GREMLIN Database
MHQN - Putative NAD(P)H nitroreductase MhqN
UniProt: P96692 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (198)
Sequences: 7075 (5279)
Seq/√Len: 375.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_L21_H4.6061.00
30_E149_K3.9251.00
25_K53_L3.0601.00
24_T27_D2.8841.00
25_K29_N2.7501.00
21_H184_K2.7091.00
49_Y138_S2.6321.00
152_D185_E2.4801.00
60_K167_I2.3831.00
165_K176_V2.3671.00
55_Q59_E2.3581.00
31_M146_A2.3011.00
151_W184_K2.1561.00
139_A178_M2.1111.00
27_D151_W2.0511.00
33_E36_A1.9761.00
34_L145_S1.9011.00
143_M155_P1.8831.00
16_N186_K1.8191.00
163_A166_R1.7991.00
57_V60_K1.7791.00
64_A163_A1.7781.00
6_H10_E1.7741.00
61_L164_V1.7701.00
146_A182_I1.7691.00
143_M153_T1.7561.00
105_K109_D1.7291.00
18_L186_K1.7071.00
62_K72_V1.7071.00
4_F7_L1.6851.00
17_F181_T1.6791.00
27_D149_K1.6681.00
147_K152_D1.6651.00
64_A167_I1.6561.00
160_D163_A1.6341.00
10_E147_K1.6301.00
146_A153_T1.6051.00
9_N37_L1.5811.00
29_N200_N1.5771.00
35_V142_F1.5511.00
4_F8_V1.5311.00
116_V120_E1.5221.00
199_V203_V1.5051.00
143_M180_I1.4851.00
197_K201_E1.4651.00
49_Y78_L1.4431.00
57_V167_I1.4401.00
54_D57_V1.4141.00
31_M151_W1.4081.00
31_M142_F1.3941.00
185_E188_E1.3891.00
59_E63_Q1.3811.00
55_Q58_K1.3761.00
78_L142_F1.3701.00
48_K174_F1.3631.00
139_A180_I1.3501.00
133_R136_S1.3391.00
92_D201_E1.3351.00
36_A202_F1.3151.00
29_N33_E1.3151.00
32_F203_V1.2901.00
5_T9_N1.2881.00
135_A177_V1.2781.00
133_R157_I1.2711.00
59_E72_V1.2681.00
81_L174_F1.2631.00
17_F154_C1.2631.00
109_D113_Q1.2511.00
137_L140_M1.2481.00
13_S154_C1.2481.00
163_A167_I1.2471.00
69_Y72_V1.2461.00
8_V141_M1.2111.00
69_Y73_S1.1981.00
34_L149_K1.1931.00
31_M182_I1.1921.00
5_T34_L1.1841.00
60_K63_Q1.1811.00
28_L182_I1.1561.00
151_W182_I1.1561.00
29_N199_V1.1511.00
23_I151_W1.1501.00
27_D30_E1.1421.00
56_D59_E1.1401.00
22_P53_L1.1371.00
162_E166_R1.1191.00
27_D184_K1.1121.00
38_A141_M1.1061.00
113_Q116_V1.1031.00
142_F182_I1.0991.00
142_F180_I1.0861.00
153_T182_I1.0621.00
9_N33_E1.0621.00
5_T149_K1.0551.00
23_I27_D1.0451.00
89_Q92_D1.0391.00
51_T76_A1.0221.00
153_T180_I1.0191.00
80_V142_F1.0021.00
104_N107_E0.9971.00
92_D95_E0.9901.00
128_R175_E0.9781.00
4_F144_L0.9761.00
4_F148_E0.9761.00
30_E34_L0.9731.00
5_T30_E0.9721.00
113_Q117_S0.9661.00
123_G126_F0.9651.00
26_E29_N0.9591.00
14_A189_S0.9581.00
129_D133_R0.9581.00
23_I184_K0.9551.00
59_E62_K0.9401.00
95_E99_V0.9291.00
6_H9_N0.9281.00
56_D60_K0.9261.00
141_M144_L0.9251.00
130_E157_I0.9251.00
49_Y80_V0.9161.00
50_V81_L0.9131.00
154_C181_T0.9111.00
28_L76_A0.9061.00
161_A176_V0.9041.00
50_V168_L0.9041.00
28_L32_F0.9001.00
85_Q88_Q0.8971.00
23_I26_E0.8931.00
51_T203_V0.8911.00
129_D132_I0.8881.00
41_A157_I0.8871.00
35_V49_Y0.8811.00
82_G131_A0.8811.00
132_I177_V0.8781.00
60_K64_A0.8751.00
16_N187_T0.8711.00
114_D117_S0.8691.00
18_L184_K0.8651.00
116_V119_Y0.8641.00
24_T184_K0.8551.00
186_K189_S0.8511.00
138_S202_F0.8461.00
77_V181_T0.8441.00
31_M149_K0.8391.00
32_F35_V0.8381.00
65_A179_M0.8351.00
164_V176_V0.8211.00
165_K175_E0.8191.00
139_A155_P0.8161.00
33_E199_V0.8151.00
15_S70_K0.8131.00
71_V74_S0.8121.00
133_R177_V0.8081.00
110_H114_D0.8071.00
70_K73_S0.8051.00
50_V174_F0.8011.00
32_F51_T0.7971.00
