GREMLIN Database
YDFB - Uncharacterized N-acetyltransferase YdfB
UniProt: P96679 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 261 (243)
Sequences: 429 (337)
Seq/√Len: 21.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_E39_A5.9551.00
118_F241_I4.6351.00
43_D48_P4.0721.00
199_I215_A3.9161.00
103_K112_Q3.6511.00
170_G187_S3.5481.00
212_Y246_K3.5181.00
185_C218_F3.0801.00
135_L205_Y3.0150.99
183_S210_L2.9050.99
221_F224_E2.8210.99
115_R196_E2.8110.99
43_D49_K2.5500.98
174_A181_V2.3840.97
135_L210_L2.3430.97
11_K14_S2.3420.97
160_W190_L2.3410.97
177_H205_Y2.2960.96
120_Y125_F2.2220.96
175_V213_C2.2220.96
232_D255_Y2.2120.96
198_D218_F2.1750.95
175_V214_V2.1020.94
32_L40_V2.0850.94
50_S68_N2.0160.93
233_C249_F1.9260.91
90_T257_I1.8070.88
160_W249_F1.7720.87
43_D68_N1.7620.87
113_M257_I1.7600.87
198_D232_D1.7550.86
19_F28_V1.7040.85
132_P137_L1.6830.84
148_S157_E1.6630.83
183_S201_T1.6200.81
155_Y186_T1.5960.80
136_V179_N1.5850.80
161_N165_Q1.5820.80
31_I62_I1.5750.80
103_K258_Y1.5720.79
215_A247_L1.5680.79
158_E166_F1.5260.77
102_L187_S1.5260.77
171_F218_F1.5010.76
195_A218_F1.4910.76
186_T233_C1.4870.75
168_S178_G1.4810.75
7_L42_A1.4750.75
44_D48_P1.4680.74
186_T200_Y1.4660.74
19_F63_A1.4530.74
15_L53_I1.4290.72
238_N242_A1.4170.72
59_I115_R1.4170.72
40_V160_W1.3900.70
78_Y118_F1.3740.69
120_Y126_K1.3470.68
53_I157_E1.3130.66
113_M236_C1.3120.66
177_H215_A1.2930.65
137_L213_C1.2890.64
145_I150_A1.2820.64
156_Y198_D1.2810.64
18_M51_F1.2730.63
160_W233_C1.2640.63
27_F189_F1.2640.63
205_Y208_L1.2590.62
58_G188_I1.2480.62
28_V196_E1.2420.61
221_F225_N1.2230.60
60_Y199_I1.2190.60
112_Q258_Y1.2170.60
27_F115_R1.2120.59
144_I174_A1.2080.59
41_Y47_F1.2040.59
115_R230_S1.2030.59
196_E219_I1.1960.58
121_Q149_T1.1910.58
5_Q135_L1.1850.58
163_V167_A1.1820.57
208_L246_K1.1620.56
240_S248_G1.1590.56
40_V138_K1.1570.56
7_L11_K1.1540.56
196_E222_C1.1500.55
65_D68_N1.1450.55
146_S163_V1.1410.55
155_Y198_D1.1300.54
198_D233_C1.1180.53
49_K100_S1.1080.53
219_I247_L1.0980.52
115_R195_A1.0870.51
59_I90_T1.0860.51
135_L175_V1.0850.51
145_I163_V1.0850.51
46_T205_Y1.0840.51
31_I53_I1.0830.51
184_E233_C1.0820.51
134_G139_R1.0770.50
121_Q250_K1.0750.50
186_T249_F1.0690.50
228_V249_F1.0660.50
199_I219_I1.0580.49
218_F222_C1.0520.49
63_A219_I1.0490.49
11_K224_E1.0450.48
121_Q124_S1.0290.47
40_V52_F1.0260.47
12_Y41_Y1.0250.47
155_Y184_E1.0220.47
156_Y200_Y1.0210.47
55_T233_C1.0210.47
203_E212_Y1.0120.46
42_A173_F1.0070.46
124_S250_K1.0060.46
220_A228_V0.9990.45
131_L175_V0.9930.45
31_I37_P0.9930.45
42_A167_A0.9920.45
177_H238_N0.9900.45
90_T115_R0.9850.44
120_Y223_M0.9820.44
