GREMLIN Database
YDFA - Putative arsenical pump membrane protein YdfA
UniProt: P96678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 435 (394)
Sequences: 4692 (3101)
Seq/√Len: 156.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_V146_S3.9521.00
93_Y96_R3.8141.00
380_P390_L3.6501.00
85_H89_A3.6471.00
404_T407_K3.4661.00
231_W235_G3.4601.00
118_A150_A3.4361.00
224_Q228_R2.9451.00
64_V286_V2.9311.00
48_D301_N2.8151.00
153_T190_L2.7391.00
118_A389_W2.6661.00
75_N276_K2.5461.00
46_F50_L2.5261.00
409_G413_T2.4871.00
105_G121_L2.4831.00
45_N48_D2.4771.00
143_I389_W2.4201.00
336_S378_I2.3701.00
166_V348_A2.3191.00
216_K219_E2.3151.00
306_D310_D2.3141.00
237_L241_Y2.3091.00
174_T177_D2.3001.00
81_W85_H2.2811.00
367_A371_G2.2511.00
406_F410_I2.2201.00
16_V20_W2.2111.00
235_G239_I2.1981.00
225_N228_R2.1821.00
332_A417_L2.1651.00
154_S161_N2.1371.00
329_F421_L2.1191.00
158_V168_A2.1141.00
9_F13_L2.0681.00
236_L240_G2.0601.00
46_F49_V2.0571.00
126_L398_M2.0251.00
103_L190_L2.0111.00
227_F231_W1.9661.00
188_F423_G1.9581.00
223_D226_M1.9561.00
15_L18_V1.9521.00
176_I180_S1.9511.00
177_D180_S1.9411.00
7_A11_F1.9381.00
47_H51_T1.9321.00
228_R231_W1.9141.00
262_F266_A1.8841.00
410_I413_T1.8391.00
48_D51_T1.8331.00
130_R396_K1.7971.00
122_T143_I1.7951.00
90_A100_Y1.7911.00
418_L422_V1.7811.00
325_I421_L1.7771.00
413_T417_L1.7641.00
183_V187_L1.7601.00
10_I37_L1.7571.00
11_F14_T1.7491.00
75_N280_E1.7451.00
18_V21_Q1.7331.00
47_H50_L1.7121.00
239_I242_F1.7081.00
263_L267_Q1.7051.00
8_V304_L1.6931.00
225_N229_L1.6531.00
230_S241_Y1.6431.00
333_I337_I1.6291.00
195_I199_L1.6271.00
17_L21_Q1.6171.00
233_I237_L1.5851.00
330_I334_L1.5751.00
180_S184_V1.5701.00
394_S399_K1.5701.00
226_M230_S1.5491.00
251_V255_A1.5471.00
147_G389_W1.5461.00
95_V198_Y1.5441.00
140_F404_T1.5431.00
155_L186_Y1.5391.00
73_L78_F1.5311.00
329_F333_I1.5211.00
64_V68_L1.5141.00
252_S262_F1.5111.00
201_F408_T1.5001.00
201_F205_I1.4991.00
14_T21_Q1.4991.00
242_F245_E1.4951.00
26_S29_W1.4901.00
258_I262_F1.4891.00
113_A116_G1.4791.00
233_I241_Y1.4761.00
251_V254_V1.4721.00
88_K217_P1.4651.00
189_S416_T1.4561.00
367_A424_L1.4511.00
259_A262_F1.4481.00
307_V310_D1.4471.00
218_V224_Q1.4261.00
230_S234_L1.4191.00
223_D227_F1.4191.00
242_F246_F1.4121.00
17_L22_P1.4091.00
15_L21_Q1.3961.00
227_F230_S1.3961.00
238_L241_Y1.3951.00
405_Y409_G1.3941.00
255_A262_F1.3921.00
135_N204_S1.3871.00
201_F204_S1.3591.00
224_Q227_F1.3451.00
311_V314_A1.3411.00
