GREMLIN Database
YDEK - Uncharacterized transporter YdeK
UniProt: P96668 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (272)
Sequences: 36453 (27024)
Seq/√Len: 1638.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_A153_M3.4221.00
10_N231_R2.9921.00
95_H150_D2.8741.00
231_R235_Q2.7981.00
256_A262_E2.7211.00
86_L152_Y2.5271.00
46_G185_V2.5131.00
24_A216_Y2.4521.00
83_L155_A2.4041.00
39_V192_L2.3661.00
231_R234_A2.3461.00
126_F278_C2.3151.00
62_A65_D2.1981.00
97_I252_G2.1951.00
106_A157_I2.1831.00
110_F165_A2.1561.00
19_S251_F2.1351.00
117_E168_A2.1221.00
83_L152_Y2.1001.00
26_R262_E2.0611.00
44_I218_S2.0521.00
25_T85_A2.0471.00
11_G232_G2.0071.00
112_V119_P1.9951.00
120_R123_F1.9481.00
79_G159_V1.8711.00
208_V212_L1.8691.00
43_A188_L1.8661.00
111_G117_E1.8611.00
65_D173_R1.8581.00
50_G181_S1.8251.00
108_A127_S1.8211.00
107_T242_G1.8011.00
102_L106_A1.7861.00
19_S255_L1.7821.00
90_H148_L1.7491.00
91_V149_G1.7461.00
91_V150_D1.7351.00
189_P193_P1.7011.00
175_G178_Q1.6741.00
207_G210_A1.6681.00
151_A155_A1.6431.00
130_G246_L1.6411.00
218_S223_L1.6351.00
16_L251_F1.6331.00
46_G188_L1.6151.00
51_G54_L1.6141.00
237_G240_A1.6001.00
83_L159_V1.5951.00
193_P196_F1.5921.00
20_G216_Y1.5851.00
265_G268_L1.5541.00
86_L90_H1.5401.00
106_A161_G1.5191.00
96_A153_M1.4981.00
167_G230_Y1.4591.00
50_G54_L1.4451.00
14_G232_G1.4381.00
28_A37_L1.4281.00
64_R68_S1.4211.00
32_F210_A1.4151.00
106_A158_V1.4111.00
86_L89_Q1.3661.00
111_G115_G1.3571.00
52_L56_F1.3541.00
266_W270_A1.3521.00
39_V188_L1.3511.00
45_A184_L1.3491.00
110_F114_R1.3251.00
10_N228_F1.3241.00
93_S256_A1.3091.00
63_K67_I1.3081.00
126_F282_A1.2951.00
251_F255_L1.2951.00
64_R67_I1.2941.00
23_P255_L1.2931.00
37_L217_V1.2921.00
136_G274_A1.2871.00
27_L213_S1.2861.00
67_I71_V1.2831.00
31_D210_A1.2801.00
63_K66_L1.2701.00
8_W244_L1.2691.00
161_G165_A1.2661.00
91_V95_H1.2641.00
18_F225_G1.2601.00
94_A253_L1.2581.00
98_V272_N1.2571.00
51_G55_I1.2541.00
209_P212_L1.2411.00
147_P150_D1.2401.00
90_H152_Y1.2361.00
269_V273_I1.2361.00
48_L223_L1.2341.00
121_P125_I1.2321.00
255_L259_I1.2251.00
65_D68_S1.2231.00
208_V211_L1.2171.00
247_L251_F1.2151.00
136_G267_A1.2131.00
47_V51_G1.2091.00
273_I277_M1.1971.00
130_G278_C1.1931.00
33_D36_F1.1921.00
126_F281_A1.1801.00
68_S166_E1.1751.00
92_T95_H1.1691.00
264_V269_V1.1591.00
128_A132_L1.1541.00
212_L216_Y1.1501.00
124_W128_A1.1491.00
20_G255_L1.1471.00
209_P213_S1.1471.00
17_I220_F1.1351.00
121_P124_W1.1321.00
168_A237_G1.1291.00
26_R30_S1.1281.00
9_I13_I1.1281.00
110_F162_L1.1251.00
190_L193_P1.1171.00
88_L96_A1.1171.00
122_V281_A1.1161.00
133_L271_V1.1111.00
35_L194_L1.1081.00
39_V195_S1.1011.00
169_K172_R1.0971.00
194_L198_F1.0961.00
14_G228_F1.0921.00
39_V43_A1.0891.00
148_L152_Y1.0851.00
110_F161_G1.0671.00
133_L275_V1.0661.00
90_H146_S1.0631.00
91_V153_M1.0611.00
84_T88_L1.0571.00
90_H149_G1.0551.00
24_A213_S1.0481.00
