GREMLIN Database
MHQO - Putative ring-cleaving dioxygenase MhqO
UniProt: P96693 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (303)
Sequences: 1303 (858)
Seq/√Len: 49.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A148_V4.3511.00
61_I84_Y3.9731.00
86_V91_M3.8951.00
95_E107_K3.8361.00
281_T284_E3.7331.00
19_Q23_D3.5591.00
221_R269_D3.5341.00
52_N56_K3.5081.00
167_A188_Y3.4441.00
23_D27_G3.2511.00
253_A267_A3.1881.00
156_A218_I3.0651.00
225_D252_N3.0041.00
11_I156_A2.8661.00
178_R181_K2.7711.00
278_T281_T2.6691.00
93_F144_V2.6001.00
274_A279_Q2.5851.00
89_G130_E2.4651.00
98_L105_Y2.4531.00
93_F97_R2.3881.00
222_A266_I2.3781.00
187_R199_D2.2771.00
6_M223_N2.2751.00
72_G214_T2.2381.00
96_K100_K2.2331.00
14_I69_A2.2031.00
51_G60_I2.1691.00
49_Y60_I2.1371.00
178_R188_Y2.0841.00
177_E189_R2.0811.00
20_E122_H2.0671.00
179_V189_R2.0021.00
295_H298_Q1.9240.99
69_A212_A1.9000.99
28_V101_F1.8780.99
109_E114_Q1.8720.99
229_L245_V1.8430.99
163_P202_L1.8330.99
257_R263_L1.8010.99
88_K132_E1.7810.99
31_L84_Y1.7780.99
167_A200_L1.7440.99
293_E296_R1.7210.99
176_L190_S1.6970.98
110_R127_E1.6970.98
84_Y153_F1.6860.98
145_T148_V1.6810.98
288_L296_R1.6780.98
40_F49_Y1.6480.98
223_N227_D1.6310.98
17_H67_A1.6180.98
168_D172_N1.6160.98
25_Y126_L1.6010.98
86_V128_I1.5900.97
104_P119_D1.5860.97
80_G159_L1.5820.97
42_D45_T1.5770.97
225_D229_L1.5660.97
74_I119_D1.5520.97
178_R186_V1.5170.97
76_D161_E1.5130.97
224_D227_D1.5070.97
37_T250_Y1.5060.96
49_Y250_Y1.4940.96
21_N50_F1.4810.96
88_K130_E1.4750.96
14_I42_D1.4650.96
292_Y295_H1.4550.96
106_T117_E1.4480.96
16_G212_A1.4090.95
32_R139_W1.4010.95
13_A124_L1.3950.95
53_E279_Q1.3770.94
176_L220_W1.3640.94
169_L174_M1.3580.94
181_K186_V1.3540.94
113_E199_D1.3510.94
185_F201_K1.3350.93
45_T66_W1.3340.93
22_T33_L1.3330.93
28_V121_P1.3320.93
11_I82_T1.3010.92
15_V18_P1.2990.92
38_V292_Y1.2970.92
256_F266_I1.2910.92
232_Q236_A1.2900.92
167_A178_R1.2810.92
250_Y287_M1.2800.92
249_N290_V1.2790.92
92_A96_K1.2780.92
226_E230_D1.2720.91
106_T119_D1.2690.91
37_T40_F1.2680.91
21_N63_F1.2610.91
113_E187_R1.2460.91
85_V131_R1.2380.90
79_V262_I1.2350.90
35_K277_E1.2330.90
234_Y238_H1.2310.90
95_E99_E1.2270.90
98_L128_I1.2210.90
54_G279_Q1.2070.89
84_Y150_I1.2020.89
33_L48_L1.2000.89
34_V51_G1.1990.89
242_V254_I1.1980.89
109_E112_G1.1910.88
163_P186_V1.1900.88
99_E105_Y1.1850.88
95_E116_V1.1850.88
16_G122_H1.1760.88
