GREMLIN Database
YDFC - Uncharacterized transporter YdfC
UniProt: P96680 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (277)
Sequences: 39178 (28698)
Seq/√Len: 1724.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_G155_I3.3291.00
11_S232_Y2.8961.00
96_V152_I2.7691.00
232_Y236_F2.6841.00
257_S263_E2.5631.00
47_S187_W2.5111.00
40_L194_L2.5101.00
87_I154_V2.4731.00
84_L157_L2.3901.00
127_G279_G2.3711.00
25_G217_Y2.3241.00
63_D66_D2.3171.00
232_Y235_S2.2331.00
107_F159_A2.1821.00
118_E170_A2.1431.00
111_L167_V2.1021.00
84_L154_V2.1001.00
27_R263_E2.0831.00
98_S253_A1.9871.00
44_L190_T1.9591.00
20_A252_L1.9561.00
12_H233_V1.9241.00
113_R120_F1.9161.00
45_I219_G1.9011.00
26_I86_N1.8961.00
80_F161_S1.8761.00
109_A128_S1.8661.00
153_L157_L1.8061.00
92_V152_I1.8041.00
51_L183_T1.7951.00
66_D175_K1.7731.00
103_T107_F1.7701.00
108_S243_T1.7611.00
52_L55_V1.7571.00
112_S118_E1.7441.00
177_G180_P1.7431.00
191_I195_V1.7171.00
121_G124_K1.7121.00
91_T150_S1.6641.00
219_G224_V1.6591.00
47_S190_T1.6581.00
20_A256_I1.6341.00
281_C285_L1.6291.00
92_V151_G1.6291.00
84_L161_S1.6221.00
238_G241_E1.6131.00
131_S247_Y1.5581.00
195_V198_P1.5571.00
107_F163_S1.5441.00
17_G252_L1.5421.00
21_S217_Y1.5381.00
40_L190_T1.5271.00
266_T269_S1.4991.00
33_Y211_A1.4781.00
127_G283_T1.4751.00
149_M152_I1.4521.00
53_F57_T1.4401.00
267_L271_L1.4251.00
87_I91_T1.4201.00
111_L115_F1.4141.00
107_F160_F1.4101.00
65_K68_P1.4081.00
97_A155_I1.4031.00
65_K69_A1.4021.00
51_L55_V1.3801.00
209_I213_L1.3761.00
15_M233_V1.3621.00
94_A257_S1.3481.00
68_P72_L1.3371.00
134_G272_G1.3341.00
18_L221_L1.3341.00
64_L67_I1.3321.00
137_L275_V1.3311.00
270_L274_V1.3291.00
169_Q231_A1.3201.00
72_L168_F1.3171.00
256_I260_W1.3101.00
112_S116_Y1.3091.00
69_A168_F1.3051.00
64_L68_P1.3041.00
48_M52_L1.3031.00
127_G282_F1.2961.00
52_L56_L1.2931.00
122_F126_L1.2871.00
204_M207_A1.2861.00
92_V96_V1.2781.00
87_I90_K1.2781.00
28_A214_S1.2781.00
29_G38_L1.2761.00
208_S211_A1.2761.00
11_S229_A1.2731.00
24_P256_I1.2681.00
19_W226_P1.2641.00
131_S279_G1.2591.00
95_G254_L1.2581.00
49_A224_V1.2541.00
125_W129_M1.2541.00
38_L218_L1.2531.00
91_T154_V1.2471.00
71_F188_G1.2471.00
252_L256_I1.2441.00
171_R175_K1.2431.00
93_S96_V1.2361.00
46_G186_I1.2361.00
274_V278_G1.2331.00
32_G211_A1.2271.00
265_P270_L1.2141.00
137_L268_L1.2141.00
163_S167_V1.2131.00
111_L164_I1.1851.00
129_M133_L1.1851.00
75_F192_P1.1841.00
9_M245_S1.1821.00
248_V252_L1.1711.00
99_L273_G1.1661.00
40_L44_L1.1631.00
149_M153_L1.1611.00
170_A238_G1.1601.00
192_P195_V1.1581.00
123_T282_F1.1541.00
213_L217_Y1.1471.00
34_T37_H1.1451.00
79_A193_M1.1431.00
150_S154_V1.1321.00
36_E196_F1.1321.00
74_G188_G1.1221.00
108_S239_A1.1211.00
79_A192_P1.1191.00
10_I14_L1.1161.00
171_R174_K1.1101.00
27_R31_E1.1051.00
8_I233_V1.0991.00
114_L117_K1.0981.00
138_I272_G1.0971.00
55_V59_M1.0921.00
91_T148_S1.0901.00
40_L197_L1.0891.00
170_A174_K1.0791.00
89_E97_A1.0681.00
47_S183_T1.0671.00