159_F179_M0.7941.00
7_L148_E0.7931.00
91_A95_E0.7901.00
65_A71_V0.7901.00
40_S47_T0.7871.00
16_N189_S0.7841.00
90_A94_Y0.7751.00
68_Q72_V0.7741.00
41_A130_E0.7631.00
22_P55_Q0.7591.00
28_L51_T0.7581.00
72_V75_S0.7581.00
39_P153_T0.7551.00
108_Y111_M0.7521.00
113_Q119_Y0.7511.00
145_S148_E0.7501.00
79_L179_M0.7481.00
155_P178_M0.7441.00
134_N157_I0.7411.00
170_I174_F0.7391.00
112_V116_V0.7351.00
187_T190_R0.7331.00
140_M144_L0.7321.00
26_E30_E0.7321.00
8_V34_L0.7311.00
14_A185_E0.7301.00
83_D86_A0.7241.00
198_P201_E0.7201.00
96_G100_L0.7161.00
62_K68_Q0.7161.00
94_Y98_K0.7151.00
36_A49_Y0.7151.00
18_L187_T0.7131.00
93_I96_G0.7121.00
30_E33_E0.7081.00
132_I175_E0.7060.99
68_Q71_V0.7060.99
40_S46_H0.7050.99
57_V168_L0.7040.99
58_K62_K0.7030.99
52_V168_L0.7020.99
23_I28_L0.6980.99
90_A93_I0.6970.99
111_M115_T0.6930.99
137_L141_M0.6910.99
88_Q92_D0.6810.99
73_S76_A0.6770.99
162_E165_K0.6730.99
133_R178_M0.6730.99
109_D112_V0.6730.99
115_T119_Y0.6730.99
165_K170_I0.6700.99
103_L106_Q0.6660.99
80_V139_A0.6660.99
106_Q109_D0.6600.99
27_D31_M0.6600.99
161_A165_K0.6580.99
22_P75_S0.6570.99
142_F153_T0.6570.99
170_I176_V0.6560.99
47_T135_A0.6560.99
96_G99_V0.6550.99
156_M181_T0.6510.99
110_H113_Q0.6500.99
117_S121_N0.6470.99
8_V148_E0.6420.99
52_V61_L0.6370.99
65_A164_V0.6330.99
93_I97_L0.6320.99
63_Q67_G0.6310.99
39_P141_M0.6300.99
7_L150_G0.6270.99
159_F164_V0.6260.99
68_Q163_A0.6240.99
64_A164_V0.6220.99
118_F121_N0.6160.99
80_V84_K0.6150.99
103_L107_E0.6140.99
132_I136_S0.6120.99
5_T148_E0.6120.99
139_A143_M0.6110.99
98_K105_K0.6110.99
31_M145_S0.6110.99
164_V167_I0.5870.98
94_Y99_V0.5830.98
130_E133_R0.5820.98
58_K61_L0.5790.98
31_M34_L0.5790.98
78_L182_I0.5770.98
98_K102_I0.5730.98
136_S140_M0.5720.98
24_T29_N0.5700.98
165_K172_D0.5670.98
197_K202_F0.5650.98
161_A175_E0.5640.98
105_K108_Y0.5610.97
102_I106_Q0.5610.97
52_V57_V0.5600.97
12_R193_R0.5590.97
94_Y97_L0.5560.97
51_T78_L0.5560.97
70_K74_S0.5550.97
115_T118_F0.5530.97
8_V144_L0.5520.97
41_A134_N0.5520.97
102_I107_E0.5520.97
61_L168_L0.5490.97
40_S138_S0.5470.97
71_V77_V0.5460.97
85_Q173_Q0.5440.97
74_S77_V0.5430.97
142_F145_S0.5430.97
100_L106_Q0.5420.97
87_Y127_K0.5410.97
57_V64_A0.5410.97
123_G127_K0.5400.97
99_V102_I0.5390.97
78_L180_I0.5370.97
62_K103_L0.5330.97
152_D155_P0.5320.97
144_L148_E0.5310.96
107_E110_H0.5250.96
111_M114_D0.5230.96
138_S142_F0.5150.96
108_Y112_V0.5140.96
4_F145_S0.5140.96
49_Y202_F0.5120.96
16_N188_E0.5100.96
37_L194_G0.5090.96
61_L179_M0.5090.96
122_R127_K0.5080.96
101_G105_K0.5080.96
98_K103_L0.5070.95
37_L193_R0.5070.95
92_D96_G0.5070.95
111_M116_V0.5060.95
101_G104_N0.5060.95
102_I105_K0.5030.95
125_Q129_D0.5020.95
39_P155_P0.5010.95
47_T202_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bemA 2 1 100 0.165 Contact Map
3gagA 4 0.9854 100 0.181 Contact Map
3ge6A 2 0.9903 100 0.184 Contact Map
3gbhA 3 0.9903 100 0.191 Contact Map
4qlxA 2 0.9903 100 0.192 Contact Map
3of4A 3 0.9903 100 0.198 Contact Map
1noxA 2 0.9612 100 0.208 Contact Map
2h0uA 2 0.8932 100 0.214 Contact Map
2b67A 2 0.9709 100 0.214 Contact Map
1vfrA 2 0.9951 100 0.216 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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