GREMLIN Database
YDDQ - Uncharacterized isochorismatase family protein YddQ
UniProt: P96654 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (163)
Sequences: 10567 (7358)
Seq/√Len: 576.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_N101_Q3.4001.00
107_E132_V2.7781.00
50_Q84_V2.7631.00
39_F44_A2.7151.00
97_N131_Y2.7001.00
89_N125_S2.5961.00
32_A111_C2.4291.00
3_T107_E2.4181.00
97_N129_H2.3941.00
10_I32_A2.2701.00
107_E134_Q2.2691.00
35_L136_V2.2571.00
110_V123_V2.1351.00
145_L149_D2.1121.00
31_N139_A1.9621.00
95_D99_K1.9501.00
13_D67_G1.9191.00
126_A133_C1.9101.00
120_D124_R1.9071.00
83_I99_K1.8561.00
12_N66_E1.8501.00
90_S122_T1.8321.00
155_E160_A1.8241.00
4_A105_V1.8181.00
31_N34_K1.8031.00
38_H42_T1.7961.00
47_F99_K1.7261.00
12_N72_E1.7071.00
31_N165_L1.6201.00
15_F71_H1.6151.00
3_T109_V1.5941.00
40_R80_E1.5691.00
49_V90_S1.5171.00
24_N27_K1.5151.00
45_P103_E1.5071.00
137_E164_A1.5061.00
81_T99_K1.4981.00
39_F109_V1.4921.00
109_V136_V1.4801.00
7_V36_L1.4771.00
137_E162_M1.4601.00
115_S148_E1.4481.00
66_E69_E1.4351.00
108_L126_A1.4081.00
33_A37_S1.3961.00
33_A73_S1.3901.00
7_V111_C1.3751.00
52_I68_V1.3731.00
115_S140_C1.3721.00
119_I135_V1.3651.00
138_D165_L1.3451.00
116_H142_T1.3401.00
110_V122_T1.3211.00
99_K103_E1.3051.00
146_Q149_D1.2831.00
34_K166_N1.2731.00
125_S129_H1.2681.00
52_I84_V1.2661.00
120_D154_A1.2601.00
28_A32_A1.2481.00
98_G102_E1.2441.00
6_L110_V1.2441.00
8_I118_C1.2361.00
135_V140_C1.2321.00
115_S152_V1.2251.00
63_P84_V1.2251.00
37_S41_N1.2081.00
142_T148_E1.2051.00
7_V10_I1.2021.00
50_Q70_I1.2001.00
101_Q131_Y1.1781.00
5_L39_F1.1761.00
30_Q73_S1.1761.00
35_L139_A1.1051.00
7_V32_A1.1041.00
12_N69_E1.0971.00
3_T44_A1.0841.00
50_Q82_V1.0781.00
149_D153_P1.0761.00
109_V134_Q1.0491.00
137_E152_V1.0451.00
36_L48_H1.0441.00
31_N138_D1.0411.00
36_L40_R1.0201.00
121_A124_R1.0121.00
139_A165_L1.0041.00
120_D151_I0.9841.00
123_V135_V0.9771.00
99_K102_E0.9761.00
52_I63_P0.9741.00
77_L80_E0.9731.00
70_I82_V0.9591.00
108_L133_C0.9521.00
115_S142_T0.9491.00
4_A47_F0.9431.00
100_L131_Y0.9291.00
91_F126_A0.9101.00
28_A141_A0.9051.00
95_D98_G0.9001.00
34_K38_H0.8881.00
54_E63_P0.8851.00
132_V161_F0.8771.00
59_H62_H0.8751.00
87_M93_N0.8641.00
35_L111_C0.8621.00
9_D85_K0.8581.00
153_P156_H0.8571.00
10_I113_M0.8471.00
6_L96_L0.8441.00
136_V139_A0.8411.00
38_H41_N0.8361.00
45_P105_V0.8331.00
90_S96_L0.8301.00
69_E75_R0.8241.00
150_K154_A0.8211.00
48_H76_P0.8181.00
148_E152_V0.8121.00
48_H70_I0.8111.00
134_Q161_F0.8011.00
34_K37_S0.7971.00
29_A33_A0.7951.00
33_A76_P0.7911.00
144_T147_I0.7861.00
106_K132_V0.7851.00
87_M130_G0.7841.00
111_C139_A0.7811.00
47_F103_E0.7781.00
76_P80_E0.7781.00
