GREMLIN Database
YDDE - Uncharacterized protein YddE
UniProt: P96642 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 831 (710)
Sequences: 2566 (1788)
Seq/√Len: 67.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
723_R741_D7.8171.00
473_G726_R7.0381.00
466_C733_Y5.8791.00
27_R113_D5.6551.00
343_G349_C5.1431.00
507_I651_I4.9641.00
480_A735_I4.8111.00
703_D735_I4.7651.00
463_S472_T4.4761.00
345_T348_E4.3061.00
27_R181_E4.2941.00
725_G730_N4.2861.00
241_A353_A4.2321.00
343_G348_E4.2081.00
468_I480_A4.0631.00
565_F581_F4.0071.00
181_E187_E3.9401.00
719_R723_R3.9001.00
25_Y117_G3.8181.00
270_V339_I3.7801.00
339_I356_V3.7221.00
468_I479_L3.5431.00
343_G352_K3.3401.00
184_S187_E3.3221.00
504_R508_Q3.2261.00
243_V367_C3.0981.00
349_C353_A3.0961.00
477_S502_E3.0851.00
242_F340_V3.0461.00
500_K727_S2.9661.00
487_I699_V2.9191.00
722_R732_E2.8791.00
588_V603_I2.8621.00
238_G344_K2.8511.00
27_R115_I2.8321.00
738_S749_G2.7941.00
607_M618_A2.7821.00
764_E768_K2.7261.00
229_L240_S2.6971.00
480_A701_F2.6931.00
478_Y806_C2.6601.00
706_W741_D2.6491.00
26_Y180_G2.6171.00
484_F701_F2.5571.00
493_K696_E2.5481.00
88_M91_A2.5041.00
193_R197_V2.5011.00
465_H472_T2.4561.00
481_K502_E2.4171.00
26_Y172_A2.4151.00
24_A182_R2.3831.00
472_T750_N2.3631.00
92_R96_E2.3461.00
274_I333_M2.3351.00
172_A182_R2.3001.00
507_I530_Y2.2861.00
740_K745_E2.2611.00
17_T21_D2.2491.00
558_K586_S2.2311.00
601_L636_H2.2121.00
812_Q816_K2.1831.00
477_S727_S2.1721.00
488_S494_S2.1651.00
648_R696_E2.0741.00
706_W723_R2.0471.00
494_S649_I2.0471.00
25_Y188_M2.0431.00
233_S236_D2.0411.00
479_L755_F2.0401.00
507_I532_Y2.0271.00
344_K348_E1.9951.00
493_K689_L1.9931.00
348_E352_K1.9911.00
736_S742_A1.9851.00
507_I649_I1.9841.00
501_K504_R1.9781.00
272_M337_S1.9601.00
470_G474_N1.9531.00
241_A369_L1.9451.00
290_R319_R1.9441.00
736_S741_D1.9351.00
755_F792_F1.9071.00
243_V353_A1.9061.00
500_K724_I1.8921.00
24_A168_E1.8911.00
496_Y507_I1.8801.00
465_H725_G1.8631.00
488_S648_R1.8581.00
699_V733_Y1.8521.00
469_T756_A1.8511.00
26_Y182_R1.8331.00
707_I724_I1.8081.00
765_E768_K1.8071.00
702_I718_E1.8031.00
532_Y651_I1.7811.00
818_V821_K1.7721.00
534_T656_N1.7481.00
449_P483_I1.7341.00
360_L367_C1.7321.00
97_E101_L1.7321.00
496_Y503_M1.7271.00
719_R741_D1.7261.00
345_T349_C1.7231.00
331_H400_Q1.7141.00
135_I139_F1.7041.00
497_I702_I1.6980.99
25_Y183_L1.6820.99
506_W510_V1.6750.99
478_Y812_Q1.6620.99
29_K179_R1.6620.99
702_I708_F1.6610.99
93_Y97_E1.6590.99
756_A770_M1.6580.99
534_T653_E1.6570.99
724_I728_Y1.6540.99
550_S639_S1.6450.99
807_L810_E1.6410.99
