GREMLIN Database
COTP - Spore coat protein P
UniProt: P96698 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (120)
Sequences: 4898 (3953)
Seq/√Len: 360.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_E116_L4.0551.00
52_Y129_S3.0661.00
57_V79_I2.8481.00
49_D52_Y2.6941.00
44_Y106_I2.5711.00
63_Y123_N2.4411.00
48_Q132_R2.3741.00
80_K103_E2.1281.00
44_Y57_V2.1001.00
58_E125_L2.0541.00
82_T101_E2.0361.00
56_I127_H2.0191.00
49_D54_F1.9861.00
63_Y66_E1.9521.00
112_A130_Y1.9451.00
67_L121_L1.9201.00
54_F127_H1.8441.00
68_T80_K1.8191.00
45_D97_R1.7431.00
92_E95_R1.7421.00
47_Y54_F1.7291.00
81_G102_I1.7121.00
76_Q105_I1.6641.00
113_E133_Q1.6181.00
71_L108_L1.6141.00
59_M121_L1.5881.00
59_M67_L1.5871.00
58_E97_R1.5771.00
62_V81_G1.5581.00
76_Q107_Q1.5501.00
134_V137_V1.5371.00
78_L105_I1.5321.00
96_E104_R1.4851.00
21_F24_N1.4561.00
24_N27_K1.4371.00
80_K101_E1.4131.00
47_Y56_I1.3731.00
42_F102_I1.3571.00
116_L131_P1.3131.00
45_D56_I1.2571.00
63_Y122_L1.2481.00
70_R73_S1.2091.00
64_E123_N1.1961.00
66_E84_T1.1921.00
120_Q127_H1.1881.00
21_F25_V1.1531.00
45_D95_R1.1521.00
55_I130_Y1.1341.00
77_L117_L1.1201.00
69_I128_I1.0701.00
66_E83_I1.0641.00
71_L117_L1.0641.00
58_E83_I1.0301.00
27_K30_A1.0201.00
75_T114_T1.0161.00
20_D24_N1.0121.00
69_I119_I1.0071.00
122_L127_H1.0061.00
85_P98_Y1.0031.00
47_Y90_E1.0001.00
64_E68_T0.9711.00
54_F129_S0.9531.00
22_W26_L0.9461.00
47_Y92_E0.9451.00
120_Q129_S0.9421.00
45_D58_E0.9381.00
55_I106_I0.9361.00
28_Y31_P0.9171.00
68_T140_N0.9161.00
70_R78_L0.9141.00
85_P95_R0.9111.00
77_L128_I0.9101.00
46_F53_N0.9081.00
56_I125_L0.9071.00
67_L97_R0.9041.00
81_G100_G0.8861.00
53_N93_V0.8841.00
24_N28_Y0.8801.00
51_E137_V0.8781.00
59_M62_V0.8701.00
108_L130_Y0.8681.00
42_F57_V0.8551.00
42_F59_M0.8501.00
53_N111_A0.8411.00
29_K33_H0.8351.00
42_F81_G0.8251.00
111_A133_Q0.8221.00
30_A33_H0.8151.00
44_Y79_I0.8151.00
71_L114_T0.8001.00
53_N110_E0.7951.00
45_D99_Y0.7941.00
53_N117_L0.7921.00
59_M81_G0.7901.00
45_D59_M0.7891.00
56_I86_V0.7811.00
109_P112_A0.7751.00
62_V67_L0.7711.00
22_W25_V0.7701.00
53_N132_R0.7661.00
78_L103_E0.7601.00
29_K32_E0.7541.00
23_T26_L0.7491.00
46_F55_I0.7461.00
93_V109_P0.7301.00
31_P34_F0.7180.99
27_K31_P0.7170.99
40_S81_G0.7130.99
84_T99_Y0.7100.99
83_I100_G0.7070.99
48_Q93_V0.7020.99
111_A132_R0.6980.99
23_T29_K0.6920.99
43_V58_E0.6830.99
82_T99_Y0.6830.99
118_Q129_S0.6800.99
20_D23_T0.6770.99
47_Y53_N0.6760.99
110_E133_Q0.6670.99
114_T131_P0.6580.99
75_T110_E0.6520.99
83_I99_Y0.6510.99
89_A94_L0.6470.99
25_V29_K0.6410.99
70_R80_K0.6280.99
136_T139_F0.6250.99
67_L128_I0.6250.99
62_V83_I0.6230.99
135_E138_A0.6210.99
43_V78_L0.6190.98
86_V89_A0.6170.98
21_F28_Y0.6130.98
57_V106_I0.6090.98
51_E132_R0.6080.98
109_P130_Y0.5960.98
68_T82_T0.5920.98
56_I97_R0.5920.98
30_A34_F0.5880.98
88_P95_R0.5850.98
26_L31_P0.5850.98
134_V139_F0.5840.98
47_Y89_A0.5770.98
73_S76_Q0.5760.98
29_K34_F0.5760.98
53_N112_A0.5730.97
85_P99_Y0.5680.97
23_T33_H0.5670.97
23_T27_K0.5620.97
55_I69_I0.5620.97
59_M102_I0.5580.97
20_D25_V0.5570.97
73_S139_F0.5530.97
32_E35_F0.5530.97
41_T45_D0.5510.97
119_I128_I0.5490.97
64_E121_L0.5470.97
52_Y132_R0.5420.97
58_E99_Y0.5410.96
133_Q136_T0.5400.96
23_T28_Y0.5380.96
48_Q64_E0.5370.96
25_V31_P0.5360.96
33_H36_D0.5350.96
98_Y130_Y0.5330.96
62_V100_G0.5270.96
49_D129_S0.5260.96
45_D94_L0.5240.96
137_V140_N0.5230.96
45_D92_E0.5170.95
21_F27_K0.5170.95
42_F79_I0.5160.95
97_R125_L0.5160.95
74_K111_A0.5130.95
71_L77_L0.5100.95
64_E122_L0.5080.95
108_L112_A0.5070.95
85_P88_P0.5050.95
95_R99_Y0.5020.95
62_V66_E0.5010.95
35_F39_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eldA 4 0.7692 100 0.251 Contact Map
3w1zA 7 0.9301 100 0.292 Contact Map
1gmeA 6 0.972 100 0.298 Contact Map
3aabA 2 0.7832 99.9 0.333 Contact Map
3glaA 2 0.6853 99.9 0.351 Contact Map
4feiA 2 0.7133 99.9 0.369 Contact Map
4ydzA 4 0.8112 99.9 0.382 Contact Map
2bolA 2 0.9441 99.9 0.4 Contact Map
2klrA 2 0.5664 99.9 0.415 Contact Map
4jutA 4 0.6224 99.9 0.418 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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