150_A205_Y0.9800.44
98_W172_G0.9750.44
181_V258_Y0.9740.44
53_I190_L0.9710.43
237_N240_S0.9700.43
184_E188_I0.9690.43
58_G198_D0.9630.43
218_F229_P0.9620.43
7_L79_Y0.9570.42
120_Y124_S0.9530.42
173_F221_F0.9460.42
57_S159_Y0.9440.42
219_I223_M0.9420.41
186_T232_D0.9410.41
198_D249_F0.9390.41
7_L14_S0.9350.41
112_Q256_T0.9290.41
188_I198_D0.9220.40
27_F55_T0.9200.40
170_G231_W0.9190.40
185_C198_D0.9140.40
152_N186_T0.9130.40
184_E196_E0.9110.39
58_G233_C0.9090.39
136_V139_R0.9080.39
55_T156_Y0.9080.39
161_N180_H0.9050.39
166_F186_T0.8990.39
90_T189_F0.8990.39
184_E198_D0.8950.38
118_F214_V0.8920.38
168_S225_N0.8890.38
155_Y188_I0.8880.38
49_K65_D0.8840.38
135_L182_V0.8750.37
166_F231_W0.8710.37
192_H208_L0.8710.37
27_F59_I0.8680.37
168_S204_E0.8640.36
14_S40_V0.8600.36
206_R214_V0.8580.36
60_Y90_T0.8580.36
178_G192_H0.8540.36
53_I93_S0.8500.36
180_H223_M0.8480.35
210_L254_E0.8430.35
37_P249_F0.8340.35
125_F220_A0.8310.34
199_I239_S0.8310.34
27_F233_C0.8290.34
201_T209_G0.8230.34
243_L247_L0.8210.34
160_W184_E0.8180.34
197_M200_Y0.8170.34
175_V207_G0.8170.34
114_R137_L0.8160.33
96_D99_D0.8110.33
17_T20_D0.8100.33
64_G166_F0.8060.33
177_H183_S0.8050.33
43_D67_G0.8050.33
90_T195_A0.8030.33
64_G231_W0.8000.33
164_S167_A0.7910.32
55_T187_S0.7880.32
110_L189_F0.7880.32
52_F173_F0.7870.32
148_S181_V0.7840.32
88_R113_M0.7830.32
188_I232_D0.7830.32
58_G155_Y0.7810.31
26_T189_F0.7810.31
195_A198_D0.7800.31
32_L183_S0.7780.31
42_A45_Q0.7770.31
161_N190_L0.7750.31
30_S112_Q0.7660.31
57_S233_C0.7640.30
17_T44_D0.7600.30
27_F196_E0.7560.30
12_Y15_L0.7530.30
229_P232_D0.7510.30
100_S133_K0.7470.29
55_T58_G0.7450.29
194_R198_D0.7410.29
16_K77_G0.7390.29
198_D230_S0.7330.29
58_G160_W0.7330.29
102_L116_A0.7280.28
144_I176_L0.7270.28
162_S166_F0.7260.28
15_L206_R0.7220.28
69_R104_P0.7210.28
208_L239_S0.7210.28
40_V207_G0.7200.28
98_W103_K0.7190.28
142_E146_S0.7190.28
152_N156_Y0.7180.28
104_P162_S0.7180.28
60_Y156_Y0.7160.28
160_W186_T0.7160.28
91_L106_L0.7160.28
140_I166_F0.7160.28
52_F62_I0.7160.28
51_F63_A0.7110.27
188_I230_S0.7090.27
183_S214_V0.7080.27
109_D134_G0.7010.27
177_H210_L0.6980.27
242_A245_A0.6960.27
155_Y249_F0.6930.27
194_R249_F0.6920.26
15_L41_Y0.6840.26
59_I186_T0.6840.26
55_T188_I0.6800.26
59_I232_D0.6780.26
143_D168_S0.6760.26
251_T254_E0.6750.26
53_I148_S0.6710.25
64_G170_G0.6700.25
138_K213_C0.6700.25
58_G243_L0.6660.25
183_S238_N0.6650.25
229_P243_L0.6640.25
186_T198_D0.6630.25
215_A241_I0.6630.25
223_M229_P0.6560.25
59_I230_S0.6550.25
70_D258_Y0.6530.24
170_G222_C0.6530.24
206_R248_G0.6480.24
43_D197_M0.6470.24
150_A153_S0.6460.24
159_Y188_I0.6450.24
