GREMLIN Database
YDEN - Putative hydrolase YdeN
UniProt: P96671 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (170)
Sequences: 1387 (998)
Seq/√Len: 76.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_R154_A4.8911.00
135_K158_E3.9201.00
54_L76_A3.6821.00
69_A77_I3.4211.00
24_K36_I3.1591.00
135_K142_F2.6741.00
8_I73_G2.3911.00
135_K161_H2.3201.00
166_L169_E2.1611.00
40_P53_T2.1171.00
136_D161_H2.1131.00
94_I184_Y2.0661.00
174_L177_V1.9741.00
21_P36_I1.9321.00
47_L79_R1.8931.00
4_Q63_E1.7791.00
72_L112_F1.7711.00
23_L177_V1.7531.00
140_V145_S1.7301.00
155_A183_S1.7161.00
142_F158_E1.6641.00
133_A156_L1.6501.00
40_P49_D1.6411.00
100_A144_F1.6231.00
81_L127_K1.6051.00
47_L51_L1.6011.00
69_A74_C1.5921.00
8_I76_A1.5780.99
162_G171_F1.5510.99
134_S162_G1.5160.99
67_L77_I1.5140.99
75_P101_K1.4940.99
46_R49_D1.4630.99
27_L34_A1.4580.99
71_S164_H1.4520.99
14_S20_F1.4500.99
112_F116_S1.4410.99
6_Y37_L1.4410.99
27_L178_Y1.4380.99
66_Y92_G1.4270.99
53_T56_L1.4130.99
55_S80_F1.3960.99
133_A142_F1.3890.99
55_S59_H1.3880.99
142_F156_L1.3770.99
131_V154_A1.3520.98
5_V68_V1.3490.98
139_I166_L1.3410.98
135_K160_Q1.3310.98
51_L76_A1.3290.98
146_K158_E1.3240.98
22_W173_S1.3200.98
99_F140_V1.3200.98
26_R178_Y1.3060.98
41_N44_Q1.2700.98
53_T57_Y1.2700.98
98_G148_L1.2670.97
162_G165_F1.2660.97
140_V148_L1.2660.97
142_F146_K1.2590.97
39_M53_T1.2580.97
130_A157_Y1.2480.97
58_Q65_T1.2180.97
77_I93_I1.1990.96
64_N91_G1.1930.96
162_G176_I1.1770.96
159_V162_G1.1650.96
125_S129_R1.1600.96
7_I34_A1.1440.95
93_I127_K1.1290.95
167_E171_F1.1140.95
94_I181_L1.1130.95
6_Y57_Y1.1110.95
133_A145_S1.1050.94
146_K150_Q1.1000.94
162_G170_G1.0970.94
146_K156_L1.0920.94
80_F84_L1.0890.94
28_L34_A1.0850.94
23_L27_L1.0810.94
22_W26_R1.0720.93
52_D56_L1.0640.93
61_L65_T1.0530.93
7_I24_K1.0500.93
15_S21_P1.0480.93
92_G128_H1.0470.93
92_G130_A1.0430.93
55_S83_H1.0320.92
13_A38_N1.0250.92
11_Y109_L1.0200.92
94_I130_A1.0080.91
8_I77_I1.0040.91
4_Q61_L0.9890.90
4_Q62_H0.9890.90
94_I177_V0.9890.90
75_P99_F0.9830.90
99_F139_I0.9720.90
140_V144_F0.9660.89
178_Y183_S0.9620.89
24_K28_L0.9460.88
23_L181_L0.9450.88
55_S84_L0.9260.87
45_P72_L0.9200.87
144_F147_D0.9140.87
4_Q35_D0.9110.86
132_I165_F0.9110.86
8_I54_L0.9020.86
93_I126_A0.9000.86
37_L54_L0.8940.85
12_R43_L0.8900.85
90_L136_D0.8690.84
117_F151_Q0.8580.83
89_Q151_Q0.8580.83
75_P115_G0.8570.83
47_L83_H0.8570.83
148_L151_Q0.8560.83
34_A37_L0.8500.82
23_L171_F0.8480.82
166_L170_G0.8440.82
14_S42_P0.8410.82
131_V149_A0.8380.81
134_S163_G0.8330.81
10_G19_W0.8320.81
34_A178_Y0.8320.81
99_F144_F0.8300.81
4_Q94_I0.8270.80
129_R153_D0.8270.80
9_H39_M0.8240.80
5_V27_L0.8230.80
130_A184_Y0.8220.80
4_Q65_T0.8180.80
11_Y106_L0.8160.80
171_F174_L0.8130.79
13_A166_L0.8120.79
60_T88_K0.8100.79
144_F148_L0.8070.79