116_Y167_V1.0641.00
91_T151_G1.0641.00
234_T242_A1.0561.00
134_G276_T1.0541.00
14_L229_A1.0521.00
111_L163_S1.0461.00
120_F125_W1.0461.00
42_R223_T1.0451.00
25_G214_S1.0441.00
210_S213_L1.0431.00
122_F125_W1.0431.00
109_A120_F1.0351.00
21_S256_I1.0291.00
18_L229_A1.0261.00
113_R119_H1.0261.00
170_A239_A1.0221.00
26_I89_E1.0201.00
213_L216_V1.0161.00
76_L164_I1.0091.00
111_L160_F1.0091.00
69_A172_Y1.0081.00
15_M229_A1.0061.00
94_A261_I1.0011.00
150_S153_L0.9991.00
92_V155_I0.9971.00
19_W230_L0.9971.00
66_D176_Y0.9951.00
123_T286_K0.9951.00
39_A86_N0.9941.00
100_L159_A0.9911.00
118_E124_K0.9871.00
209_I212_T0.9831.00
123_T285_L0.9811.00
15_M19_W0.9801.00
108_S166_F0.9791.00
212_T216_V0.9751.00
85_L89_E0.9701.00
36_E83_I0.9691.00
29_G211_A0.9581.00
35_P39_A0.9551.00
59_M177_G0.9551.00
130_I279_G0.9541.00
68_P71_F0.9471.00
151_G155_I0.9471.00
267_L270_L0.9441.00
103_T135_V0.9421.00
121_G125_W0.9271.00
140_F266_T0.9241.00
76_L161_S0.9241.00
100_L152_I0.9221.00
43_L189_G0.9181.00
119_H123_T0.9141.00
108_S163_S0.9121.00
195_V199_G0.9111.00
234_T238_G0.9091.00
136_L140_F0.9011.00
24_P260_W0.9001.00
100_L155_I0.8981.00
159_A163_S0.8971.00
55_V58_Q0.8941.00
29_G214_S0.8901.00
133_L137_L0.8831.00
205_M208_S0.8781.00
206_N209_I0.8771.00
37_H197_L0.8761.00
111_L114_L0.8751.00
187_W191_I0.8741.00
44_L194_L0.8691.00
66_D69_A0.8691.00
99_L136_L0.8681.00
238_G242_A0.8661.00
63_D67_I0.8641.00
39_A193_M0.8641.00
51_L187_W0.8631.00
49_A52_L0.8601.00
49_A220_L0.8521.00
94_A263_E0.8511.00
119_H122_F0.8501.00
16_I252_L0.8461.00
196_F199_G0.8461.00
148_S152_I0.8431.00
258_W265_P0.8341.00
83_I87_I0.8311.00
67_I188_G0.8301.00
8_I236_F0.8281.00
16_I20_A0.8271.00
69_A171_R0.8271.00
55_V60_R0.8181.00
237_V242_A0.8171.00
78_F165_Y0.8171.00
216_V219_G0.8171.00
237_V241_E0.8161.00
56_L59_M0.8141.00
248_V251_A0.7951.00
251_A273_G0.7941.00
24_P257_S0.7921.00
133_L275_V0.7901.00
79_A83_I0.7881.00
215_I219_G0.7871.00
113_R117_K0.7831.00
221_L225_I0.7801.00
268_L271_L0.7791.00
126_L130_I0.7761.00
32_G208_S0.7751.00
137_L271_L0.7741.00
69_A73_L0.7731.00
135_V139_A0.7691.00
164_I168_F0.7661.00
205_M209_I0.7651.00
70_I176_Y0.7601.00
76_L168_F0.7591.00
190_T194_L0.7561.00
233_V242_A0.7561.00
106_I131_S0.7541.00
254_L265_P0.7511.00
271_L275_V0.7491.00
47_S51_L0.7421.00
67_I71_F0.7401.00
50_L224_V0.7401.00
12_H245_S0.7391.00
210_S214_S0.7361.00
162_E166_F0.7341.00
110_M114_L0.7341.00
74_G79_A0.7341.00
155_I159_A0.7331.00
216_V220_L0.7321.00
183_T187_W0.7251.00
254_L273_G0.7231.00
13_S252_L0.7231.00
41_F45_I0.7221.00
109_A124_K0.7201.00
107_F156_L0.7121.00
72_L75_F0.7111.00
188_G191_I0.7101.00
273_G277_V0.7081.00
188_G192_P0.7081.00
211_A214_S0.7061.00
100_L156_L0.7061.00
53_F179_I0.7031.00
184_F188_G0.7031.00
278_G282_F0.7031.00
57_T177_G0.7001.00
80_F84_L0.6991.00
108_S167_V0.6981.00
225_I229_A0.6971.00
120_F124_K0.6961.00
146_T149_M0.6961.00
81_Y161_S0.6911.00
103_T106_I0.6891.00
67_I70_I0.6871.00
