GREMLIN Database
YDFH - Sensor histidine kinase YdfH
UniProt: P96685 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (359)
Sequences: 28522 (25897)
Seq/√Len: 1366.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
342_R397_T4.0581.00
348_K393_Q3.8791.00
224_L246_S3.8751.00
346_T395_E3.3821.00
346_T393_Q3.3611.00
383_N395_E3.1841.00
228_H247_M3.1471.00
372_Q376_R3.1171.00
221_N250_V2.9941.00
344_H397_T2.9371.00
228_H244_Q2.8901.00
294_L332_W2.8311.00
318_C394_I2.7581.00
330_T350_N2.7341.00
322_A331_I2.7341.00
334_S346_T2.7121.00
344_H395_E2.7001.00
371_I382_F2.6681.00
296_D334_S2.6631.00
326_A350_N2.6441.00
314_I375_V2.6251.00
220_L250_V2.5891.00
294_L330_T2.5691.00
375_V396_I2.4761.00
375_V380_G2.4231.00
384_I394_I2.4211.00
296_D332_W2.4051.00
227_I243_I2.3391.00
387_T390_K2.2861.00
385_K393_Q2.2461.00
221_N251_K2.2361.00
179_A183_L2.2351.00
329_K350_N2.2201.00
179_A182_T2.2121.00
225_D247_M2.1981.00
349_D353_G2.1551.00
381_Q397_T2.1541.00
336_W344_H2.1521.00
332_W348_K2.1151.00
292_A330_T2.0401.00
175_E179_A1.9931.00
314_I396_I1.9901.00
337_D400_I1.9891.00
306_R378_I1.9501.00
345_L396_I1.8761.00
386_S392_T1.8501.00
334_S348_K1.8341.00
336_W346_T1.8261.00
187_E190_H1.8211.00
385_K395_E1.8111.00
235_N238_R1.8071.00
176_K180_Q1.7971.00
315_I345_L1.7921.00
304_D307_T1.7711.00
314_I371_I1.7701.00
354_F392_T1.7471.00
349_D391_G1.7381.00
247_M251_K1.7081.00
228_H240_K1.7051.00
314_I374_R1.7051.00
220_L246_S1.6541.00
183_L187_E1.6511.00
190_H194_E1.6391.00
375_V382_F1.6141.00
223_Q242_I1.6131.00
326_A329_K1.5981.00
236_T239_A1.5961.00
383_N397_T1.5821.00
339_E344_H1.5601.00
187_E191_Q1.5571.00
190_H193_V1.5561.00
313_Y316_G1.5541.00
374_R378_I1.5511.00
235_N239_A1.5461.00
189_A192_Q1.5461.00
176_K179_A1.5221.00
254_I258_R1.5101.00
326_A331_I1.5031.00
167_A170_F1.4931.00
185_R189_A1.4751.00
376_R381_Q1.4551.00
183_L186_L1.4501.00
275_K279_T1.4401.00
186_L190_H1.4391.00
224_L247_M1.4371.00
227_I239_A1.4341.00
223_Q245_Q1.4261.00
186_L189_A1.4221.00
320_T324_K1.4211.00
343_L400_I1.4171.00
318_C347_V1.4071.00
200_N204_R1.4041.00
279_T283_D1.3971.00
175_E180_Q1.3921.00
221_N247_M1.3881.00
224_L250_V1.3761.00
277_R280_S1.3761.00
224_L243_I1.3571.00
181_L185_R1.3561.00
277_R281_L1.3461.00
189_A193_V1.3411.00
199_Q202_R1.3181.00
233_K240_K1.3161.00
333_I347_V1.3161.00
219_S223_Q1.3121.00
317_E371_I1.2861.00
348_K387_T1.2831.00
232_A240_K1.2771.00
182_T186_L1.2721.00
298_R336_W1.2711.00
199_Q203_Q1.2671.00
281_L284_H1.2661.00
307_T310_N1.2541.00
182_T185_R1.2521.00
244_Q248_K1.2351.00
283_D287_E1.2311.00
164_T167_A1.2301.00
318_C371_I1.2271.00
221_N254_I1.2271.00
277_R312_Y1.2251.00
310_N313_Y1.2221.00
386_S390_K1.2211.00
386_S389_L1.2191.00
297_Y335_I1.2181.00
311_C398_V1.2171.00
280_S284_H1.2151.00
184_E188_L1.2141.00
312_Y316_G1.1941.00
221_N225_D1.1941.00
180_Q184_E1.1791.00
178_K182_T1.1791.00
