GREMLIN Database
BMR3 - Multidrug resistance protein 3
UniProt: P96712 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 512 (417)
Sequences: 32815 (23009)
Seq/√Len: 1126.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_Q102_Q5.2621.00
88_L176_G4.4941.00
86_F113_G3.8371.00
95_G170_Y3.6621.00
93_L106_F3.3151.00
209_S242_F3.1241.00
205_T248_V3.0301.00
101_N105_I2.9391.00
386_L394_A2.8811.00
347_L363_F2.8661.00
76_R127_D2.7511.00
260_W390_F2.7051.00
99_T102_Q2.6911.00
55_S108_A2.6761.00
11_T133_K2.6531.00
317_G369_F2.5151.00
216_A235_F2.4731.00
208_V241_F2.4611.00
201_G248_V2.4151.00
313_G365_M2.4141.00
81_L184_I2.3221.00
299_S302_S2.2391.00
213_L238_F2.2201.00
199_D202_G2.2051.00
90_G113_G2.1821.00
94_C106_F2.1761.00
63_G112_I2.1711.00
59_A108_A2.1491.00
181_F185_R2.1161.00
243_I247_I2.1011.00
163_I167_W2.0981.00
81_L180_L2.0981.00
387_E390_F2.0711.00
133_K136_K2.0181.00
258_S390_F2.0141.00
279_G409_G2.0141.00
45_S48_K2.0051.00
90_G109_I1.9921.00
275_F405_G1.9871.00
344_G367_S1.9811.00
159_I167_W1.9551.00
102_Q106_F1.9161.00
183_I187_Y1.8731.00
232_I236_I1.8511.00
35_A160_T1.8381.00
67_Y116_A1.8341.00
164_S167_W1.8331.00
19_L144_V1.8121.00
283_I413_F1.7901.00
293_Q303_A1.7781.00
21_G80_F1.7721.00
90_G106_F1.7721.00
252_A255_P1.7681.00
83_G116_A1.7671.00
100_M104_I1.7111.00
209_S238_F1.7001.00
282_I406_M1.6831.00
212_C234_L1.6811.00
48_K100_M1.6731.00
129_F137_M1.6701.00
94_C103_L1.6691.00
323_I327_K1.6611.00
291_F296_Y1.6501.00
72_D392_G1.6451.00
92_A96_I1.6421.00
77_K81_L1.6281.00
356_A359_W1.5921.00
55_S104_I1.5901.00
161_D301_T1.5881.00
248_V252_A1.5691.00
197_K254_E1.5451.00
92_A173_V1.5421.00
209_S241_F1.5401.00
14_V128_L1.5391.00
38_N41_A1.5311.00
91_S172_N1.5251.00
135_G326_T1.5171.00
23_L148_S1.5131.00
71_S76_R1.5111.00
62_A207_V1.4971.00
233_G237_V1.4951.00
298_S306_I1.4881.00
212_C241_F1.4801.00
130_P133_K1.4791.00
337_S373_F1.4791.00
131_P134_R1.4781.00
229_I233_G1.4761.00
81_L183_I1.4731.00
97_A102_Q1.4531.00
97_A106_F1.4471.00
212_C237_V1.4441.00
340_A370_G1.4411.00
250_R260_W1.4401.00
342_F346_L1.4351.00
246_F250_R1.4321.00
247_I251_K1.4301.00
52_V103_L1.4261.00
270_A382_S1.4231.00
28_D31_I1.4221.00
219_L224_Y1.4201.00
69_K73_M1.4191.00
85_I180_L1.4191.00
344_G370_G1.4111.00
302_S305_F1.4111.00
245_F249_E1.4071.00
358_V362_V1.4061.00
35_A168_V1.4021.00
268_A272_I1.3991.00
70_L79_F1.3981.00
126_F134_R1.3981.00
344_G363_F1.3971.00
262_F268_A1.3931.00
332_N335_L1.3881.00
40_V49_F1.3871.00
200_W204_I1.3841.00
56_Y114_G1.3821.00
71_S120_I1.3811.00
216_A238_F1.3771.00
12_K16_L1.3561.00
205_T241_F1.3551.00
313_G317_G1.3541.00
