GREMLIN Database
ARAR - Arabinose metabolism transcriptional repressor
UniProt: P96711 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (321)
Sequences: 31954 (23812)
Seq/√Len: 1329.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_V224_Q3.4461.00
201_H267_T3.3561.00
290_K293_E3.2121.00
192_A298_V2.8491.00
201_H296_S2.6641.00
302_D317_K2.6001.00
219_M223_I2.5991.00
179_P334_C2.5201.00
190_M228_E2.4311.00
138_G331_V2.4281.00
54_Q58_Y2.3371.00
251_L286_E2.2651.00
255_K287_M2.2071.00
58_Y62_G2.1751.00
104_Y107_E2.1521.00
104_Y329_K2.1371.00
197_L229_R2.1341.00
47_A60_V2.1051.00
326_A329_K2.0791.00
57_L61_Q2.0371.00
187_K191_M2.0331.00
255_K283_M2.0291.00
194_E225_A2.0141.00
48_I64_G2.0031.00
105_L328_A1.9971.00
190_M224_Q1.9931.00
199_L357_A1.9851.00
194_E198_S1.9801.00
190_M225_A1.9711.00
100_G324_G1.9651.00
189_G193_A1.9451.00
284_L295_M1.9361.00
31_N41_R1.9301.00
250_L279_K1.9061.00
186_V220_N1.8771.00
189_G270_L1.8721.00
188_G300_Y1.8681.00
317_K350_E1.8611.00
259_E287_M1.8421.00
194_E229_R1.8051.00
36_Q63_G1.7971.00
193_A222_F1.7941.00
37_F63_G1.7791.00
104_Y325_K1.7791.00
326_A345_V1.7551.00
285_R310_E1.7491.00
312_K355_Q1.7241.00
251_L283_M1.7211.00
190_M194_E1.7151.00
254_V280_V1.7061.00
196_L268_A1.7061.00
206_G272_Y1.7051.00
103_S321_S1.7011.00
333_D338_K1.6961.00
191_M349_P1.6961.00
100_G321_S1.6741.00
319_P322_V1.6711.00
289_L294_D1.6541.00
271_C280_V1.6491.00
33_L63_G1.6461.00
290_K294_D1.6381.00
83_G136_I1.6361.00
47_A64_G1.5981.00
283_M287_M1.5911.00
205_M266_P1.5751.00
169_I327_A1.5421.00
104_Y108_Q1.5161.00
61_Q64_G1.5151.00
239_V256_A1.5101.00
184_D187_K1.5101.00
322_V326_A1.4861.00
220_N224_Q1.4781.00
197_L225_A1.4781.00
188_G349_P1.4771.00
283_M286_E1.4691.00
298_V314_T1.4661.00
302_D354_R1.4641.00
195_H353_I1.4611.00
203_H265_M1.4371.00
108_Q332_I1.4311.00
203_H234_S1.4241.00
80_K137_D1.4091.00
187_K190_M1.4021.00
82_I105_L1.3811.00
322_V325_K1.3801.00
284_L289_L1.3751.00
217_K220_N1.3711.00
193_A221_G1.3701.00
33_L37_F1.3661.00
195_H199_L1.3601.00
195_H198_S1.3591.00
31_N35_Q1.3581.00
104_Y328_A1.3521.00
46_K51_L1.3401.00
195_H357_A1.3391.00
254_V269_I1.3331.00
32_E35_Q1.3321.00
223_I227_R1.3311.00
80_K110_Y1.3301.00
193_A225_A1.3281.00
189_G221_G1.3261.00
234_S237_M1.3251.00
225_A228_E1.3091.00
59_S63_G1.3061.00
194_E228_E1.3001.00
255_K286_E1.2991.00
193_A197_L1.2981.00
53_S56_L1.2911.00
255_K259_E1.2861.00
201_H268_A1.2861.00
54_Q57_L1.2781.00
30_E41_R1.2751.00
329_K333_D1.2701.00
254_V284_L1.2631.00
251_L255_K1.2601.00
205_M257_T1.2581.00
221_G225_A1.2371.00
281_I297_I1.2331.00
