GREMLIN Database
YDEI - Uncharacterized protein YdeI
UniProt: P96666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (189)
Sequences: 460 (364)
Seq/√Len: 26.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_L144_F6.4101.00
157_L165_Y4.0231.00
13_F24_F3.7081.00
24_F59_G3.2251.00
136_I166_T3.1651.00
94_I109_L3.1101.00
13_F59_G2.8481.00
151_K155_E2.7921.00
40_F43_M2.7481.00
10_V14_L2.7140.99
75_Q115_E2.6410.99
83_Q88_V2.4440.99
84_Q88_V2.2900.98
141_Q145_D2.2740.98
70_K120_E2.2330.98
31_I113_I2.0290.96
78_D108_I2.0170.96
85_T88_V1.8950.94
28_R38_E1.8670.94
80_I94_I1.8610.94
58_H85_T1.8270.93
49_Y121_K1.7780.92
58_H88_V1.7400.91
136_I141_Q1.6710.89
82_I93_Q1.6030.87
70_K73_L1.5570.86
13_F17_A1.5500.85
168_Y185_Y1.5500.85
118_E122_A1.5240.84
58_H67_L1.5200.84
147_I186_V1.5160.84
72_V90_A1.5090.84
164_A169_F1.4890.83
66_L109_L1.4890.83
71_G92_R1.4880.83
38_E45_P1.4850.83
78_D104_E1.4680.82
119_V124_L1.4530.81
89_Q129_N1.4500.81
140_L166_T1.4310.80
98_N101_E1.4290.80
78_D149_A1.4220.80
21_K25_E1.4120.79
56_L85_T1.4060.79
90_A102_I1.3940.78
44_H58_H1.3770.78
20_W23_E1.3760.77
58_H63_Y1.3730.77
58_H84_Q1.3690.77
134_L166_T1.3660.77
56_L84_Q1.3510.76
73_L126_V1.3480.76
40_F44_H1.3330.75
142_N179_E1.3290.75
143_K183_E1.3200.74
55_V66_L1.3190.74
119_V187_Q1.3130.74
15_S25_E1.3060.74
28_R45_P1.2940.73
67_L93_Q1.2930.73
168_Y187_Q1.2680.71
82_I95_R1.2600.71
44_H69_H1.2430.70
80_I108_I1.2330.69
63_Y93_Q1.2210.68
56_L88_V1.2180.68
111_A148_P1.2130.68
175_S179_E1.2110.68
143_K147_I1.2000.67
74_L77_T1.1930.67
103_N106_E1.1760.65
51_N137_P1.1690.65
67_L84_Q1.1570.64
56_L83_Q1.1490.64
67_L85_T1.1410.63
31_I55_V1.1370.63
44_H59_G1.1270.62
140_L169_F1.1240.62
67_L88_V1.1190.62
56_L67_L1.1160.61
185_Y188_K1.1140.61
136_I191_D1.1070.61
165_Y193_K1.0870.59
8_P40_F1.0730.58
157_L161_R1.0700.58
90_A126_V1.0690.58
65_A93_Q1.0670.58
63_Y82_I1.0650.58
23_E102_I1.0640.58
167_L171_Q1.0480.56
107_N113_I1.0450.56
23_E30_I1.0440.56
43_M69_H1.0420.56
15_S191_D1.0340.55
114_H172_A1.0270.55
26_K106_E1.0160.54
24_F58_H1.0040.53
100_Q104_E1.0040.53
107_N191_D0.9900.52
12_E40_F0.9840.52
143_K186_V0.9770.51
143_K148_P0.9750.51
134_L167_L0.9700.51
97_T101_E0.9370.48
51_N172_A0.9360.48
70_K119_V0.9320.48
118_E121_K0.9300.48
63_Y85_T0.9300.48
114_H140_L0.9280.47
29_T100_Q0.9280.47
166_T169_F0.9250.47
54_I188_K0.9200.47
46_C56_L0.9150.47
13_F45_P0.9140.46
53_N194_G0.9020.46
39_D44_H0.8970.45
7_N39_D0.8920.45
19_K109_L0.8880.45
127_D180_S0.8870.44
139_E153_A0.8830.44
142_N145_D0.8760.44
189_I194_G0.8590.42
161_R194_G0.8520.42
131_N134_L0.8460.41
55_V113_I0.8440.41
35_E49_Y0.8420.41
11_D43_M0.8420.41
82_I85_T0.8420.41
58_H65_A0.8280.40
135_N149_A0.8230.40
153_A189_I0.8160.39
35_E74_L0.8100.39
139_E178_R0.8100.39
13_F133_E0.8090.39
112_Y115_E0.8010.38
52_K75_Q0.7990.38
150_L186_V0.7960.38
49_Y114_H0.7940.38
144_F150_L0.7890.37
76_D112_Y0.7850.37
69_H85_T0.7850.37
33_D60_F0.7840.37
185_Y189_I0.7780.37
64_C70_K0.7750.36
144_F151_K0.7720.36
36_L157_L0.7720.36
16_K149_A0.7680.36
29_T145_D0.7590.35
60_F91_A0.7580.35
142_N147_I0.7550.35
