GREMLIN Database
YDDG - Uncharacterized membrane protein YddG
UniProt: P96644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 815 (663)
Sequences: 140 (112)
Seq/√Len: 4.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
245_F285_Y4.7210.94
240_F245_F4.3580.90
244_N282_K3.8770.84
265_R290_E3.8350.83
99_L244_N3.2440.71
231_Y240_F3.2050.70
245_F519_P3.0860.67
282_K307_Q3.0770.66
340_L370_G2.9810.64
280_K284_D2.8690.61
95_G358_L2.8140.59
103_Q296_N2.6940.55
265_R296_N2.6900.55
358_L407_L2.6250.53
282_K387_Y2.5850.52
188_Q307_Q2.5500.51
237_M250_E2.5430.51
249_S315_V2.5270.50
282_K336_Q2.5070.50
191_L300_T2.5030.50
50_K237_M2.4960.50
301_S351_I2.4910.49
86_G311_S2.4600.48
21_T245_F2.4070.47
59_Y356_P2.3770.46
76_G108_F2.3650.46
228_R232_F2.3650.46
102_L265_R2.3520.45
199_V270_L2.3250.44
245_F270_L2.3170.44
116_S396_L2.3070.44
61_A307_Q2.3010.44
102_L336_Q2.2940.43
246_D285_Y2.2900.43
101_N587_G2.2810.43
310_E595_A2.2730.43
594_R597_I2.2700.43
254_N339_A2.2540.42
278_G458_A2.2540.42
590_D669_N2.2340.42
315_V369_L2.2230.41
610_Q616_Q2.2060.41
162_V269_L2.2030.41
245_F289_T2.1780.40
628_D667_N2.1600.40
122_T412_L2.1430.39
147_G307_Q2.1360.39
131_L245_F2.1350.39
54_F103_Q2.1330.39
95_G393_V2.1280.39
240_F244_N2.1130.38
284_D527_I2.1090.38
426_I454_A2.0960.38
81_T264_N2.0790.37
21_T130_A2.0730.37
75_V82_F2.0720.37
290_E296_N2.0660.37
96_M318_S2.0440.36
431_T556_A2.0410.36
103_Q347_P2.0180.36
82_F232_F2.0080.35
246_D255_E2.0070.35
223_T327_A2.0070.35
110_N178_K1.9970.35
110_N189_G1.9940.35
233_D389_T1.9530.34
115_V322_G1.9200.33
119_V194_A1.8590.31
103_Q265_R1.8540.31
96_M407_L1.8410.31
122_T394_D1.8380.31
309_G422_K1.8210.30
359_A430_V1.8100.30
98_I245_F1.8050.30
319_I369_L1.8030.30
296_N347_P1.7980.30
307_Q336_Q1.7900.30
282_K311_S1.7810.29
283_K456_E1.7780.29
307_Q412_L1.7740.29
339_A387_Y1.7550.29
185_V407_L1.7440.28
59_Y181_N1.7430.28
230_L329_A1.7340.28
443_M457_Q1.7200.28
669_N673_D1.7150.28
162_V361_S1.7050.27
136_C411_V1.6900.27
354_Y376_K1.6750.27
27_T193_T1.6700.27
245_F315_V1.6670.27
223_T353_A1.6610.26
270_L315_V1.6560.26
184_S188_Q1.6550.26
122_T282_K1.6530.26
319_I391_F1.6420.26
108_F531_N1.6230.26
354_Y404_M1.6200.25
244_N394_D1.6160.25
152_A232_F1.6010.25
153_M407_L1.5860.25
21_T110_N1.5840.25
192_L307_Q1.5780.24
393_V458_A1.5770.24
265_R347_P1.5750.24
45_G463_G1.5680.24
253_I265_R1.5600.24
304_V457_Q1.5540.24
172_N197_G1.5540.24
567_L570_L1.5470.24
390_C412_L1.5240.23
193_T319_I1.5180.23
122_T244_N1.5150.23
113_T416_L1.5140.23
611_K616_Q1.5050.23
160_I284_D1.5010.23
661_Y681_Q1.5000.23
172_N353_A1.4990.23
95_G407_L1.4930.23
16_V316_V1.4920.23
640_S651_K1.4910.23
610_Q617_L1.4890.23
235_A392_I1.4810.22
672_T681_Q1.4780.22
452_Q455_W1.4740.22
143_F384_L1.4740.22
12_V426_I1.4700.22
