GREMLIN Database
YDEQ - Uncharacterized NAD(P)H oxidoreductase YdeQ
UniProt: P96674 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (169)
Sequences: 3743 (2729)
Seq/√Len: 209.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_T59_A3.6641.00
80_Q84_E2.4681.00
37_H56_Q2.4021.00
38_D41_E2.3691.00
11_V77_L2.3281.00
5_K33_D2.2471.00
54_Q90_W2.1371.00
35_T56_Q2.0851.00
69_L108_M2.0271.00
103_E144_T2.0111.00
10_V21_N2.0061.00
55_Q59_A1.9931.00
104_W138_A1.9561.00
37_H42_K1.9561.00
62_R103_E1.9381.00
63_I143_M1.8661.00
51_E55_Q1.8571.00
5_K59_A1.8501.00
25_K29_L1.8251.00
46_Q80_Q1.8051.00
159_D163_A1.7891.00
6_T62_R1.7701.00
55_Q58_L1.7671.00
126_S129_E1.7661.00
158_S161_E1.7481.00
52_F56_Q1.7461.00
7_L56_Q1.7441.00
79_K83_D1.7421.00
22_K26_E1.7371.00
58_L90_W1.7351.00
167_N170_V1.7071.00
35_T60_H1.6361.00
27_A170_V1.6101.00
76_P80_Q1.5891.00
161_E164_E1.5861.00
11_V40_Y1.5821.00
20_I109_S1.5331.00
42_K56_Q1.5271.00
66_Q169_Y1.5201.00
53_E81_W1.5081.00
107_A169_Y1.5001.00
8_V25_K1.4841.00
82_F86_F1.4811.00
26_E29_L1.4691.00
163_A167_N1.4621.00
165_S168_R1.4371.00
26_E30_S1.3931.00
6_T32_P1.3781.00
7_L60_H1.3581.00
169_Y173_I1.3561.00
100_K142_G1.3561.00
54_Q91_A1.3541.00
37_H53_E1.3451.00
23_K170_V1.3441.00
27_A30_S1.3301.00
23_K27_A1.3171.00
93_G96_G1.3121.00
149_F168_R1.3101.00
50_V54_Q1.2911.00
42_K52_F1.2881.00
104_W143_M1.2501.00
21_N36_V1.2351.00
97_N100_K1.2261.00
157_I162_I1.2251.00
52_F55_Q1.2221.00
66_Q107_A1.2171.00
127_I150_A1.2141.00
17_S109_S1.1581.00
138_A143_M1.1521.00
69_L127_I1.1481.00
24_W28_V1.1441.00
27_A31_E1.1381.00
11_V78_L1.1251.00
93_G98_K1.1241.00
23_K26_E1.1191.00
114_E152_Y1.1171.00
167_N171_K1.1091.00
18_S21_N1.1071.00
40_Y77_L1.1011.00
171_K175_N1.0951.00
169_Y172_H1.0891.00
42_K53_E1.0881.00
27_A174_T1.0831.00
171_K174_T1.0821.00
17_S66_Q1.0751.00
25_K36_V1.0651.00
129_E132_K1.0621.00
162_I166_A1.0591.00
49_D52_F1.0571.00
164_E168_R1.0531.00
64_V105_V1.0501.00
136_A139_H1.0401.00
99_L143_M1.0371.00
151_E157_I1.0361.00
74_S78_L1.0361.00
86_F141_V1.0321.00
44_R47_P1.0301.00
107_A149_F1.0231.00
170_V174_T1.0091.00
30_S170_V1.0051.00
114_E118_Q1.0021.00
51_E54_Q1.0021.00
151_E165_S0.9981.00
101_G144_T0.9971.00
67_F106_T0.9941.00
56_Q59_A0.9941.00
60_H63_I0.9941.00
71_W83_D0.9931.00
110_I152_Y0.9881.00
61_D102_K0.9581.00
58_L98_K0.9571.00
54_Q87_T0.9240.99
9_L37_H0.9210.99
11_V39_L0.8970.99
10_V18_S0.8940.99
26_E170_V0.8930.99
13_P70_Y0.8860.99
31_E174_T0.8810.99
44_R80_Q0.8770.99
29_L33_D0.8630.99
5_K61_D0.8590.99
33_D59_A0.8530.99
107_A151_E0.8420.99
113_P116_S0.8420.99
27_A173_I0.8360.99
69_L130_L0.8320.99
76_P84_E0.8240.99
72_Y140_L0.8200.99
105_V172_H0.8120.98
137_S141_V0.8050.98
19_R162_I0.8020.98
37_H81_W0.8010.98
162_I165_S0.7980.98
108_M150_A0.7960.98
82_F137_S0.7950.98