105_L112_M1.2301.00
203_H267_T1.2201.00
296_S357_A1.2001.00
115_T127_G1.1991.00
251_L282_D1.1991.00
47_A52_V1.1981.00
101_I140_I1.1971.00
191_M194_E1.1951.00
186_V217_K1.1891.00
84_V101_I1.1861.00
256_A260_K1.1841.00
56_L59_S1.1831.00
140_I327_A1.1701.00
50_D57_L1.1691.00
263_K266_P1.1661.00
157_L161_K1.1661.00
186_V190_M1.1651.00
274_D315_S1.1611.00
332_I336_E1.1591.00
207_I280_V1.1561.00
115_T131_L1.1511.00
83_G131_L1.1501.00
204_M226_H1.1471.00
321_S325_K1.1411.00
101_I328_A1.1391.00
279_K283_M1.1261.00
222_F226_H1.1211.00
269_I280_V1.1171.00
330_Y345_V1.1121.00
84_V112_M1.1071.00
198_S229_R1.1031.00
30_E44_I1.1021.00
106_S123_N1.0991.00
224_Q228_E1.0841.00
253_K256_A1.0781.00
108_Q329_K1.0781.00
203_H264_H1.0761.00
324_G328_A1.0761.00
225_A229_R1.0741.00
108_Q336_E1.0711.00
226_H231_L1.0651.00
102_E106_S1.0561.00
271_C277_A1.0561.00
326_A330_Y1.0551.00
274_D299_G1.0551.00
206_G219_M1.0431.00
186_V221_G1.0381.00
199_L353_I1.0381.00
202_T267_T1.0321.00
69_S72_A1.0301.00
325_K329_K1.0261.00
125_R129_E1.0181.00
58_Y61_Q1.0161.00
242_T249_K1.0111.00
197_L231_L1.0111.00
37_F44_I1.0091.00
71_S74_S1.0081.00
317_K352_I1.0061.00
81_T113_L1.0051.00
220_N223_I1.0021.00
281_I291_V1.0011.00
331_V335_L1.0011.00
326_A347_F0.9991.00
250_L254_V0.9971.00
192_A270_L0.9961.00
187_K348_E0.9901.00
50_D61_Q0.9851.00
180_S344_D0.9781.00
204_M268_A0.9681.00
271_C276_I0.9661.00
123_N126_R0.9651.00
216_V220_N0.9621.00
211_D240_T0.9601.00
199_L296_S0.9591.00
203_H237_M0.9581.00
84_V98_I0.9581.00
223_I233_P0.9571.00
110_Y332_I0.9541.00
222_F270_L0.9511.00
197_L202_T0.9501.00
183_L319_P0.9491.00
129_E158_N0.9471.00
193_A226_H0.9461.00
260_K263_K0.9451.00
252_E256_A0.9381.00
281_I309_S0.9321.00
202_T231_L0.9271.00
107_E325_K0.9241.00
129_E133_S0.9231.00
350_E353_I0.9221.00
319_P347_F0.9191.00
254_V258_L0.9171.00
192_A316_V0.9171.00
47_A61_Q0.9151.00
187_K349_P0.9071.00
68_A73_K0.9021.00
269_I295_M0.8971.00
81_T111_S0.8941.00
29_T32_E0.8921.00
195_H314_T0.8911.00
179_P330_Y0.8911.00
184_D346_I0.8891.00
182_T346_I0.8861.00
99_R103_S0.8831.00
328_A332_I0.8811.00
299_G315_S0.8791.00
179_P343_E0.8791.00
140_I331_V0.8771.00
103_S325_K0.8771.00
213_T217_K0.8751.00
319_P350_E0.8751.00
182_T344_D0.8751.00
82_I140_I0.8741.00
183_L349_P0.8711.00
101_I324_G0.8691.00
246_K252_E0.8671.00
249_K252_E0.8621.00
184_D348_E0.8621.00
181_F330_Y0.8561.00
79_N137_D0.8551.00
239_V253_K0.8511.00
330_Y333_D0.8501.00
244_E249_K0.8461.00
289_L295_M0.8421.00
353_I357_A0.8371.00
258_L283_M0.8351.00
205_M269_I0.8311.00
183_L318_H0.8291.00
302_D352_I0.8271.00