595_A639_T1.4660.22
147_G281_D1.4650.22
169_W324_P1.4580.22
646_L667_N1.4560.22
353_A542_L1.4520.22
284_D638_S1.4490.22
244_N390_C1.4360.21
148_S223_T1.4340.21
107_E252_K1.4320.21
244_N307_Q1.4230.21
383_V415_I1.4220.21
59_Y282_K1.4210.21
376_K423_R1.4160.21
202_V219_E1.4050.21
236_L243_V1.4050.21
102_L244_N1.4010.21
100_Y195_G1.4000.21
240_F310_E1.3980.21
15_I488_A1.3980.21
281_D457_Q1.3940.21
240_F332_N1.3920.21
119_V231_Y1.3910.21
194_A245_F1.3850.20
241_L265_R1.3840.20
131_L369_L1.3820.20
82_F418_I1.3810.20
20_L53_R1.3800.20
80_V326_L1.3800.20
223_T354_Y1.3760.20
253_I296_N1.3740.20
136_C350_F1.3650.20
82_F86_G1.3630.20
232_F309_G1.3620.20
35_T365_T1.3600.20
110_N530_H1.3540.20
524_A535_L1.3530.20
160_I578_P1.3490.20
342_I426_I1.3460.20
147_G412_L1.3440.20
88_I351_I1.3410.20
578_P600_D1.3410.20
178_K304_V1.3390.20
516_S519_P1.3370.20
681_Q693_A1.3360.19
326_L353_A1.3280.19
50_K466_G1.3240.19
123_L322_G1.3230.19
202_V639_T1.3220.19
93_D232_F1.3200.19
136_C422_K1.3160.19
672_T693_A1.3110.19
624_Q659_K1.3050.19
239_P245_F1.3030.19
300_T312_F1.3020.19
181_N356_P1.3020.19
192_L336_Q1.3010.19
396_L447_R1.2990.19
150_K322_G1.2980.19
146_R170_M1.2970.19
100_Y180_L1.2960.19
426_I549_Q1.2930.19
428_K594_R1.2930.19
128_G156_S1.2910.19
649_N666_Q1.2860.19
307_Q387_Y1.2840.19
699_E702_R1.2840.19
382_I584_L1.2820.18
82_F163_M1.2800.18
195_G373_Y1.2790.18
525_N572_K1.2790.18
322_G405_Y1.2770.18
61_A65_A1.2750.18
108_F180_L1.2750.18
672_T690_E1.2720.18
202_V449_N1.2690.18
254_N387_Y1.2680.18
58_R77_L1.2600.18
117_K122_T1.2590.18
315_V337_V1.2560.18
308_L350_F1.2550.18
272_Y285_Y1.2520.18
396_L458_A1.2480.18
283_K406_L1.2470.18
355_V570_L1.2440.18
57_S540_Q1.2380.18
240_F282_K1.2340.18
16_V505_T1.2300.18
325_F366_L1.2240.17
20_L691_P1.2230.17
323_I593_K1.2220.17
66_S333_F1.2180.17
102_L296_N1.2180.17
240_F350_F1.2180.17
252_K337_V1.2140.17
23_A182_A1.2120.17
352_L410_A1.2120.17
221_E375_L1.2100.17
99_L188_Q1.2080.17
79_N152_A1.2070.17
20_L23_A1.2060.17
108_F369_L1.2050.17
599_Q610_Q1.2040.17
549_Q595_A1.2020.17
270_L355_V1.2010.17
88_I395_K1.1990.17
307_Q404_M1.1980.17
663_Y682_K1.1960.17
401_G582_D1.1960.17
229_N405_Y1.1960.17
93_D244_N1.1940.17
383_V391_F1.1940.17
282_K412_L1.1930.17
426_I609_D1.1920.17
249_S252_K1.1910.17
95_G396_L1.1900.17
226_V353_A1.1900.17
159_F365_T1.1820.17
170_M420_F1.1820.17
82_F96_M1.1800.17
112_I350_F1.1760.17
69_L393_V1.1750.17
12_V53_R1.1750.17
129_E240_F1.1750.17
422_K508_G1.1730.17
82_F242_I1.1690.17
119_V363_F1.1670.16
432_A457_Q1.1670.16
336_Q412_L1.1640.16
170_M406_L1.1640.16
358_L396_L1.1630.16
368_R505_T1.1610.16
30_S344_F1.1540.16
464_V530_H1.1540.16
170_M416_L1.1530.16
590_D624_Q1.1530.16
350_F366_L1.1530.16
101_N358_L1.1520.16
304_V531_N1.1510.16
245_F337_V1.1490.16