233_R237_S1.1650.87
15_V65_P1.1640.87
113_E197_V1.1630.87
76_D205_I1.1550.87
83_S129_V1.1460.86
276_D282_M1.1440.86
14_I66_W1.1280.86
40_F249_N1.1220.85
93_F145_T1.1180.85
295_H299_I1.1170.85
79_V215_V1.1110.85
17_H20_E1.1070.84
222_A227_D1.1000.84
158_L262_I1.0910.84
158_L166_T1.0870.83
250_Y273_F1.0860.83
25_Y63_F1.0750.83
85_V154_G1.0740.83
52_N55_G1.0730.83
29_L150_I1.0650.82
48_L306_F1.0590.82
12_T66_W1.0590.82
92_A95_E1.0590.82
83_S154_G1.0590.82
298_Q302_G1.0570.82
232_Q246_R1.0570.82
210_M214_T1.0440.81
198_I220_W1.0340.80
13_A61_I1.0320.80
231_W266_I1.0310.80
233_R236_A1.0250.80
142_G149_A1.0250.80
12_T45_T1.0250.80
82_T215_V1.0220.79
42_D66_W1.0190.79
117_E127_E1.0110.79
232_Q245_V1.0060.78
18_P45_T1.0040.78
11_I153_F1.0040.78
40_F60_I0.9870.77
18_P48_L0.9860.77
170_L264_F0.9860.77
167_A171_E0.9850.77
296_R300_E0.9840.77
40_F287_M0.9830.77
98_L101_F0.9810.76
22_T306_F0.9790.76
288_L293_E0.9650.75
83_S157_T0.9620.75
35_K250_Y0.9470.74
294_P299_I0.9470.74
130_E195_G0.9470.74
20_E23_D0.9420.73
96_K99_E0.9390.73
277_E282_M0.9330.73
78_Q208_G0.9320.73
293_E299_I0.9280.72
81_V127_E0.9250.72
114_Q130_E0.9130.71
228_Q253_A0.9130.71
45_T65_P0.9090.71
166_T258_E0.9080.71
38_V288_L0.9030.70
115_Y127_E0.9010.70
49_Y287_M0.8970.70
246_R254_I0.8970.70
141_F144_V0.8960.70
230_D233_R0.8930.69
228_Q245_V0.8890.69
274_A282_M0.8870.69
36_Q46_Y0.8830.69
19_Q307_E0.8770.68
52_N279_Q0.8680.67
52_N57_P0.8610.67
140_T146_P0.8600.66
298_Q301_Q0.8590.66
16_G59_T0.8570.66
37_T60_I0.8510.66
14_I45_T0.8490.65
39_N64_F0.8460.65
164_D168_D0.8460.65
73_V209_Q0.8440.65
14_I210_M0.8430.65
55_G59_T0.8400.65
85_V136_A0.8360.64
8_I79_V0.8350.64
224_D270_P0.8350.64
119_D125_H0.8330.64
40_F246_R0.8300.64
93_F142_G0.8290.64
249_N287_M0.8290.64
93_F148_V0.8290.64
291_Q294_P0.8240.63
201_K205_I0.8220.63
228_Q246_R0.8220.63
70_R73_V0.8190.63
219_A267_A0.8150.62
247_D291_Q0.8130.62
6_M222_A0.8110.62
272_G283_G0.8100.62
187_R197_V0.8100.62
23_D185_F0.8080.62
97_R101_F0.8060.61
15_V48_L0.8050.61
41_D46_Y0.8050.61
244_P249_N0.8040.61
119_D123_G0.8030.61
81_V119_D0.8010.61
93_F141_F0.7940.60
107_K114_Q0.7930.60
65_P304_L0.7900.60
17_H304_L0.7890.60
245_V252_N0.7870.60
41_D64_F0.7850.59
41_D215_V0.7830.59
297_T301_Q0.7810.59
196_N231_W0.7780.59
291_Q299_I0.7750.58
229_L232_Q0.7730.58
219_A253_A0.7700.58
303_L306_F0.7690.58
54_G274_A0.7670.58
93_F143_E0.7610.57