243_A246_F1.3321.00
275_K279_K1.3181.00
228_R232_Y1.3081.00
380_P387_L1.3051.00
74_D280_E1.3041.00
14_T295_V1.3031.00
107_I111_L1.3011.00
29_W33_G1.2991.00
234_L238_L1.2851.00
344_V372_S1.2821.00
37_L40_I1.2801.00
144_I148_F1.2681.00
99_V198_Y1.2611.00
18_V22_P1.2571.00
331_A372_S1.2461.00
403_G407_K1.2291.00
243_A247_F1.2221.00
129_V142_F1.2181.00
233_I236_L1.2141.00
321_F425_Y1.2111.00
251_V262_F1.2071.00
195_I198_Y1.2071.00
241_Y245_E1.2061.00
39_L43_V1.2061.00
99_V194_I1.2031.00
260_I264_I1.1941.00
122_T389_W1.1891.00
196_V415_P1.1881.00
11_F18_V1.1831.00
135_N140_F1.1831.00
39_L42_G1.1781.00
28_G31_A1.1751.00
35_A291_G1.1741.00
407_K410_I1.1731.00
102_S145_A1.1561.00
8_V12_L1.1521.00
185_P189_S1.1491.00
10_I20_W1.1461.00
12_L16_V1.1441.00
108_V117_A1.1411.00
185_P370_I1.1371.00
192_A419_I1.1371.00
36_V40_I1.1351.00
311_V315_A1.1351.00
16_V22_P1.1311.00
163_V373_D1.1251.00
235_G238_L1.1211.00
13_L17_L1.1171.00
103_L107_I1.1131.00
65_A259_A1.1101.00
229_L265_A1.1050.99
178_Y182_M1.1030.99
260_I263_L1.1020.99
68_L278_V1.0960.99
10_I14_T1.0810.99
21_Q27_I1.0720.99
11_F21_Q1.0670.99
13_L20_W1.0630.99
234_L237_L1.0590.99
199_L203_K1.0590.99
31_A35_A1.0580.99
162_L293_Y1.0530.99
252_S266_A1.0530.99
39_L44_V1.0500.99
17_L20_W1.0490.99
10_I18_V1.0470.99
263_L266_A1.0460.99
51_T54_G1.0450.99
12_L19_I1.0410.99
45_N49_V1.0360.99
401_S404_T1.0340.99
331_A368_N1.0330.99
66_I116_G1.0330.99
369_V372_S1.0310.99
240_G244_S1.0280.99
17_L30_S1.0270.99
26_S32_C1.0230.99
252_S255_A1.0210.99
237_L240_G1.0190.99
230_S238_L1.0150.99
28_G32_C1.0140.99
289_S376_P1.0120.99
55_I290_I1.0110.99
115_D161_N1.0100.99
307_V311_V1.0100.99
376_P386_T1.0080.99
219_E223_D1.0060.99
32_C40_I1.0050.99
328_G421_L1.0040.99
7_A302_A1.0040.99
101_V125_V0.9990.99
202_R205_I0.9930.99
410_I414_I0.9900.99
235_G246_F0.9900.99
232_Y235_G0.9880.99
229_L232_Y0.9880.99
38_A42_G0.9870.99
191_L195_I0.9860.99
156_P186_Y0.9830.99
259_A263_L0.9780.99
143_I393_L0.9710.99
175_F179_A0.9710.99
297_Y301_N0.9680.99
261_I265_A0.9680.99
251_V266_A0.9660.99
141_P197_L0.9600.99
35_A38_A0.9590.99
148_F152_T0.9520.98
221_I227_F0.9510.98
85_H88_K0.9500.98
91_K96_R0.9490.98
240_G245_E0.9410.98
198_Y201_F0.9390.98
104_L108_V0.9340.98
399_K403_G0.9330.98
237_L242_F0.9310.98
226_M229_L0.9310.98
229_L233_I0.9310.98
401_S407_K0.9240.98
343_T347_D0.9230.98
252_S259_A0.9230.98
288_F291_G0.9220.98
144_I408_T0.9210.98
32_C39_L0.9210.98
335_S372_S0.9200.98
241_Y244_S0.9150.98
371_G375_G0.9110.98
