GREMLIN Database
MHQP - Putative oxidoreductase MhqP
UniProt: P96694 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 129 (118)
Sequences: 2205 (1550)
Seq/√Len: 142.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_F80_I2.9211.00
81_T111_I2.6061.00
12_M112_A2.3911.00
40_W44_I2.3731.00
22_T26_F2.2701.00
80_I114_S2.1361.00
54_A58_L2.0231.00
14_G64_G1.9861.00
104_F108_L1.9471.00
37_T41_F1.9141.00
92_H107_N1.9121.00
16_V110_L1.8951.00
16_V97_F1.8711.00
18_L68_I1.8641.00
67_F80_I1.7551.00
22_T61_L1.7131.00
13_I113_V1.6971.00
56_S83_I1.6891.00
88_I111_I1.6781.00
106_Y110_L1.6631.00
34_I54_A1.6611.00
9_I116_G1.6531.00
40_W43_S1.6451.00
66_L76_G1.6361.00
84_M87_A1.5951.00
16_V109_V1.5861.00
77_A114_S1.5561.00
58_L62_V1.5271.00
71_V128_H1.5161.00
99_N102_G1.5001.00
14_G68_I1.4991.00
6_L120_I1.4851.00
7_L11_I1.4431.00
34_I57_G1.4311.00
117_V120_I1.4281.00
116_G120_I1.4051.00
20_Y105_E1.3871.00
89_V93_G1.3791.00
62_V66_L1.3331.00
73_L122_S1.3221.00
6_L116_G1.3171.00
59_G83_I1.3141.00
109_V113_V1.3011.00
38_G49_G1.2771.00
5_G120_I1.2641.00
65_I69_L1.2591.00
72_F75_L1.2501.00
38_G50_N1.2321.00
12_M16_V1.2251.00
63_S76_G1.2041.00
25_L57_G1.1991.00
18_L65_I1.1991.00
77_A81_T1.1961.00
75_L79_I1.1931.00
122_S126_A1.1681.00
19_F98_A1.1560.99
9_I113_V1.1360.99
18_L64_G1.1240.99
71_V127_L1.1120.99
24_K60_E1.1100.99
57_G64_G1.0950.99
50_N54_A1.0750.99
92_H95_K1.0580.99
46_V52_A1.0420.99
59_G79_I1.0360.99
81_T118_A1.0180.99
88_I107_N1.0020.99
55_L59_G0.9800.98
56_S59_G0.9720.98
82_I86_G0.9710.98
36_G40_W0.9670.98
85_L89_V0.9510.98
88_I93_G0.9510.98
73_L117_V0.9460.98
115_I119_L0.9250.98
34_I38_G0.9210.97
59_G76_G0.9170.97
111_I114_S0.9110.97
34_I53_A0.9060.97
18_L22_T0.8930.97
15_V68_I0.8910.97
88_I108_L0.8770.97
63_S80_I0.8740.97
11_I68_I0.8590.96
74_P82_I0.8570.96
110_L114_S0.8430.96
42_E49_G0.8300.95
59_G63_S0.8170.95
21_G64_G0.8120.95
96_G104_F0.8100.95
39_Q43_S0.8090.95
35_K39_Q0.8020.94
6_L122_S0.7970.94
37_T53_A0.7830.94
46_V86_G0.7820.94
35_K38_G0.7800.94
39_Q42_E0.7790.94
16_V19_F0.7780.93
23_Q33_G0.7770.93
83_I86_G0.7700.93
32_Y37_T0.7420.92
23_Q32_Y0.7280.91
78_A82_I0.7250.91
25_L61_L0.7200.91
13_I114_S0.7190.90
107_N111_I0.7140.90
74_P118_A0.7050.90
5_G119_L0.7020.89
21_G62_V0.7010.89
83_I87_A0.6990.89
33_G103_G0.6970.89
7_L125_Y0.6960.89
109_V112_A0.6950.89
106_Y109_V0.6930.89
38_G53_A0.6900.89
51_V54_A0.6700.87
15_V65_I0.6650.87
122_S128_H0.6650.87
25_L58_L0.6630.87
79_I82_I0.6620.86
95_K102_G0.6580.86
34_I37_T0.6550.86
90_K94_A0.6540.86
96_G103_G0.6500.85
8_L112_A0.6470.85
19_F64_G0.6390.85
76_G80_I0.6360.84
16_V106_Y0.6310.84
113_V117_V0.6280.83
32_Y35_K0.6210.83
41_F46_V0.6160.82
14_G18_L0.6130.82
89_V104_F0.6100.82
61_L65_I0.6100.82
13_I110_L0.6030.81
52_A86_G0.6030.81
80_I83_I0.6020.81
81_T115_I0.6000.81
97_F106_Y0.5980.80
53_A57_G0.5970.80
57_G61_L0.5890.79
100_G106_Y0.5870.79
73_L128_H0.5840.79
76_G79_I0.5830.79
37_T42_E0.5790.78
97_F108_L0.5780.78
69_L127_L0.5720.77
104_F107_N0.5690.77
12_M109_V0.5680.77
13_I109_V0.5670.77
75_L118_A0.5650.77
13_I82_I0.5630.76
32_Y36_G0.5630.76
66_L71_V0.5620.76
8_L15_V0.5610.76
56_S86_G0.5570.76
21_G61_L0.5550.75
42_E101_A0.5520.75
41_F54_A0.5490.75
78_A118_A0.5430.74
63_S79_I0.5400.73
116_G119_L0.5380.73
23_Q57_G0.5310.72
23_Q98_A0.5300.72
32_Y40_W0.5290.72
51_V71_V0.5260.71
108_L111_I0.5260.71
85_L111_I0.5250.71
13_I92_H0.5230.71
54_A57_G0.5200.71
111_I115_I0.5140.70
14_G21_G0.5120.69
91_V96_G0.5110.69
49_G57_G0.5070.69
21_G72_F0.5050.68
17_F73_L0.5030.68
4_A62_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m4fA 1 0.2326 1.8 0.954 Contact Map
2vgdA 1 0.2791 1.8 0.954 Contact Map
1rijA 1 0.1783 1.4 0.956 Contact Map
2l16A 1 0.2326 1.2 0.958 Contact Map
4ui9A 1 0.6899 1 0.961 Contact Map
2lzrA 1 0.2248 0.9 0.961 Contact Map
2gsmB 1 0.7132 0.8 0.963 Contact Map
3rv1A 2 0.3178 0.7 0.964 Contact Map
1xaxA 1 0.3411 0.7 0.964 Contact Map
2hy5A 2 0.3566 0.7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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