88_F92_H0.7940.98
57_L63_I0.7930.98
112_S123_N0.7920.98
67_F131_T0.7900.98
132_K135_Q0.7870.98
130_L136_A0.7840.98
19_R159_D0.7830.98
138_A145_Y0.7810.98
24_W169_Y0.7800.98
23_K166_A0.7800.98
65_F138_A0.7780.98
19_R166_A0.7750.98
103_E146_L0.7700.98
67_F127_I0.7700.98
108_M131_T0.7690.98
110_I117_Y0.7660.98
110_I127_I0.7650.98
43_Y48_I0.7610.98
88_F94_P0.7510.97
166_A169_Y0.7440.97
8_V64_V0.7420.97
24_W107_A0.7420.97
15_I41_E0.7290.97
164_E167_N0.7200.97
71_W92_H0.7160.97
105_V149_F0.7130.96
110_I150_A0.7110.96
158_S162_I0.7040.96
21_N66_Q0.7020.96
57_L65_F0.6990.96
4_M32_P0.6980.96
57_L81_W0.6960.96
129_E135_Q0.6910.96
23_K163_A0.6870.96
53_E56_Q0.6850.96
5_K38_D0.6850.96
9_L81_W0.6730.95
9_L65_F0.6730.95
147_P172_H0.6690.95
62_R105_V0.6680.95
91_A99_L0.6580.94
7_L37_H0.6560.94
55_Q171_K0.6560.94
104_W145_Y0.6530.94
24_W173_I0.6500.94
157_I161_E0.6500.94
49_D53_E0.6450.94
11_V38_D0.6430.94
97_N142_G0.6420.94
14_N17_S0.6410.94
54_Q85_V0.6380.93
46_Q84_E0.6350.93
67_F108_M0.6350.93
46_Q77_L0.6330.93
24_W151_E0.6140.92
44_R84_E0.6090.92
69_L117_Y0.6090.92
123_N136_A0.6070.92
149_F172_H0.6050.92
75_P83_D0.6040.92
124_L136_A0.6020.91
74_S82_F0.6000.91
157_I165_S0.6000.91
94_P141_V0.5970.91
166_A173_I0.5960.91
8_V24_W0.5950.91
89_G93_G0.5950.91
103_E142_G0.5930.91
135_Q148_S0.5870.90
159_D162_I0.5870.90
154_A157_I0.5840.90
47_P80_Q0.5740.89
67_F78_L0.5740.89
19_R23_K0.5740.89
20_I107_A0.5730.89
44_R48_I0.5720.89
108_M127_I0.5720.89
57_L86_F0.5710.89
168_R171_K0.5700.89
132_K136_A0.5700.89
153_R156_T0.5700.89
112_S153_R0.5700.89
149_F169_Y0.5690.89
30_S174_T0.5690.89
77_L81_W0.5670.89
84_E87_T0.5630.88
67_F74_S0.5610.88
51_E164_E0.5600.88
28_V169_Y0.5550.88
67_F75_P0.5530.88
117_Y152_Y0.5530.88
21_N24_W0.5520.87
92_H95_G0.5500.87
10_V15_I0.5490.87
20_I165_S0.5450.87
166_A170_V0.5440.87
154_A162_I0.5390.86
116_S122_Y0.5380.86
5_K35_T0.5370.86
54_Q88_F0.5360.86
65_F78_L0.5350.86
28_V32_P0.5330.86
72_Y112_S0.5330.86
4_M62_R0.5320.85
51_E87_T0.5300.85
111_G155_N0.5270.85
32_P62_R0.5260.85
131_T148_S0.5250.85
72_Y136_A0.5200.84
9_L82_F0.5190.84
10_V36_V0.5180.84
18_S22_K0.5170.84
117_Y121_G0.5160.84
14_N84_E0.5120.83
10_V25_K0.5110.83
90_W99_L0.5090.83
69_L110_I0.5060.83
135_Q138_A0.5030.82
112_S152_Y0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d4aA 2 0.9898 100 0.377 Contact Map
4gi5A 2 0.9949 100 0.392 Contact Map
4fglA 2 0.9695 100 0.431 Contact Map
3l9wA 2 0.8883 100 0.462 Contact Map
2amjA 2 0.8426 100 0.466 Contact Map
3f2vA 2 0.8629 100 0.475 Contact Map
3rpeA 2 0.868 100 0.484 Contact Map
4r81A 4 0.9036 100 0.489 Contact Map
3ha2A 2 0.8376 100 0.49 Contact Map
3lcmA 2 0.8883 100 0.5 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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