GREMLIN Database
YDEC - Uncharacterized HTH-type transcriptional regulator YdeC
UniProt: P96660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (250)
Sequences: 30021 (25924)
Seq/√Len: 1639.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_L279_M3.3191.00
231_K239_D3.2021.00
242_I279_M3.1371.00
198_H240_Y3.0961.00
254_S262_Q3.0871.00
208_E218_R2.9651.00
244_K247_L2.8611.00
196_W200_H2.8241.00
200_H203_E2.7821.00
239_D278_A2.6251.00
193_M221_C2.4041.00
248_L262_Q2.3341.00
245_S271_F2.3251.00
275_F286_Y2.3201.00
225_F236_Y2.1911.00
206_T209_D2.0431.00
248_L263_V2.0391.00
57_L64_K2.0321.00
201_Y240_Y1.9691.00
197_I237_V1.9661.00
254_S258_E1.9461.00
57_L66_E1.8951.00
190_M229_L1.8651.00
234_L238_M1.8581.00
193_M214_G1.8311.00
196_W213_A1.8291.00
242_I278_A1.8151.00
248_L254_S1.7891.00
59_Q64_K1.7841.00
194_L229_L1.7821.00
207_L222_C1.7671.00
255_N258_E1.7361.00
249_L256_V1.7111.00
268_T272_I1.7031.00
220_E224_Y1.6951.00
274_K277_Q1.6951.00
162_Q165_L1.6761.00
195_N199_L1.6701.00
55_I66_E1.6681.00
210_I233_P1.6651.00
231_K235_R1.6571.00
246_L286_Y1.6501.00
196_W205_I1.6361.00
68_H71_D1.6261.00
138_L142_K1.6221.00
165_L169_N1.5881.00
221_C233_P1.5871.00
257_T268_T1.5861.00
240_Y244_K1.5591.00
198_H236_Y1.5441.00
233_P237_V1.5401.00
53_K92_T1.5361.00
55_I68_H1.5361.00
270_Y274_K1.5341.00
244_K248_L1.5231.00
201_Y244_K1.5141.00
220_E223_R1.5101.00
218_R222_C1.5101.00
247_L251_H1.5051.00
59_Q82_M1.4991.00
46_I77_S1.4961.00
216_L220_E1.4811.00
265_F274_K1.4791.00
281_M285_S1.4761.00
258_E262_Q1.4641.00
57_L84_E1.4411.00
202_V262_Q1.4401.00
259_V263_V1.4311.00
222_C233_P1.4261.00
257_T261_Y1.4221.00
197_I240_Y1.4201.00
258_E261_Y1.4181.00
61_N79_Y1.4101.00
187_S228_M1.3921.00
284_L288_K1.3821.00
269_S272_I1.3811.00
209_D213_A1.3741.00
245_S263_V1.3731.00
244_K263_V1.3701.00
208_E212_K1.3661.00
52_L94_I1.3531.00
219_S223_R1.3431.00
193_M210_I1.3351.00
161_M168_K1.3331.00
232_T235_R1.3131.00
161_M165_L1.3071.00
239_D243_Q1.3071.00
161_M164_T1.2791.00
194_L198_H1.2781.00
272_I282_T1.2771.00
252_P287_K1.2721.00
216_L221_C1.2661.00
203_E209_D1.2651.00
238_M274_K1.2641.00
41_H81_H1.2381.00
217_S220_E1.2311.00
240_Y243_Q1.2281.00
272_I284_L1.2171.00
254_S259_V1.1951.00
189_R216_L1.1901.00
53_K69_E1.1891.00
76_N79_Y1.1851.00
273_S277_Q1.1741.00
139_D143_K1.1671.00
43_H81_H1.1551.00
52_L92_T1.1491.00
139_D142_K1.1261.00
246_L250_Q1.1221.00
205_I210_I1.0951.00
47_Q81_H1.0931.00
158_D162_Q1.0891.00
207_L233_P1.0841.00
224_Y227_R1.0711.00
202_V244_K1.0671.00
210_I213_A1.0601.00
243_Q246_L1.0531.00
204_K266_N1.0521.00
284_L287_K1.0481.00
151_K155_Y1.0431.00
188_H192_Q1.0421.00
192_Q213_A1.0421.00
267_S273_S1.0411.00
285_S288_K1.0361.00
40_L80_L1.0351.00