182_F186_Y1.3421.00
215_F219_L1.3341.00
82_F86_F1.3331.00
78_R189_E1.3301.00
15_V129_F1.3281.00
298_S302_S1.3021.00
158_I162_S1.2981.00
420_V424_K1.2961.00
357_R361_T1.2961.00
11_T129_F1.2931.00
93_L102_Q1.2841.00
101_N104_I1.2821.00
17_G179_S1.2741.00
88_L180_L1.2731.00
31_I168_V1.2671.00
192_E195_K1.2641.00
63_G115_G1.2641.00
322_G326_T1.2631.00
17_G186_Y1.2511.00
310_M368_G1.2451.00
19_L140_M1.2431.00
17_G182_F1.2391.00
167_W174_P1.2251.00
339_I343_I1.2181.00
202_G248_V1.2141.00
331_R335_L1.2091.00
247_I250_R1.2081.00
246_F259_F1.2021.00
161_D299_S1.1951.00
238_F242_F1.1921.00
237_V241_F1.1891.00
59_A111_G1.1851.00
205_T244_A1.1831.00
323_I326_T1.1801.00
337_S374_N1.1701.00
98_Q101_N1.1671.00
26_A145_F1.1641.00
292_V360_L1.1621.00
265_R269_T1.1581.00
329_S332_N1.1541.00
89_I93_L1.1531.00
271_Q401_L1.1441.00
344_G366_I1.1431.00
341_F370_G1.1391.00
292_V306_I1.1381.00
420_V423_N1.1371.00
216_A231_I1.1341.00
177_A181_F1.1281.00
302_S306_I1.1261.00
258_S393_T1.1201.00
77_K184_I1.1171.00
96_I170_Y1.1171.00
81_L85_I1.1161.00
317_G372_G1.1141.00
88_L173_V1.1121.00
80_F183_I1.1051.00
28_D172_N1.0991.00
224_Y230_Q1.0961.00
20_L179_S1.0961.00
264_N268_A1.0911.00
321_G373_F1.0911.00
132_E136_K1.0851.00
66_I203_A1.0831.00
332_N336_I1.0821.00
358_V361_T1.0811.00
208_V212_C1.0791.00
267_F271_Q1.0721.00
31_I156_G1.0721.00
125_I141_F1.0711.00
126_F391_R1.0701.00
94_C169_F1.0691.00
362_V365_M1.0621.00
157_A300_A1.0601.00
324_F328_A1.0601.00
202_G252_A1.0601.00
29_N57_M1.0581.00
75_G78_R1.0561.00
336_I373_F1.0541.00
244_A247_I1.0471.00
277_Y374_N1.0451.00
70_L74_Y1.0431.00
224_Y228_S1.0431.00
88_L92_A1.0421.00
84_L179_S1.0371.00
224_Y231_I1.0291.00
24_M176_G1.0271.00
306_I357_R1.0241.00
260_W263_K1.0211.00
86_F90_G1.0211.00
346_L350_N1.0161.00
346_L349_S1.0151.00
405_G409_G1.0141.00
347_L350_N1.0121.00
51_W55_S1.0101.00
68_G72_D1.0071.00
257_I397_T1.0071.00
159_I163_I1.0051.00
78_R82_F1.0021.00
242_F246_F1.0021.00
221_G226_W1.0011.00
267_F394_A0.9991.00
235_F239_A0.9931.00
337_S370_G0.9891.00
13_F186_Y0.9861.00
191_L194_R0.9851.00
424_K428_A0.9811.00
72_D76_R0.9791.00
216_A234_L0.9771.00
166_H170_Y0.9741.00
76_R189_E0.9741.00
38_N42_D0.9731.00
350_N363_F0.9721.00
55_S59_A0.9711.00
18_L121_A0.9701.00
102_Q105_I0.9691.00
79_F116_A0.9681.00
359_W363_F0.9671.00
189_E192_E0.9591.00
320_I323_I0.9591.00
382_S398_N0.9591.00
59_A63_G0.9561.00
424_K427_D0.9521.00
204_I208_V0.9501.00
264_N390_F0.9491.00
219_L223_T0.9481.00
317_G321_G0.9481.00
264_N387_E0.9451.00
185_R188_K0.9441.00
310_M367_S0.9381.00
239_A243_I0.9361.00
275_F401_L0.9361.00
287_F414_G0.9331.00
93_L96_I0.9321.00
