GREMLIN Database
NAP - Uncharacterized carboxylesterase nap
UniProt: P96688 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (252)
Sequences: 60692 (49632)
Seq/√Len: 3126.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_A83_R4.8801.00
125_H149_S4.2661.00
90_I111_W3.5981.00
74_N285_N2.9991.00
243_E270_K2.8211.00
113_L139_F2.8201.00
280_Q283_Y2.6841.00
267_E287_R2.6531.00
125_H148_K2.5881.00
238_L291_F2.5831.00
123_K148_K2.5041.00
154_S245_E2.5021.00
269_I287_R2.3791.00
153_L284_V2.3491.00
44_Q97_I2.3301.00
113_L143_M2.1791.00
113_L146_R2.1251.00
139_F143_M2.1241.00
113_L117_D2.0981.00
48_I68_S2.0891.00
39_S44_Q2.0361.00
126_M136_T1.9791.00
258_S264_I1.9561.00
46_H95_K1.9551.00
117_D146_R1.9441.00
116_F124_S1.9341.00
243_E268_V1.9171.00
133_G155_P1.8991.00
81_K289_M1.8601.00
138_N142_R1.8501.00
110_N142_R1.8191.00
47_V115_V1.8191.00
77_D285_N1.8161.00
125_H292_F1.8031.00
57_P85_Y1.7961.00
41_R114_D1.7811.00
49_A85_Y1.7701.00
272_A280_Q1.7451.00
140_L150_A1.7191.00
62_H89_I1.7171.00
57_P121_I1.7141.00
125_H151_A1.6771.00
250_P268_V1.6711.00
50_S86_A1.6661.00
57_P83_R1.6521.00
82_Y125_H1.6471.00
106_T142_R1.6471.00
56_P125_H1.6421.00
256_R260_F1.6401.00
46_H68_S1.6271.00
238_L267_E1.6101.00
287_R290_R1.5871.00
56_P148_K1.5741.00
89_I135_H1.5541.00
136_T150_A1.5351.00
237_I261_V1.5311.00
46_H88_D1.4911.00
104_T107_D1.4751.00
109_A138_N1.4691.00
286_E290_R1.4621.00
87_V112_L1.4611.00
66_F70_M1.4591.00
61_L112_L1.4301.00
61_L89_I1.4291.00
139_F147_V1.4151.00
112_L139_F1.4101.00
143_M146_R1.3991.00
80_S289_M1.3841.00
77_D289_M1.3271.00
229_E232_S1.3221.00
51_G83_R1.3211.00
68_S88_D1.3111.00
151_A288_V1.3001.00
45_T111_W1.2891.00
152_I155_P1.2881.00
61_L136_T1.2861.00
194_H197_F1.2751.00
283_Y287_R1.2741.00
85_Y115_V1.2681.00
241_L254_L1.2631.00
139_F146_R1.2371.00
137_M152_I1.2331.00
138_N141_L1.2301.00
65_L130_S1.2201.00
60_L127_I1.2171.00
75_I86_A1.2041.00
50_S75_I1.2021.00
151_A238_L1.2011.00
130_S274_H1.1961.00
117_D143_M1.1931.00
129_L277_S1.1911.00
77_D80_S1.1901.00
127_I153_L1.1841.00
68_S95_K1.1791.00
283_Y286_E1.1781.00
60_L84_T1.1711.00
255_H259_S1.1571.00
261_V264_I1.1421.00
121_I124_S1.1411.00
58_L82_Y1.1351.00
250_P255_H1.1181.00
59_V116_F1.1111.00
87_V115_V1.1051.00
77_D282_T1.0981.00
115_V119_L1.0951.00
231_R260_F1.0831.00
63_G130_S1.0781.00
141_L229_E1.0631.00
241_L250_P1.0451.00
240_L269_I1.0441.00
256_R259_S1.0401.00
56_P82_Y1.0361.00
61_L126_M1.0311.00
116_F139_F1.0301.00
258_S266_A1.0291.00
269_I272_A1.0271.00
265_E287_R1.0261.00
81_K293_N1.0261.00
68_S86_A1.0251.00
241_L266_A1.0221.00
241_L268_V1.0101.00
284_V288_V1.0091.00
267_E290_R1.0081.00
88_D94_N1.0071.00
47_V119_L1.0041.00
289_M293_N1.0001.00
238_L265_E0.9991.00