26_I30_L0.6851.00
54_A58_Q0.6821.00
182_V231_A0.6821.00
44_L48_M0.6761.00
258_W264_I0.6761.00
16_I248_V0.6751.00
28_A261_I0.6731.00
140_F143_G0.6671.00
203_E206_N0.6631.00
67_I184_F0.6631.00
279_G283_T0.6611.00
70_I181_F0.6611.00
37_H41_F0.6601.00
33_Y38_L0.6601.00
54_A183_T0.6591.00
214_S217_Y0.6581.00
189_G193_M0.6571.00
134_G279_G0.6571.00
176_Y181_F0.6561.00
49_A219_G0.6561.00
69_A72_L0.6561.00
118_E240_S0.6551.00
24_P94_A0.6521.00
88_G97_A0.6481.00
23_F85_L0.6481.00
63_D68_P0.6471.00
88_G151_G0.6431.00
62_P66_D0.6401.00
92_V97_A0.6391.00
257_S261_I0.6381.00
187_W190_T0.6361.00
57_T60_R0.6351.00
81_Y165_Y0.6341.00
78_F227_Y0.6331.00
191_I194_L0.6331.00
244_L283_T0.6331.00
12_H237_V0.6321.00
265_P269_S0.6291.00
56_L60_R0.6261.00
61_L64_L0.6251.00
53_F56_L0.6251.00
162_E230_L0.6221.00
9_M241_E0.6211.00
144_D147_Y0.6201.00
102_T105_P0.6171.00
130_I282_F0.6171.00
22_A222_P0.6151.00
18_L226_P0.6141.00
217_Y221_L0.6141.00
109_A113_R0.6141.00
264_I268_L0.6121.00
45_I49_A0.6081.00
105_P247_Y0.6071.00
116_Y171_R0.6061.00
8_I237_V0.6061.00
46_G224_V0.6051.00
85_L158_A0.6051.00
154_V157_L0.6041.00
254_L258_W0.6001.00
23_F98_S0.5981.00
103_T159_A0.5941.00
124_K238_G0.5941.00
228_F232_Y0.5931.00
78_F185_T0.5931.00
196_F200_L0.5851.00
85_L97_A0.5841.00
269_S273_G0.5841.00
71_F75_F0.5831.00
79_A196_F0.5811.00
180_P184_F0.5801.00
147_Y150_S0.5761.00
266_T270_L0.5651.00
102_T135_V0.5641.00
256_I259_L0.5631.00
121_G286_K0.5621.00
84_L158_A0.5571.00
115_F164_I0.5571.00
99_L139_A0.5561.00
86_N90_K0.5551.00
255_I259_L0.5541.00
176_Y180_P0.5491.00
99_L138_I0.5461.00
70_I74_G0.5441.00
165_Y231_A0.5421.00
139_A152_I0.5421.00
182_V185_T0.5401.00
166_F230_L0.5391.00
48_M51_L0.5391.00
110_M128_S0.5391.00
184_F187_W0.5381.00
9_M13_S0.5351.00
18_L222_P0.5341.00
264_I269_S0.5341.00
14_L18_L0.5341.00
259_L262_G0.5331.00
255_I258_W0.5321.00
52_L57_T0.5321.00
16_I249_T0.5311.00
194_L198_P0.5311.00
78_F82_H0.5311.00
24_P253_A0.5271.00
258_W270_L0.5231.00
102_T159_A0.5231.00
282_F286_K0.5231.00
41_F215_I0.5221.00
33_Y37_H0.5211.00
116_Y170_A0.5211.00
280_V283_T0.5201.00
30_L89_E0.5181.00
78_F189_G0.5141.00
152_I156_L0.5141.00
71_F192_P0.5141.00
81_Y85_L0.5141.00
146_T150_S0.5141.00
137_L269_S0.5111.00
88_G92_V0.5051.00
141_G268_L0.5051.00
277_V281_C0.5051.00
126_L133_L0.5051.00
13_S16_I0.5041.00
103_T131_S0.5031.00
54_A180_P0.5031.00
18_L225_I0.5021.00
66_D70_I0.5021.00
57_T179_I0.5021.00
247_Y280_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2516 98.9 0.754 Contact Map
3b5dA 2 0.3301 98.3 0.802 Contact Map
4j05A 3 0.9379 77.7 0.908 Contact Map
2cfqA 1 0.6111 68.5 0.914 Contact Map
4he8J 1 0.5098 63.9 0.916 Contact Map
3wdoA 1 0.9575 63.4 0.917 Contact Map
1pw4A 1 0.8791 60.4 0.918 Contact Map
3l1lA 2 0.8791 59.7 0.919 Contact Map
4bwzA 2 0.9444 54.9 0.921 Contact Map
4czbA 2 0.9346 50.9 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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