GREMLIN Database
RAPI - Response regulator aspartate phosphatase I
UniProt: P96649 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (330)
Sequences: 1495 (1344)
Seq/√Len: 74.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_N281_V4.8251.00
199_E202_R4.7391.00
110_G126_Y4.1431.00
353_N356_L3.9251.00
239_E242_K3.8471.00
150_S166_A3.8041.00
231_G247_L3.7961.00
191_A207_F3.6541.00
146_F165_Y3.4541.00
204_L230_I3.2251.00
345_A361_Y2.8381.00
118_E121_S2.8131.00
158_Q161_F2.7491.00
344_V348_F2.6221.00
244_S273_E2.5101.00
356_L359_E2.5081.00
187_Q206_Q2.4331.00
231_G246_H2.4151.00
227_H246_H2.3851.00
195_I207_F2.3801.00
273_E281_V2.2081.00
106_Y125_A2.1681.00
163_M190_V2.1601.00
248_I269_L2.1391.00
188_F229_N2.1241.00
270_T286_F2.0771.00
34_Q37_I2.0631.00
269_L273_E2.0561.00
166_A189_I2.0331.00
349_H362_R2.0261.00
162_S193_N2.0191.00
149_V165_Y2.0061.00
240_Y272_V1.9881.00
163_M193_N1.9381.00
266_L285_Y1.9281.00
244_S269_L1.9201.00
231_G243_A1.9171.00
234_Y242_K1.9121.00
227_H249_L1.9051.00
247_L268_T1.8641.00
204_L237_L1.8611.00
244_S272_V1.8451.00
39_K43_E1.8341.00
184_V210_S1.8121.00
146_F168_R1.7961.00
150_S169_A1.7831.00
33_E37_I1.7791.00
103_Y129_A1.7741.00
273_E278_N1.7521.00
168_R171_K1.7511.00
126_Y148_K1.7321.00
309_E313_F1.6901.00
244_S276_Q1.6891.00
284_I288_K1.6751.00
281_V284_I1.6721.00
348_F356_L1.6281.00
269_L285_Y1.6231.00
308_L312_F1.6180.99
30_D33_E1.6140.99
251_L266_L1.6120.99
187_Q209_K1.5830.99
329_A363_M1.5670.99
190_V206_Q1.5650.99
305_F312_F1.5520.99
211_L223_I1.4930.99
251_L265_T1.4900.99
146_F149_V1.4880.99
255_E288_K1.4810.99
192_G207_F1.4670.99
242_K245_Q1.4540.99
107_F126_Y1.4490.99
31_Q34_Q1.4420.99
272_V276_Q1.4310.99
202_R205_E1.4290.99
148_K151_Y1.4290.99
35_A42_V1.4130.99
110_G125_A1.4020.99
184_V214_S1.3900.98
318_T322_K1.3850.98
328_L340_F1.3780.98
354_L357_S1.3740.98
268_T271_Y1.3690.98
36_E43_E1.3460.98
316_G319_Q1.3380.98
208_L230_I1.3360.98
161_F164_N1.3320.98
153_Y161_F1.3310.98
32_V36_E1.3230.98
123_I153_Y1.3050.98
365_I369_R1.2940.98
231_G361_Y1.2940.98
142_K146_F1.2730.97
304_K336_D1.2700.97
241_K276_Q1.2660.97
234_Y239_E1.2580.97
110_G129_A1.2570.97
32_V43_E1.2560.97
190_V194_L1.2540.97
194_L202_R1.2520.97
113_E125_A1.2390.97
235_D247_L1.2380.97
113_E118_E1.2370.97
46_L49_M1.2200.96
188_F207_F1.2190.96
204_L208_L1.2180.96
147_F189_I1.2130.96
345_A357_S1.2080.96
248_I281_V1.2060.96
163_M194_L1.2050.96
204_L234_Y1.1950.96
345_A364_S1.1920.96
53_Q56_L1.1920.96
270_T289_G1.1910.96
167_N202_R1.1880.96
366_E369_R1.1810.96
244_S248_I1.1700.95
305_F308_L1.1650.95
89_K93_K1.1630.95
49_M61_L1.1620.95