196_L298_V0.8251.00
185_D218_R0.8191.00
43_T46_K0.8191.00
239_V260_K0.8171.00
265_M289_L0.8101.00
226_H233_P0.8081.00
237_M260_K0.8061.00
274_D302_D0.8041.00
39_V60_V0.8031.00
55_G58_Y0.8031.00
217_K221_G0.8021.00
254_V283_M0.8021.00
42_H46_K0.7981.00
195_H351_L0.7971.00
97_I169_I0.7961.00
209_K243_T0.7911.00
302_D306_A0.7861.00
78_S137_D0.7851.00
206_G270_L0.7851.00
191_M316_V0.7851.00
233_P236_D0.7831.00
270_L298_V0.7821.00
258_L287_M0.7801.00
224_Q227_R0.7781.00
284_L297_I0.7751.00
252_E255_K0.7731.00
100_G104_Y0.7731.00
78_S336_E0.7731.00
254_V257_T0.7681.00
301_D318_H0.7661.00
120_N123_N0.7651.00
96_S321_S0.7651.00
274_D277_A0.7641.00
93_I320_K0.7601.00
278_L309_S0.7591.00
47_A57_L0.7591.00
314_T357_A0.7571.00
267_T296_S0.7561.00
138_G335_L0.7541.00
314_T351_L0.7531.00
208_F219_M0.7531.00
67_V133_S0.7501.00
207_I271_C0.7481.00
219_M238_I0.7461.00
83_G139_L0.7451.00
282_D312_K0.7391.00
70_R73_K0.7391.00
82_I328_A0.7381.00
28_P63_G0.7381.00
55_G59_S0.7371.00
158_N161_K0.7301.00
81_T134_Q0.7301.00
284_L291_V0.7291.00
102_E112_M0.7281.00
239_V257_T0.7251.00
249_K253_K0.7241.00
212_D216_V0.7231.00
132_L162_N0.7201.00
126_R129_E0.7181.00
204_M267_T0.7171.00
100_G325_K0.7141.00
197_L226_H0.7131.00
87_T94_F0.7111.00
282_D310_E0.7111.00
256_A259_E0.7081.00
241_F276_I0.7061.00
103_S107_E0.7051.00
219_M240_T0.7041.00
309_S312_K0.7031.00
333_D337_H0.7031.00
101_I112_M0.7011.00
168_M173_Y0.6991.00
98_I114_L0.6901.00
172_S344_D0.6891.00
282_D285_R0.6881.00
260_K264_H0.6841.00
52_V57_L0.6841.00
282_D286_E0.6801.00
222_F233_P0.6771.00
250_L253_K0.6731.00
28_P65_T0.6701.00
260_K266_P0.6701.00
138_G167_A0.6691.00
160_E178_A0.6661.00
160_E166_F0.6651.00
260_K265_M0.6651.00
206_G222_F0.6631.00
99_R102_E0.6601.00
122_D126_R0.6581.00
333_D343_E0.6581.00
102_E116_S0.6571.00
96_S320_K0.6561.00
33_L44_I0.6551.00
168_M178_A0.6541.00
166_F178_A0.6541.00
39_V56_L0.6531.00
140_I169_I0.6521.00
204_M222_F0.6521.00
312_K354_R0.6501.00
159_L166_F0.6491.00
44_I64_G0.6461.00
190_M221_G0.6451.00
113_L136_I0.6431.00
254_V279_K0.6431.00
337_H340_P0.6411.00
191_M195_H0.6381.00
118_N123_N0.6381.00
209_K215_G0.6321.00
321_S324_G0.6301.00
67_V129_E0.6301.00
99_R118_N0.6281.00
205_M237_M0.6271.00
46_K52_V0.6231.00
190_M193_A0.6211.00
99_R321_S0.6211.00
273_N301_D0.6201.00
31_N75_A0.6201.00
208_F240_T0.6181.00
157_L160_E0.6181.00
105_L332_I0.6171.00
300_Y318_H0.6171.00
179_P342_Q0.6131.00
308_I311_V0.6131.00
97_I320_K0.6101.00
170_N185_D0.6101.00
245_E282_D0.6081.00
170_N214_Q0.6071.00
281_I285_R0.6071.00
284_L287_M0.6051.00
330_Y334_C0.6021.00