124_S147_V0.9981.00
127_I288_V0.9971.00
52_P83_R0.9951.00
273_G279_E0.9931.00
149_S236_P0.9781.00
82_Y292_F0.9771.00
282_T286_E0.9761.00
106_T138_N0.9761.00
114_D117_D0.9751.00
113_L142_R0.9571.00
109_A135_H0.9531.00
129_L275_V0.9501.00
70_M277_S0.9401.00
182_F186_M0.9371.00
79_S84_T0.9341.00
56_P123_K0.9311.00
50_S79_S0.9311.00
269_I283_Y0.9311.00
138_N229_E0.9231.00
175_A178_G0.9231.00
255_H258_S0.9191.00
255_H268_V0.9191.00
45_T96_S0.9161.00
195_P199_K0.9151.00
255_H266_A0.9151.00
59_V124_S0.9141.00
200_Q203_A0.9141.00
39_S42_F0.9111.00
114_D118_N0.9031.00
52_P55_A0.9021.00
116_F121_I0.8931.00
85_Y119_L0.8911.00
272_A279_E0.8851.00
240_L287_R0.8841.00
124_S146_R0.8841.00
150_A237_I0.8791.00
113_L116_F0.8761.00
82_Y293_N0.8711.00
199_K202_K0.8651.00
38_I47_V0.8651.00
72_Y86_A0.8651.00
56_P149_S0.8611.00
58_L84_T0.8591.00
199_K203_A0.8591.00
107_D110_N0.8551.00
76_A79_S0.8501.00
128_G136_T0.8451.00
272_A276_L0.8431.00
243_E271_N0.8431.00
153_L277_S0.8411.00
40_T114_D0.8371.00
212_R216_P0.8351.00
61_L87_V0.8321.00
57_P82_Y0.8321.00
196_I200_Q0.8281.00
89_I131_L0.8241.00
58_L127_I0.8191.00
110_N113_L0.8191.00
73_P76_A0.8181.00
267_E283_Y0.8161.00
110_N114_D0.8111.00
153_L276_L0.8071.00
181_T184_N0.8061.00
216_P219_D0.8041.00
40_T43_G0.8041.00
65_L131_L0.8031.00
181_T185_W0.8001.00
69_T72_Y0.7981.00
197_F200_Q0.7851.00
215_N219_D0.7851.00
59_V112_L0.7851.00
128_G133_G0.7851.00
239_L264_I0.7831.00
140_L147_V0.7771.00
126_M139_F0.7751.00
109_A142_R0.7671.00
242_G276_L0.7641.00
218_A221_F0.7611.00
120_G123_K0.7611.00
168_K171_L0.7591.00
200_Q204_G0.7581.00
149_S291_F0.7571.00
38_I118_N0.7561.00
234_R262_P0.7561.00
75_I84_T0.7501.00
214_P217_N0.7481.00
164_H168_K0.7481.00
43_G90_I0.7461.00
41_R110_N0.7441.00
198_V201_F0.7421.00
254_L266_A0.7421.00
166_F170_A0.7391.00
228_E231_R0.7381.00
285_N289_M0.7371.00
48_I72_Y0.7371.00
167_Y170_A0.7361.00
108_Y131_L0.7331.00
60_L71_W0.7331.00
213_N216_P0.7321.00
55_A83_R0.7321.00
43_G97_I0.7301.00
57_P124_S0.7301.00
226_T229_E0.7291.00
68_S87_V0.7241.00
82_Y289_M0.7171.00
109_A139_F0.7121.00
167_Y171_L0.7031.00
217_N220_G0.7031.00
210_G213_N0.7021.00
49_A53_E0.7001.00
64_A131_L0.6991.00
180_E184_N0.6991.00
207_W210_G0.6991.00
179_V182_F0.6991.00
169_Y172_G0.6971.00
129_L154_S0.6961.00
154_S276_L0.6951.00
46_H96_S0.6941.00
140_L235_V0.6911.00
126_M147_V0.6891.00
151_A291_F0.6881.00
88_D95_K0.6871.00
154_S241_L0.6851.00
89_I108_Y0.6841.00
129_L153_L0.6841.00
240_L284_V0.6811.00
58_L292_F0.6791.00
184_N188_N0.6771.00
58_L125_H0.6721.00
170_A173_L0.6691.00
253_A256_R0.6681.00
243_E250_P0.6671.00
124_S148_K0.6651.00
149_S292_F0.6621.00
38_I43_G0.6611.00
59_V126_M0.6611.00
214_P218_A0.6591.00
269_I280_Q0.6541.00