18_F229_W1.0471.00
70_L73_A1.0421.00
112_V118_R1.0381.00
115_G165_A1.0371.00
233_L241_V1.0361.00
14_G18_F1.0351.00
137_F271_V1.0341.00
70_L186_L1.0321.00
74_F190_L1.0231.00
212_L215_A1.0211.00
169_K173_R1.0191.00
68_S72_V1.0181.00
119_P124_W1.0181.00
54_L58_Q1.0171.00
38_T85_A1.0161.00
93_S260_L1.0131.00
13_I228_F1.0131.00
203_W206_I1.0061.00
46_G181_S1.0061.00
107_T238_I1.0011.00
168_A238_I0.9991.00
99_F157_I0.9901.00
99_F150_D0.9881.00
107_T164_Y0.9851.00
78_I190_L0.9821.00
25_T88_L0.9811.00
43_A192_L0.9801.00
233_L237_G0.9791.00
67_I70_L0.9761.00
211_L215_A0.9741.00
139_L265_G0.9701.00
78_I191_M0.9691.00
266_W269_V0.9641.00
17_I228_F0.9561.00
102_L134_V0.9501.00
28_A213_S0.9401.00
237_G241_V0.9351.00
148_L151_A0.9341.00
236_G241_V0.9321.00
168_A172_R0.9281.00
42_A187_S0.9281.00
107_T161_G0.9271.00
23_P259_I0.9251.00
65_D174_L0.9251.00
147_P151_A0.9241.00
99_F153_M0.9211.00
117_E123_F0.9201.00
35_L82_L0.9181.00
110_F158_V0.9171.00
149_G153_M0.9171.00
250_F272_N0.9161.00
28_A210_A0.9161.00
193_P197_F0.9141.00
71_V166_E0.9141.00
108_A119_P0.9121.00
215_A218_S0.9101.00
34_P38_T0.9091.00
68_S170_L0.9051.00
58_Q175_G0.8981.00
135_A139_L0.8941.00
157_I161_G0.8941.00
120_R124_W0.8891.00
98_V135_A0.8801.00
41_R222_M0.8781.00
15_V19_S0.8721.00
110_F113_L0.8711.00
118_R122_V0.8691.00
129_A278_C0.8671.00
69_L73_A0.8671.00
31_D207_G0.8661.00
113_L116_G0.8631.00
66_L186_L0.8591.00
36_F195_S0.8591.00
54_L59_Q0.8581.00
236_G240_A0.8581.00
71_V74_F0.8521.00
50_G185_V0.8521.00
205_A208_V0.8511.00
82_L86_L0.8501.00
93_S262_E0.8451.00
185_V189_P0.8431.00
54_L57_R0.8421.00
48_L219_L0.8371.00
15_V247_L0.8261.00
15_V251_F0.8261.00
253_L264_V0.8241.00
134_V138_A0.8221.00
66_L70_L0.8201.00
232_G241_V0.8191.00
12_F251_F0.8111.00
197_F200_P0.8011.00
118_R121_P0.8001.00
132_L136_G0.7961.00
257_S264_V0.7941.00
23_P256_A0.7941.00
68_S169_K0.7921.00
78_I82_L0.7891.00
174_L179_V0.7851.00
136_G270_A0.7821.00
194_L197_F0.7821.00
21_S221_S0.7821.00
144_G147_P0.7801.00
75_G159_V0.7801.00
73_A186_L0.7761.00
55_I58_Q0.7751.00
80_F159_V0.7751.00
38_T191_M0.7711.00
186_L189_P0.7701.00
267_A270_A0.7621.00
182_W186_L0.7611.00
132_L274_A0.7571.00
40_C44_I0.7561.00
48_L51_G0.7561.00
224_I228_F0.7501.00
105_L130_G0.7481.00
109_V113_L0.7451.00
11_G244_L0.7441.00
49_A223_L0.7431.00
108_A123_F0.7421.00
215_A219_L0.7401.00
107_T165_A0.7271.00
70_L74_F0.7251.00
77_V163_G0.7251.00
22_L84_T0.7221.00
53_L181_S0.7181.00
253_L272_N0.7181.00
153_M157_I0.7171.00
46_G50_G0.7101.00
162_L166_E0.7091.00
69_L174_L0.7091.00
270_A274_A0.7071.00
213_S216_Y0.7071.00
66_L69_L0.7051.00
180_I183_A0.7051.00
143_G146_S0.7041.00
91_V96_A0.7041.00
257_S263_K0.7031.00
181_S185_V0.7031.00
125_I129_A0.7011.00
160_C164_Y0.6971.00
188_L192_L0.6971.00
207_G211_L0.6911.00
8_W240_A0.6911.00
196_F199_T0.6861.00
272_N276_I0.6851.00
23_P93_S0.6851.00
214_L218_S0.6831.00
68_S71_V0.6791.00