266_F352_K1.6390.99
757_F790_C1.6310.99
330_V401_D1.6210.99
762_E766_V1.6210.99
11_H14_L1.6200.99
549_I585_T1.6170.99
211_K216_I1.6170.99
419_G425_V1.6110.99
723_R738_S1.6080.99
776_K793_K1.6050.99
599_G636_H1.6020.99
721_M732_E1.5950.99
479_L483_I1.5930.99
94_Y98_T1.5790.99
721_M725_G1.5740.99
496_Y651_I1.5710.99
91_A95_N1.5630.99
14_L24_A1.5570.99
335_W398_T1.5500.99
464_P731_A1.5490.99
346_K350_V1.5440.99
26_Y168_E1.5380.99
321_L332_V1.5360.99
313_T323_D1.5330.99
706_W736_S1.5310.99
723_R736_S1.5310.99
789_Q803_S1.5290.99
772_M776_K1.5280.99
566_E578_N1.5250.99
17_T23_W1.5150.99
726_R737_Q1.5100.99
583_R623_N1.4990.99
340_V381_M1.4810.99
465_H730_N1.4770.99
400_Q404_A1.4680.98
577_I617_K1.4540.98
110_T267_P1.4520.98
37_N40_K1.4470.98
496_Y649_I1.4460.98
279_K328_E1.4440.98
25_Y191_I1.4250.98
701_F733_Y1.4140.98
214_R217_T1.4100.98
588_V606_K1.4040.98
238_G342_H1.4000.98
477_S481_K1.4000.98
604_I626_V1.3990.98
627_S632_K1.3970.98
232_H236_D1.3930.98
690_F730_N1.3880.98
466_C753_V1.3800.98
274_I403_V1.3790.98
312_V316_T1.3750.98
172_A180_G1.3750.98
557_A684_G1.3630.98
333_M403_V1.3630.98
465_H722_R1.3580.97
14_L165_E1.3430.97
449_P733_Y1.3400.97
315_A319_R1.3360.97
158_T162_E1.3310.97
545_A637_D1.3220.97
468_I733_Y1.3070.97
214_R223_P1.3070.97
341_V356_V1.3060.97
536_D542_N1.3020.97
168_E172_A1.2990.97
501_K653_E1.2970.97
449_P466_C1.2940.97
60_D63_L1.2930.97
320_H324_E1.2930.97
420_F423_G1.2920.97
98_T101_L1.2910.97
591_A606_K1.2890.97
16_L22_V1.2880.97
754_A761_N1.2860.97
481_K503_M1.2840.96
239_Y345_T1.2800.96
741_D746_E1.2780.96
268_V339_I1.2750.96
99_V103_E1.2700.96
88_M92_R1.2700.96
492_I699_V1.2610.96
346_K349_C1.2600.96
562_Q582_L1.2580.96
419_G423_G1.2550.96
484_F494_S1.2550.96
738_S741_D1.2540.96
484_F699_V1.2290.95
722_R734_F1.2280.95
223_P229_L1.2240.95
601_L605_R1.2240.95
781_M801_K1.2230.95
97_E100_R1.2190.95
134_N140_N1.2170.95
230_H237_E1.2170.95
547_D589_I1.2140.95
710_T719_R1.2130.95
722_R751_F1.2020.95
603_I622_L1.2000.95
484_F496_Y1.1990.95
96_E100_R1.1990.95
33_I41_V1.1950.95
64_M119_K1.1940.95
587_E606_K1.1890.95
421_F424_W1.1880.95
615_V618_A1.1850.94
260_E359_H1.1830.94
283_K322_Q1.1790.94
576_D617_K1.1770.94
134_N137_S1.1760.94
91_A98_T1.1740.94
287_N322_Q1.1740.94
230_H233_S1.1650.94
11_H165_E1.1650.94
353_A369_L1.1620.94
504_R532_Y1.1600.94
645_L652_L1.1580.94
487_I492_I1.1520.94
474_N758_D1.1510.94
686_F690_F1.1500.94
561_V589_I1.1480.93
294_K315_A1.1280.93
420_F424_W1.1240.93
246_D368_R1.1240.93
574_K577_I1.1230.93
222_D230_H1.1190.93
71_E74_K1.1140.92
753_V792_F1.1120.92
88_M488_S1.1120.92