196_L270_L0.6011.00
298_V357_A0.6001.00
44_I47_A0.6001.00
91_D94_F0.6001.00
203_H232_F0.6001.00
100_G320_K0.5991.00
160_E177_A0.5981.00
278_L303_S0.5981.00
277_A299_G0.5971.00
316_V349_P0.5971.00
125_R155_Y0.5941.00
132_L164_I0.5931.00
241_F249_K0.5911.00
138_G327_A0.5861.00
110_Y137_D0.5861.00
167_A181_F0.5851.00
93_I97_I0.5841.00
42_H51_L0.5831.00
123_N127_G0.5821.00
37_F47_A0.5811.00
128_L139_L0.5811.00
185_D217_K0.5791.00
199_L267_T0.5791.00
117_T124_E0.5771.00
91_D275_E0.5761.00
154_G157_L0.5731.00
307_Q312_K0.5721.00
110_Y335_L0.5711.00
167_A327_A0.5681.00
167_A331_V0.5661.00
129_E132_L0.5641.00
59_S62_G0.5621.00
286_E310_E0.5621.00
233_P238_I0.5621.00
28_P36_Q0.5611.00
219_M233_P0.5611.00
82_I335_L0.5601.00
67_V71_S0.5591.00
270_L300_Y0.5571.00
323_L347_F0.5551.00
231_L234_S0.5541.00
203_H266_P0.5531.00
51_L57_L0.5531.00
285_R290_K0.5521.00
172_S180_S0.5521.00
280_V284_L0.5521.00
139_L164_I0.5501.00
195_H298_V0.5451.00
307_Q311_V0.5421.00
167_A330_Y0.5421.00
155_Y158_N0.5411.00
44_I60_V0.5411.00
282_D307_Q0.5401.00
82_I110_Y0.5401.00
215_G272_Y0.5401.00
192_A268_A0.5401.00
306_A315_S0.5401.00
167_A334_C0.5391.00
73_K76_L0.5381.00
278_L305_F0.5341.00
88_Y99_R0.5331.00
82_I138_G0.5321.00
181_F326_A0.5321.00
326_A333_D0.5311.00
85_L127_G0.5311.00
251_L254_V0.5301.00
32_E36_Q0.5291.00
236_D260_K0.5281.00
39_V44_I0.5281.00
98_I102_E0.5281.00
45_R49_G0.5271.00
190_M229_R0.5261.00
310_E355_Q0.5261.00
30_E64_G0.5251.00
37_F60_V0.5251.00
34_M37_F0.5241.00
266_P269_I0.5241.00
48_I51_L0.5221.00
47_A51_L0.5221.00
94_F142_E0.5221.00
251_L279_K0.5181.00
113_L134_Q0.5171.00
271_C299_G0.5161.00
334_C337_H0.5161.00
57_L60_V0.5161.00
194_E197_L0.5151.00
169_I323_L0.5131.00
249_K276_I0.5131.00
186_V189_G0.5111.00
79_N110_Y0.5101.00
30_E46_K0.5101.00
273_N276_I0.5101.00
258_L284_L0.5091.00
319_P323_L0.5091.00
183_L300_Y0.5081.00
314_T353_I0.5061.00
90_S96_S0.5041.00
303_S315_S0.5021.00
119_N171_A0.5021.00
182_T185_D0.5021.00
265_M294_D0.5011.00
274_D303_S0.5011.00
60_V63_G0.5011.00
106_S126_R0.5001.00
121_P125_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.884 100 0.176 Contact Map
2o20A 2 0.7541 100 0.177 Contact Map
3e3mA 2 0.7376 100 0.178 Contact Map
4o5aA 2 0.7431 100 0.179 Contact Map
3dbiA 2 0.7624 100 0.182 Contact Map
3kjxA 2 0.9006 100 0.184 Contact Map
3h5oA 2 0.7459 100 0.187 Contact Map
1qpzA 2 0.9006 100 0.188 Contact Map
3bilA 2 0.7044 100 0.19 Contact Map
3ctpA 2 0.732 100 0.203 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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