87_A149_G0.6791.00
11_G236_G0.6751.00
186_L190_L0.6731.00
69_L72_V0.6701.00
43_A47_V0.6691.00
146_S150_D0.6681.00
247_L250_F0.6671.00
62_A66_L0.6671.00
99_F154_L0.6641.00
256_A260_L0.6631.00
32_F36_F0.6631.00
57_R60_H0.6621.00
56_F175_G0.6601.00
279_V282_A0.6591.00
112_V116_G0.6571.00
36_F40_C0.6541.00
264_V268_L0.6541.00
119_P123_F0.6511.00
75_G162_L0.6511.00
102_L105_L0.6501.00
106_A154_L0.6491.00
160_C229_W0.6471.00
139_L142_G0.6471.00
22_L97_I0.6471.00
87_A96_A0.6471.00
52_L177_W0.6461.00
117_E239_A0.6391.00
182_W185_V0.6391.00
80_F163_G0.6381.00
25_T29_V0.6331.00
33_D199_T0.6321.00
178_Q182_W0.6271.00
108_A112_V0.6261.00
187_S191_M0.6231.00
176_N180_I0.6221.00
278_C282_A0.6221.00
48_L218_S0.6211.00
204_S207_G0.6211.00
227_V231_R0.6201.00
220_F224_I0.6191.00
253_L257_S0.6151.00
27_L260_L0.6121.00
68_S73_A0.6091.00
268_L272_N0.6061.00
101_G134_V0.6001.00
255_L258_V0.5991.00
180_I184_L0.5971.00
85_A89_Q0.5971.00
152_Y155_A0.5971.00
79_G83_L0.5951.00
32_F37_L0.5941.00
277_M281_A0.5941.00
189_P192_L0.5911.00
210_A213_S0.5901.00
84_T96_A0.5871.00
62_A67_I0.5861.00
29_V88_L0.5851.00
138_A150_D0.5831.00
206_I211_L0.5771.00
185_V188_L0.5761.00
163_G230_Y0.5751.00
265_G269_V0.5751.00
78_I194_L0.5731.00
216_Y220_F0.5721.00
29_V89_Q0.5711.00
263_K267_A0.5651.00
56_F60_H0.5651.00
77_V226_F0.5651.00
104_P246_L0.5621.00
52_L55_I0.5611.00
216_Y219_L0.5601.00
83_L156_S0.5581.00
180_I230_Y0.5571.00
115_G169_K0.5511.00
114_R162_L0.5511.00
254_L257_S0.5491.00
245_Q248_Q0.5481.00
109_V127_S0.5471.00
56_F177_W0.5471.00
101_G157_I0.5461.00
40_C214_L0.5451.00
12_F15_V0.5411.00
98_V138_A0.5391.00
44_I48_L0.5391.00
55_I59_Q0.5391.00
41_R221_S0.5381.00
35_L198_F0.5381.00
163_G183_A0.5381.00
102_L157_I0.5371.00
21_S217_V0.5311.00
129_A281_A0.5311.00
258_V261_H0.5301.00
158_V162_L0.5291.00
73_A78_I0.5291.00
246_L279_V0.5291.00
232_G236_G0.5281.00
97_I101_G0.5281.00
254_L258_V0.5271.00
27_L30_S0.5251.00
77_V183_A0.5241.00
8_W12_F0.5241.00
45_A223_L0.5241.00
174_L178_Q0.5241.00
75_G166_E0.5241.00
196_F200_P0.5231.00
131_S246_L0.5221.00
163_G167_G0.5221.00
164_Y229_W0.5211.00
263_K268_L0.5201.00
23_P252_G0.5181.00
19_S248_Q0.5181.00
70_L190_L0.5181.00
123_F237_G0.5161.00
87_A91_V0.5141.00
115_G168_A0.5141.00
65_D69_L0.5111.00
164_Y242_G0.5111.00
17_I225_G0.5101.00
15_V248_Q0.5091.00
21_S85_A0.5061.00
228_F231_R0.5051.00
98_V137_F0.5011.00
206_I210_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2683 98.7 0.768 Contact Map
3b5dA 2 0.3519 98.5 0.782 Contact Map
1u7gA 3 0.8223 26.1 0.932 Contact Map
4pgrA 1 0.676 6.9 0.948 Contact Map
4uc1A 3 0.5192 5.9 0.949 Contact Map
3o7qA 1 0.7875 5.8 0.949 Contact Map
4j05A 3 0.9443 5.2 0.95 Contact Map
2gfpA 2 0.7875 5 0.951 Contact Map
4o9uB 2 0.2544 4.8 0.952 Contact Map
2cfqA 1 0.5819 4.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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