245_I339_I1.1100.92
535_L546_L1.1090.92
585_T588_V1.1090.92
267_P352_K1.1060.92
242_F338_V1.1050.92
500_K655_E1.1030.92
214_R218_N1.1030.92
707_I723_R1.1010.92
773_E776_K1.1000.92
772_M782_M1.0980.92
699_V731_A1.0960.92
813_G816_K1.0910.92
532_Y653_E1.0910.92
601_L627_S1.0900.92
270_V337_S1.0900.92
266_F341_V1.0870.91
95_N98_T1.0860.91
245_I337_S1.0820.91
568_V600_S1.0810.91
29_K181_E1.0790.91
705_A718_E1.0780.91
137_S143_T1.0740.91
776_K799_T1.0730.91
549_I564_I1.0680.91
706_W724_I1.0660.91
277_E334_N1.0640.91
245_I365_I1.0630.91
419_G424_W1.0600.90
479_L757_F1.0590.90
767_L774_V1.0580.90
7_M382_L1.0570.90
92_R95_N1.0530.90
655_E724_I1.0490.90
549_I561_V1.0490.90
502_E653_E1.0450.90
595_G598_V1.0430.90
488_S649_I1.0390.90
25_Y115_I1.0370.89
219_T222_D1.0360.89
450_F731_A1.0340.89
217_T221_I1.0330.89
237_E344_K1.0310.89
206_E211_K1.0250.89
240_S342_H1.0240.89
781_M785_M1.0240.89
360_L365_I1.0240.89
266_F356_V1.0230.89
278_S281_I1.0230.89
495_L686_F1.0230.89
700_E732_E1.0220.89
560_L564_I1.0210.89
484_F649_I1.0190.89
168_E182_R1.0150.88
137_S144_D1.0150.88
213_V216_I1.0150.88
137_S140_N1.0120.88
370_P373_D1.0110.88
790_C802_I1.0090.88
212_D219_T1.0090.88
91_A488_S1.0080.88
62_H65_M1.0050.88
205_N208_S1.0030.88
501_K656_N1.0010.88
157_S161_F1.0000.88
466_C755_F0.9970.87
421_F425_V0.9940.87
274_I546_L0.9920.87
793_K799_T0.9890.87
599_G602_D0.9890.87
720_Q724_I0.9850.87
767_L779_K0.9810.87
89_D95_N0.9810.87
332_V654_V0.9800.87
139_F143_T0.9790.87
243_V357_K0.9770.86
602_D605_R0.9770.86
741_D749_G0.9760.86
812_Q821_K0.9710.86
485_N510_V0.9710.86
717_V721_M0.9690.86
761_N764_E0.9680.86
493_K698_T0.9650.86
657_M678_A0.9640.86
134_N138_F0.9630.86
27_R187_E0.9620.86
719_R746_E0.9610.85
90_V95_N0.9610.85
718_E734_F0.9590.85
28_I581_F0.9580.85
599_G638_G0.9580.85
681_F684_G0.9570.85
220_I223_P0.9570.85
91_A94_Y0.9530.85
740_K765_E0.9520.85
702_I732_E0.9520.85
766_V770_M0.9520.85
49_Q400_Q0.9490.85
445_V802_I0.9460.85
228_V346_K0.9450.85
171_L175_M0.9440.84
501_K534_T0.9440.84
70_Y267_P0.9420.84
681_F685_K0.9400.84
502_E727_S0.9370.84
202_H206_E0.9350.84
27_R39_E0.9340.84
139_F142_A0.9330.84
622_L625_V0.9320.84
229_L233_S0.9280.83
465_H530_Y0.9270.83
816_K821_K0.9250.83
596_E602_D0.9240.83
51_L171_L0.9240.83
98_T105_R0.9230.83
48_W52_F0.9200.83
89_D92_R0.9180.83
419_G422_L0.9180.83
117_G121_K0.9140.83
626_V632_K0.9140.83
216_I224_T0.9130.82
531_N650_T0.9120.82
472_T746_E0.9120.82
476_K737_Q0.9110.82
66_Y69_E0.9100.82
258_F262_Q0.9090.82
603_I607_M0.9090.82
241_A349_C0.9090.82
654_V708_F0.9080.82
548_P741_D0.9080.82
