GREMLIN Database
YDEO - UPF0750 membrane protein YdeO
UniProt: P96672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (272)
Sequences: 3740 (2704)
Seq/√Len: 164.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_I90_I5.8281.00
213_Q216_L4.9851.00
233_E242_K3.9731.00
234_A245_E3.8821.00
219_E223_D3.4741.00
212_T243_F3.4281.00
211_T217_M3.2071.00
26_I98_G2.8991.00
207_F258_L2.7531.00
119_V181_L2.7421.00
46_V68_I2.5921.00
235_Y240_H2.5631.00
220_T261_I2.3891.00
232_K245_E2.3471.00
235_Y244_K2.3441.00
211_T214_P2.3291.00
215_E219_E2.2921.00
220_T224_Q2.2481.00
205_K275_D2.2121.00
233_E244_K2.1211.00
229_A237_G2.1131.00
53_G57_F2.1011.00
18_I90_I2.0741.00
33_E102_F2.0281.00
17_Q87_L1.9891.00
24_G127_G1.9571.00
93_V97_A1.9281.00
22_I94_S1.8911.00
227_R254_E1.8861.00
31_G124_L1.8841.00
29_A98_G1.8701.00
30_Y34_T1.8661.00
28_A95_L1.8651.00
172_S180_A1.8591.00
192_K196_V1.8231.00
20_M134_N1.8081.00
172_S177_L1.7701.00
62_G100_S1.7651.00
131_A138_L1.7471.00
112_D182_L1.7251.00
262_I269_A1.7251.00
218_V237_G1.7131.00
157_S195_H1.7031.00
221_I258_L1.6811.00
53_G64_L1.6781.00
212_T241_E1.6591.00
231_Y246_I1.6461.00
39_N116_I1.6301.00
229_A246_I1.6051.00
214_P244_K1.6031.00
262_I271_V1.5771.00
17_Q134_N1.5751.00
235_Y242_K1.5371.00
74_W78_K1.5261.00
225_L258_L1.5011.00
218_V240_H1.4881.00
212_T268_T1.4851.00
114_L185_I1.4721.00
176_G179_G1.4701.00
129_G197_V1.4531.00
206_T274_Y1.4411.00
220_T265_I1.4371.00
247_T272_T1.4221.00
84_F137_A1.4141.00
24_G131_A1.4021.00
26_I102_F1.3911.00
215_E240_H1.3911.00
30_Y102_F1.3811.00
208_Q247_T1.3671.00
21_V91_G1.3651.00
166_F170_F1.3611.00
218_V231_Y1.3561.00
162_F166_F1.3431.00
33_E103_H1.3431.00
46_V72_F1.3181.00
234_A243_F1.2921.00
49_L53_G1.2851.00
268_T282_S1.2851.00
62_G96_A1.2821.00
70_I74_W1.2811.00
80_I84_F1.2791.00
65_I99_T1.2781.00
168_F187_Y1.2741.00
221_I248_C1.2731.00
216_L265_I1.2721.00
36_L120_G1.2601.00
125_G129_G1.2571.00
250_I258_L1.2531.00
161_L191_S1.2361.00
206_T272_T1.2201.00
86_L90_I1.1981.00
31_G127_G1.1821.00
60_P100_S1.1771.00
77_Y82_K1.1701.00
76_G85_A1.1691.00
21_V136_G1.1681.00
40_S179_G1.1671.00
18_I87_L1.1531.00
145_A160_I1.1501.00
73_V92_I1.1491.00
188_Y192_K1.1471.00
206_T276_V1.1461.00
259_K278_E1.1451.00
255_E273_V1.1411.00
25_G94_S1.1401.00
66_A96_A1.1331.00
208_Q274_Y1.1311.00
148_L152_L1.1291.00
220_T264_D1.1201.00
266_D269_A1.1191.00
31_G123_I1.1111.00
222_R237_G1.1091.00
37_I61_L1.1081.00
231_Y244_K1.1031.00
115_L119_V1.0981.00
15_I19_I1.0961.00
122_I193_V1.0951.00
207_F255_E1.0861.00
165_L169_I1.0851.00
209_I262_I1.0841.00
59_L64_L1.0770.99
62_G66_A1.0760.99
230_T234_A1.0690.99
77_Y85_A1.0640.99
19_I23_I1.0600.99
117_T121_G1.0510.99
236_G239_S1.0490.99
94_S98_G1.0470.99
113_T179_G1.0380.99
90_I94_S1.0360.99
16_L20_M1.0350.99
261_I264_D1.0230.99
49_L170_F1.0220.99
218_V229_A1.0210.99
231_Y237_G1.0200.99
42_S171_V1.0130.99
18_I22_I1.0110.99