316_V622_N1.1480.16
157_I389_T1.1470.16
128_G169_W1.1470.16
241_L270_L1.1450.16
148_S314_A1.1430.16
162_V592_S1.1390.16
122_T147_G1.1370.16
191_L428_K1.1370.16
690_E693_A1.1370.16
246_D426_I1.1340.16
346_V365_T1.1330.16
307_Q380_G1.1330.16
522_E582_D1.1310.16
164_V548_K1.1260.16
176_Y350_F1.1260.16
672_T694_Q1.1250.16
153_M247_E1.1250.16
265_R318_S1.1240.16
325_F387_Y1.1240.16
596_P665_E1.1220.16
117_K141_Y1.1210.16
6_K281_D1.1200.16
383_V426_I1.1200.16
612_E615_E1.1190.16
189_G322_G1.1170.16
124_K177_M1.1140.16
126_N313_I1.1120.16
93_D123_L1.1100.16
106_D180_L1.1100.16
353_A412_L1.1080.16
223_T314_A1.1070.16
509_Y535_L1.1040.15
127_F356_P1.1040.15
333_F394_D1.1000.15
162_V348_F1.0980.15
601_K658_Q1.0980.15
245_F252_K1.0960.15
105_I224_V1.0940.15
159_F314_A1.0880.15
697_T704_D1.0860.15
194_A374_L1.0850.15
127_F391_F1.0840.15
59_Y239_P1.0840.15
245_F287_K1.0820.15
594_R604_E1.0800.15
102_L411_V1.0780.15
333_F368_R1.0780.15
96_M253_I1.0750.15
122_T146_R1.0750.15
278_G333_F1.0730.15
603_D688_N1.0730.15
244_N274_L1.0700.15
669_N672_T1.0690.15
128_G170_M1.0680.15
316_V691_P1.0660.15
549_Q663_Y1.0640.15
501_S567_L1.0630.15
280_K312_F1.0610.15
128_G188_Q1.0580.15
240_F307_Q1.0570.15
102_L192_L1.0540.15
302_G369_L1.0540.15
148_S417_W1.0530.15
682_K687_S1.0530.15
13_S497_G1.0520.15
88_I435_V1.0510.15
101_N249_S1.0490.15
184_S336_Q1.0490.15
497_G647_Q1.0490.15
255_E281_D1.0480.15
184_S282_K1.0450.15
245_F294_Y1.0450.15
59_Y243_V1.0430.15
679_E683_D1.0420.15
232_F365_T1.0400.14
166_G231_Y1.0380.14
278_G393_V1.0360.14
385_F612_E1.0360.14
20_L153_M1.0350.14
232_F244_N1.0340.14
136_C236_L1.0330.14
31_A380_G1.0320.14
99_L325_F1.0320.14
268_K280_K1.0310.14
173_A265_R1.0300.14
119_V409_V1.0290.14
67_D117_K1.0280.14
270_L460_K1.0280.14
25_A280_K1.0260.14
153_M358_L1.0260.14
483_K637_E1.0240.14
553_E652_D1.0220.14
441_N473_T1.0170.14
86_G282_K1.0170.14
117_K146_R1.0150.14
191_L510_D1.0140.14
84_F110_N1.0100.14
322_G451_V1.0100.14
616_Q619_K1.0080.14
285_Y454_A1.0060.14
489_D582_D1.0030.14
92_V413_A1.0030.14
82_F305_F1.0020.14
296_N387_Y1.0010.14
355_V374_L0.9990.14
57_S426_I0.9980.14
155_R240_F0.9960.14
201_I330_F0.9960.14
405_Y423_R0.9950.14
318_S412_L0.9940.14
421_H448_Q0.9910.14
284_D464_V0.9890.14
620_Q625_Q0.9880.14
47_V164_V0.9880.14
67_D113_T0.9870.14
78_T142_L0.9870.14
674_Q689_S0.9840.14
76_G115_V0.9840.14
683_D690_E0.9840.14
169_W188_Q0.9830.14
509_Y675_Q0.9830.14
433_G437_S0.9770.14
322_G439_D0.9760.14
231_Y384_L0.9750.14
244_N381_V0.9740.14
59_Y412_L0.9720.13
108_F303_N0.9710.13
117_K339_A0.9690.13
688_N695_E0.9680.13
224_V245_F0.9670.13
608_T653_T0.9660.13
231_Y236_L0.9640.13
189_G552_K0.9630.13
245_F428_K0.9630.13
596_P641_N0.9620.13
433_G459_K0.9580.13
30_S162_V0.9570.13
19_F23_A0.9560.13