493_K648_R0.9070.82
136_L143_T0.9060.82
703_D729_N0.9030.82
423_G426_D0.9030.82
14_L22_V0.9010.82
704_E737_Q0.9000.82
566_E573_G0.9000.82
587_E590_D0.8990.81
341_V349_C0.8970.81
181_E672_S0.8950.81
214_R219_T0.8950.81
245_I248_F0.8940.81
562_Q581_F0.8930.81
499_P720_Q0.8900.81
411_N441_S0.8870.81
274_I335_W0.8870.81
375_L379_Y0.8860.81
241_A350_V0.8860.81
606_K609_S0.8820.80
257_L406_S0.8810.80
467_L751_F0.8810.80
134_N141_T0.8770.80
476_K704_E0.8760.80
274_I364_G0.8750.80
212_D220_I0.8740.80
479_L802_I0.8700.79
350_V369_L0.8700.79
101_L105_R0.8700.79
135_I141_T0.8670.79
231_L247_E0.8670.79
579_T583_R0.8630.79
510_V649_I0.8620.79
675_K679_V0.8620.79
652_L682_A0.8600.78
134_N143_T0.8600.78
192_N325_I0.8600.78
759_E762_E0.8600.78
570_D574_K0.8590.78
488_S510_V0.8580.78
172_A176_A0.8580.78
135_I142_A0.8560.78
475_G737_Q0.8550.78
509_R814_A0.8550.78
195_H269_E0.8530.78
482_L486_Y0.8530.78
172_A491_N0.8530.78
243_V356_V0.8520.78
608_Q623_N0.8520.78
95_N99_V0.8510.78
530_Y651_I0.8500.78
169_E351_G0.8490.78
283_K326_K0.8470.77
13_N16_L0.8470.77
244_V338_V0.8460.77
62_H66_Y0.8440.77
579_T623_N0.8430.77
102_L654_V0.8410.77
482_L804_I0.8400.77
12_K345_T0.8390.77
529_K647_K0.8390.77
336_L408_F0.8390.77
795_Y798_R0.8380.77
244_V370_P0.8350.76
23_W384_G0.8330.76
702_I710_T0.8320.76
495_L698_T0.8290.76
134_N142_A0.8290.76
351_G355_I0.8240.75
91_A97_E0.8220.75
547_D551_F0.8220.75
62_H273_K0.8210.75
274_I402_G0.8210.75
753_V795_Y0.8210.75
103_E768_K0.8210.75
98_T102_L0.8200.75
30_S411_N0.8200.75
325_I332_V0.8160.75
620_D623_N0.8160.75
491_N648_R0.8150.75
683_L686_F0.8150.75
580_A583_R0.8150.75
473_G476_K0.8150.75
136_L142_A0.8140.75
26_Y171_L0.8130.74
325_I702_I0.8130.74
690_F700_E0.8110.74
496_Y535_L0.8110.74
421_F426_D0.8080.74
71_E267_P0.8080.74
290_R318_I0.8060.74
18_R213_V0.8030.74
252_M402_G0.8030.74
754_A793_K0.8030.74
215_S218_N0.8010.73
704_E726_R0.8000.73
618_A645_L0.7990.73
478_Y735_I0.7980.73
729_N819_E0.7940.73
463_S752_G0.7940.73
8_K16_L0.7930.73
531_N647_K0.7920.73
686_F730_N0.7910.72
483_I755_F0.7900.72
272_M403_V0.7900.72
136_L140_N0.7880.72
286_L318_I0.7860.72
657_M680_M0.7850.72
561_V585_T0.7840.72
568_V582_L0.7840.72
553_P558_K0.7830.72
477_S703_D0.7830.72
207_E211_K0.7820.72
472_T561_V0.7820.72
787_Q803_S0.7810.71
476_K726_R0.7800.71
817_T822_A0.7790.71
66_Y269_E0.7790.71
324_E329_D0.7790.71
212_D215_S0.7790.71
112_Y120_L0.7780.71
585_T603_I0.7760.71
775_T780_K0.7760.71
768_K774_V0.7740.71
63_L66_Y0.7740.71
690_F725_G0.7730.71
607_M635_I0.7730.71
65_M68_S0.7720.71
790_C804_I0.7720.71
91_A105_R0.7710.71