378_I413_T0.9110.98
310_D314_A0.9100.98
15_L19_I0.9070.98
65_A255_A0.9060.98
222_K225_N0.9040.98
237_L245_E0.9030.98
159_V175_F0.9010.98
27_I339_N0.8950.98
15_L22_P0.8950.98
232_Y243_A0.8930.98
29_W39_L0.8920.98
115_D154_S0.8910.98
14_T22_P0.8890.98
414_I418_L0.8880.98
240_G243_A0.8860.98
163_V341_L0.8860.98
252_S256_G0.8850.98
116_G288_F0.8840.98
219_E222_K0.8760.97
259_A266_A0.8750.97
389_W393_L0.8690.97
251_V259_A0.8670.97
184_V423_G0.8670.97
198_Y202_R0.8650.97
289_S341_L0.8630.97
336_S339_N0.8590.97
402_W413_T0.8580.97
113_A154_S0.8530.97
59_A67_I0.8500.97
129_V136_E0.8500.97
255_A258_I0.8470.97
10_I41_A0.8420.97
114_N383_S0.8380.97
33_G260_I0.8350.97
60_T290_I0.8340.97
112_F143_I0.8340.97
235_G242_F0.8340.97
64_V283_W0.8330.97
199_L202_R0.8320.96
383_S386_T0.8320.96
10_I13_L0.8290.96
228_R239_I0.8290.96
331_A347_D0.8280.96
411_I414_I0.8260.96
36_V39_L0.8240.96
182_M369_V0.8240.96
10_I19_I0.8240.96
232_Y236_L0.8230.96
327_M368_N0.8210.96
58_N252_S0.8200.96
71_L74_D0.8180.96
179_A183_V0.8170.96
251_V267_Q0.8130.96
289_S340_N0.8100.96
237_L243_A0.8090.96
56_V59_A0.8090.96
160_S376_P0.8060.96
229_L236_L0.8050.96
233_I238_L0.8050.96
33_G37_L0.8010.96
255_A259_A0.7990.96
50_L54_G0.7960.95
198_Y204_S0.7960.95
41_A44_V0.7950.95
155_L182_M0.7950.95
236_L239_I0.7950.95
334_L343_T0.7920.95
166_V341_L0.7910.95
373_D386_T0.7900.95
162_L376_P0.7890.95
331_A371_G0.7880.95
10_I34_G0.7860.95
254_V258_I0.7850.95
409_G412_L0.7820.95
69_I237_L0.7820.95
157_F160_S0.7810.95
332_A413_T0.7810.95
58_N169_D0.7800.95
13_L18_V0.7800.95
149_I190_L0.7770.95
235_G241_Y0.7760.95
104_L150_A0.7760.95
261_I266_A0.7670.94
377_K386_T0.7640.94
256_G260_I0.7620.94
221_I224_Q0.7620.94
19_I22_P0.7620.94
38_A298_G0.7610.94
324_T367_A0.7600.94
215_K219_E0.7580.94
216_K220_A0.7570.94
66_I113_A0.7560.94
340_N381_I0.7560.94
35_A39_L0.7550.94
9_F17_L0.7520.94
222_K226_M0.7510.94
221_I225_N0.7510.94
148_F412_L0.7500.94
8_V17_L0.7500.94
26_S30_S0.7500.94
9_F16_V0.7450.94
230_S235_G0.7440.94
15_L20_W0.7430.93
136_E140_F0.7420.93
177_D181_R0.7420.93
27_I30_S0.7410.93
306_D313_Q0.7390.93
100_Y104_L0.7380.93
109_A341_L0.7380.93
27_I32_C0.7330.93
249_I256_G0.7320.93
421_L425_Y0.7320.93
188_F419_I0.7310.93
339_N376_P0.7300.93
185_P188_F0.7300.93
194_I198_Y0.7280.93
168_A175_F0.7280.93
275_K278_V0.7270.93
320_L324_T0.7260.93
62_A66_I0.7260.93
63_F342_P0.7250.93
234_L241_Y0.7250.93
27_I39_L0.7240.93
166_V345_M0.7230.93
56_V162_L0.7220.92
37_L258_I0.7200.92