191_A210_S1.1620.95
109_K113_E1.1560.95
40_T44_K1.1500.95
113_E121_S1.1480.95
36_E45_E1.1460.95
106_Y128_I1.1390.95
34_Q38_I1.1290.95
154_Y166_A1.1100.94
224_A250_A1.1100.94
356_L360_Y1.1010.94
249_L253_I1.0990.94
30_D34_Q1.0980.94
191_A206_Q1.0970.94
247_L272_V1.0910.93
58_Y63_E1.0890.93
232_I268_T1.0890.93
357_S361_Y1.0850.93
235_D268_T1.0710.93
44_K47_L1.0560.92
108_F111_M1.0550.92
194_L199_E1.0490.92
165_Y168_R1.0480.92
235_D240_Y1.0460.92
150_S162_S1.0460.92
32_V38_I1.0450.92
172_I229_N1.0440.92
43_E46_L1.0390.92
235_D272_V1.0390.92
80_D88_I1.0320.91
38_I47_L1.0290.91
203_A243_A1.0270.91
365_I368_R1.0220.91
82_N85_Y1.0190.91
364_S368_R1.0180.91
340_F344_V1.0180.91
228_M268_T1.0080.90
83_N86_E1.0050.90
84_A92_E1.0050.90
235_D289_G1.0000.90
73_M76_K0.9970.90
37_I40_T0.9960.90
34_Q48_N0.9960.90
188_F192_G0.9950.90
230_I234_Y0.9940.90
121_S124_S0.9930.90
52_N59_Y0.9920.90
42_V45_E0.9920.90
345_A358_N0.9880.90
303_A308_L0.9830.89
341_S360_Y0.9820.89
251_L269_L0.9740.89
146_F169_A0.9730.89
107_F111_M0.9730.89
59_Y62_L0.9720.89
32_V37_I0.9700.89
37_I42_V0.9660.88
35_A38_I0.9650.88
32_V47_L0.9640.88
343_E346_D0.9640.88
323_N326_S0.9640.88
310_G315_D0.9610.88
40_T47_L0.9580.88
53_Q60_Q0.9550.88
191_A203_A0.9540.88
214_S222_L0.9530.88
279_Y283_L0.9390.87
311_L314_S0.9380.87
88_I92_E0.9350.87
134_S142_K0.9340.87
170_L183_T0.9320.87
187_Q194_L0.9310.87
144_E148_K0.9270.86
31_Q40_T0.9270.86
153_Y158_Q0.9210.86
55_A59_Y0.9190.86
207_F230_I0.9110.85
326_S329_A0.9060.85
49_M58_Y0.9060.85
130_E146_F0.9010.85
91_I277_Q0.8990.85
68_I127_R0.8960.84
89_K92_E0.8960.84
31_Q39_K0.8950.84
35_A39_K0.8890.84
247_L265_T0.8890.84
344_V360_Y0.8880.84
267_F271_Y0.8860.84
234_Y348_F0.8810.83
40_T43_E0.8790.83
204_L233_C0.8780.83
224_A251_L0.8770.83
263_T270_T0.8760.83
110_G114_F0.8760.83
200_Y240_Y0.8750.83
250_A265_T0.8740.83
231_G234_Y0.8710.83
201_E237_L0.8710.83
104_Y108_F0.8710.83
232_I235_D0.8670.82
35_A45_E0.8660.82
183_T187_Q0.8660.82
180_A183_T0.8650.82
60_Q63_E0.8640.82
211_L230_I0.8630.82
55_A60_Q0.8600.82
38_I45_E0.8520.81
191_A228_M0.8490.81
350_E361_Y0.8490.81
311_L325_F0.8470.81
32_V50_E0.8470.81
150_S222_L0.8470.81
39_K49_M0.8460.81
85_Y88_I0.8460.81
55_A62_L0.8460.81
337_V341_S0.8440.81
123_I127_R0.8430.81
167_N171_K0.8400.80
76_K92_E0.8350.80
191_A195_I0.8240.79
87_T91_I0.8230.79
228_M265_T0.8230.79
38_I41_E0.8210.79
189_I268_T0.8190.79
34_Q40_T0.8190.79
33_E45_E0.8160.78
224_A253_I0.8150.78
245_Q249_L0.8120.78
126_Y129_A0.8070.78
123_I152_V0.8050.77
66_H70_L0.7980.77
31_Q36_E0.7950.77
301_Y304_K0.7940.76
215_K223_I0.7930.76
358_N362_R0.7910.76
150_S210_S0.7910.76