54_A218_E0.9271.00
173_V177_A0.9261.00
182_F185_R0.9251.00
352_T355_T0.9221.00
155_L158_I0.9171.00
271_Q397_T0.9091.00
198_I203_A0.9091.00
180_L184_I0.9081.00
135_G322_G0.9061.00
265_R268_A0.9041.00
336_I340_A0.9021.00
158_I301_T0.8981.00
317_G320_I0.8961.00
359_W362_V0.8961.00
105_I108_A0.8951.00
82_F85_I0.8931.00
317_G373_F0.8921.00
244_A248_V0.8911.00
293_Q300_A0.8911.00
96_I106_F0.8911.00
214_M407_T0.8901.00
230_Q234_L0.8871.00
159_I171_I0.8861.00
52_V100_M0.8851.00
25_S117_L0.8841.00
53_T286_V0.8831.00
361_T365_M0.8831.00
203_A207_V0.8821.00
98_Q106_F0.8781.00
79_F82_F0.8761.00
39_I103_L0.8731.00
227_N232_I0.8711.00
135_G139_G0.8701.00
226_W231_I0.8691.00
72_D393_T0.8681.00
250_R259_F0.8671.00
274_A398_N0.8651.00
83_G113_G0.8631.00
127_D391_R0.8621.00
230_Q233_G0.8611.00
416_V420_V0.8611.00
196_Q254_E0.8601.00
362_V366_I0.8601.00
162_S301_T0.8551.00
248_V251_K0.8531.00
338_V374_N0.8501.00
292_V296_Y0.8481.00
266_L385_D0.8481.00
105_I109_I0.8471.00
335_L339_I0.8471.00
121_A141_F0.8471.00
312_I316_I0.8441.00
319_M323_I0.8441.00
240_V244_A0.8441.00
222_K225_D0.8371.00
355_T359_W0.8331.00
62_A211_V0.8301.00
32_V52_V0.8251.00
48_K101_N0.8191.00
174_P177_A0.8181.00
33_A53_T0.8181.00
181_F184_I0.8161.00
74_Y79_F0.8151.00
207_V211_V0.8141.00
208_V237_V0.8131.00
76_R123_T0.8111.00
345_M367_S0.8101.00
351_M363_F0.8091.00
264_N385_D0.8041.00
292_V298_S0.8031.00
243_I246_F0.8031.00
167_W170_Y0.8031.00
324_F333_L0.8031.00
36_M49_F0.8011.00
98_Q166_H0.7991.00
197_K253_E0.7981.00
338_V342_F0.7981.00
305_F309_P0.7961.00
210_I400_F0.7951.00
84_L180_L0.7911.00
78_R81_L0.7911.00
90_G93_L0.7901.00
39_I49_F0.7891.00
321_G372_G0.7851.00
123_T392_G0.7851.00
231_I234_L0.7841.00
351_M355_T0.7831.00
212_C238_F0.7801.00
340_A366_I0.7761.00
27_M31_I0.7741.00
65_P206_L0.7731.00
26_A148_S0.7721.00
174_P178_L0.7641.00
125_I137_M0.7621.00
215_F234_L0.7611.00
325_Q377_L0.7611.00
228_S231_I0.7601.00
333_L336_I0.7601.00
124_I128_L0.7591.00
71_S123_T0.7571.00
209_S246_F0.7541.00
22_I145_F0.7501.00
353_P356_A0.7501.00
345_M349_S0.7491.00
328_A333_L0.7491.00
21_G84_L0.7471.00
17_G183_I0.7441.00
290_I294_A0.7441.00
289_P303_A0.7431.00
316_I319_M0.7421.00
328_A332_N0.7401.00
122_F141_F0.7401.00
329_S333_L0.7401.00
263_K268_A0.7391.00
143_A147_L0.7391.00
161_D300_A0.7351.00
157_A304_G0.7351.00
339_I342_F0.7331.00
35_A39_I0.7331.00
306_I309_P0.7331.00
59_A112_I0.7311.00
399_S402_R0.7311.00
379_P398_N0.7291.00
201_G205_T0.7251.00
330_F381_A0.7251.00
152_G156_G0.7241.00
12_K129_F0.7211.00
228_S232_I0.7201.00
61_M407_T0.7201.00
425_L428_A0.7181.00
273_L338_V0.7181.00
239_A242_F0.7171.00