232_Q242_V0.7590.57
5_T190_S0.7570.57
25_Y61_I0.7530.56
110_R199_D0.7520.56
48_L129_V0.7490.56
160_S163_P0.7490.56
122_H212_A0.7460.55
18_P36_Q0.7460.55
7_G30_G0.7440.55
38_V291_Q0.7380.55
232_Q243_T0.7350.54
35_K276_D0.7320.54
21_N258_E0.7320.54
72_G208_G0.7300.54
74_I78_Q0.7300.54
106_T116_V0.7260.53
179_V197_V0.7260.53
251_F255_Y0.7250.53
22_T222_A0.7250.53
100_K105_Y0.7250.53
63_F271_P0.7220.53
38_V296_R0.7210.53
174_M234_Y0.7190.53
286_L300_E0.7150.52
292_Y299_I0.7040.51
249_N291_Q0.6990.51
94_W219_A0.6980.51
46_Y216_H0.6960.50
181_K184_D0.6950.50
34_V283_G0.6910.50
169_L256_F0.6900.50
250_Y283_G0.6880.50
40_F244_P0.6870.50
37_T287_M0.6830.49
225_D270_P0.6820.49
98_L103_V0.6810.49
73_V116_V0.6800.49
32_R284_E0.6790.49
69_A306_F0.6740.48
86_V116_V0.6740.48
236_A239_G0.6730.48
296_R299_I0.6710.48
140_T145_T0.6700.48
168_D238_H0.6680.48
160_S193_D0.6670.47
156_A198_I0.6660.47
8_I153_F0.6640.47
232_Q254_I0.6620.47
90_A97_R0.6560.46
157_T201_K0.6560.46
172_N237_S0.6560.46
45_T212_A0.6550.46
243_T263_L0.6540.46
71_Q212_A0.6530.46
34_V282_M0.6520.46
82_T124_L0.6510.46
169_L259_H0.6510.46
66_W212_A0.6500.46
146_P151_K0.6490.46
250_Y277_E0.6490.46
40_F250_Y0.6490.46
74_I214_T0.6470.45
70_R212_A0.6470.45
164_D202_L0.6470.45
276_D283_G0.6450.45
258_E261_E0.6430.45
15_V122_H0.6420.45
253_A275_H0.6400.45
25_Y120_D0.6360.44
90_A105_Y0.6320.44
256_F264_F0.6310.44
61_I82_T0.6300.44
57_P221_R0.6300.44
32_R282_M0.6300.44
156_A176_L0.6290.44
178_R200_L0.6260.43
173_I234_Y0.6240.43
166_T218_I0.6240.43
74_I125_H0.6220.43
78_Q124_L0.6220.43
27_G101_F0.6200.43
256_F263_L0.6200.43
116_V301_Q0.6190.43
96_K146_P0.6160.42
72_G149_A0.6140.42
125_H221_R0.6140.42
259_H262_I0.6120.42
159_L203_T0.6120.42
174_M229_L0.6110.42
249_N299_I0.6110.42
47_H62_T0.6110.42
277_E283_G0.6110.42
21_N122_H0.6100.42
44_G233_R0.6090.42
111_F180_G0.6090.42
86_V95_E0.6080.42
253_A270_P0.6080.42
101_F144_V0.6070.41
222_A228_Q0.6060.41
78_Q214_T0.6060.41
208_G214_T0.6050.41
52_N58_G0.6020.41
209_Q299_I0.6010.41
239_G242_V0.6000.41
291_Q295_H0.6000.41
184_D203_T0.6000.41
162_Q168_D0.5990.41
31_L274_A0.5980.41
22_T26_A0.5980.41
53_E149_A0.5970.40
39_N296_R0.5970.40
23_D28_V0.5950.40
66_W210_M0.5930.40
12_T208_G0.5930.40
235_I256_F0.5910.40
189_R197_V0.5860.39
38_V45_T0.5840.39
123_G263_L0.5820.39
19_Q27_G0.5820.39
98_L126_L0.5820.39
19_Q28_V0.5800.39
169_L200_L0.5780.39