80_V232_F0.9550.13
358_L393_V0.9540.13
128_G240_F0.9530.13
160_I520_Q0.9520.13
62_N227_M0.9500.13
105_I269_L0.9470.13
313_I326_L0.9470.13
534_S567_L0.9460.13
21_T479_F0.9460.13
590_D687_S0.9450.13
307_Q356_P0.9450.13
340_L405_Y0.9430.13
695_E700_I0.9420.13
428_K608_T0.9400.13
65_A351_I0.9400.13
269_L394_D0.9390.13
152_A228_R0.9380.13
282_K339_A0.9350.13
50_K249_S0.9350.13
236_L239_P0.9330.13
18_L280_K0.9310.13
65_A104_P0.9310.13
106_D462_G0.9300.13
461_I464_V0.9290.13
162_V456_E0.9290.13
187_A245_F0.9280.13
111_S316_V0.9270.13
119_V441_N0.9270.13
481_G657_D0.9270.13
26_V344_F0.9270.13
117_K381_V0.9260.13
246_D264_N0.9240.13
541_T569_R0.9230.13
359_A383_V0.9230.13
95_G313_I0.9210.13
350_F422_K0.9200.13
108_F414_S0.9190.13
280_K360_Y0.9180.13
472_F480_G0.9180.13
80_V420_F0.9170.13
124_K404_M0.9160.13
199_V460_K0.9160.13
82_F148_S0.9140.13
105_I265_R0.9140.13
169_W244_N0.9140.13
20_L448_Q0.9120.13
192_L309_G0.9070.13
59_Y229_N0.9060.13
264_N463_G0.9060.13
282_K356_P0.9050.13
67_D141_Y0.9030.13
324_P405_Y0.9030.13
235_A410_A0.9020.13
492_T612_E0.9000.13
325_F423_R0.8980.12
324_P386_V0.8980.12
333_F379_L0.8970.12
180_L225_A0.8970.12
103_Q318_S0.8950.12
89_V240_F0.8910.12
373_Y377_A0.8910.12
152_A345_F0.8910.12
339_A373_Y0.8900.12
312_F584_L0.8870.12
395_K452_Q0.8870.12
297_E393_V0.8860.12
627_T651_K0.8850.12
95_G431_T0.8850.12
667_N699_E0.8810.12
234_I405_Y0.8800.12
231_Y332_N0.8790.12
454_A545_E0.8790.12
578_P681_Q0.8790.12
173_A241_L0.8780.12
634_H664_D0.8770.12
88_I476_T0.8760.12
124_K195_G0.8750.12
130_A245_F0.8740.12
93_D240_F0.8730.12
632_L642_R0.8720.12
244_N387_Y0.8680.12
408_N532_S0.8670.12
582_D673_D0.8660.12
93_D228_R0.8660.12
189_G451_V0.8660.12
93_D231_Y0.8650.12
569_R591_L0.8610.12
694_Q697_T0.8610.12
184_S384_L0.8610.12
30_S555_F0.8590.12
29_F507_M0.8580.12
273_K448_Q0.8580.12
249_S426_I0.8560.12
490_G526_G0.8560.12
248_T326_L0.8550.12
241_L253_I0.8540.12
314_A330_F0.8520.12
58_R307_Q0.8510.12
524_A544_K0.8500.12
191_L354_Y0.8490.12
333_F447_R0.8470.12
304_V369_L0.8460.12
224_V344_F0.8450.12
99_L240_F0.8440.12
311_S387_Y0.8430.12
385_F402_F0.8430.12
278_G297_E0.8370.12
499_G656_T0.8360.12
284_D662_I0.8360.12
620_Q637_E0.8350.12
285_Y316_V0.8340.12
358_L587_G0.8320.12
693_A700_I0.8300.12
68_D416_L0.8290.12
162_V615_E0.8280.12
146_R181_N0.8270.12
181_N228_R0.8270.12
127_F369_L0.8260.12
620_Q642_R0.8250.12
26_V329_A0.8220.12
99_L113_T0.8220.12
594_R611_K0.8210.12
160_I476_T0.8200.11
493_G552_K0.8180.11
324_P384_L0.8160.11
677_D680_V0.8160.11
123_L128_G0.8150.11
682_K691_P0.8140.11
228_R365_T0.8140.11
244_N412_L0.8140.11
682_K704_D0.8140.11
178_K473_T0.8120.11
7_K540_Q0.8110.11
245_F290_E0.8100.11
95_G441_N0.8090.11
697_T703_S0.8070.11
493_G500_N0.8070.11
245_F565_S0.8060.11
478_H633_Q0.8060.11