271_Q381_M0.7710.71
472_T737_Q0.7660.70
92_R101_L0.7660.70
495_L652_L0.7660.70
503_M506_W0.7650.70
468_I735_I0.7650.70
702_I721_M0.7650.70
532_Y706_W0.7640.70
676_S679_V0.7640.70
289_K292_Q0.7630.70
89_D97_E0.7630.70
265_P355_I0.7620.70
99_V102_L0.7620.70
10_I15_L0.7610.70
705_A734_F0.7610.70
175_M316_T0.7610.70
293_L296_E0.7600.69
466_C701_F0.7600.69
503_M507_I0.7590.69
674_L717_V0.7590.69
498_D548_P0.7580.69
193_R216_I0.7540.69
473_G741_D0.7540.69
450_F497_I0.7530.69
280_S361_K0.7530.69
138_F144_D0.7530.69
216_I717_V0.7530.69
215_S221_I0.7520.69
448_H451_L0.7500.68
14_L581_F0.7500.68
724_I727_S0.7500.68
190_Y200_L0.7500.68
139_F144_D0.7500.68
12_K594_K0.7490.68
23_W119_K0.7480.68
134_N139_F0.7480.68
96_E99_V0.7460.68
776_K785_M0.7460.68
15_L23_W0.7450.68
584_A618_A0.7430.68
709_T715_K0.7420.68
463_S473_G0.7410.67
272_M335_W0.7410.67
474_N757_F0.7400.67
336_L380_K0.7390.67
39_E179_R0.7390.67
408_F727_S0.7380.67
725_G732_E0.7370.67
165_E182_R0.7350.67
627_S636_H0.7350.67
584_A607_M0.7340.67
484_F652_L0.7340.67
483_I699_V0.7340.67
580_A615_V0.7340.67
341_V353_A0.7330.67
450_F464_P0.7330.67
90_V94_Y0.7280.66
694_Q698_T0.7280.66
14_L18_R0.7260.66
447_F482_L0.7250.66
6_P385_E0.7240.66
501_K723_R0.7230.66
473_G737_Q0.7220.65
7_M10_I0.7210.65
96_E590_D0.7210.65
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37_N43_S0.5570.46
316_T646_E0.5570.46
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167_V474_N0.5560.46
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88_M343_G0.5440.45
817_T821_K0.5440.45
341_V352_K0.5430.45
546_L639_S0.5430.45
577_I614_A0.5430.45
684_G687_C0.5430.45
94_Y97_E0.5430.45
63_L68_S0.5430.45
163_K351_G0.5420.45
259_Y698_T0.5420.45
345_T590_D0.5410.44
228_V349_C0.5410.44
31_N178_V0.5410.44
214_R222_D0.5410.44
292_Q404_A0.5410.44
499_P724_I0.5400.44
450_F753_V0.5400.44
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719_R738_S0.5400.44
53_E331_H0.5400.44
306_R538_E0.5390.44
257_L416_S0.5390.44
28_I317_M0.5390.44
727_S737_Q0.5380.44
73_E175_M0.5380.44
683_L721_M0.5380.44
687_C720_Q0.5380.44
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15_L316_T0.5370.44
320_H327_K0.5360.44
718_E732_E0.5360.44
88_M101_L0.5360.44
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648_R743_L0.5350.44
628_D632_K0.5350.44
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313_T316_T0.5340.44
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792_F802_I0.5330.44
29_K158_T0.5330.44
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36_Q751_F0.5330.44
90_V97_E0.5320.43