160_S165_K0.5780.39
228_Q254_I0.5780.39
59_T196_N0.5780.39
172_N200_L0.5770.39
8_I176_L0.5760.38
60_I249_N0.5760.38
33_L174_M0.5760.38
84_Y262_I0.5760.38
77_G161_E0.5750.38
166_T260_G0.5750.38
51_G59_T0.5740.38
175_G198_I0.5740.38
38_V293_E0.5720.38
60_I273_F0.5700.38
255_Y265_E0.5700.38
236_A242_V0.5680.38
36_Q300_E0.5670.38
72_G127_E0.5670.38
43_P87_P0.5660.37
64_F299_I0.5640.37
65_P260_G0.5630.37
42_D209_Q0.5610.37
107_K116_V0.5600.37
279_Q282_M0.5590.37
252_N266_I0.5590.37
13_A195_G0.5570.37
134_G151_K0.5560.37
271_P276_D0.5560.37
77_G243_T0.5550.36
30_G52_N0.5510.36
249_N275_H0.5500.36
34_V60_I0.5480.36
278_T284_E0.5470.36
102_N226_E0.5470.36
5_T222_A0.5470.36
220_W264_F0.5460.36
222_A253_A0.5440.35
86_V156_A0.5440.35
158_L264_F0.5420.35
89_G147_D0.5420.35
272_G276_D0.5400.35
83_S155_G0.5400.35
54_G137_N0.5390.35
161_E205_I0.5380.35
236_A301_Q0.5380.35
50_F214_T0.5360.35
170_L200_L0.5360.35
163_P200_L0.5350.35
106_T239_G0.5350.35
242_V246_R0.5340.34
81_V117_E0.5330.34
128_I183_G0.5320.34
166_T199_D0.5320.34
126_L158_L0.5310.34
51_G222_A0.5300.34
89_G92_A0.5280.34
106_T183_G0.5280.34
8_I218_I0.5260.34
251_F265_E0.5260.34
99_E206_G0.5240.34
110_R115_Y0.5230.33
8_I118_F0.5220.33
15_V52_N0.5210.33
92_A116_V0.5210.33
12_T65_P0.5200.33
219_A255_Y0.5200.33
7_G12_T0.5200.33
250_Y276_D0.5200.33
25_Y258_E0.5190.33
63_F120_D0.5180.33
152_G216_H0.5180.33
97_R143_E0.5170.33
57_P269_D0.5160.33
80_G157_T0.5160.33
173_I238_H0.5160.33
186_V202_L0.5160.33
19_Q304_L0.5150.33
68_G214_T0.5150.33
51_G254_I0.5150.33
76_D159_L0.5140.33
70_R209_Q0.5130.33
94_W253_A0.5120.32
131_R193_D0.5110.32
155_G159_L0.5090.32
52_N300_E0.5090.32
120_D258_E0.5080.32
73_V168_D0.5080.32
5_T231_W0.5070.32
116_V211_G0.5070.32
179_V188_Y0.5060.32
59_T97_R0.5050.32
8_I12_T0.5040.32
87_P150_I0.5040.32
130_E194_I0.5030.32
45_T122_H0.5030.32
65_P208_G0.5000.31
97_R105_Y0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oajA 2 0.9904 100 0.437 Contact Map
4huzA 2 0.9679 100 0.572 Contact Map
1zswA 1 0.9904 100 0.592 Contact Map
3e0rA 1 0.7372 100 0.739 Contact Map
4ro6A 1 0.8397 100 0.756 Contact Map
3vb0A 1 0.8333 100 0.76 Contact Map
2ehzA 5 0.8814 100 0.761 Contact Map
2zyqA 2 0.8526 100 0.763 Contact Map
3hpyA 4 0.859 100 0.764 Contact Map
1mpyA 3 0.9006 100 0.764 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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