185_C194_R0.6410.24
159_Y184_E0.6400.24
116_A232_D0.6390.24
69_R173_F0.6370.24
218_F232_D0.6360.24
90_T184_E0.6310.23
45_Q100_S0.6300.23
71_F91_L0.6300.23
171_F222_C0.6270.23
137_L239_S0.6230.23
185_C188_I0.6180.23
61_F195_A0.6180.23
44_D250_K0.6140.23
159_Y186_T0.6140.23
24_C173_F0.6090.22
238_N241_I0.6070.22
156_Y160_W0.6070.22
114_R254_E0.6040.22
96_D143_D0.6000.22
42_A256_T0.5990.22
194_R232_D0.5970.22
12_Y214_V0.5970.22
43_D50_S0.5950.22
49_K168_S0.5950.22
24_C57_S0.5940.22
13_S127_K0.5940.22
42_A48_P0.5930.22
172_G247_L0.5920.22
46_T242_A0.5900.21
231_W240_S0.5900.21
129_L133_K0.5900.21
58_G242_A0.5880.21
31_I38_G0.5880.21
93_S99_D0.5860.21
131_L137_L0.5820.21
187_S241_I0.5820.21
178_G211_A0.5790.21
97_T246_K0.5780.21
168_S217_R0.5770.21
160_W170_G0.5730.21
152_N162_S0.5720.21
111_N257_I0.5700.21
206_R241_I0.5700.21
90_T117_A0.5690.21
139_R173_F0.5680.20
165_Q190_L0.5670.20
66_Q171_F0.5660.20
209_G219_I0.5630.20
67_G133_K0.5580.20
197_M222_C0.5580.20
31_I160_W0.5550.20
180_H202_L0.5550.20
108_D211_A0.5550.20
117_A232_D0.5540.20
59_I156_Y0.5540.20
16_K40_V0.5510.20
79_Y180_H0.5500.20
188_I218_F0.5490.20
58_G159_Y0.5490.20
122_P126_K0.5480.20
75_I167_A0.5480.20
90_T155_Y0.5460.20
165_Q169_K0.5450.19
244_A248_G0.5440.19
136_V178_G0.5440.19
40_V173_F0.5440.19
126_K182_V0.5430.19
108_D204_E0.5430.19
88_R236_C0.5420.19
34_Q103_K0.5420.19
49_K205_Y0.5420.19
75_I93_S0.5420.19
26_T230_S0.5420.19
30_S34_Q0.5410.19
98_W247_L0.5410.19
168_S226_G0.5400.19
90_T198_D0.5380.19
155_Y232_D0.5370.19
137_L245_A0.5360.19
96_D100_S0.5350.19
25_P28_V0.5320.19
230_S233_C0.5310.19
47_F108_D0.5290.19
132_P179_N0.5270.19
68_N71_F0.5230.19
130_Q133_K0.5230.19
182_V192_H0.5210.19
183_S258_Y0.5210.19
41_Y207_G0.5200.18
100_S256_T0.5190.18
11_K81_E0.5170.18
58_G152_N0.5170.18
57_S158_E0.5170.18
156_Y186_T0.5160.18
139_R144_I0.5150.18
125_F128_T0.5120.18
81_E176_L0.5120.18
9_K204_E0.5110.18
162_S174_A0.5100.18
17_T136_V0.5090.18
118_F245_A0.5080.18
122_P217_R0.5080.18
41_Y77_G0.5080.18
71_F101_V0.5050.18
115_R187_S0.5030.18
28_V31_I0.5020.18
117_A156_Y0.5020.18
108_D164_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g3sA 2 0.9195 100 0.523 Contact Map
1sqhA 1 0.9655 99.8 0.754 Contact Map
3frmA 3 0.908 99.5 0.795 Contact Map
3iwgA 2 0.931 99.4 0.809 Contact Map
3tt2A 1 0.954 99.4 0.81 Contact Map
1p0hA 1 0.9425 99.4 0.811 Contact Map
1yvkA 3 0.4828 99.4 0.813 Contact Map
3blnA 2 0.4866 99.4 0.814 Contact Map
2ob0A 1 0.5057 99.3 0.818 Contact Map
3ec4A 1 0.8199 99.3 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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