GREMLIN Database
YDED - Uncharacterized transporter YdeD
UniProt: P96661 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (277)
Sequences: 39270 (28479)
Seq/√Len: 1711.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_S166_G3.2051.00
12_Y243_K2.8511.00
105_V163_V2.8081.00
243_K247_S2.7201.00
268_T274_A2.6401.00
96_A165_W2.4891.00
50_G198_I2.4281.00
43_T205_G2.3461.00
93_T168_L2.3121.00
136_T290_I2.3061.00
26_V228_F2.2861.00
243_K246_E2.2521.00
72_H75_S2.2431.00
127_T181_V2.1801.00
116_I170_G2.1781.00
28_K274_A2.0921.00
107_T264_A2.0511.00
120_Y178_L2.0451.00
93_T165_W2.0371.00
13_V244_S2.0261.00
220_A224_A2.0041.00
48_T230_I2.0031.00
27_A95_M1.9671.00
21_G263_S1.9311.00
122_L129_L1.8781.00
47_L201_G1.8651.00
89_A172_A1.8631.00
118_I137_V1.8241.00
121_T127_T1.8011.00
101_G163_V1.7711.00
54_L194_G1.7681.00
112_L116_I1.7621.00
117_V254_S1.7541.00
130_T133_D1.7461.00
75_S186_K1.7401.00
164_V168_L1.7341.00
101_G162_A1.7031.00
100_H161_A1.6631.00
21_G267_T1.6591.00
292_L296_L1.6581.00
55_M58_L1.6481.00
202_F206_F1.6361.00
230_I235_M1.6101.00
219_T222_A1.6081.00
249_S252_E1.5781.00
50_G201_G1.5701.00
22_I228_F1.5661.00
188_D191_V1.5591.00
140_A258_S1.5521.00
206_F209_P1.5391.00
93_T172_A1.5341.00
116_I174_A1.5241.00
18_T263_S1.5171.00
277_G280_Q1.5061.00
215_F218_L1.4881.00
136_T294_L1.4781.00
56_L60_R1.4711.00
96_A100_H1.4491.00
106_A166_G1.4341.00
54_L58_L1.4161.00
120_Y124_R1.4091.00
36_I222_A1.4041.00
74_A78_Q1.3891.00
116_I171_F1.3891.00
78_Q179_Y1.3881.00
43_T201_G1.3821.00
160_A163_V1.3751.00
30_L41_L1.3641.00
180_A242_I1.3641.00
16_G244_S1.3561.00
136_T293_I1.3541.00
55_M59_F1.3511.00
32_Q35_Q1.3421.00
29_K225_Y1.3291.00
51_M55_M1.3281.00
220_A223_Y1.3161.00
20_W237_A1.3121.00
73_K77_G1.3081.00
96_A99_Q1.3041.00
160_A164_V1.3031.00
140_A290_I1.3021.00
278_S282_I1.2911.00
131_K135_I1.2851.00
49_A197_M1.2791.00
41_L229_V1.2761.00
81_I179_Y1.2751.00
77_G81_I1.2721.00
102_N105_V1.2721.00
121_T125_K1.2681.00
143_G283_G1.2661.00
104_A265_V1.2651.00
103_A268_T1.2581.00
35_Q222_A1.2581.00
74_A77_G1.2501.00
101_G105_V1.2431.00
263_S267_T1.2361.00
221_E224_A1.2341.00
174_A178_L1.2291.00
25_T267_T1.2281.00
146_F286_C1.2261.00
100_H165_W1.2251.00
267_T271_W1.2241.00
285_I289_G1.2221.00
12_Y240_F1.2221.00
52_L235_M1.2211.00
281_W285_I1.2161.00
221_E225_Y1.2031.00
182_G186_K1.2001.00
73_K76_A1.1981.00
80_L199_I1.1951.00
146_F279_F1.1911.00
132_Q293_I1.1911.00
259_L263_S1.1891.00
134_I138_V1.1841.00
203_A206_F1.1801.00
37_D40_W1.1781.00
10_L256_L1.1731.00
276_F281_W1.1591.00
147_L283_G1.1461.00
161_A165_W1.1331.00
108_L284_A1.1281.00
138_V142_V1.1171.00
181_V249_S1.1141.00
83_G199_I1.1111.00
224_A228_F1.1111.00
98_I106_A1.1051.00
181_V185_N1.1021.00
39_N207_I1.0991.00
182_G185_N1.0981.00
245_L253_T1.0911.00
43_T47_L1.0861.00
143_G287_I1.0821.00
58_L62_D1.0801.00
50_G194_G1.0781.00
78_Q183_L1.0761.00
100_H159_P1.0751.00
20_W241_F1.0691.00
117_V250_P1.0681.00
43_T208_H1.0651.00
