GREMLIN Database
YDFK - Uncharacterized membrane protein YdfK
UniProt: P96689 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (217)
Sequences: 986 (789)
Seq/√Len: 53.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_G208_L5.6421.00
6_F128_L4.7421.00
118_A124_Y4.1191.00
77_N80_L3.7391.00
11_I156_L3.3771.00
10_M131_G3.3131.00
8_T157_F3.3011.00
81_R84_K3.0141.00
48_A187_G2.9221.00
74_Q207_N2.8571.00
43_A188_I2.8251.00
4_T160_Q2.7971.00
5_I9_V2.6991.00
117_E123_D2.6971.00
72_L214_I2.6321.00
79_E206_L2.5891.00
36_A66_L2.5631.00
117_E121_H2.4181.00
42_V194_G2.3031.00
15_S150_A2.2011.00
2_F128_L2.1891.00
40_A66_L2.1721.00
72_L76_I2.1101.00
32_I70_G2.0341.00
11_I111_S1.9651.00
4_T164_Y1.8360.99
196_S201_K1.8320.99
115_P119_A1.7700.99
195_L200_I1.7690.99
97_G101_A1.7690.99
68_I214_I1.7590.99
214_I218_V1.7480.99
86_V206_L1.7400.99
199_G202_K1.7210.99
43_A49_I1.7170.99
66_L188_I1.6570.99
105_F138_S1.6490.99
27_D30_Q1.6490.99
94_L151_A1.6200.98
189_L211_S1.6010.98
27_D31_D1.6000.98
147_F151_A1.5920.98
104_L141_L1.5750.98
61_L218_V1.5700.98
82_F206_L1.5190.97
101_A141_L1.4880.97
31_D35_Q1.4850.97
29_Y75_I1.4840.97
12_I150_A1.4830.97
93_N96_E1.4770.97
111_S159_W1.4480.97
4_T118_A1.4270.96
17_I139_I1.4130.96
98_L102_V1.4120.96
113_L126_Y1.4040.96
87_N95_A1.3990.96
26_K29_Y1.3970.96
203_F208_L1.3460.95
124_Y128_L1.3360.95
40_A63_I1.3350.95
8_T153_A1.3070.94
65_S214_I1.2920.94
126_Y129_T1.2890.93
80_L84_K1.2710.93
215_P218_V1.2680.93
56_S181_E1.2510.92
37_M137_T1.2360.92
116_V120_L1.2220.91
118_A164_Y1.2040.91
79_E83_N1.1970.91
39_F192_S1.1820.90
90_S94_L1.1360.88
138_S141_L1.1230.88
116_V163_I1.1160.87
105_F139_I1.1120.87
97_G145_F1.1110.87
67_A136_I1.1070.87
215_P219_I1.1000.87
185_V215_P1.0960.86
28_E74_Q1.0580.84
86_V99_S1.0510.84
162_S165_L1.0450.84
111_S155_V1.0440.83
63_I129_T1.0390.83
204_K216_P1.0310.83
157_F161_G1.0300.83
36_A70_G1.0250.82
15_S142_A1.0190.82
90_S95_A1.0180.82
58_Y181_E1.0180.82
10_M135_G1.0160.82
78_L206_L1.0150.82
125_T129_T1.0030.81
153_A156_L0.9960.80
154_L158_S0.9880.80
49_I191_L0.9870.80
6_F124_Y0.9860.80
41_A111_S0.9840.80
160_Q212_L0.9830.80
3_G118_A0.9830.80
87_N90_S0.9800.79
46_I49_I0.9800.79
181_E184_I0.9550.78
6_F131_G0.9540.78
112_I182_I0.9530.77
12_I16_I0.9480.77
3_G127_L0.9400.76
32_I74_Q0.9320.76
115_P163_I0.9290.76
21_F24_G0.9220.75
41_A137_T0.9190.75
86_V102_V0.9160.75
121_H126_Y0.9160.75
38_G197_I0.9140.74
181_E219_I0.9120.74
72_L75_I0.9110.74
218_V222_I0.9100.74
172_S175_N0.9100.74
102_V156_L0.9070.74
44_L59_P0.9040.74
22_K30_Q0.9020.73
57_K177_D0.8960.73
213_L216_P0.8910.73
153_A157_F0.8850.72
128_L131_G0.8840.72
47_N51_Q0.8820.72
19_G150_A0.8750.71
57_K181_E0.8740.71
137_T140_V0.8710.71
84_K88_K0.8680.71
6_F10_M0.8640.70
88_K91_K0.8630.70
110_L126_Y0.8630.70
128_L157_F0.8610.70
184_I187_G0.8600.70
31_D204_K0.8490.69
48_A215_P0.8450.68
24_G140_V0.8440.68
32_I36_A0.8440.68
105_F187_G0.8320.67
64_V214_I0.8320.67
16_I80_L0.8290.67
61_L215_P0.8280.67
43_A66_L0.8240.67
133_L137_T0.8210.66
135_G138_S0.8130.65
116_V119_A0.8120.65
12_I153_A0.8070.65
133_L140_V0.8010.64
123_D126_Y0.7970.64
190_I193_S0.7970.64
90_S96_E0.7960.64
117_E126_Y0.7940.64
10_M133_L0.7930.64
41_A197_I0.7900.63
32_I35_Q0.7890.63
89_F151_A0.7890.63
104_L159_W0.7830.63
77_N81_R0.7810.62
78_L81_R0.7780.62
219_I222_I0.7660.61
75_I217_V0.7660.61
115_P164_Y0.7650.61
149_I159_W0.7580.60
109_S113_L0.7560.60
61_L185_V0.7480.59
13_A135_G0.7460.59
195_L203_F0.7440.59
4_T8_T0.7430.58
41_A190_I0.7410.58