286_V410_V0.7171.00
203_A256_I0.7171.00
288_I364_M0.7141.00
237_V244_A0.7141.00
267_F382_S0.7141.00
309_P313_G0.7131.00
93_L109_I0.7131.00
85_I89_I0.7131.00
423_N427_D0.7121.00
91_S110_Q0.7101.00
236_I240_V0.7081.00
325_Q380_A0.7081.00
39_I43_L0.7071.00
88_L177_A0.7071.00
313_G369_F0.7071.00
227_N230_Q0.7061.00
94_C97_A0.7051.00
126_F138_S0.7051.00
383_M395_N0.7041.00
343_I347_L0.7021.00
43_L100_M0.7021.00
298_S357_R0.7011.00
42_D166_H0.6991.00
68_G396_S0.6981.00
349_S352_T0.6971.00
60_V403_S0.6961.00
198_I202_G0.6961.00
156_G160_T0.6951.00
206_L256_I0.6951.00
201_G204_I0.6931.00
36_M53_T0.6921.00
208_V211_V0.6901.00
335_L342_F0.6891.00
136_K323_I0.6881.00
271_Q398_N0.6861.00
373_F377_L0.6851.00
421_F425_L0.6841.00
150_V311_M0.6831.00
57_M406_M0.6821.00
250_R263_K0.6801.00
107_R110_Q0.6791.00
412_I415_T0.6771.00
21_G117_L0.6761.00
145_F149_S0.6761.00
138_S142_G0.6741.00
235_F238_F0.6731.00
92_A170_Y0.6731.00
228_S233_G0.6721.00
306_I361_T0.6711.00
380_A384_N0.6691.00
336_I339_I0.6691.00
273_L378_L0.6681.00
139_G143_A0.6681.00
202_G249_E0.6671.00
14_V17_G0.6661.00
106_F109_I0.6651.00
210_I404_F0.6651.00
63_G66_I0.6651.00
233_G236_I0.6651.00
146_G314_S0.6631.00
77_K189_E0.6631.00
72_D75_G0.6621.00
148_S153_P0.6621.00
190_S195_K0.6591.00
201_G252_A0.6581.00
422_T426_N0.6541.00
23_L144_V0.6541.00
343_I346_L0.6531.00
136_K140_M0.6521.00
67_Y119_P0.6521.00
153_P304_G0.6501.00
178_L182_F0.6461.00
190_S193_H0.6461.00
350_N359_W0.6451.00
266_L381_A0.6431.00
341_F344_G0.6421.00
67_Y83_G0.6421.00
209_S212_C0.6411.00
49_F52_V0.6401.00
245_F257_I0.6391.00
18_L128_L0.6381.00
40_V45_S0.6371.00
189_E193_H0.6361.00
57_M407_T0.6331.00
60_V114_G0.6321.00
62_A203_A0.6281.00
396_S400_F0.6281.00
77_K188_K0.6271.00
170_Y174_P0.6271.00
206_L210_I0.6251.00
87_F113_G0.6241.00
305_F308_T0.6241.00
275_F408_L0.6221.00
80_F124_I0.6211.00
28_D107_R0.6211.00
151_L154_L0.6201.00
241_F244_A0.6201.00
287_F417_Q0.6201.00
205_T245_F0.6191.00
41_A44_G0.6171.00
347_L359_W0.6171.00
266_L270_A0.6161.00
42_D165_W0.6151.00
320_I324_F0.6141.00
134_R384_N0.6131.00
348_L351_M0.6131.00
61_M404_F0.6121.00
310_M364_M0.6121.00
284_L367_S0.6121.00
266_L269_T0.6111.00
325_Q329_S0.6101.00
229_I232_I0.6091.00
132_E326_T0.6071.00
95_G166_H0.6021.00
410_V414_G0.6011.00
39_I42_D0.6001.00
84_L176_G0.5991.00
225_D228_S0.5991.00
76_R190_S0.5971.00
71_S392_G0.5961.00
147_L151_L0.5951.00
337_S377_L0.5941.00
59_A113_G0.5921.00
148_S152_G0.5911.00
144_V148_S0.5901.00
333_L373_F0.5881.00
51_W58_V0.5881.00
219_L231_I0.5871.00
128_L188_K0.5831.00
340_A369_F0.5831.00
391_R395_N0.5811.00
123_T395_N0.5791.00
