2 0.8186 100 0.359 Contact Map
1wcv1 2 0.789 100 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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