149_I153_T0.7200.92
85_H248_S0.7170.92
251_V261_I0.7120.92
179_A186_Y0.7100.92
13_L19_I0.7070.92
402_W409_G0.7060.92
303_G306_D0.7060.92
373_D376_P0.7040.92
239_I243_A0.7020.91
86_M100_Y0.7020.91
230_S236_L0.6970.91
167_S369_V0.6950.91
161_N164_N0.6920.91
186_Y190_L0.6920.91
31_A36_V0.6890.91
223_D230_S0.6890.91
238_L246_F0.6880.91
105_G146_S0.6850.90
247_F250_P0.6850.90
14_T34_G0.6840.90
31_A39_L0.6840.90
193_S197_L0.6820.90
324_T424_L0.6800.90
98_F142_F0.6790.90
30_S33_G0.6780.90
177_D362_E0.6780.90
380_P402_W0.6770.90
153_T160_S0.6760.90
109_A117_A0.6730.90
251_V256_G0.6720.90
151_D383_S0.6710.89
416_T420_T0.6710.89
298_G302_A0.6710.89
296_V385_A0.6700.89
223_D228_R0.6670.89
228_R235_G0.6670.89
63_F113_A0.6670.89
25_L29_W0.6640.89
284_A287_F0.6630.89
321_F422_V0.6620.89
102_S197_L0.6610.89
179_A182_M0.6600.89
74_D127_A0.6590.89
378_I410_I0.6540.88
114_N161_N0.6540.88
232_Y239_I0.6520.88
114_N385_A0.6520.88
59_A343_T0.6500.88
170_Y348_A0.6490.88
38_A43_V0.6450.88
116_G377_K0.6440.88
403_G406_F0.6410.87
258_I261_I0.6410.87
369_V386_T0.6410.87
31_A34_G0.6390.87
125_V129_V0.6380.87
115_D164_N0.6370.87
134_F142_F0.6350.87
149_I160_S0.6350.87
155_L373_D0.6340.87
254_V261_I0.6340.87
378_I382_G0.6330.87
386_T389_W0.6330.87
230_S233_I0.6260.86
14_T30_S0.6250.86
160_S341_L0.6240.86
379_T382_G0.6210.86
10_I15_L0.6200.85
147_G409_G0.6180.85
198_Y205_I0.6180.85
163_V388_L0.6180.85
340_N376_P0.6180.85
63_F153_T0.6170.85
84_L88_K0.6150.85
155_L374_L0.6140.85
363_A425_Y0.6130.85
252_S263_L0.6110.85
114_N342_P0.6090.84
14_T20_W0.6090.84
16_V217_P0.6080.84
238_L245_E0.6080.84
182_M185_P0.6070.84
373_D383_S0.6060.84
335_S340_N0.6050.84
11_F299_V0.6050.84
289_S298_G0.6030.84
56_V163_V0.6020.84
406_F409_G0.6000.84
406_F413_T0.6000.84
288_F292_M0.5990.83
163_V339_N0.5990.83
233_I240_G0.5980.83
30_S35_A0.5980.83
299_V308_L0.5960.83
392_V396_K0.5960.83
276_K279_K0.5960.83
162_L167_S0.5960.83
150_A385_A0.5960.83
334_L337_I0.5950.83
34_G39_L0.5950.83
47_H224_Q0.5930.83
34_G37_L0.5890.82
10_I21_Q0.5890.82
106_A377_K0.5880.82
66_I147_G0.5860.82
84_L131_A0.5860.82
265_A268_K0.5850.82
93_Y191_L0.5850.82
176_I179_A0.5830.82
32_C38_A0.5820.82
237_L244_S0.5810.82
14_T18_V0.5810.82
192_A196_V0.5800.82
245_E249_I0.5790.81
114_N340_N0.5780.81
250_P253_V0.5780.81
109_A114_N0.5770.81
160_S386_T0.5770.81
312_I326_G0.5770.81
161_N342_P0.5770.81
13_L21_Q0.5760.81
413_T420_T0.5760.81
154_S343_T0.5740.81
182_M186_Y0.5740.81
115_D388_L0.5740.81