211_A218_R1.0331.00
158_D165_L1.0291.00
224_Y228_M1.0261.00
160_T164_T1.0261.00
214_G221_C1.0261.00
197_I233_P1.0251.00
196_W214_G1.0231.00
282_T285_S1.0221.00
209_D212_K1.0151.00
169_N173_N1.0131.00
56_A91_C1.0101.00
204_K209_D1.0071.00
165_L168_K0.9971.00
189_R224_Y0.9961.00
164_T168_K0.9941.00
191_K195_N0.9921.00
248_L259_V0.9921.00
252_P259_V0.9871.00
189_R214_G0.9851.00
272_I276_Q0.9761.00
142_K146_Q0.9691.00
168_K172_V0.9601.00
43_H47_Q0.9581.00
194_L236_Y0.9571.00
241_R263_V0.9561.00
196_W210_I0.9541.00
71_D126_F0.9471.00
274_K278_A0.9361.00
238_M277_Q0.9351.00
246_L275_F0.9341.00
51_I56_A0.9311.00
192_Q195_N0.9301.00
235_R238_M0.9281.00
60_I63_E0.9261.00
279_M286_Y0.9191.00
219_S222_C0.9091.00
235_R239_D0.9031.00
234_L270_Y0.8921.00
256_V259_V0.8911.00
46_I74_F0.8891.00
238_M278_A0.8871.00
56_A67_V0.8851.00
59_Q84_E0.8701.00
201_Y237_V0.8691.00
207_L218_R0.8671.00
225_F229_L0.8651.00
270_Y273_S0.8641.00
216_L224_Y0.8611.00
242_I274_K0.8561.00
234_L237_V0.8531.00
190_M224_Y0.8501.00
59_Q62_E0.8471.00
143_K147_L0.8461.00
191_K194_L0.8421.00
57_L86_K0.8381.00
50_L72_G0.8351.00
225_F233_P0.8331.00
53_K90_D0.8321.00
91_C95_C0.8311.00
40_L82_M0.8291.00
190_M193_M0.8291.00
192_Q214_G0.8201.00
135_K139_D0.8151.00
210_I221_C0.8141.00
55_I86_K0.7991.00
200_H213_A0.7991.00
157_I160_T0.7981.00
276_Q282_T0.7981.00
249_L259_V0.7981.00
58_F73_L0.7921.00
201_Y263_V0.7901.00
49_V95_C0.7891.00
136_N169_N0.7881.00
56_A66_E0.7871.00
143_K162_Q0.7851.00
47_Q97_N0.7821.00
125_L129_G0.7811.00
245_S248_L0.7741.00
222_C232_T0.7731.00
250_Q286_Y0.7681.00
242_I271_F0.7661.00
134_A138_L0.7661.00
158_D161_M0.7641.00
75_I81_H0.7631.00
51_I54_G0.7611.00
193_M233_P0.7581.00
100_P104_L0.7571.00
201_Y205_I0.7571.00
186_K227_R0.7541.00
201_Y241_R0.7501.00
267_S270_Y0.7491.00
67_V73_L0.7481.00
260_S268_T0.7471.00
261_Y266_N0.7461.00
276_Q285_S0.7461.00
200_H209_D0.7441.00
235_R278_A0.7381.00
136_N139_D0.7381.00
114_Q118_F0.7371.00
223_R227_R0.7361.00
269_S282_T0.7341.00
189_R192_Q0.7331.00
236_Y240_Y0.7321.00
156_E160_T0.7301.00
281_M286_Y0.7301.00
158_D172_V0.7291.00
145_N149_Q0.7291.00
222_C234_L0.7261.00
193_M225_F0.7241.00
190_M228_M0.7191.00
135_K138_L0.7121.00
197_I236_Y0.7091.00
222_C226_K0.6971.00
158_D168_K0.6961.00
205_I209_D0.6951.00
136_N143_K0.6941.00
194_L225_F0.6931.00
266_N270_Y0.6861.00
249_L287_K0.6841.00
190_M194_L0.6831.00
187_S224_Y0.6821.00
49_V75_I0.6771.00
207_L234_L0.6741.00
193_M196_W0.6731.00
42_W80_L0.6691.00
169_N172_V0.6621.00
51_I67_V0.6601.00
113_V117_M0.6581.00
101_H104_L0.6571.00
269_S273_S0.6561.00
275_F281_M0.6541.00
231_K236_Y0.6471.00
162_Q169_N0.6451.00
55_I89_S0.6431.00
259_V287_K0.6411.00
186_K189_R0.6411.00
140_A144_I0.6411.00
