GREMLIN Database
YDGE - Uncharacterized N-acetyltransferase YdgE
UniProt: P96703 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (130)
Sequences: 3557 (2869)
Seq/√Len: 251.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_D145_Y4.4861.00
76_L113_L2.8881.00
107_Q142_K2.7981.00
73_M100_F2.7091.00
74_G109_A2.3571.00
110_L143_M2.2081.00
116_R119_E2.1611.00
64_N72_R2.1591.00
107_Q143_M2.1531.00
114_D125_L2.1061.00
127_L140_Y1.9981.00
137_V141_Q1.9301.00
66_T72_R1.9181.00
74_G96_L1.8931.00
89_A117_A1.8731.00
112_T115_E1.8661.00
66_T70_G1.8271.00
30_T97_Y1.7841.00
138_Y141_Q1.7501.00
20_S27_Q1.7281.00
67_N100_F1.6601.00
100_F103_K1.6041.00
61_Y116_R1.6041.00
71_E99_A1.5821.00
27_Q31_S1.5161.00
71_E100_F1.5161.00
63_W112_T1.4861.00
44_E48_E1.4731.00
45_Q48_E1.4701.00
111_Q143_M1.4671.00
80_A122_A1.4661.00
67_N103_K1.4311.00
136_A140_Y1.4221.00
71_E97_Y1.4001.00
107_Q111_Q1.3771.00
67_N73_M1.3741.00
127_L136_A1.3721.00
147_M150_I1.3531.00
78_L117_A1.2961.00
63_W116_R1.2911.00
26_K30_T1.2401.00
91_I110_L1.2371.00
129_V133_N1.2161.00
65_I109_A1.2101.00
22_Q44_E1.2051.00
133_N140_Y1.1881.00
117_A125_L1.1791.00
48_E52_P1.1751.00
111_Q115_E1.1691.00
74_G105_L1.1411.00
78_L113_L1.1271.00
97_Y100_F1.1221.00
112_T116_R1.1201.00
88_E126_A1.1101.00
62_F66_T1.0981.00
20_S24_F1.0821.00
65_I105_L1.0651.00
89_A122_A1.0621.00
94_F127_L1.0561.00
110_L140_Y1.0531.00
129_V140_Y1.0521.00
101_R135_T1.0481.00
23_N26_K1.0341.00
141_Q147_M1.0321.00
134_E138_Y1.0301.00
22_Q26_K1.0261.00
28_N31_S1.0261.00
139_L142_K1.0241.00
76_L91_I1.0241.00
104_G107_Q1.0221.00
75_W95_G1.0201.00
88_E124_R1.0111.00
115_E119_E0.9921.00
24_F27_Q0.9891.00
94_F110_L0.9711.00
94_F140_Y0.9671.00
96_L106_A0.9661.00
62_F77_W0.9591.00
43_S46_A0.9511.00
27_Q30_T0.9501.00
28_N32_G0.9481.00
91_I127_L0.9401.00
35_T38_E0.9301.00
21_V24_F0.9271.00
43_S47_Y0.9251.00
79_Y92_Y0.9231.00
135_T138_Y0.9181.00
25_A29_I0.9141.00
129_V136_A0.9091.00
108_L111_Q0.8991.00
137_V147_M0.8811.00
127_L133_N0.8791.00
110_L139_L0.8701.00
115_E118_R0.8650.99
96_L109_A0.8590.99
27_Q72_R0.8580.99
90_F126_A0.8550.99
91_I145_Y0.8440.99
27_Q97_Y0.8420.99
116_R120_L0.8410.99
29_I33_T0.8390.99
18_G21_V0.8300.99
46_A49_N0.8280.99
30_T98_E0.8250.99
19_M22_Q0.8190.99
20_S23_N0.8020.99
133_N137_V0.8020.99
102_G135_T0.7920.99
80_A120_L0.7890.99
26_K29_I0.7830.99
94_F136_A0.7790.99
65_I96_L0.7770.99
96_L105_L0.7720.99
47_Y50_M0.7700.99
36_E39_A0.7680.99
133_N136_A0.7640.99
73_M105_L0.7640.99
91_I94_F0.7600.99
78_L116_R0.7540.99
45_Q49_N0.7540.99
21_V51_I0.7470.99
93_S130_F0.7380.98
91_I125_L0.7310.98
36_E40_F0.7280.98
44_E47_Y0.7160.98
108_L115_E0.7080.98
114_D143_M0.7060.98
136_A139_L0.6980.98
65_I74_G0.6960.98
134_E141_Q0.6950.98
110_L136_A0.6880.97
19_M23_N0.6880.97
18_G44_E0.6860.97
38_E41_E0.6840.97
42_K47_Y0.6840.97
22_Q25_A0.6820.97
77_W92_Y0.6740.97
95_G130_F0.6670.97
94_F143_M0.6650.97
25_A32_G0.6620.97
139_L143_M0.6610.97
22_Q28_N0.6530.97
132_H137_V0.6500.96
94_F139_L0.6220.95
110_L127_L0.6200.95
24_F32_G0.6130.95
126_A148_T0.6100.95
35_T40_F0.6050.95
78_L89_A0.6010.95
60_H66_T0.5970.94
102_G138_Y0.5960.94
35_T97_Y0.5880.94
58_S67_N0.5840.94
87_K123_E0.5810.93
93_S128_H0.5800.93
107_Q139_L0.5800.93
81_D122_A0.5790.93
117_A122_A0.5750.93
52_P57_S0.5740.93
47_Y51_I0.5710.93
57_S60_H0.5700.93
87_K122_A0.5700.93
118_R141_Q0.5680.93
94_F109_A0.5650.93
39_A45_Q0.5580.92
105_L108_L0.5580.92
110_L145_Y0.5560.92
51_I54_G0.5540.92
24_F31_S0.5540.92
141_Q146_A0.5520.92
40_F128_H0.5490.91
130_F133_N0.5490.91
124_R148_T0.5480.91
101_R136_A0.5450.91
19_M27_Q0.5420.91
28_N75_W0.5400.91
102_G139_L0.5390.91
111_Q142_K0.5360.90
80_A89_A0.5350.90
131_A151_R0.5280.90
62_F75_W0.5270.90
24_F28_N0.5260.90
94_F133_N0.5250.90
33_T78_L0.5220.89
40_F46_A0.5200.89
137_V150_I0.5180.89
67_N71_E0.5150.89
73_M97_Y0.5130.88
65_I68_D0.5120.88
131_A150_I0.5090.88
90_F128_H0.5080.88
91_I113_L0.5050.88
68_D71_E0.5020.87
74_G113_L0.5000.87
114_D139_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ufhA 3 0.9873 99.9 0.323 Contact Map
1on0A 4 0.9936 99.8 0.335 Contact Map
3fixA 2 0.9554 99.8 0.372 Contact Map
1vkcA 2 0.9236 99.8 0.395 Contact Map
3fynA 2 0.8726 99.8 0.399 Contact Map
2j8mA 2 0.9427 99.8 0.401 Contact Map
1p0hA 1 0.9682 99.7 0.408 Contact Map
1tiqA 1 0.9809 99.7 0.409 Contact Map
1z4eA 2 0.9299 99.7 0.41 Contact Map
3jvnA 2 0.7452 99.7 0.413 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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