19_C232_F1.0651.00
85_L175_F1.0641.00
100_H162_A1.0641.00
125_K178_L1.0611.00
16_G20_W1.0611.00
88_L203_A1.0541.00
131_K134_I1.0511.00
16_G240_F1.0501.00
101_G166_G1.0501.00
84_L203_A1.0491.00
117_V177_T1.0481.00
120_Y175_F1.0481.00
28_K32_Q1.0441.00
11_F15_T1.0421.00
120_Y174_A1.0391.00
122_L128_V1.0381.00
127_T133_D1.0301.00
181_V250_P1.0291.00
9_G244_S1.0181.00
19_C240_F1.0141.00
22_I267_T1.0091.00
88_L204_L1.0081.00
27_A98_I1.0051.00
103_A272_L1.0051.00
30_L222_A1.0011.00
132_Q297_H1.0011.00
38_V42_V1.0001.00
15_T240_F0.9961.00
75_S187_F0.9941.00
118_I129_L0.9881.00
94_Y98_I0.9871.00
26_V225_Y0.9861.00
85_L172_A0.9771.00
129_L134_I0.9751.00
109_L170_G0.9711.00
112_L144_C0.9701.00
161_A164_V0.9691.00
30_L225_Y0.9671.00
47_L205_G0.9671.00
278_S281_W0.9631.00
149_T277_G0.9601.00
58_L61_K0.9601.00
207_I211_W0.9581.00
132_Q296_L0.9551.00
42_V95_M0.9491.00
139_L290_I0.9481.00
224_A227_L0.9471.00
62_D188_D0.9441.00
249_S253_T0.9411.00
120_Y123_L0.9391.00
78_Q182_G0.9381.00
77_G80_L0.9301.00
123_L126_Q0.9261.00
170_G174_A0.9261.00
76_A199_I0.9251.00
117_V174_A0.9241.00
227_L230_I0.9221.00
145_F149_T0.9211.00
109_L163_V0.9161.00
39_N92_Y0.9161.00
9_G247_S0.9131.00
223_Y227_L0.9121.00
130_T134_I0.9111.00
248_L253_T0.9111.00
87_M176_Y0.9101.00
120_Y171_F0.9091.00
162_A166_G0.9061.00
35_Q219_T0.9051.00
245_L249_S0.9041.00
25_T271_W0.8971.00
40_W208_H0.8961.00
109_L166_G0.8921.00
207_I210_P0.8901.00
206_F210_P0.8871.00
23_G233_G0.8851.00
103_A274_A0.8831.00
17_A21_G0.8661.00
108_L145_F0.8601.00
157_S160_A0.8591.00
46_L200_G0.8581.00
52_L55_M0.8571.00
92_Y96_A0.8431.00
248_L252_E0.8351.00
17_A263_S0.8341.00
45_R234_T0.8331.00
85_L179_Y0.8291.00
128_V132_Q0.8251.00
27_A31_F0.8211.00
219_T223_Y0.8181.00
72_H76_A0.8151.00
265_V276_F0.8121.00
52_L231_L0.8101.00
142_V146_F0.8021.00
54_L198_I0.8001.00
198_I202_F0.8001.00
159_P163_V0.7991.00
279_F282_I0.7981.00
166_G170_G0.7951.00
244_S253_T0.7951.00
262_L284_A0.7851.00
226_I230_I0.7841.00
128_V131_K0.7771.00
199_I202_F0.7731.00
13_V256_L0.7711.00
144_C148_L0.7701.00
269_V276_F0.7691.00
25_T268_T0.7671.00
75_S78_Q0.7661.00
284_A288_I0.7661.00
175_F179_Y0.7641.00
142_V286_C0.7591.00
57_Q61_K0.7561.00
88_L92_Y0.7561.00
194_G198_I0.7561.00
265_V284_A0.7511.00
44_T48_T0.7481.00
146_F282_I0.7471.00
201_G205_G0.7451.00
115_V140_A0.7421.00
50_G54_L0.7331.00
83_G88_L0.7331.00
282_I286_C0.7271.00
259_L262_L0.7261.00
87_M238_F0.7261.00
42_V204_L0.7241.00
53_L235_M0.7201.00
14_I263_S0.7181.00
156_L159_P0.7171.00
276_F280_Q0.7141.00
135_I139_L0.7141.00
59_F62_D0.7131.00
187_F192_V0.7121.00
236_I240_F0.7121.00
90_V172_A0.7111.00
189_S193_V0.7101.00
227_L231_L0.7081.00
195_W199_I0.7051.00
202_F205_G0.7051.00
193_V196_A0.7031.00
56_L190_L0.7031.00
97_S162_A0.7031.00
119_I123_L0.7021.00
79_L187_F0.7001.00
289_G293_I0.6981.00
60_R188_D0.6981.00
118_I133_D0.6951.00
173_A177_T0.6921.00
143_G290_I0.6921.00
89_A93_T0.6891.00
57_Q194_G0.6881.00
109_L167_V0.6881.00