205_I241_R0.6371.00
139_D146_Q0.6371.00
226_K232_T0.6361.00
190_M221_C0.6341.00
193_M197_I0.6261.00
267_S277_Q0.6261.00
256_V284_L0.6251.00
157_I161_M0.6251.00
198_H244_K0.6241.00
237_V241_R0.6241.00
154_L157_I0.6221.00
242_I265_F0.6201.00
271_F283_P0.6201.00
56_A83_A0.6201.00
49_V73_L0.6181.00
104_L107_E0.6171.00
92_T95_C0.6151.00
155_Y158_D0.6151.00
210_I214_G0.6151.00
121_N124_Y0.6141.00
61_N80_L0.6121.00
243_Q278_A0.6041.00
193_M213_A0.6031.00
255_N259_V0.6021.00
221_C229_L0.6011.00
268_T271_F0.5981.00
71_D128_A0.5971.00
155_Y159_I0.5971.00
229_L236_Y0.5951.00
247_L250_Q0.5951.00
153_S156_E0.5941.00
197_I205_I0.5921.00
212_K215_Q0.5891.00
237_V240_Y0.5891.00
49_V58_F0.5881.00
58_F75_I0.5871.00
205_I237_V0.5851.00
110_S114_Q0.5851.00
100_P103_V0.5841.00
184_M187_S0.5841.00
207_L219_S0.5831.00
147_L172_V0.5811.00
190_M214_G0.5811.00
146_Q150_Q0.5801.00
238_M242_I0.5791.00
211_A214_G0.5781.00
111_S115_P0.5771.00
51_I93_Y0.5761.00
195_N198_H0.5761.00
122_L125_L0.5751.00
226_K229_L0.5731.00
60_I75_I0.5721.00
243_Q279_M0.5711.00
186_K228_M0.5711.00
159_I162_Q0.5701.00
159_I163_L0.5701.00
48_F74_F0.5681.00
49_V93_Y0.5671.00
51_I91_C0.5651.00
238_M265_F0.5651.00
136_N140_A0.5651.00
143_K165_L0.5641.00
238_M270_Y0.5641.00
50_L141_V0.5621.00
115_P118_F0.5601.00
157_I168_K0.5591.00
245_S259_V0.5571.00
265_F270_Y0.5571.00
152_T155_Y0.5551.00
157_I164_T0.5541.00
140_A143_K0.5511.00
83_A93_Y0.5501.00
271_F275_F0.5481.00
249_L286_Y0.5481.00
187_S191_K0.5461.00
101_H105_S0.5461.00
52_L142_K0.5441.00
58_F83_A0.5441.00
133_W136_N0.5411.00
251_H254_S0.5401.00
140_A162_Q0.5391.00
124_Y128_A0.5391.00
163_L167_W0.5361.00
214_G218_R0.5341.00
41_H47_Q0.5341.00
274_K279_M0.5331.00
46_I49_V0.5331.00
188_H228_M0.5321.00
122_L127_L0.5321.00
196_W209_D0.5311.00
158_D169_N0.5301.00
52_L138_L0.5291.00
244_K262_Q0.5271.00
248_L251_H0.5261.00
37_Y84_E0.5231.00
58_F67_V0.5221.00
83_A95_C0.5161.00
210_I241_R0.5151.00
44_D78_G0.5141.00
162_Q166_M0.5131.00
111_S114_Q0.5111.00
260_S263_V0.5081.00
260_S265_F0.5071.00
196_W201_Y0.5061.00
148_I151_K0.5061.00
200_H205_I0.5051.00
50_L134_A0.5051.00
133_W173_N0.5041.00
45_E97_N0.5021.00
154_L158_D0.5011.00
143_K146_Q0.5011.00
124_Y127_L0.5011.00
67_V71_D0.5011.00
145_N148_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.866 100 0.255 Contact Map
1bl0A 1 0.3643 100 0.477 Contact Map
3oioA 1 0.3746 100 0.478 Contact Map
3oouA 1 0.3608 100 0.483 Contact Map
3mn2A 1 0.3608 100 0.488 Contact Map
3mklA 1 0.3746 100 0.492 Contact Map
2k9sA 1 0.3643 100 0.496 Contact Map
3lsgA 2 0.3505 100 0.497 Contact Map
3w6vA 1 0.3608 100 0.497 Contact Map
1d5yA 1 0.3643 100 0.501 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.