240_K244_Q1.1741.00
202_R206_A1.1651.00
375_V398_V1.1631.00
384_I392_T1.1621.00
306_R311_C1.1581.00
281_L285_F1.1481.00
332_W350_N1.1471.00
163_I167_A1.1451.00
213_L253_T1.1431.00
369_L373_E1.1381.00
163_I166_A1.1361.00
185_R188_L1.1221.00
222_M226_A1.1191.00
275_K278_I1.1191.00
319_M331_I1.1141.00
213_L257_A1.1121.00
327_E352_K1.1121.00
198_L202_R1.1121.00
176_K183_L1.1091.00
282_M285_F1.1021.00
355_D388_K1.0821.00
224_L228_H1.0781.00
250_V254_I1.0751.00
201_E204_R1.0691.00
310_N374_R1.0661.00
241_E244_Q1.0641.00
176_K182_T1.0631.00
166_A170_F1.0601.00
178_K181_L1.0571.00
175_E178_K1.0561.00
177_I180_Q1.0511.00
373_E377_A1.0501.00
259_S310_N1.0501.00
184_E187_E1.0481.00
175_E183_L1.0421.00
162_I166_A1.0391.00
212_T313_Y1.0331.00
180_Q183_L1.0321.00
308_A312_Y1.0291.00
241_E245_Q1.0221.00
245_Q249_R1.0191.00
242_I245_Q1.0161.00
217_L253_T1.0101.00
279_T282_M1.0031.00
255_A259_S0.9991.00
322_A326_A0.9991.00
301_Q337_D0.9961.00
219_S249_R0.9961.00
339_E342_R0.9941.00
191_Q194_E0.9911.00
147_E150_H0.9871.00
277_R286_I0.9811.00
168_T172_Q0.9741.00
315_I319_M0.9731.00
299_L337_D0.9721.00
188_L192_Q0.9681.00
275_K286_I0.9631.00
237_E240_K0.9611.00
226_A242_I0.9561.00
214_A258_R0.9561.00
204_R208_D0.9561.00
244_Q247_M0.9501.00
243_I246_S0.9501.00
302_V337_D0.9421.00
192_Q197_T0.9421.00
336_W339_E0.9411.00
311_C343_L0.9391.00
291_M295_L0.9361.00
380_G398_V0.9351.00
170_F173_V0.9341.00
212_T216_G0.9231.00
115_Q119_M0.9221.00
205_M209_L0.9181.00
319_M333_I0.9181.00
175_E182_T0.9171.00
298_R334_S0.9101.00
215_Q219_S0.9071.00
248_K252_S0.9051.00
188_L191_Q0.9041.00
146_G150_H0.9021.00
373_E376_R0.9021.00
249_R253_T0.9011.00
387_T393_Q0.9001.00
318_C396_I0.8971.00
198_L201_E0.8891.00
319_M323_A0.8891.00
311_C345_L0.8871.00
227_I246_S0.8831.00
275_K281_L0.8821.00
315_I347_V0.8811.00
358_K361_K0.8711.00
283_D286_I0.8691.00
275_K335_I0.8691.00
212_T256_D0.8681.00
238_R241_E0.8661.00
170_F174_D0.8611.00
266_S269_E0.8611.00
349_D392_T0.8601.00
213_L216_G0.8591.00
310_N378_I0.8571.00
382_F394_I0.8521.00
145_K148_V0.8511.00
148_V151_F0.8491.00
325_H361_K0.8471.00
354_F394_I0.8421.00
307_T378_I0.8411.00
386_S391_G0.8371.00
64_F68_H0.8341.00
197_T200_N0.8341.00
342_R381_Q0.8331.00
167_A171_A0.8311.00
37_I41_V0.8301.00
281_L312_Y0.8301.00
380_G396_I0.8281.00
354_F386_S0.8281.00
279_T295_L0.8241.00
183_L190_H0.8221.00
366_Y370_G0.8161.00
249_R252_S0.8131.00
197_T201_E0.8131.00
368_L371_I0.8051.00
239_A242_I0.8021.00
58_T61_I0.7961.00
236_T240_K0.7961.00
182_T187_E0.7951.00
154_I157_P0.7931.00
155_A159_M0.7911.00
209_L260_A0.7901.00
211_D215_Q0.7881.00
50_S53_L0.7861.00
382_F396_I0.7851.00
117_I120_A0.7851.00
86_Q91_F0.7831.00
282_M286_I0.7821.00
126_F129_L0.7821.00
116_I119_M0.7811.00
210_H216_G0.7791.00
280_S283_D0.7761.00
55_Y58_T0.7741.00
77_K80_I0.7731.00
111_F114_G0.7711.00
287_E290_G0.7701.00