151_I155_E0.7721.00
134_Q163_A0.7701.00
62_H65_T0.7641.00
146_Q153_P0.7641.00
30_Q33_A0.7601.00
123_V155_E0.7601.00
36_L46_V0.7601.00
125_S128_E0.7551.00
92_F129_H0.7501.00
76_P82_V0.7481.00
113_M141_A0.7291.00
48_H79_K0.7251.00
140_C148_E0.7221.00
8_I110_V0.7211.00
30_Q34_K0.7201.00
81_T103_E0.7201.00
45_P99_K0.7111.00
12_N71_H0.7101.00
4_A100_L0.7091.00
123_V133_C0.7061.00
27_K30_Q0.6991.00
116_H154_A0.6981.00
29_A71_H0.6911.00
33_A75_R0.6891.00
110_V133_C0.6891.00
136_V163_A0.6881.00
66_E72_E0.6881.00
65_T68_V0.6821.00
110_V119_I0.6821.00
32_A139_A0.6821.00
153_P157_V0.6801.00
5_L111_C0.6801.00
10_I71_H0.6701.00
40_R77_L0.6701.00
28_A113_M0.6681.00
14_Y118_C0.6661.00
37_S77_L0.6641.00
147_I150_K0.6611.00
150_K153_P0.6611.00
47_F81_T0.6571.00
5_L35_L0.6551.00
57_I60_F0.6541.00
98_G101_Q0.6511.00
72_E75_R0.6491.00
152_V162_M0.6431.00
37_S75_R0.6401.00
17_N21_A0.6381.00
40_R79_K0.6351.00
114_M142_T0.6311.00
114_M143_T0.6291.00
127_V160_A0.6271.00
7_V48_H0.6241.00
29_A74_V0.6221.00
86_H93_N0.6201.00
34_K165_L0.6161.00
15_F29_A0.6141.00
48_H82_V0.6131.00
23_T27_K0.6121.00
146_Q150_K0.6071.00
154_A157_V0.6071.00
29_A73_S0.6051.00
48_H80_E0.6041.00
47_F83_I0.5991.00
5_L36_L0.5961.00
114_M117_M0.5961.00
23_T141_A0.5961.00
18_G21_A0.5951.00
116_H143_T0.5941.00
71_H74_V0.5941.00
50_Q68_V0.5931.00
123_V160_A0.5911.00
36_L39_F0.5871.00
35_L109_V0.5861.00
25_P113_M0.5861.00
92_F125_S0.5811.00
140_C152_V0.5741.00
133_C136_V0.5711.00
45_P80_E0.5680.99
87_M92_F0.5660.99
40_R46_V0.5650.99
92_F128_E0.5640.99
48_H74_V0.5630.99
161_F164_A0.5610.99
89_N128_E0.5580.99
88_P122_T0.5550.99
24_N141_A0.5540.99
54_E86_H0.5530.99
88_P127_V0.5510.99
119_I140_C0.5510.99
36_L80_E0.5490.99
13_D18_G0.5470.99
39_F45_P0.5430.99
15_F25_P0.5430.99
55_G59_H0.5380.99
8_I119_I0.5370.99
61_F67_G0.5350.99
50_Q69_E0.5300.99
5_L46_V0.5290.99
135_V155_E0.5270.99
27_K31_N0.5250.99
45_P81_T0.5230.99
10_I28_A0.5220.99
152_V155_E0.5200.99
51_H61_F0.5200.99
116_H147_I0.5190.99
64_N69_E0.5180.99
117_M143_T0.5170.99
11_Q50_Q0.5140.99
88_P128_E0.5070.99
26_E73_S0.5070.99
23_T26_E0.5070.99
76_P79_K0.5060.99
135_V152_V0.5060.99
35_L39_F0.5050.99
152_V156_H0.5050.99
147_I153_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lqyA 2 0.9333 100 0.154 Contact Map
1nbaA 4 0.9944 100 0.155 Contact Map
3irvA 2 0.9778 100 0.156 Contact Map
3ot4A 4 0.9611 100 0.158 Contact Map
3hb7A 3 0.9611 100 0.158 Contact Map
2fq1A 2 1 100 0.16 Contact Map
3hu5A 3 0.9667 100 0.164 Contact Map
4l07A 4 0.9833 100 0.164 Contact Map
3eefA 4 0.9222 100 0.168 Contact Map
3o94A 4 0.95 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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