80_I146_V1.0070.99
91_G136_G1.0010.99
221_I227_R0.9990.99
51_I54_S0.9920.99
112_D178_Q0.9880.99
35_V119_V0.9880.99
79_Q151_K0.9850.99
258_L262_I0.9720.99
63_I100_S0.9630.99
20_M130_L0.9620.99
208_Q232_K0.9520.99
42_S164_N0.9520.99
25_G91_G0.9360.99
217_M261_I0.9350.99
47_T99_T0.9330.99
14_M17_Q0.9320.99
122_I188_Y0.9290.98
206_T249_V0.9260.98
64_L68_I0.9260.98
157_S194_I0.9180.98
206_T247_T0.9150.98
272_T276_V0.9110.98
195_H252_R0.9070.98
205_K278_E0.9070.98
117_T185_I0.9060.98
157_S191_S0.8980.98
208_Q272_T0.8940.98
222_R229_A0.8890.98
113_T117_T0.8860.98
256_T260_E0.8840.98
71_P74_W0.8830.98
36_L186_A0.8710.98
40_S55_Q0.8700.98
121_G125_G0.8640.98
79_Q147_L0.8590.97
160_I164_N0.8540.97
75_L79_Q0.8500.97
222_R228_S0.8500.97
211_T266_D0.8470.97
128_M132_L0.8460.97
80_I137_A0.8440.97
128_M194_I0.8410.97
83_S87_L0.8390.97
204_S248_C0.8350.97
100_S103_H0.8330.97
126_F197_V0.8270.97
207_F262_I0.8240.97
52_V56_L0.8230.97
42_S183_S0.8210.97
232_K247_T0.8180.97
25_G131_A0.8180.97
41_V117_T0.8140.97
137_A146_V0.8140.97
207_F250_I0.8120.96
190_A194_I0.8100.96
52_V175_F0.8080.96
231_Y235_Y0.8050.96
251_N254_E0.8050.96
115_L181_L0.8030.96
132_L146_V0.7980.96
261_I265_I0.7970.96
154_F159_L0.7940.96
63_I67_V0.7900.96
249_V272_T0.7870.96
28_A127_G0.7860.96
49_L52_V0.7860.96
27_I126_F0.7830.96
31_G35_V0.7800.96
26_I94_S0.7800.96
67_V71_P0.7780.96
220_T223_D0.7780.96
147_L151_K0.7700.95
113_T116_I0.7690.95
73_V88_S0.7680.95
155_G195_H0.7660.95
72_F144_L0.7660.95
66_A93_V0.7650.95
219_E240_H0.7640.95
129_G133_R0.7620.95
138_L142_D0.7530.95
218_V222_R0.7510.95
54_S61_L0.7450.94
14_M87_L0.7430.94
214_P217_M0.7410.94
148_L159_L0.7400.94
192_K195_H0.7400.94
16_L134_N0.7380.94
260_E264_D0.7370.94
118_V189_I0.7370.94
162_F165_L0.7360.94
259_K280_K0.7350.94
161_L188_Y0.7350.94
52_V170_F0.7290.94
32_L95_L0.7280.94
73_V89_I0.7260.94
66_A70_I0.7240.93
187_Y191_S0.7240.93
71_P75_L0.7220.93
213_Q265_I0.7170.93
86_L89_I0.7160.93
227_R251_N0.7120.93
144_L148_L0.7120.93
72_F88_S0.7120.93
73_V76_G0.7090.93
57_F64_L0.7080.93
76_G84_F0.7080.93
25_G95_L0.7050.93
224_Q261_I0.7020.92
116_I178_Q0.7020.92
49_L68_I0.7000.92
98_G101_F0.7000.92
230_T236_G0.6990.92
155_G158_D0.6980.92
141_I163_L0.6980.92
229_A248_C0.6980.92
166_F169_I0.6950.92
202_S285_R0.6900.92
205_K273_V0.6900.92
141_I175_F0.6890.92
207_F273_V0.6890.92
141_I164_N0.6890.92
117_T189_I0.6870.92
213_Q266_D0.6800.91
131_A136_G0.6790.91
102_F105_T0.6770.91
228_S238_F0.6750.91
146_V156_T0.6740.91
92_I96_A0.6730.91
84_F146_V0.6730.91
34_T102_F0.6720.91
217_M265_I0.6710.91
28_A124_L0.6710.91
224_Q257_K0.6710.91
53_G68_I0.6700.91
48_G182_L0.6700.91
227_R284_F0.6690.90
111_G178_Q0.6680.90
50_S65_I0.6670.90
20_M23_I0.6670.90
236_G243_F0.6660.90
139_D142_D0.6640.90
15_I18_I0.6620.90
87_L135_G0.6620.90
128_M138_L0.6620.90
110_E178_Q0.6600.90
124_L190_A0.6600.90
227_R283_N0.6590.90
32_L50_S0.6570.90
118_V185_I0.6570.90