58_T62_A0.7701.00
282_M293_C0.7691.00
223_Q249_R0.7651.00
223_Q246_S0.7641.00
238_R242_I0.7641.00
337_D340_K0.7591.00
275_K284_H0.7591.00
228_H243_I0.7591.00
353_G392_T0.7561.00
214_A254_I0.7541.00
277_R285_F0.7521.00
315_I333_I0.7511.00
181_L184_E0.7491.00
63_I67_L0.7421.00
341_G400_I0.7411.00
239_A243_I0.7411.00
79_V83_F0.7401.00
352_K361_K0.7391.00
359_G362_K0.7391.00
232_A239_A0.7341.00
112_L115_Q0.7341.00
289_T323_A0.7321.00
246_S250_V0.7291.00
148_V152_I0.7271.00
233_K239_A0.7261.00
76_K79_V0.7251.00
318_C375_V0.7251.00
274_L277_R0.7241.00
277_R282_M0.7231.00
285_F323_A0.7211.00
164_T168_T0.7211.00
370_G374_R0.7211.00
225_D228_H0.7191.00
61_I64_F0.7181.00
81_L84_A0.7181.00
302_V343_L0.7171.00
282_M316_G0.7171.00
280_S312_Y0.7151.00
168_T171_A0.7121.00
182_T189_A0.7121.00
226_A230_H0.7111.00
166_A169_F0.7091.00
216_G253_T0.7081.00
220_L224_L0.7081.00
311_C378_I0.7051.00
300_H337_D0.7011.00
150_H153_V0.7011.00
333_I345_L0.7011.00
218_V222_M0.7001.00
258_R262_D0.6981.00
276_E279_T0.6981.00
335_I343_L0.6951.00
177_I181_L0.6931.00
354_F384_I0.6921.00
205_M208_D0.6901.00
125_T128_I0.6901.00
245_Q248_K0.6881.00
310_N314_I0.6871.00
275_K285_F0.6851.00
296_D336_W0.6851.00
168_T173_V0.6821.00
80_I83_F0.6801.00
62_A66_L0.6801.00
169_F172_Q0.6791.00
291_M323_A0.6791.00
291_M326_A0.6791.00
335_I345_L0.6791.00
115_Q120_A0.6791.00
223_Q226_A0.6781.00
118_G121_D0.6781.00
265_R366_Y0.6771.00
214_A253_T0.6751.00
84_A87_G0.6721.00
78_R82_Y0.6721.00
144_H147_E0.6711.00
167_A172_Q0.6681.00
214_A261_I0.6681.00
325_H352_K0.6651.00
225_D251_K0.6641.00
133_L136_V0.6631.00
281_L316_G0.6631.00
263_D369_L0.6601.00
247_M250_V0.6591.00
371_I375_V0.6591.00
253_T256_D0.6551.00
260_A264_L0.6541.00
40_I43_Q0.6541.00
41_V45_V0.6541.00
256_D259_S0.6531.00
380_G399_P0.6511.00
52_L55_Y0.6501.00
276_E280_S0.6491.00
150_H154_I0.6481.00
257_A260_A0.6451.00
351_G391_G0.6451.00
114_G118_G0.6401.00
250_V253_T0.6401.00
78_R81_L0.6381.00
274_L308_A0.6361.00
107_G110_A0.6361.00
339_E397_T0.6361.00
291_M329_K0.6331.00
161_V164_T0.6321.00
120_A123_R0.6311.00
317_E324_K0.6291.00
224_L227_I0.6291.00
372_Q381_Q0.6271.00
253_T257_A0.6261.00
110_A114_G0.6221.00
342_R400_I0.6221.00
255_A309_E0.6211.00
59_I63_I0.6211.00
114_G117_I0.6191.00
165_Y168_T0.6181.00
210_H261_I0.6161.00
119_M123_R0.6131.00
110_A113_I0.6131.00
118_G122_R0.6121.00
53_L57_F0.6101.00
117_I121_D0.6081.00
54_L57_F0.6061.00
153_V156_A0.6051.00
202_R207_R0.6041.00
293_C333_I0.6011.00
279_T286_I0.6011.00
346_T385_K0.6011.00
166_A173_V0.6001.00
243_I247_M0.5991.00
77_K81_L0.5981.00
211_D317_E0.5981.00
79_V86_Q0.5971.00
200_N203_Q0.5951.00
69_W72_Y0.5921.00
159_M162_I0.5921.00
211_D214_A0.5911.00
385_K392_T0.5901.00
252_S256_D0.5891.00
52_L56_A0.5881.00
65_A68_H0.5871.00
90_T94_A0.5871.00
115_Q118_G0.5861.00
57_F60_L0.5851.00
37_I40_I0.5841.00
316_G320_T0.5831.00
194_E197_T0.5831.00