176_K180_S0.7500.35
143_K146_E0.7460.34
150_L168_Y0.7450.34
33_D110_K0.7440.34
54_I99_V0.7410.34
137_P166_T0.7390.34
106_E130_K0.7390.34
135_N138_E0.7380.34
31_I66_L0.7320.33
63_Y67_L0.7320.33
188_K195_L0.7310.33
172_A180_S0.7300.33
101_E152_I0.7240.33
85_T93_Q0.7180.33
25_E152_I0.7170.33
66_L86_E0.7170.33
44_H85_T0.7100.32
24_F57_I0.7080.32
52_K127_D0.7070.32
12_E16_K0.7070.32
57_I63_Y0.7030.32
28_R137_P0.7020.32
53_N189_I0.7010.31
138_E152_I0.7010.31
23_E120_E0.6940.31
12_E15_S0.6940.31
43_M88_V0.6930.31
191_D196_K0.6930.31
190_L195_L0.6860.31
135_N172_A0.6860.31
118_E182_V0.6850.30
33_D104_E0.6850.30
125_K155_E0.6810.30
56_L95_R0.6800.30
145_D151_K0.6790.30
140_L150_L0.6740.30
9_K146_E0.6670.29
141_Q151_K0.6590.29
24_F69_H0.6590.29
17_A24_F0.6570.29
67_L91_A0.6560.29
9_K12_E0.6550.29
160_G163_R0.6540.29
16_K196_K0.6540.29
16_K130_K0.6520.28
158_T194_G0.6480.28
26_K191_D0.6470.28
55_V110_K0.6450.28
8_P12_E0.6440.28
44_H56_L0.6430.28
13_F69_H0.6420.28
37_T62_E0.6420.28
79_G115_E0.6420.28
34_C193_K0.6390.28
169_F172_A0.6320.27
18_K40_F0.6320.27
132_I135_N0.6290.27
12_E43_M0.6270.27
13_F19_K0.6250.27
58_H93_Q0.6200.26
53_N96_F0.6200.26
100_Q106_E0.6190.26
75_Q114_H0.6170.26
108_I112_Y0.6170.26
52_K125_K0.6160.26
18_K49_Y0.6160.26
65_A84_Q0.6110.26
58_H83_Q0.6100.26
106_E182_V0.6070.26
88_V91_A0.6060.26
15_S142_N0.6010.25
86_E130_K0.5990.25
101_E104_E0.5980.25
24_F51_N0.5900.25
29_T35_E0.5880.25
16_K22_E0.5870.25
10_V117_I0.5860.25
120_E125_K0.5820.24
51_N106_E0.5810.24
149_A152_I0.5810.24
59_G67_L0.5780.24
52_K111_A0.5780.24
155_E162_Q0.5770.24
112_Y154_F0.5760.24
67_L167_L0.5730.24
26_K100_Q0.5730.24
139_E160_G0.5700.24
187_Q191_D0.5700.24
65_A85_T0.5690.24
25_E149_A0.5650.23
94_I113_I0.5640.23
98_N108_I0.5600.23
188_K193_K0.5580.23
29_T37_T0.5580.23
65_A95_R0.5570.23
39_D51_N0.5560.23
156_A176_K0.5550.23
100_Q142_N0.5550.23
77_T114_H0.5550.23
27_L137_P0.5540.23
74_L81_L0.5470.22
30_I112_Y0.5470.22
161_R167_L0.5450.22
71_G117_I0.5440.22
169_F182_V0.5420.22
77_T115_E0.5390.22
109_L178_R0.5390.22
90_A164_A0.5380.22
96_F133_E0.5380.22
56_L89_Q0.5350.22
132_I163_R0.5330.22
45_P137_P0.5330.22
31_I44_H0.5300.22
60_F93_Q0.5250.21
72_V88_V0.5240.21
134_L163_R0.5230.21
29_T52_K0.5230.21
103_N142_N0.5210.21
185_Y195_L0.5200.21
30_I102_I0.5200.21
26_K29_T0.5190.21
11_D40_F0.5170.21
101_E107_N0.5160.21
175_S187_Q0.5160.21
144_F182_V0.5160.21
184_K195_L0.5120.21
78_D111_A0.5110.21
59_G93_Q0.5100.21
30_I75_Q0.5040.20
134_L137_P0.5040.20
53_N161_R0.5030.20
98_N190_L0.5010.20
16_K191_D0.5000.20
12_E29_T0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i8dA 2 0.5939 99.9 0.704 Contact Map
2oc6A 1 0.6091 99.9 0.711 Contact Map
2kl4A 1 0.5787 99.9 0.716 Contact Map
2fkiA 1 0.5431 59.2 0.951 Contact Map
2a1vA 1 0.6294 26.3 0.96 Contact Map
3fnvA 2 0.1117 18.2 0.963 Contact Map
3u4qB 1 0.4213 15.8 0.964 Contact Map
4fvgA 2 0.5228 12.1 0.966 Contact Map
4w7sA 2 0.4061 11.8 0.966 Contact Map
3k9dA 2 0.335 10.5 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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