407_K411_I0.5740.81
13_L16_V0.5740.81
80_E131_A0.5730.81
32_C36_V0.5720.81
385_A389_W0.5710.80
236_L243_A0.5700.80
165_I371_G0.5700.80
106_A148_F0.5700.80
255_A266_A0.5690.80
163_V336_S0.5690.80
44_V51_T0.5690.80
215_K239_I0.5680.80
239_I246_F0.5680.80
401_S405_Y0.5670.80
114_N151_D0.5670.80
203_K218_V0.5670.80
32_C35_A0.5660.80
122_T392_V0.5630.80
231_W241_Y0.5620.79
372_S375_G0.5620.79
80_E84_L0.5570.79
413_T416_T0.5570.79
14_T17_L0.5560.79
33_G38_A0.5560.79
122_T154_S0.5560.79
315_A326_G0.5550.79
102_S149_I0.5550.79
72_I277_V0.5540.78
341_L344_V0.5540.78
31_A38_A0.5530.78
182_M366_Y0.5520.78
71_L277_V0.5510.78
344_V348_A0.5500.78
120_I390_L0.5500.78
417_L420_T0.5470.78
34_G49_V0.5470.78
348_A352_A0.5450.77
113_A339_N0.5430.77
67_I383_S0.5430.77
218_V223_D0.5430.77
341_L384_L0.5420.77
309_S312_I0.5410.77
197_L201_F0.5400.77
28_G33_G0.5380.76
282_P289_S0.5380.76
8_V13_L0.5380.76
254_V262_F0.5370.76
147_G382_G0.5360.76
335_S339_N0.5350.76
109_A163_V0.5350.76
233_I245_E0.5330.76
160_S293_Y0.5320.76
101_V121_L0.5320.76
63_F341_L0.5310.76
180_S280_E0.5310.76
11_F20_W0.5300.75
359_M362_E0.5280.75
343_T346_I0.5280.75
99_V103_L0.5270.75
153_T339_N0.5260.75
162_L386_T0.5260.75
153_T341_L0.5250.75
217_P221_I0.5250.75
121_L379_T0.5250.75
115_D123_P0.5250.75
114_N162_L0.5240.75
14_T19_I0.5220.74
29_W36_V0.5220.74
154_S163_V0.5220.74
113_A341_L0.5220.74
157_F184_V0.5210.74
409_G420_T0.5200.74
148_F193_S0.5190.74
336_S346_I0.5190.74
238_L242_F0.5190.74
7_A298_G0.5180.74
310_D313_Q0.5180.74
63_F67_I0.5160.73
230_S240_G0.5160.73
278_V287_F0.5150.73
16_V21_Q0.5150.73
36_V41_A0.5140.73
345_M384_L0.5120.73
81_W84_L0.5110.73
321_F359_M0.5110.73
335_S344_V0.5100.73
312_I364_L0.5090.72
218_V222_K0.5090.72
113_A117_A0.5090.72
284_A387_L0.5090.72
91_K203_K0.5070.72
43_V49_V0.5060.72
339_N346_I0.5050.72
33_G64_V0.5050.72
115_D340_N0.5040.72
217_P220_A0.5040.72
115_D384_L0.5030.72
183_V186_Y0.5030.72
214_V218_V0.5010.71
234_L240_G0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.9195 100 0.475 Contact Map
4r1iA 2 0.9655 99.9 0.73 Contact Map
4r0cA 3 0.9563 99.8 0.749 Contact Map
3tdsE 3 0.5103 53.3 0.955 Contact Map
3w9iA 3 0.3701 33.2 0.96 Contact Map
4dx5A 3 0.3908 29.3 0.961 Contact Map
4fc4A 3 0.5057 16.2 0.966 Contact Map
3aqpA 1 0.3586 15.8 0.966 Contact Map
3klyA 3 0.4759 15 0.966 Contact Map
3qe7A 2 0.4529 14.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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