147_D150_Q0.8060.79
7_I27_L0.8060.79
22_W25_K0.8020.78
21_P24_K0.8010.78
110_D113_T0.8000.78
149_A156_L0.7900.77
48_E83_H0.7890.77
132_I180_V0.7840.77
17_N22_W0.7820.77
94_I180_V0.7740.76
15_S167_E0.7690.75
106_L109_L0.7660.75
5_V34_A0.7590.74
81_L95_L0.7580.74
157_Y180_V0.7520.74
71_S166_L0.7500.74
102_S144_F0.7470.73
7_I68_V0.7410.73
58_Q61_L0.7390.73
50_W72_L0.7380.72
50_W96_V0.7340.72
12_R109_L0.7340.72
130_A155_A0.7300.72
79_R116_S0.7280.71
103_L141_P0.7240.71
101_K144_F0.7180.70
10_G20_F0.7160.70
35_D57_Y0.7050.69
14_S166_L0.7030.69
51_L79_R0.7020.69
10_G71_S0.6970.68
20_F71_S0.6930.68
98_G131_V0.6900.67
93_I131_V0.6870.67
74_C140_V0.6860.67
20_F98_G0.6800.66
124_E153_D0.6750.66
60_T179_D0.6740.65
5_V181_L0.6730.65
72_L75_P0.6710.65
13_A42_P0.6670.65
147_D151_Q0.6630.64
131_V156_L0.6600.64
36_I42_P0.6530.63
180_V183_S0.6520.63
17_N167_E0.6510.63
45_P50_W0.6480.62
20_F99_F0.6410.62
52_D82_E0.6340.61
73_G77_I0.6340.61
175_P178_Y0.6330.61
48_E52_D0.6230.59
15_S36_I0.6210.59
41_N49_D0.6190.59
74_C78_L0.6180.59
24_K34_A0.6160.59
26_R63_E0.6110.58
42_P50_W0.6070.57
99_F103_L0.6000.57
39_M45_P0.6000.57
8_I67_L0.5980.56
66_Y181_L0.5950.56
80_F173_S0.5920.56
23_L139_I0.5900.55
111_E115_G0.5890.55
9_H37_L0.5870.55
173_S178_Y0.5860.55
98_G140_V0.5850.55
133_A158_E0.5830.54
176_I180_V0.5810.54
83_H150_Q0.5800.54
7_I178_Y0.5800.54
138_Q166_L0.5740.53
10_G149_A0.5730.53
22_W159_V0.5730.53
136_D163_G0.5710.53
66_Y91_G0.5710.53
163_G166_L0.5700.53
96_V165_F0.5700.53
39_M42_P0.5660.52
163_G169_E0.5640.52
40_P46_R0.5590.51
52_D58_Q0.5590.51
54_L67_L0.5580.51
143_S150_Q0.5570.51
177_V181_L0.5560.51
68_V128_H0.5550.51
5_V179_D0.5490.50
100_A132_I0.5460.50
72_L99_F0.5450.50
90_L175_P0.5430.49
10_G96_V0.5420.49
160_Q163_G0.5420.49
47_L72_L0.5410.49
93_I154_A0.5390.49
46_R111_E0.5380.49
178_Y182_T0.5360.48
49_D88_K0.5350.48
179_D182_T0.5340.48
10_G18_H0.5330.48
79_R112_F0.5270.47
113_T118_D0.5270.47
16_T25_K0.5260.47
69_A99_F0.5200.46
42_P177_V0.5190.46
159_V165_F0.5190.46
72_L139_I0.5180.46
49_D53_T0.5180.46
45_P76_A0.5150.46
103_L109_L0.5130.46
10_G14_S0.5130.46
100_A152_I0.5120.45
155_A180_V0.5120.45
152_I163_G0.5110.45
98_G144_F0.5100.45
97_S139_I0.5090.45
63_E89_Q0.5070.45
111_E114_Q0.5010.44
58_Q80_F0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uxoA 1 0.9684 100 0.477 Contact Map
2qs9A 1 0.9526 100 0.515 Contact Map
3bdvA 1 0.9158 99.9 0.553 Contact Map
2wtmA 2 0.9684 99.8 0.652 Contact Map
2qjwA 2 0.8684 99.8 0.655 Contact Map
1xklA 3 0.9474 99.8 0.663 Contact Map
4k5qA 1 0.9737 99.8 0.665 Contact Map
4fleA 1 0.8895 99.8 0.666 Contact Map
3hjuA 2 0.9789 99.8 0.666 Contact Map
3pfbA 2 0.9474 99.8 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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