266_L288_K0.7910.76
169_A172_I0.7890.76
209_K212_E0.7850.76
46_L56_L0.7780.75
54_D57_L0.7780.75
46_L51_E0.7750.75
127_R131_S0.7740.75
248_I273_E0.7730.75
167_N190_V0.7720.74
114_F126_Y0.7710.74
152_V165_Y0.7700.74
56_L64_F0.7690.74
194_L206_Q0.7590.73
102_E106_Y0.7570.73
214_S226_S0.7560.73
83_N87_T0.7560.73
346_D361_Y0.7520.72
36_E39_K0.7520.72
228_M231_G0.7500.72
345_A360_Y0.7500.72
38_I55_A0.7500.72
242_K246_H0.7490.72
270_T285_Y0.7480.72
231_G250_A0.7440.72
164_N171_K0.7420.71
37_I48_N0.7410.71
81_L84_A0.7390.71
90_E256_K0.7390.71
341_S363_M0.7380.71
357_S365_I0.7380.71
327_Y330_S0.7360.71
131_S134_S0.7350.71
62_L65_R0.7340.71
58_Y62_L0.7330.71
86_E92_E0.7300.70
61_L69_M0.7300.70
303_A310_G0.7290.70
141_E147_F0.7270.70
166_A170_L0.7240.70
56_L60_Q0.7240.70
143_A169_A0.7210.69
103_Y133_L0.7160.69
320_L323_N0.7110.68
99_G120_I0.7080.68
61_L65_R0.7000.67
145_F207_F0.7000.67
188_F226_S0.6990.67
355_M359_E0.6990.67
287_R291_F0.6970.67
227_H250_A0.6970.67
92_E128_I0.6960.67
145_F148_K0.6960.67
190_V230_I0.6940.66
109_K125_A0.6940.66
186_C189_I0.6930.66
274_A286_F0.6920.66
223_I227_H0.6910.66
34_Q51_E0.6900.66
191_A197_S0.6900.66
32_V35_A0.6900.66
88_I93_K0.6870.66
147_F269_L0.6810.65
37_I46_L0.6780.65
128_I131_S0.6720.64
218_N223_I0.6710.64
238_K279_Y0.6710.64
230_I246_H0.6700.64
157_K198_L0.6690.63
31_Q47_L0.6670.63
134_S137_E0.6670.63
40_T46_L0.6670.63
58_Y61_L0.6650.63
130_E145_F0.6630.63
130_E149_V0.6630.63
49_M56_L0.6620.63
332_K356_L0.6620.63
209_K213_I0.6610.63
32_V42_V0.6590.62
317_E320_L0.6590.62
263_T293_A0.6580.62
68_I72_Y0.6540.62
183_T186_C0.6510.61
119_L123_I0.6500.61
127_R365_I0.6490.61
210_S231_G0.6490.61
54_D65_R0.6490.61
201_E205_E0.6470.61
321_I328_L0.6470.61
159_T162_S0.6440.61
360_Y363_M0.6430.60
230_I269_L0.6400.60
185_R188_F0.6390.60
282_A286_F0.6360.60
215_K231_G0.6360.60
265_T269_L0.6350.59
42_V310_G0.6330.59
38_I49_M0.6330.59
354_L358_N0.6330.59
33_E63_E0.6320.59
348_F360_Y0.6270.59
360_Y364_S0.6250.58
309_E314_S0.6240.58
190_V278_N0.6230.58
49_M53_Q0.6230.58
36_E49_M0.6230.58
103_Y231_G0.6230.58
67_E70_L0.6230.58
252_E315_D0.6200.58
97_L103_Y0.6190.58
36_E47_L0.6180.57
170_L187_Q0.6170.57
35_A49_M0.6130.57
32_V49_M0.6130.57
86_E90_E0.6130.57
211_L274_A0.6120.57
347_Y350_E0.6090.56
231_G269_L0.6080.56
35_A46_L0.6080.56
208_L242_K0.6070.56
325_F346_D0.6070.56
349_H354_L0.6060.56
254_F265_T0.6060.56
37_I41_E0.6040.56
309_E312_F0.6030.56
285_Y289_G0.6030.56
39_K54_D0.6030.56
166_A190_V0.6020.55
150_S359_E0.6010.55
338_E368_R0.5990.55
277_Q352_G0.5990.55
45_E48_N0.5980.55
57_L61_L0.5960.55
98_T101_L0.5950.55