269_V275_P0.6871.00
209_P212_Q0.6861.00
78_Q82_F0.6851.00
25_T103_A0.6851.00
112_L115_V0.6801.00
17_A259_L0.6801.00
76_A80_L0.6791.00
29_K272_L0.6791.00
228_F232_F0.6771.00
117_V178_L0.6771.00
10_L252_E0.6751.00
219_T224_A0.6731.00
122_L126_Q0.6731.00
173_A241_F0.6711.00
199_I203_A0.6701.00
47_L51_M0.6691.00
24_G94_Y0.6661.00
90_V176_Y0.6651.00
81_I84_L0.6651.00
79_L192_V0.6611.00
56_L59_F0.6611.00
127_T251_K0.6581.00
13_V248_L0.6541.00
268_T272_L0.6511.00
101_G106_A0.6491.00
129_L133_D0.6481.00
40_W44_T0.6471.00
255_L294_L0.6461.00
290_I294_L0.6411.00
76_A195_W0.6361.00
239_W243_K0.6361.00
116_I167_V0.6341.00
48_T52_L0.6331.00
217_R220_A0.6301.00
265_V269_V0.6291.00
24_G107_T0.6281.00
195_W198_I0.6271.00
111_Y170_G0.6221.00
232_F236_I0.6221.00
158_V161_A0.6201.00
36_I41_L0.6201.00
139_L293_I0.6151.00
111_Y114_P0.6151.00
19_C237_A0.6121.00
222_A225_Y0.6111.00
176_Y242_I0.6101.00
210_P213_L0.6101.00
78_Q81_I0.6091.00
97_S106_A0.6091.00
94_Y169_S0.6051.00
275_P279_F0.6041.00
114_P258_S0.6021.00
45_R233_G0.6021.00
267_T270_V0.6011.00
60_R190_L0.6001.00
72_H77_G0.5961.00
165_W168_L0.5951.00
225_Y228_F0.5941.00
133_D249_S0.5941.00
125_K182_G0.5941.00
198_I201_G0.5931.00
112_L170_G0.5911.00
36_I40_W0.5891.00
193_V242_I0.5861.00
280_Q284_A0.5841.00
118_I122_L0.5821.00
17_A260_E0.5791.00
15_T19_C0.5791.00
9_G248_L0.5761.00
44_T226_I0.5761.00
124_R175_F0.5741.00
211_W214_D0.5741.00
155_Q158_V0.5711.00
49_A235_M0.5711.00
111_Y144_C0.5681.00
95_M99_Q0.5661.00
82_F179_Y0.5661.00
87_M196_A0.5661.00
258_S291_T0.5641.00
191_V195_W0.5631.00
277_G281_W0.5621.00
94_Y106_A0.5611.00
52_L230_I0.5551.00
90_V94_Y0.5551.00
266_V270_V0.5531.00
88_L207_I0.5531.00
78_Q186_K0.5511.00
10_L14_I0.5501.00
148_L163_V0.5501.00
130_T297_H0.5491.00
157_S161_A0.5491.00
270_V273_K0.5471.00
31_F98_I0.5471.00
93_T169_S0.5451.00
51_M54_L0.5431.00
257_G260_E0.5361.00
42_V92_Y0.5321.00
87_M91_Q0.5311.00
291_T294_L0.5311.00
82_F180_A0.5291.00
37_D212_Q0.5261.00
244_S248_L0.5241.00
177_T241_F0.5241.00
25_T264_A0.5221.00
125_K181_V0.5211.00
87_M200_G0.5181.00
80_L84_L0.5181.00
193_V197_M0.5161.00
150_N279_F0.5141.00
48_T51_M0.5141.00
97_S101_G0.5131.00
75_S79_L0.5131.00
13_V241_F0.5121.00
74_A186_K0.5111.00
228_F231_L0.5111.00
281_W284_A0.5091.00
143_G286_C0.5071.00
266_V269_V0.5071.00
108_L147_L0.5061.00
112_L140_A0.5051.00
177_T254_S0.5051.00
39_N211_W0.5041.00
62_D68_E0.5031.00
180_A245_L0.5011.00
19_C236_I0.5011.00
76_A79_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2414 99 0.755 Contact Map
3b5dA 2 0.3166 98.1 0.816 Contact Map
4j05A 3 0.9342 92.5 0.887 Contact Map
3wdoA 1 0.9342 88.1 0.898 Contact Map
1pw4A 1 0.9498 85 0.903 Contact Map
4pypA 1 0.906 84.7 0.903 Contact Map
2cfqA 1 0.5987 81 0.907 Contact Map
4tphA 2 0.8558 80.9 0.907 Contact Map
4zw9A 1 0.9373 80.5 0.907 Contact Map
4he8J 1 0.4859 69.3 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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