324_K360_K0.5831.00
120_A124_R0.5821.00
383_N396_I0.5811.00
288_S291_M0.5811.00
51_I55_Y0.5811.00
134_L138_N0.5811.00
99_G103_L0.5801.00
212_T317_E0.5801.00
119_M122_R0.5801.00
155_A158_I0.5791.00
40_I44_F0.5791.00
253_T258_R0.5791.00
44_F47_G0.5791.00
317_E320_T0.5791.00
231_L234_G0.5781.00
261_I265_R0.5761.00
231_L239_A0.5761.00
215_Q222_M0.5761.00
251_K254_I0.5751.00
265_R364_G0.5741.00
61_I65_A0.5741.00
109_Y112_L0.5741.00
64_F67_L0.5731.00
348_K391_G0.5721.00
111_F115_Q0.5711.00
169_F173_V0.5711.00
60_L64_F0.5701.00
213_L217_L0.5681.00
179_A186_L0.5681.00
331_I335_I0.5671.00
80_I84_A0.5671.00
203_Q267_K0.5671.00
107_G111_F0.5661.00
127_L130_Y0.5661.00
206_A210_H0.5661.00
108_L111_F0.5621.00
278_I286_I0.5621.00
208_D212_T0.5621.00
82_Y86_Q0.5611.00
51_I54_L0.5601.00
82_Y85_V0.5601.00
43_Q47_G0.5601.00
277_R284_H0.5591.00
110_A115_Q0.5581.00
91_F94_A0.5571.00
314_I378_I0.5561.00
75_V80_I0.5561.00
230_H233_K0.5551.00
263_D267_K0.5551.00
313_Y370_G0.5541.00
310_N377_A0.5541.00
204_R373_E0.5531.00
121_D124_R0.5521.00
366_Y369_L0.5511.00
284_H312_Y0.5481.00
202_R215_Q0.5481.00
217_L220_L0.5471.00
234_G239_A0.5471.00
83_F87_G0.5461.00
342_R399_P0.5461.00
219_S245_Q0.5441.00
39_S43_Q0.5441.00
317_E370_G0.5431.00
233_K236_T0.5431.00
81_L85_V0.5431.00
75_V79_V0.5421.00
291_M331_I0.5421.00
232_A236_T0.5401.00
219_S222_M0.5391.00
72_Y75_V0.5391.00
344_H383_N0.5371.00
108_L114_G0.5361.00
129_L133_L0.5361.00
262_D313_Y0.5361.00
375_V378_I0.5361.00
332_W346_T0.5351.00
42_L46_S0.5341.00
56_A59_I0.5341.00
331_I347_V0.5331.00
322_A347_V0.5301.00
38_A41_V0.5281.00
98_T101_F0.5281.00
217_L257_A0.5281.00
298_R335_I0.5271.00
210_H215_Q0.5261.00
79_V82_Y0.5251.00
214_A260_A0.5231.00
254_I257_A0.5221.00
305_V401_Q0.5211.00
293_C297_Y0.5201.00
162_I168_T0.5201.00
251_K255_A0.5201.00
151_F155_A0.5191.00
167_A173_V0.5181.00
206_A209_L0.5181.00
354_F357_E0.5181.00
183_L189_A0.5181.00
58_T65_A0.5181.00
132_L135_L0.5171.00
212_T215_Q0.5161.00
55_Y67_L0.5141.00
99_G102_I0.5131.00
86_Q94_A0.5131.00
337_D343_L0.5131.00
166_A172_Q0.5111.00
309_E313_Y0.5091.00
69_W73_R0.5081.00
294_L297_Y0.5081.00
218_V221_N0.5081.00
216_G256_D0.5061.00
286_I293_C0.5051.00
314_I318_C0.5041.00
216_G249_R0.5041.00
135_L138_N0.5031.00
149_L152_I0.5011.00
194_E199_Q0.5011.00
249_R261_I0.5011.00
194_E198_L0.5001.00
227_I242_I0.5001.00
53_L56_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6143 100 0.461 Contact Map
4q20A 2 0.5184 100 0.474 Contact Map
4r39A 1 0.5012 100 0.477 Contact Map
4bixA 2 0.5184 100 0.481 Contact Map
2c2aA 2 0.5283 100 0.485 Contact Map
3ehhA 2 0.4791 100 0.495 Contact Map
3d36A 2 0.5012 100 0.497 Contact Map
4ctiA 2 0.5553 100 0.499 Contact Map
3jz3A 2 0.3735 100 0.503 Contact Map
4gczA 2 0.8698 100 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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