GREMLIN Database
ASER - HTH-type transcriptional repressor AseR
UniProt: P96677 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 111 (88)
Sequences: 3786 (2554)
Seq/√Len: 272.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E64_D4.4661.00
63_E70_R3.0451.00
62_N73_S2.8611.00
62_N75_N2.3711.00
65_R70_R2.3071.00
53_R57_N2.1451.00
43_M47_A2.0971.00
14_T58_A2.0881.00
82_D86_L2.0231.00
34_V52_L1.8961.00
31_E73_S1.7421.00
10_R57_N1.7201.00
26_L40_M1.5711.00
43_M48_I1.5701.00
38_V45_Q1.5411.00
6_A18_Q1.5401.00
27_F61_V1.5371.00
24_M60_F1.5211.00
26_L32_Y1.4461.00
85_Q89_H1.4391.00
14_T54_K1.4031.00
52_L61_V1.3811.00
37_L48_I1.3541.00
31_E71_Y1.3481.00
56_K63_E1.3301.00
54_K58_A1.3081.00
9_T18_Q1.2911.00
35_C69_W1.2561.00
32_Y36_Q1.2461.00
27_F32_Y1.2391.00
44_S47_A1.2081.00
86_L89_H1.1991.00
12_L15_L1.1471.00
23_M37_L1.1211.00
32_Y40_M1.1121.00
50_Q68_Q1.1041.00
59_G75_N1.0991.00
24_M74_I1.0861.00
34_V56_K1.0711.00
7_A59_G1.0701.00
8_M87_I1.0651.00
17_D50_Q1.0621.00
47_A50_Q1.0531.00
33_C36_Q1.0491.00
28_L85_Q1.0181.00
82_D85_Q1.0151.00
12_L87_I1.0031.00
47_A51_H0.9821.00
13_K16_S0.9801.00
53_R56_K0.9771.00
78_C93_Q0.9761.00
41_F48_I0.9731.00
50_Q53_R0.9561.00
6_A10_R0.9551.00
78_C90_Q0.9471.00
33_C69_W0.8961.00
23_M27_F0.8941.00
62_N76_G0.8881.00
11_C84_L0.8871.00
76_G90_Q0.8761.00
9_T21_L0.8551.00
90_Q93_Q0.8541.00
52_L56_K0.8441.00
12_L16_S0.8441.00
25_R28_L0.8391.00
5_V25_R0.8250.99
15_L18_Q0.8220.99
39_D69_W0.8130.99
36_Q39_D0.8110.99
19_T48_I0.8090.99
11_C60_F0.8010.99
38_V48_I0.7910.99
82_D89_H0.7910.99
55_L61_V0.7800.99
15_L24_M0.7780.99
54_K57_N0.7740.99
8_M88_L0.7620.99
43_M46_P0.7590.99
78_C83_T0.7490.99
24_M84_L0.7480.99
80_E85_Q0.7450.99
14_T55_L0.7410.99
16_S51_H0.7330.99
56_K70_R0.7090.98
19_T43_M0.7080.98
17_D44_S0.7010.98
7_A82_D0.6960.98
80_E86_L0.6890.98
26_L37_L0.6880.98
19_T65_R0.6770.98
31_E66_R0.6760.98
50_Q54_K0.6640.98
77_S82_D0.6510.97
7_A10_R0.6450.97
21_L25_R0.6380.97
44_S50_Q0.6330.97
11_C58_A0.6240.96
36_Q71_Y0.6200.96
77_S80_E0.6110.96
19_T68_Q0.6010.96
46_P51_H0.6000.96
46_P50_Q0.6000.96
86_L90_Q0.5960.95
44_S68_Q0.5850.95
47_A68_Q0.5790.95
5_V9_T0.5780.95
28_L80_E0.5780.95
17_D47_A0.5770.95
32_Y37_L0.5760.94
7_A18_Q0.5760.94
78_C84_L0.5750.94
13_K47_A0.5740.94
11_C83_T0.5700.94
22_I25_R0.5700.94
28_L74_I0.5690.94
76_G93_Q0.5690.94
66_R71_Y0.5620.94
19_T41_F0.5530.93
9_T16_S0.5500.93
5_V8_M0.5460.93
17_D69_W0.5460.93
76_G80_E0.5430.93
34_V40_M0.5340.92
34_V45_Q0.5320.92
38_V42_E0.5300.92
45_Q69_W0.5240.91
75_N93_Q0.5170.91
75_N78_C0.5170.91
50_Q65_R0.5130.90
36_Q51_H0.5090.90
35_C38_V0.5000.89
25_R29_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r1tA 2 0.8378 99.7 0.509 Contact Map
1u2wA 2 0.8468 99.7 0.527 Contact Map
2jscA 2 0.8649 99.7 0.527 Contact Map
2kkoA 2 0.9099 99.6 0.538 Contact Map
3pqkA 2 0.8739 99.6 0.539 Contact Map
1r1uA 2 0.8559 99.6 0.54 Contact Map
2zkzA 2 0.7928 99.6 0.548 Contact Map
4k2eA 2 0.8288 99.6 0.548 Contact Map
1q1hA 1 0.7207 99.6 0.553 Contact Map
3f6vA 2 0.8649 99.6 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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