574_G582_D0.8050.11
638_S703_S0.8040.11
676_Q683_D0.8040.11
68_D185_V0.8030.11
419_G436_V0.8020.11
106_D115_V0.8020.11
192_L387_Y0.8020.11
146_R413_A0.8010.11
160_I272_Y0.8010.11
48_E268_K0.8000.11
59_Y254_N0.8000.11
535_L587_G0.8000.11
101_N407_L0.7990.11
407_L524_A0.7990.11
324_P332_N0.7960.11
667_N679_E0.7940.11
182_A306_N0.7930.11
186_E406_L0.7920.11
70_I337_V0.7910.11
113_T173_A0.7890.11
65_A163_M0.7880.11
450_I571_R0.7840.11
169_W390_C0.7840.11
61_A240_F0.7820.11
188_Q332_N0.7820.11
200_G312_F0.7810.11
15_I407_L0.7770.11
147_G231_Y0.7770.11
134_F488_A0.7760.11
276_E568_A0.7760.11
387_Y412_L0.7760.11
10_L57_S0.7730.11
200_G651_K0.7700.11
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457_Q462_G0.5820.09
628_D671_E0.5810.09
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62_N113_T0.5720.09
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462_G594_R0.5310.08
681_Q698_A0.5310.08
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309_G381_V0.5290.08
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264_N280_K0.5280.08
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351_I490_G0.5280.08
312_F414_S0.5270.08
600_D659_K0.5270.08
338_V354_Y0.5260.08
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102_L390_C0.5240.08
79_N100_Y0.5240.08
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109_A194_A0.5190.08
253_I437_S0.5190.08
246_D280_K0.5190.08
348_F527_I0.5180.08
307_Q390_C0.5180.08
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241_L290_E0.5170.08
319_I526_G0.5160.08
246_D296_N0.5160.08
186_E346_V0.5160.08
594_R623_N0.5160.08
144_C240_F0.5150.08
53_R426_I0.5150.08
232_F265_R0.5150.08
181_N387_Y0.5140.08
146_R282_K0.5140.08
187_A430_V0.5140.08
91_V124_K0.5130.08
101_N145_V0.5130.08
136_C324_P0.5120.08
599_Q656_T0.5110.08
608_T621_P0.5110.08
682_K698_A0.5110.08
485_G496_S0.5110.08
226_V393_V0.5090.08
57_S618_L0.5080.08
56_I406_L0.5070.08
329_A344_F0.5070.08
336_Q356_P0.5070.08
307_Q314_A0.5060.08
82_F423_R0.5060.08
302_G319_I0.5060.08
392_I410_A0.5060.08
673_D690_E0.5050.08
474_D654_E0.5040.08
30_S130_A0.5040.08
20_L519_P0.5040.08
69_L407_L0.5030.08
290_E347_P0.5020.08
232_F377_A0.5010.08
54_F236_L0.5010.08
237_M466_G0.5000.08
400_N441_N0.5000.08
305_F376_K0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pj0U 1 0.1043 30.4 0.982 Contact Map
4ryoA 1 0.1693 29.9 0.982 Contact Map
3j46n 1 0.1117 23.8 0.983 Contact Map
4h33A 3 0.108 21.2 0.984 Contact Map
3vouA 4 0.1669 17.5 0.984 Contact Map
3effK 4 0.1706 16 0.985 Contact Map
4cbcA 3 0.1129 15.4 0.985 Contact Map
1iflA 10 0.065 13.8 0.985 Contact Map
4cctA 7 0.1779 9.3 0.986 Contact Map
4cbfA 7 0.1779 9.3 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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