30_T149_S0.5791.00
281_F371_V0.5781.00
268_A271_Q0.5771.00
136_K326_T0.5771.00
365_M369_F0.5761.00
206_L245_F0.5761.00
61_M403_S0.5751.00
368_G372_G0.5741.00
24_M84_L0.5741.00
49_F290_I0.5721.00
226_W232_I0.5691.00
132_E135_G0.5661.00
24_M172_N0.5651.00
86_F112_I0.5641.00
282_I285_A0.5631.00
64_M119_P0.5631.00
56_Y107_R0.5631.00
12_K136_K0.5621.00
335_L338_V0.5611.00
160_T168_V0.5611.00
28_D171_I0.5601.00
318_S322_G0.5601.00
68_G392_G0.5591.00
160_T163_I0.5581.00
301_T305_F0.5561.00
222_K226_W0.5551.00
262_F267_F0.5551.00
274_A378_L0.5541.00
94_C110_Q0.5541.00
138_S380_A0.5531.00
170_Y173_V0.5521.00
158_I163_I0.5501.00
221_G224_Y0.5491.00
129_F133_K0.5481.00
219_L230_Q0.5471.00
291_F295_V0.5471.00
415_T419_N0.5471.00
299_S303_A0.5441.00
76_R124_I0.5431.00
74_Y198_I0.5431.00
215_F230_Q0.5421.00
250_R253_E0.5411.00
15_V137_M0.5401.00
172_N176_G0.5401.00
32_V94_C0.5401.00
154_L305_F0.5391.00
69_K254_E0.5391.00
288_I292_V0.5391.00
119_P122_F0.5381.00
249_E252_A0.5381.00
411_T415_T0.5371.00
184_I188_K0.5361.00
80_F121_A0.5321.00
154_L308_T0.5321.00
62_A115_G0.5321.00
49_F100_M0.5321.00
205_T209_S0.5311.00
221_G225_D0.5311.00
13_F17_G0.5311.00
314_S318_S0.5301.00
142_G146_G0.5301.00
334_M378_L0.5301.00
64_M399_S0.5291.00
209_S243_I0.5281.00
39_I160_T0.5281.00
68_G120_I0.5271.00
73_M197_K0.5271.00
348_L364_M0.5271.00
181_F186_Y0.5251.00
361_T364_M0.5251.00
73_M195_K0.5251.00
74_Y78_R0.5241.00
278_G402_R0.5241.00
96_I102_Q0.5221.00
383_M391_R0.5211.00
191_L195_K0.5211.00
30_T152_G0.5211.00
126_F383_M0.5201.00
124_I187_Y0.5191.00
151_L155_L0.5181.00
200_W203_A0.5171.00
28_D91_S0.5161.00
219_L222_K0.5151.00
277_Y281_F0.5151.00
24_M28_D0.5151.00
15_V125_I0.5151.00
160_T164_S0.5141.00
97_A103_L0.5141.00
272_I276_L0.5131.00
315_V318_S0.5131.00
379_P383_M0.5131.00
13_F16_L0.5121.00
407_T411_T0.5121.00
127_D190_S0.5121.00
337_S344_G0.5111.00
28_D87_F0.5101.00
22_I121_A0.5101.00
324_F327_K0.5081.00
308_T311_M0.5071.00
388_P391_R0.5051.00
415_T418_T0.5051.00
236_I239_A0.5051.00
354_D357_R0.5031.00
52_V55_S0.5031.00
284_L345_M0.5021.00
238_F243_I0.5021.00
38_N293_Q0.5001.00
90_G110_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8066 100 0.44 Contact Map
4j05A 3 0.7383 100 0.472 Contact Map
4pypA 1 0.8066 100 0.478 Contact Map
3wdoA 1 0.7793 100 0.479 Contact Map
2gfpA 2 0.7305 100 0.481 Contact Map
4gc0A 1 0.8457 100 0.491 Contact Map
4zw9A 1 0.8496 100 0.499 Contact Map
4xnjA 1 0.8438 100 0.501 Contact Map
4tphA 2 0.8223 100 0.501 Contact Map
3o7qA 1 0.748 100 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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