40_A187_G0.7380.58
27_D175_N0.7310.57
166_F169_V0.7300.57
15_S138_S0.7300.57
28_E77_N0.7270.57
25_I145_F0.7260.57
97_G141_L0.7230.56
195_L201_K0.7190.56
77_N84_K0.7190.56
74_Q204_K0.7190.56
46_I191_L0.7100.55
196_S202_K0.7090.55
103_L190_I0.7090.55
211_S215_P0.7060.55
25_I32_I0.7040.54
15_S22_K0.7040.54
105_F135_G0.7000.54
37_M67_A0.6990.54
62_F188_I0.6980.54
96_E202_K0.6940.53
32_I208_L0.6940.53
9_V68_I0.6910.53
94_L148_G0.6890.53
17_I44_L0.6850.52
176_T180_N0.6830.52
3_G124_Y0.6780.52
101_A105_F0.6780.52
162_S166_F0.6770.52
64_V68_I0.6770.52
138_S142_A0.6700.51
172_S183_T0.6700.51
137_T188_I0.6680.51
39_F188_I0.6650.50
5_I8_T0.6630.50
201_K204_K0.6600.50
105_F149_I0.6570.49
34_M145_F0.6570.49
5_I183_T0.6570.49
40_A190_I0.6530.49
78_L201_K0.6520.49
97_G149_I0.6520.49
191_L194_G0.6510.49
48_A126_Y0.6500.49
8_T12_I0.6490.49
170_M173_A0.6470.48
161_G165_L0.6450.48
45_G194_G0.6420.48
86_V94_L0.6410.48
44_L179_I0.6400.48
33_L136_I0.6380.47
141_L178_L0.6360.47
112_I178_L0.6330.47
64_V132_M0.6320.47
19_G116_V0.6300.47
43_A187_G0.6300.47
160_Q164_Y0.6290.46
102_V115_P0.6280.46
38_G194_G0.6250.46
51_Q138_S0.6220.46
13_A93_N0.6210.46
82_F103_L0.6190.45
133_L141_L0.6160.45
142_A150_A0.6150.45
15_S147_F0.6150.45
37_M141_L0.6130.45
195_L204_K0.6130.45
166_F172_S0.6120.45
100_T207_N0.6120.45
109_S137_T0.6110.45
16_I162_S0.6070.44
193_S206_L0.6060.44
119_A126_Y0.6030.44
117_E164_Y0.6030.44
76_I80_L0.6030.44
106_C175_N0.5980.43
138_S149_I0.5960.43
98_L148_G0.5950.43
76_I81_R0.5930.43
5_I157_F0.5930.43
182_I213_L0.5920.43
152_A156_L0.5920.43
9_V13_A0.5920.43
79_E207_N0.5900.42
90_S116_V0.5880.42
165_L169_V0.5870.42
143_S147_F0.5860.42
106_C129_T0.5850.42
46_I50_T0.5850.42
10_M158_S0.5840.42
15_S19_G0.5820.42
13_A200_I0.5820.42
131_G135_G0.5810.41
141_L145_F0.5810.41
34_M144_T0.5780.41
66_L166_F0.5780.41
30_Q38_G0.5780.41
67_A167_A0.5780.41
43_A47_N0.5750.41
193_S205_T0.5750.41
59_P131_G0.5710.40
115_P155_V0.5700.40
104_L149_I0.5690.40
113_L160_Q0.5680.40
60_I205_T0.5670.40
19_G147_F0.5650.40
40_A133_L0.5640.40
25_I140_V0.5630.40
42_V176_T0.5600.39
178_L213_L0.5590.39
47_N185_V0.5590.39
106_C169_V0.5540.39
206_L209_L0.5540.39
26_K81_R0.5530.39
143_S154_L0.5530.39
107_I190_I0.5520.39
169_V173_A0.5510.38
31_D199_G0.5500.38
75_I211_S0.5500.38
188_I191_L0.5500.38
93_N100_T0.5490.38
72_L80_L0.5490.38
16_I68_I0.5480.38
63_I109_S0.5480.38
62_F181_E0.5470.38
32_I145_F0.5440.38
65_S129_T0.5440.38
152_A155_V0.5420.38
48_A110_L0.5410.37
30_Q79_E0.5390.37
33_L159_W0.5370.37
56_S62_F0.5370.37
136_I215_P0.5350.37
79_E204_K0.5350.37
119_A130_N0.5330.37
38_G155_V0.5310.36
15_S105_F0.5280.36
7_N102_V0.5280.36
105_F132_M0.5230.36
165_L211_S0.5230.36
143_S169_V0.5210.35
16_I150_A0.5210.35
90_S99_S0.5170.35
33_L107_I0.5170.35
35_Q198_L0.5130.35
25_I36_A0.5130.35
145_F158_S0.5120.35
86_V90_S0.5110.34
155_V158_S0.5110.34
217_V222_I0.5070.34
46_I214_I0.5060.34
86_V103_L0.5050.34
148_G152_A0.5040.34
172_S211_S0.5020.34
13_A80_L0.5010.34
30_Q43_A0.5000.33
98_L119_A0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.6419 11.1 0.965 Contact Map
1t5jA 1 0.2271 4.5 0.971 Contact Map
2gfpA 2 0.607 3.9 0.972 Contact Map
4eneA 2 0.4061 2.9 0.973 Contact Map
2llyA 1 0.4672 2.7 0.974 Contact Map
4o93B 1 0.7817 2.7 0.974 Contact Map
3rqwA 4 0.4454 2.5 0.974 Contact Map
3nd0A 2 0.1921 2 0.976 Contact Map
4c48C 1 0.1921 2 0.976 Contact Map
3qnqA 2 0.6332 2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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