333_M336_D0.5940.54
213_I225_M0.5930.54
31_Q43_E0.5920.54
327_Y340_F0.5920.54
187_Q266_L0.5920.54
168_R227_H0.5910.54
311_L317_E0.5910.54
31_Q44_K0.5900.54
142_K145_F0.5880.54
126_Y145_F0.5870.54
45_E49_M0.5870.54
51_E56_L0.5870.54
187_Q210_S0.5830.53
161_F273_E0.5810.53
147_F186_C0.5810.53
39_K60_Q0.5810.53
349_H361_Y0.5800.53
110_G203_A0.5800.53
150_S165_Y0.5790.53
80_D83_N0.5790.53
31_Q37_I0.5780.52
114_F148_K0.5750.52
342_I365_I0.5730.52
31_Q48_N0.5730.52
43_E59_Y0.5720.52
346_D350_E0.5710.52
55_A58_Y0.5690.51
95_G191_A0.5670.51
126_Y130_E0.5670.51
234_Y244_S0.5650.51
58_Y125_A0.5640.51
170_L251_L0.5640.51
147_F188_F0.5630.51
358_N361_Y0.5630.51
147_F169_A0.5610.50
123_I149_V0.5610.50
103_Y144_E0.5610.50
33_E44_K0.5610.50
341_S346_D0.5600.50
156_M165_Y0.5600.50
289_G305_F0.5590.50
38_I46_L0.5580.50
133_L138_D0.5570.50
181_V242_K0.5550.50
289_G324_A0.5530.49
318_T324_A0.5530.49
207_F229_N0.5520.49
226_S239_E0.5520.49
53_Q63_E0.5510.49
39_K46_L0.5510.49
33_E42_V0.5500.49
304_K312_F0.5490.49
81_L85_Y0.5490.49
61_L64_F0.5470.49
207_F226_S0.5450.48
33_E47_L0.5440.48
127_R149_V0.5430.48
359_E363_M0.5430.48
299_K302_S0.5420.48
286_F290_R0.5420.48
186_C265_T0.5420.48
304_K310_G0.5390.48
72_Y75_S0.5380.48
160_Y164_N0.5350.47
99_G284_I0.5350.47
129_A145_F0.5330.47
153_Y247_L0.5330.47
307_I311_L0.5310.47
111_M148_K0.5310.47
216_E226_S0.5310.47
165_Y169_A0.5310.47
243_A272_V0.5280.46
206_Q210_S0.5270.46
58_Y65_R0.5270.46
65_R108_F0.5270.46
106_Y340_F0.5270.46
220_E253_I0.5250.46
240_Y244_S0.5240.46
30_D36_E0.5220.46
130_E133_L0.5210.45
299_K303_A0.5200.45
31_Q49_M0.5190.45
225_M228_M0.5190.45
110_G122_A0.5190.45
215_K249_L0.5180.45
30_D49_M0.5180.45
70_L74_K0.5170.45
252_E283_L0.5140.45
111_M126_Y0.5130.44
183_T204_L0.5130.44
114_F185_R0.5120.44
46_L50_E0.5120.44
352_G363_M0.5110.44
34_Q43_E0.5110.44
101_L126_Y0.5100.44
268_T296_S0.5100.44
44_K48_N0.5090.44
71_S85_Y0.5080.44
206_Q244_S0.5070.44
51_E57_L0.5070.44
56_L62_L0.5070.44
300_E304_K0.5060.44
220_E350_E0.5060.44
135_E138_D0.5060.44
35_A41_E0.5040.43
226_S237_L0.5030.43
302_S306_K0.5010.43
57_L60_Q0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i1aA 2 0.913 100 0.254 Contact Map
4gyoA 2 0.9207 100 0.286 Contact Map
3q15A 2 0.9335 100 0.292 Contact Map
3ulqA 1 0.9437 100 0.292 Contact Map
4gpkA 3 0.8772 100 0.344 Contact Map
1w3bA 2 0.8414 100 0.441 Contact Map
4ui9C 2 0.8747 100 0.446 Contact Map
3q7aA 1 0.7084 100 0.455 Contact Map
3sf4A 1 0.8389 100 0.455 Contact Map
3ro2A 1 0.7826 100 0.458 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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