557_A688_E0.5320.43
356_V608_Q0.5320.43
502_E817_T0.5310.43
71_E108_R0.5300.43
449_P699_V0.5300.43
266_F585_T0.5290.43
738_S762_E0.5290.43
799_T819_E0.5290.43
198_R238_G0.5280.43
595_G768_K0.5280.43
155_N642_A0.5280.43
97_E105_R0.5280.43
477_S789_Q0.5270.43
324_E401_D0.5270.43
502_E788_G0.5270.43
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495_L554_P0.5250.43
319_R322_Q0.5250.43
251_N327_K0.5240.43
37_N622_L0.5240.43
537_H559_E0.5240.43
17_T119_K0.5240.43
217_T220_I0.5240.43
48_W483_I0.5240.43
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240_S498_D0.5230.42
447_F792_F0.5230.42
88_M98_T0.5230.42
96_E417_K0.5230.42
470_G788_G0.5220.42
221_I236_D0.5220.42
474_N801_K0.5220.42
553_P557_A0.5210.42
77_K367_C0.5210.42
445_V683_L0.5210.42
448_H724_I0.5210.42
801_K806_C0.5200.42
444_F700_E0.5200.42
491_N686_F0.5200.42
89_D173_N0.5190.42
702_I706_W0.5190.42
655_E731_A0.5190.42
100_R572_K0.5180.42
585_T589_I0.5180.42
791_L801_K0.5180.42
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286_L321_L0.5170.42
726_R741_D0.5170.42
483_I489_M0.5170.42
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247_E335_W0.5160.42
345_T509_R0.5160.42
674_L680_M0.5160.42
271_Q340_V0.5160.42
716_K720_Q0.5160.42
503_M510_V0.5150.41
575_D620_D0.5130.41
246_D358_R0.5130.41
198_R332_V0.5130.41
45_K496_Y0.5130.41
546_L705_A0.5120.41
112_Y262_Q0.5120.41
535_L657_M0.5120.41
380_K387_L0.5110.41
417_K491_N0.5110.41
222_D581_F0.5110.41
118_V168_E0.5110.41
782_M785_M0.5100.41
290_R322_Q0.5100.41
802_I807_L0.5100.41
447_F701_F0.5090.41
741_D757_F0.5090.41
268_V613_E0.5090.41
88_M216_I0.5080.41
330_V533_I0.5080.41
280_S284_P0.5080.41
270_V356_V0.5080.41
321_L600_S0.5070.41
423_G791_L0.5070.41
136_L160_F0.5070.41
620_D624_E0.5070.41
68_S113_D0.5070.41
119_K755_F0.5060.40
83_I712_Q0.5040.40
23_W117_G0.5040.40
34_P636_H0.5030.40
320_H323_D0.5030.40
75_R79_L0.5030.40
571_F574_K0.5020.40
77_K695_D0.5020.40
10_I14_L0.5020.40
478_Y549_I0.5020.40
366_T581_F0.5010.40
243_V312_V0.5010.40
343_G353_A0.5000.40
245_I733_Y0.5000.40
164_Y324_E0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ag6A 2 0.4152 100 0.648 Contact Map
4d2iA 3 0.5078 100 0.754 Contact Map
1e9rA 3 0.4332 100 0.796 Contact Map
2iusA 1 0.4332 99.3 0.91 Contact Map
2iutA 2 0.4031 98.7 0.928 Contact Map
4lyaA 1 0.3237 98.7 0.929 Contact Map
4nh0A 1 0.3237 98.3 0.937 Contact Map
4kfuA 1 0.2443 98.1 0.939 Contact Map
2i1qA 1 0.3502 98.1 0.94 Contact Map
1pznA 5 0.3381 97.8 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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