45_T90_I0.6541.00
54_D83_R0.6521.00
74_N77_D0.6521.00
151_A292_F0.6501.00
62_H87_V0.6491.00
286_E289_M0.6481.00
167_Y174_T0.6461.00
222_P225_F0.6451.00
50_S76_A0.6441.00
244_H271_N0.6431.00
167_Y173_L0.6431.00
154_S242_G0.6411.00
128_G132_G0.6411.00
122_E146_R0.6401.00
85_Y121_I0.6391.00
183_L186_M0.6381.00
201_F204_G0.6371.00
179_V183_L0.6371.00
141_L232_S0.6351.00
271_N280_Q0.6331.00
170_A174_T0.6311.00
106_T110_N0.6301.00
90_I108_Y0.6291.00
182_F185_W0.6281.00
72_Y76_A0.6271.00
245_E274_H0.6241.00
105_R138_N0.6241.00
41_R107_D0.6231.00
74_N284_V0.6181.00
53_E83_R0.6171.00
83_R121_I0.6151.00
165_D168_K0.6151.00
75_I79_S0.6121.00
168_K172_G0.6111.00
166_F169_Y0.6101.00
147_V235_V0.6091.00
213_N217_N0.6091.00
60_L86_A0.6091.00
197_F201_F0.6071.00
165_D169_Y0.6061.00
133_G152_I0.6051.00
158_T161_P0.6031.00
140_L233_A0.6021.00
134_L156_A0.6011.00
219_D223_Y0.6001.00
108_Y135_H0.5931.00
239_L254_L0.5911.00
254_L258_S0.5881.00
281_P285_N0.5881.00
130_S275_V0.5841.00
89_I112_L0.5821.00
59_V87_V0.5821.00
265_E290_R0.5811.00
49_A119_L0.5781.00
142_R229_E0.5781.00
196_I199_K0.5751.00
221_F224_V0.5691.00
61_L135_H0.5681.00
48_I86_A0.5661.00
55_A81_K0.5621.00
137_M155_P0.5601.00
207_W211_S0.5591.00
39_S43_G0.5581.00
127_I151_A0.5561.00
151_A240_L0.5551.00
110_N143_M0.5551.00
198_V202_K0.5501.00
109_A113_L0.5501.00
240_L267_E0.5501.00
257_A261_V0.5501.00
160_L164_H0.5491.00
124_S139_F0.5491.00
220_G224_V0.5481.00
227_D260_F0.5451.00
71_W75_I0.5451.00
290_R293_N0.5431.00
221_F225_F0.5391.00
161_P164_H0.5391.00
152_I239_L0.5381.00
227_D256_R0.5371.00
288_V292_F0.5361.00
191_N194_H0.5331.00
163_H166_F0.5291.00
48_I69_T0.5281.00
277_S284_V0.5281.00
178_G181_T0.5271.00
185_W188_N0.5241.00
190_Q194_H0.5221.00
202_K206_M0.5201.00
134_L137_M0.5201.00
195_P198_V0.5181.00
270_K283_Y0.5181.00
179_V186_M0.5181.00
219_D222_P0.5151.00
115_V118_N0.5141.00
215_N218_A0.5141.00
64_A130_S0.5121.00
78_W84_T0.5111.00
239_L261_V0.5111.00
66_F275_V0.5111.00
239_L258_S0.5101.00
71_W74_N0.5101.00
116_F146_R0.5091.00
239_L266_A0.5091.00
166_F173_L0.5081.00
112_L135_H0.5071.00
230_L233_A0.5071.00
129_L276_L0.5061.00
233_A261_V0.5051.00
69_T95_K0.5051.00
171_L174_T0.5051.00
70_M129_L0.5041.00
205_V210_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.86 100 0.235 Contact Map
4inzA 1 0.8533 100 0.244 Contact Map
3oosA 1 0.86 100 0.245 Contact Map
2pujA 4 0.8767 100 0.247 Contact Map
3om8A 4 0.8667 100 0.249 Contact Map
1iupA 2 0.86 100 0.253 Contact Map
2wueA 4 0.88 100 0.254 Contact Map
4psuA 1 0.9067 100 0.257 Contact Map
2xuaA 2 0.8467 100 0.258 Contact Map
4ccwA 1 0.9433 100 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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