143_M157_S0.6570.90
130_L134_N0.6550.90
170_F173_T0.6530.89
158_D195_H0.6510.89
32_L37_I0.6500.89
146_V150_R0.6490.89
209_I248_C0.6480.89
27_I123_I0.6450.89
23_I27_I0.6430.89
168_F171_V0.6430.89
132_L142_D0.6430.89
112_D117_T0.6400.88
210_I247_T0.6400.88
74_W77_Y0.6380.88
201_L204_S0.6360.88
171_V180_A0.6340.88
78_K96_A0.6330.88
215_E244_K0.6300.88
47_T95_L0.6290.88
119_V184_V0.6260.87
37_I54_S0.6240.87
164_N183_S0.6240.87
160_I194_I0.6230.87
263_N280_K0.6230.87
199_E277_A0.6220.87
43_D142_D0.6210.87
29_A95_L0.6200.87
37_I51_I0.6190.87
97_A101_F0.6190.87
273_V278_E0.6150.86
128_M190_A0.6130.86
88_S143_M0.6090.86
64_L67_V0.6090.86
164_N283_N0.6090.86
75_L147_L0.6090.86
249_V276_V0.6040.85
60_P63_I0.6020.85
257_K260_E0.5990.85
42_S51_I0.5990.85
270_F279_V0.5980.85
41_V110_E0.5970.85
121_G189_I0.5940.84
224_Q264_D0.5930.84
54_S58_N0.5880.84
208_Q245_E0.5870.84
209_I258_L0.5870.84
87_L183_S0.5850.84
34_T38_P0.5800.83
125_G194_I0.5790.83
250_I255_E0.5790.83
230_T270_F0.5770.83
158_D161_L0.5760.83
115_L188_Y0.5760.83
183_S250_I0.5750.83
117_T186_A0.5720.82
50_S68_I0.5720.82
214_P218_V0.5720.82
81_G204_S0.5710.82
260_E263_N0.5700.82
259_K263_N0.5700.82
113_T182_L0.5650.81
16_L133_R0.5640.81
143_M194_I0.5570.81
180_A186_A0.5570.81
75_L78_K0.5560.80
53_G59_L0.5550.80
54_S64_L0.5550.80
28_A128_M0.5550.80
88_S92_I0.5550.80
50_S247_T0.5540.80
208_Q276_V0.5540.80
59_L67_V0.5510.80
169_I173_T0.5490.80
91_G138_L0.5490.80
60_P104_H0.5480.79
132_L156_T0.5460.79
132_L198_E0.5450.79
32_L47_T0.5420.79
56_L71_P0.5400.78
227_R236_G0.5390.78
175_F179_G0.5390.78
82_K85_A0.5330.78
126_F193_V0.5330.78
26_I105_T0.5320.77
146_V164_N0.5300.77
163_L167_V0.5290.77
113_T178_Q0.5280.77
231_Y240_H0.5250.77
73_V144_L0.5250.77
89_I92_I0.5240.76
110_E183_S0.5230.76
121_G190_A0.5210.76
109_I113_T0.5200.76
156_T195_H0.5200.76
51_I55_Q0.5200.76
39_N181_L0.5190.76
211_T244_K0.5180.76
110_E116_I0.5180.76
46_V50_S0.5170.75
162_F170_F0.5170.75
136_G149_S0.5170.75
38_P133_R0.5160.75
71_P192_K0.5150.75
41_V44_G0.5140.75
218_V244_K0.5140.75
102_F135_G0.5130.75
203_G277_A0.5130.75
17_Q83_S0.5130.75
62_G65_I0.5120.75
51_I61_L0.5120.75
51_I115_L0.5100.74
114_L124_L0.5090.74
216_L219_E0.5090.74
61_L65_I0.5090.74
212_T217_M0.5070.74
16_L264_D0.5050.74
22_I98_G0.5050.74
239_S268_T0.5050.74
197_V248_C0.5020.73
26_I30_Y0.5010.73
41_V113_T0.5010.73
118_V243_F0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hluA 2 0.2517 99.9 0.7 Contact Map
3ncqA 4 0.3069 87.9 0.938 Contact Map
2dclA 5 0.3069 82.4 0.942 Contact Map
4rwwA 3 0.2897 82.2 0.943 Contact Map
3t9zA 3 0.2862 81 0.943 Contact Map
2eg2A 5 0.2931 78.4 0.945 Contact Map
4affA 3 0.3069 78.3 0.945 Contact Map
4co3A 3 0.2966 77.3 0.945 Contact Map
4r25A 3 0.3138 75.7 0.946 Contact Map
2gw8A 3 0.3034 75.5 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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